Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.

scientific article

Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NM.2251
P932PMC publication ID3859448
P698PubMed publication ID21076395
P5875ResearchGate publication ID47791801

P50authorCourtney G SansamQ57992464
Pablo TamayoQ59551108
Charles W RobertsQ60678094
P2093author name stringJill P Mesirov
Justin Klekota
Tewis Bouwmeester
Peter J Park
Sarah J Luchansky
Joshua Murtie
William R Sellers
Heinz Ruffner
Yoon-Jae Cho
Scott L Pomeroy
Silvia Buonamici
Markus Warmuth
Boris Wilson
Dongshu Chen
Marion Dorsch
Zainab Jagani
E Lorena Mora-Blanco
Kathy Hsiao
Elizabeth S McKenna
Joseph F Kelleher
Michael Tolstorukov
Phuong T L Nguyen
P2860cites workA physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathwayQ21735927
Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1Q22010791
SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcriptionQ24294282
Constitutional mutations of the hSNF5/INI1 gene predispose to a variety of cancersQ24534231
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profilesQ24536351
Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonistsQ24794838
Exploration, normalization, and summaries of high density oligonucleotide array probe level dataQ27861098
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastomaQ28237604
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancerQ28277002
The role of the human homologue of Drosophila patched in sporadic basal cell carcinomasQ28288407
Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumorsQ28294240
Identification of an amplified, highly expressed gene in a human gliomaQ28300727
Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by HedgehogQ29615369
Sonic hedgehog mediates the polarizing activity of the ZPAQ29616565
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1Q29617043
Prediction of central nervous system embryonal tumour outcome based on gene expressionQ29618619
Epigenetics and cancer without genomic instability.Q33346513
Gli genes and limb developmentQ33592073
Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 lossQ33922936
Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformation.Q34202062
The Gli code: an information nexus regulating cell fate, stemness and cancer.Q34685494
The SWI/SNF complex--chromatin and cancer.Q35667471
Gli1 is a target of Sonic hedgehog that induces ventral neural tube developmentQ36870138
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockadeQ37291730
Hedgehog signaling in development and cancer.Q37350250
Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex.Q37389731
Hijacking the chromatin remodeling machinery: impact of SWI/SNF perturbations in cancerQ37618471
Discovery of NVP-LDE225, a Potent and Selective Smoothened AntagonistQ39151730
Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.Q39949572
Loss of the hSNF5 gene concomitantly inactivates p21CIP/WAF1 and p16INK4a activity associated with replicative senescence in A204 rhabdoid tumor cellsQ40351489
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449Q42031842
Understanding the words of chromatin regulationQ42274324
Sporadic medulloblastomas contain PTCH mutations.Q42434884
The c-myc gene is a direct target of mammalian SWI/SNF-related complexes during differentiation-associated cell cycle arrestQ42805596
Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases.Q44086955
Chromatin immunoprecipitation assay for mammalian tissuesQ44920785
Identification of a prx1 limb enhancer.Q52169507
Expression of Cre recombinase in the developing mouse limb bud driven by aPrxl enhancerQ64965676
Highly penetrant, rapid tumorigenesis through conditional inversion of the tumor suppressor gene Snf5Q78570048
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)1429-1433
P577publication date2010-11-14
P1433published inNature MedicineQ1633234
P1476titleLoss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway
P478volume16

