Maintaining cell identity: PRC2-mediated regulation of transcription and cancer

scientific article published on 23 September 2016

Maintaining cell identity: PRC2-mediated regulation of transcription and cancer is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P6179Dimensions Publication ID1027309366
P356DOI10.1038/NRC.2016.83
P698PubMed publication ID27658528

P50authorKristian HelinQ24704761
Itys CometQ55458625
Benjamin LeblancQ55458627
Eva M RiisingQ55459503
P2860cites workASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repressionQ24296658
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaBQ24299235
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activityQ24305075
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomasQ24339074
The genetic basis of early T-cell precursor acute lymphoblastic leukaemiaQ24601515
Loss of miR-200 Inhibition of Suz12 Leads to Polycomb-Mediated Repression Required for the Formation and Maintenance of Cancer Stem CellsQ24610880
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencingQ24612248
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomasQ24629777
Frequent mutation of histone-modifying genes in non-Hodgkin lymphomaQ24630610
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cellsQ24672969
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cellsQ24680814
Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic markerQ84025680
A687V EZH2 is a gain-of-function mutation found in lymphoma patientsQ84689750
Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformationQ88128182
The molecular basis for metameric pattern in the Drosophila embryoQ114755591
EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesisQ41543905
Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancerQ41942526
A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemiaQ42053261
Expression of enhancer of zeste homologue 2 is significantly associated with increased tumor cell proliferation and is a marker of aggressive breast cancerQ42491095
H3K36me3 key to Polycomb-mediated gene silencing in lineage specificationQ42566361
PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapiesQ42704491
Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylationQ43571544
The Polycomb-group gene eed regulates thymocyte differentiation and suppresses the development of carcinogen-induced T-cell lymphomasQ43861822
EED mutants impair polycomb repressive complex 2 in myelodysplastic syndrome and related neoplasmsQ44617220
Multiple mechanisms deregulate EZH2 and histone H3 lysine 27 epigenetic changes in myeloid malignancies.Q46045890
Ten different Polycomb group genes are required for spatial control of the abdA and AbdB homeotic productsQ47070468
Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma.Q47687051
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastomaQ48329991
Ectopic expression of the histone methyltransferase Ezh2 in haematopoietic stem cells causes myeloproliferative disease.Q50594569
Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide.Q50650644
Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia.Q50803016
Inactivation of polycomb repressive complex 2 components in myeloproliferative and myelodysplastic/myeloproliferative neoplasms.Q51848454
Lineage-specific polycomb targets and de novo DNA methylation define restriction and potential of neuronal progenitors.Q51956004
Polycomb Group proteins: an evolutionary perspective.Q51971914
Recruitment of components of Polycomb Group chromatin complexes in Drosophila.Q52584270
Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer.Q52889035
A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesisQ57261238
Revolution in the Polycomb hierarchyQ60483612
A double take on bivalent promotersQ26823816
Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoidsQ27314878
Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic MutationsQ27681082
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center originQ27851546
Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromesQ27851571
Control of developmental regulators by Polycomb in human embryonic stem cellsQ28235841
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2Q28269618
Deregulated expression of miR-26a and Ezh2 in rhabdomyosarcomaQ28304953
The dynamics and prognostic potential of DNA methylation changes at stem cell gene loci in women's cancerQ28480584
The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylationQ28508260
EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomasQ28741454
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27)Q29147438
Occupying Chromatin: Polycomb Mechanisms for Getting to Genomic Targets, Stopping Transcriptional Traffic, and Staying PutQ29301233
Polycomb complexes repress developmental regulators in murine embryonic stem cellsQ29547274
The Polycomb complex PRC2 and its mark in lifeQ29547358
A gene complex controlling segmentation in DrosophilaQ29547506
Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disordersQ29614510
Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitionsQ29614512
The polycomb group protein EZH2 is involved in progression of prostate cancerQ29614514
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutationsQ29615392
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastomaQ29616862
Epigenetic stem cell signature in cancerQ29622897
