New insights in the development of pancreatic cancer

scientific article

New insights in the development of pancreatic cancer is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/MOG.0000000000000295
P932PMC publication ID6028298
P698PubMed publication ID27454028

P2093author name stringSteven D Leach
Smrita Sinha
P2860cites workBruton Tyrosine Kinase-Dependent Immune Cell Cross-talk Drives Pancreas Cancer.Q38808099
p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells.Q38817859
Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual MechanismsQ38905926
Loss of Somatostatin Receptor Subtype 2 Promotes Growth of KRAS-Induced Pancreatic Tumors in Mice by Activating PI3K Signaling and Overexpression of CXCL16.Q38909479
NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas.Q38916311
The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in miceQ38919135
Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticityQ38920277
Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.Q39008845
miR-219-1-3p is a negative regulator of the mucin MUC4 expression and is a tumor suppressor in pancreatic cancer.Q39017335
Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United StatesQ39190004
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinomaQ41856856
MicroRNA-206 functions as a pleiotropic modulator of cell proliferation, invasion and lymphangiogenesis in pancreatic adenocarcinoma by targeting ANXA2 and KRAS genesQ42016960
Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancerQ45339155
IL35-Producing B Cells Promote the Development of Pancreatic NeoplasiaQ47098673
Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer.Q53215067
Microenvironmental hCAP-18/LL-37 promotes pancreatic ductal adenocarcinoma by activating its cancer stem cell compartment.Q53221266
SOX9 regulates ERBB signalling in pancreatic cancer development.Q53229089
Stat3/Socs3 Activation by IL-6 Transsignaling Promotes Progression of Pancreatic Intraepithelial Neoplasia and Development of Pancreatic CancerQ60594558
Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasisQ24336049
Core signaling pathways in human pancreatic cancers revealed by global genomic analysesQ24606006
Aberrant methylation of the 5' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNsQ28214865
SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growthQ28258574
Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolismQ28834389
Pancreatic cancers require autophagy for tumor growthQ29620331
Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinomaQ30502257
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.Q33858490
Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinomaQ33896442
Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterationsQ34017017
Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapyQ34253198
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survivalQ34269713
Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinomaQ35134601
Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formationQ35228755
Dual PI3K/mTOR Inhibitors Induce Rapid Overactivation of the MEK/ERK Pathway in Human Pancreatic Cancer Cells through Suppression of mTORC2.Q35374899
Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targetsQ35487646
Smoking accelerates pancreatic cancer progression by promoting differentiation of MDSCs and inducing HB-EGF expression in macrophagesQ35687807
Aberrant methylation of preproenkephalin and p16 genes in pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinomaQ35748110
Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancyQ36000807
IL17 Functions through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic CancerQ36296837
BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages.Q36319886
Hif1a Deletion Reveals Pro-Neoplastic Function of B Cells in Pancreatic Neoplasia.Q36664869
The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression.Q36803448
Radiation Therapy Induces Macrophages to Suppress T-Cell Responses Against Pancreatic Tumors in MiceQ37008807
Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma.Q37016288
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasiaQ37040899
Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinomaQ37123636
Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapyQ37127423
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolismQ37378754
Stromal biology and therapy in pancreatic cancer: a changing paradigmQ38494338
Genomic analyses identify molecular subtypes of pancreatic cancerQ38791499
P921main subjectpancreatic cancerQ212961
P577publication date2016-07-21
P1433published inCurrent Opinion in GastroenterologyQ15758708
P1476titleNew insights in the development of pancreatic cancer

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cites work (P2860)
Q60609732Commonly Used Pancreatic Stellate Cell Cultures Differ Phenotypically and in Their Interactions with Pancreatic Cancer Cells.
Q91792642Dendritic cell immunotherapy induces anti-tumor effect in a transgenic mouse model of pancreatic ductal adenocarcinoma
Q38849004PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk.
Q99403350Promising xenograft animal model recapitulating the features of human pancreatic cancer
Q92076388Targeting the complexity of Src signalling in the tumour microenvironment of pancreatic cancer: from mechanism to therapy

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