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cites work (P2860)
Q48278066A New Way Forward in Cancer Drug Discovery: Inhibiting the SWI/SNF Chromatin Remodelling Complex
Q42350797A novel independence test for somatic alterations in cancer shows that biology drives mutual exclusivity but chance explains most co-occurrence
Q91725342A proteomic approach identifies SAFB-like transcription modulator (SLTM) as a bidirectional regulator of GLI family zinc finger transcription factors
Q38220523A rationale to target the SWI/SNF complex for cancer therapy
Q42102894Activation of β-catenin/TCF targets following loss of the tumor suppressor SNF5.
Q36547802Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma.
Q52878923Altered primary chromatin structures and their implications in cancer development.
Q35950995Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway
Q53073070Arsenic trioxide inhibits tumor cell growth in malignant rhabdoid tumors in vitro and in vivo by targeting overexpressed Gli1.
Q36893203Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies
Q41183040BRD9 Inhibition, Alone or in Combination with Cytostatic Compounds as a Therapeutic Approach in Rhabdoid Tumors
Q92641658CDK7 inhibition suppresses aberrant hedgehog pathway and overcomes resistance to smoothened antagonists
Q99594988COMPASS and SWI/SNF complexes in development and disease
Q55177661Cancer epigenetics: Moving forward.
Q34287662Cancer genetics and epigenetics: two sides of the same coin?
Q92446415Case-based review: atypical teratoid/rhabdoid tumor
Q33907067Chromatin-regulating proteins as targets for cancer therapy
Q47098738Combined BRD4 and CDK9 inhibition as a new therapeutic approach in malignant rhabdoid tumors
Q89899078Concurrent Control of KSHV Life Cycle through Chromatin Modulation and Host Hedgehog Signaling: A New Prospect to the Therapeutic Potential of Lipoxin A4
Q55409347Concurrent IDH1 and SMARCB1 Mutations in Pediatric Medulloblastoma: A Case Report.
Q27027214Context-dependent signal integration by the GLI code: the oncogenic load, pathways, modifiers and implications for cancer therapy
Q36658489Contextualizing the Genes Altered in Bladder Neoplasms in Pediatric andTeen Patients Allows Identifying Two Main Classes of Biological ProcessesInvolved and New Potential Therapeutic Targets
Q82769625Crippling SWI-SNF makes tumors GLI-ful
Q38011541Crosstalk between TGF-β and hedgehog signaling in cancer.
Q40172063Diagnostic value of next-generation sequencing in an unusual sphenoid tumor.
Q37970954Diverse functions of ATP-dependent chromatin remodeling complexes in development and cancer
Q38639828Driver mutations of cancer epigenomes.
Q35149722Dual role of Brg chromatin remodeling factor in Sonic hedgehog signaling during neural development
Q36835530Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.
Q38058972Epigenetic alterations involved in cancer stem cell reprogramming
Q42024622Epigenetic inactivation of the tumor suppressor BIN1 drives proliferation of SNF5-deficient tumors.
Q39069889Epigenetic modification in chromatin machinery and its deregulation in pediatric brain tumors: Insight into epigenetic therapies
Q34426872Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition
Q39441283Epigenetics and Cancer Stem Cells: Unleashing, Hijacking, and Restricting Cellular Plasticity.
Q38709544Epigenomic regulation of oncogenesis by chromatin remodeling
Q26782730Epithelioid Sarcoma: Opportunities for Biology-Driven Targeted Therapy
Q35621426Epithelioid malignant peripheral nerve sheath tumor arising in a schwannoma, in a patient with "neuroblastoma-like" schwannomatosis and a novel germline SMARCB1 mutation
Q27027021Extracranial rhabdoid tumours: what we have learned so far and future directions
Q35035462Fibroblast growth factor receptors as novel therapeutic targets in SNF5-deleted malignant rhabdoid tumors
Q92989376GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling
Q48740583GLI1 Blockade Potentiates the Antitumor Activity of PI3K Antagonists in Lung Squamous Cell Carcinoma
Q39013082GLI1, a master regulator of the hallmark of pancreatic cancer
Q30671578Generation of a mouse model of atypical teratoid/rhabdoid tumor of the central nervous system through combined deletion of Snf5 and p53.
Q37392280Genome-Wide Profiles of Extra-cranial Malignant Rhabdoid Tumors Reveal Heterogeneity and Dysregulated Developmental Pathways.
Q48593235Germline SMARCE1 mutations predispose to both spinal and cranial clear cell meningiomas
Q64245029Gli Proteins: Regulation in Development and Cancer
Q34981146Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors.
Q99591085Hedgehog Signaling and Truncated GLI1 in Cancer
Q40575110INI1 (SMARCB1)-Deficient Sinonasal Carcinoma: A Clinicopathologic Report of 2 Cases
Q48738953Identification of genes involved in the biology of atypical teratoid/rhabdoid tumours using Drosophila melanogaster
Q39126217Loss of IGFBP7 expression and persistent AKT activation contribute to SMARCB1/Snf5-mediated tumorigenesis
Q48265018Loss of Smarc proteins impairs cerebellar development
Q45167839Loss-of-function mutations in SMARCE1 cause an inherited disorder of multiple spinal meningiomas
Q26781877Malignant teratoma in Klippel-Feil syndrome: a case report and review of the literature
Q34332647Mechanisms by which SMARCB1 loss drives rhabdoid tumor growth.