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancerQ29622925
Chromosomal distribution of PcG proteins during Drosophila developmentQ33239849
A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencingQ33268624
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylationQ33691942
Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinomaQ33710169
GC-rich sequence elements recruit PRC2 in mammalian ES cellsQ33775517
The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia.Q33915185
Altered distributions of Ultrabithorax transcripts in extra sex combs mutant embryos of DrosophilaQ33932029
Genetic analysis of the enhancer of zeste locus and its role in gene regulation in Drosophila melanogasterQ33956903
Chromatin proteins and modifications as drug targetsQ34038652
Regulation of tumor angiogenesis by EZH2.Q34073170
Short sequences can efficiently recruit histone H3 lysine 27 trimethylation in the absence of enhancer activity and DNA methylationQ34082870
Analysis of the coding genome of diffuse large B-cell lymphomaQ34205133
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformationQ34213023
The controversial role of the Polycomb group proteins in transcription and cancer: how much do we not understand Polycomb proteins?Q38260253
Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies.Q38329285
Context-dependent actions of Polycomb repressors in cancerQ38518851
Targeting Polycomb systems to regulate gene expression: modifications to a complex storyQ38595464
An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation.Q38773915
A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylationQ38953489
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors.Q38954754
Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphomaQ39021479
Sox4 is a master regulator of epithelial-mesenchymal transition by controlling Ezh2 expression and epigenetic reprogrammingQ39140073
EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activityQ39175582
The molecular basis for metameric pattern in the Drosophila embryoQ39467660
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation statesQ39487525
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylationQ39614645
Genome-wide analysis of Polycomb targets in Drosophila melanogasterQ40274308
Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogasterQ40289607
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancerQ34268216
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cellsQ34302726
Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferationQ34317380
An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1Q34341058
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomasQ34397318
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitorsQ34460151
EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signalingQ34584872
Suz12 binds to silenced regions of the genome in a cell-type-specific mannerQ34703113
Chromatin sampling--an emerging perspective on targeting polycomb repressor proteinsQ34976950
Ras-induced changes in H3K27me3 occur after those in transcriptional activityQ34979388
Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferationQ35208075
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemiaQ35742745
Polycomb repressive complex 2 is required for MLL-AF9 leukemiaQ35882496
A DNA hypermethylation module for the stem/progenitor cell signature of cancer.Q35914847
Impaired PRC2 activity promotes transcriptional instability and favors breast tumorigenesisQ36424889
SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locusQ36710858
Ezh1 and Ezh2 maintain repressive chromatin through different mechanismsQ36810306
Epigenetics: core misconceptQ36820068
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2.Q36835530
The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expressionQ36850449
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformationQ36926825
Three-dimensional culture sensitizes epithelial ovarian cancer cells to EZH2 methyltransferase inhibitionQ37079770
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancerQ37198891
Repression of E-cadherin by the polycomb group protein EZH2 in cancerQ37212534
EZH2 mutations are frequent and represent an early event in follicular lymphomaQ37272035
BRCA1-deficient mammary tumor cells are dependent on EZH2 expression and sensitive to Polycomb Repressive Complex 2-inhibitor 3-deazaneplanocin A.Q37360243
Integrated genomic analysis identifies recurrent mutations and evolution patterns driving the initiation and progression of follicular lymphomaQ37533656
EZH2 expands breast stem cells through activation of NOTCH1 signalingQ37612687
Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteinsQ37791830
Silencing chromatin: comparing modes and mechanismsQ37827337
The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigeneticsQ38059391
A new world of Polycombs: unexpected partnerships and emerging functionsQ38161767
Chromatin repressive complexes in stem cells, development, and cancerQ38218179
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastomaQ38259785
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)803-810
P577publication date2016-09-23
P1433published inNature Reviews CancerQ641657
P1476titleMaintaining cell identity: PRC2-mediated regulation of transcription and cancer
P478volume16

Reverse relations

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