A New Way Forward in Cancer Drug Discovery: Inhibiting the SWI/SNF Chromatin Remodelling Complex

scientific article published on 18 December 2015

A New Way Forward in Cancer Drug Discovery: Inhibiting the SWI/SNF Chromatin Remodelling Complex is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/CBIC.201500565
P698PubMed publication ID26684344

P50authorGiovanna ZinzallaQ38544637
P2860cites workAkirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complexQ24301828
BAF60a interacts with p53 to recruit the SWI/SNF complexQ24317756
CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasisQ24320341
Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcomaQ24337483
Targeted disruption of the BCL9/β-catenin complex inhibits oncogenic Wnt signalingQ24632740
Regulation of chromatin by histone modificationsQ24635070
Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 InhibitionQ27700161
Structure and organization of chromatin fiber in the nucleusQ28080958
c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation functionQ28143677
Targeting bromodomains: epigenetic readers of lysine acetylationQ28238635
LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain InhibitorQ28260305
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2Q28269618
MAX inactivation in small cell lung cancer disrupts MYC-SWI/SNF programs and is synthetic lethal with BRG1Q28304512
The murine SNF5/INI1 chromatin remodeling factor is essential for embryonic development and tumor suppressionQ28508923
An essential switch in subunit composition of a chromatin remodeling complex during neural developmentQ28585238
LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain InhibitorQ28834025
The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell ProliferationQ30659086
Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B.Q33725449
The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapyQ33979793
SWI/SNF unwraps, slides, and rewraps the nucleosomeQ34181702
BAF60 A, B, and Cs of muscle determination and renewalQ34316322
Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulationQ34388531
Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cellsQ34480997
Rational design of small-molecule inhibitors for β-catenin/T-cell factor protein-protein interactions by bioisostere replacementQ34526416
ATP-dependent chromatin remodeling: genetics, genomics and mechanismsQ34627244
Modelling Myc inhibition as a cancer therapyQ34811008
Small-molecule inhibitors of the MDM2-p53 protein-protein interaction (MDM2 Inhibitors) in clinical trials for cancer treatment.Q35087851
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancersQ35092542
Finding cancer's weakest linkQ35764388
The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor StudiesQ36584337
Small molecule therapeutics targeting F-box proteins in cancerQ36600976
Inhibition of Myc family proteins eradicates KRas-driven lung cancer in miceQ36708046
Mechanisms and functions of ATP-dependent chromatin-remodeling enzymesQ38126255
Mutant p53 in cancer: new functions and therapeutic opportunitiesQ38197826
Vulnerabilities of mutant SWI/SNF complexes in cancer.Q38247363
SWI/SNF chromatin remodeling and human malignanciesQ38267106
Essential role of BRG, the ATPase subunit of BAF chromatin remodeling complexes, in leukemia maintenance.Q38272367
ARID1B is a specific vulnerability in ARID1A-mutant cancers.Q38276153
Loss of the tumor suppressor Snf5 leads to aberrant activation of the Hedgehog-Gli pathway.Q38339385
Targeting protein-protein interactions (PPIs) of transcription factors: Challenges of intrinsically disordered proteins (IDPs) and regions (IDRs).Q38540836
FBI1/Akirin2 promotes tumorigenicity and metastasis of Lewis lung carcinoma cellsQ39030106
Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancerQ41942526
Molecular pathways: SWI/SNF (BAF) complexes are frequently mutated in cancer--mechanisms and potential therapeutic insights.Q42416688
P433issue8
P921main subjectdrug discoveryQ1418791
P304page(s)677-682
P577publication date2015-12-18
P1433published inChemBioChemQ634395
P1476titleA New Way Forward in Cancer Drug Discovery: Inhibiting the SWI/SNF Chromatin Remodelling Complex
P478volume17

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cites work (P2860)
Q28074465Alterations of Epigenetic Regulators in Pancreatic Cancer and Their Clinical Implications
Q40093518Candida albicans Swi/Snf and Mediator Complexes Differentially Regulate Mrr1-induced MDR1 Expression and Fluconazole Resistance
Q47128083Chemical probes and inhibitors of bromodomains outside the BET family
Q57281865Domain architecture of BAF250a reveals the ARID and ARM-repeat domains with implication in function and assembly of the BAF remodeling complex
Q28076548Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon?
Q97653022Epigenetics in modulating immune functions of stromal and immune cells in the tumor microenvironment
Q49647261Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes

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