Q39794708Menin directly represses Gli1 expression independent of canonical Hedgehog signaling
Q36401173MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma
Q26829103Minireview: Conversing with chromatin: the language of nuclear receptors
Q38359284Molecular biology of pediatric brain tumors and impact on novel therapies
Q36561734Molecular characterization of metastatic exon 11 mutant gastrointestinal stromal tumors (GIST) beyond KIT/PDGFRα genotype evaluated by next generation sequencing (NGS)
Q42416688Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.
Q34315290Morphogen pathways as molecular targets for the treatment of fibrosis in systemic sclerosis
Q42514400Mutations in ACTRT1 and its enhancer RNA elements lead to aberrant activation of Hedgehog signaling in inherited and sporadic basal cell carcinomas.
Q26783611Non-Canonical Hh Signaling in Cancer-Current Understanding and Future Directions
Q64992804Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened.
Q30441193Novel insight into mutational landscape of head and neck squamous cell carcinoma
Q46075208Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation
Q33607443Oncogenic roles of SMARCB1/INI1 and its deficient tumors
Q36125613Prediction of response to therapy with ezatiostat in lower risk myelodysplastic syndrome
Q57962903Reproducibility of academic preclinical translational research: lessons from the development of Hedgehog pathway inhibitors to treat cancer
Q38083797Rhabdoid tumors: an initial clue to the role of chromatin remodeling in cancer
Q38121136Rhabdoid tumors: clinical approaches and molecular targets for innovative therapy
Q55384318Role and inhibition of GLI1 protein in cancer.
Q38734099SMARCA4/Brg1 coordinates genetic and epigenetic networks underlying Shh-type medulloblastoma development
Q91976791SMARCB1 Gene Mutation Predisposes to Earlier Development of Glioblastoma: A Case Report of Familial GBM
Q47925228SNF5 as a prognostic factor in skull base chordoma
Q39824572SNF5 is Involved in Suppression of Hepatocellular Carcinoma Progression via TGF-Beta 1 Signaling
Q34699803SNF5 is an essential executor of epigenetic regulation during differentiation.
Q34518342SNF5/INI1 deficiency redefines chromatin remodeling complex composition during tumor development.
Q27009284SWI/SNF chromatin-remodeling factors: multiscale analyses and diverse functions
Q37886668SWI/SNF nucleosome remodellers and cancer.
Q36456479Studying the role of the immune system on the antitumor activity of a Hedgehog inhibitor against murine osteosarcoma
Q48743328Syndromes predisposing to pediatric central nervous system tumors: lessons learned and new promises
Q35369863TCR-dependent transformation of mature memory phenotype T cells in mice
Q38467989Targeted exploration and analysis of large cross-platform human transcriptomic compendia
Q35904534Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
Q37232227Targeting hedgehog signaling in cancer: research and clinical developments
Q37689120Targeting signal transduction pathways of cancer stem cells for therapeutic opportunities of metastasis
Q60954611Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors
Q52323206Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study.
Q34738018The BET bromodomain inhibitor I-BET151 acts downstream of smoothened protein to abrogate the growth of hedgehog protein-driven cancers.
Q36240079The Hedgehog pathway: role in cell differentiation, polarity and proliferation
Q38896059The Many Roles of BAF (mSWI/SNF) and PBAF Complexes in Cancer
Q24338138The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis
Q92025302The SWI/SNF complex in cancer - biology, biomarkers and therapy
Q38826541The developmental and pathogenic roles of BAF57, a special subunit of the BAF chromatin-remodeling complex
Q34771550The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells
Q34306294The limitations of simple gene set enrichment analysis assuming gene independence
Q37601480The molecular pathogenesis of schwannomatosis, a paradigm for the co-involvement of multiple tumour suppressor genes in tumorigenesis
Q36536422The occurrence of intracranial rhabdoid tumours in mice depends on temporal control of Smarcb1 inactivation
Q34649133The role of genetics in the establishment and maintenance of the epigenome.
Q87131861Towards risk-adapted therapy for rhabdoid tumour subgroups
Q40009547Tumor Suppressor Function of CYLD in Nonmelanoma Skin Cancer
Q55251323Tumorigenic Cell Reprogramming and Cancer Plasticity: Interplay between Signaling, Microenvironment, and Epigenetics.
Q38160739Unraveling the therapeutic potential of the Hedgehog pathway in cancer
Q53116195Update from the 2011 International Schwannomatosis Workshop: From genetics to diagnostic criteria.
Q38053857What underlies the diversity of brain tumors?
Q36657085Whole Exome- and mRNA-Sequencing of an AT/RT Case Reveals Few Somatic Mutations and Several Deregulated Signalling Pathways in the Context of SMARCB1 Deficiency
Q58753351Widespread Expression of Hedgehog Pathway Components in a Large Panel of Human Tumor Cells and Inhibition of Tumor Growth by GANT61: Implications for Cancer Therapy
Q34991075Wongabel rhabdovirus accessory protein U3 targets the SWI/SNF chromatin remodeling complex

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