SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer

scientific article published on 23 October 2017

SOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1092337803
P356DOI10.1038/ONC.2017.393
P932PMC publication ID6545484
P698PubMed publication ID29059173

P2093author name stringY Qin
X Fan
H Zhou
J Fu
X Yu
L Song
Z Zhuang
J Ling
S Ji
P J Chiao
P2860cites workSLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinomaQ23920671
Genetics and biology of pancreatic ductal adenocarcinomaQ26765438
The Mcm2-7 replicative helicase: a promising chemotherapeutic targetQ26861045
Initiating DNA synthesis: from recruiting to activating the MCM complexQ28209642
Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cellsQ30536268
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in miceQ33604913
Secreted interleukin-1alpha induces a metastatic phenotype in pancreatic cancer by sustaining a constitutive activation of nuclear factor-kappaBQ33799457
Oncogenic activation of NF-kappaB.Q33849388
Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesisQ33910221
Modulation of pancreatic cancer chemoresistance by inhibition of TAK1Q35143975
MDC1 functionally identified as an androgen receptor co-activator participates in suppression of prostate cancer.Q35656832
Eukaryotic MCM proteins: beyond replication initiationQ35684975
MDC1 Enhances Estrogen Receptor-mediated Transactivation and Contributes to Breast Cancer SuppressionQ35891320
KrasG12D-induced IKK2/β/NF-κB activation by IL-1α and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma.Q35990138
NF-kB in development and progression of human cancerQ36108761
SOX9, a potential tumor suppressor in cervical cancer, transactivates p21WAF1/CIP1 and suppresses cervical tumor growthQ36299791
Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolismQ36319414
Signaling networks controlled by the MRN complex and MDC1 during early DNA damage responsesQ36476150
Upregulation of sex-determining region Y-box 9 (SOX9) promotes cell proliferation and tumorigenicity in esophageal squamous cell carcinomaQ36544540
NF-kappa B as a target for cancer therapyQ36709532
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaksQ36837486
Epigenetic regulation of SOX9 by the NF-κB signaling pathway in pancreatic cancer stem cellsQ37179115
The cellular response to DNA damage: a focus on MDC1 and its interacting proteinsQ37843633
Roles for KRAS in pancreatic tumor development and progressionQ38102106
Sox9 and programming of liver and pancreatic progenitorsQ38103364
The role of SOX9 transcription factor in pancreatic and duodenal developmentQ38117400
Transcriptional up-regulation of Sox9 by NF-κB in endometrial carcinoma cells, modulating cell proliferation through alteration in the p14(ARF)/p53/p21(WAF1) pathwayQ39331266
Bone morphogenetic protein 4 (BMP4) is required for migration and invasion of breast cancerQ39428841
Notch 2-positive progenitors with the intrinsic ability to give rise to pancreatic ductal cellsQ40415546
Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesisQ40666413
Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppressionQ41689907
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinomaQ41856856
Prognostic value of interleukin 2 and interleukin 15 in peritumoral hepatic tissues for patients with hepatitis B-related hepatocellular carcinoma after curative resectionQ44476147
Clinical implication of Sox9 and activated Akt expression in pancreatic ductal adenocarcinomaQ44907312
GSEA-P: a desktop application for Gene Set Enrichment Analysis.Q51909999
Novel SOX9 expression during human pancreas development correlates to abnormalities in Campomelic dysplasia.Q52117028
SOX9 expression predicts relapse of stage II colon cancer patients.Q53147256
SOX9 regulates ERBB signalling in pancreatic cancer development.Q53229089
The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cellsQ77904111
P433issue7
P407language of work or nameEnglishQ1860
P304page(s)912-923
P577publication date2017-10-23
P1433published inOncogeneQ1568657
P1476titleSOX9 activity is induced by oncogenic Kras to affect MDC1 and MCMs expression in pancreatic cancer
P478volume37

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cites work (P2860)
Q64259744Exopolysaccharide, Isolated From a Novel Strain lw01 Possess an Anticancer Effect on Head and Neck Cancer - Genetic and Biochemical Evidences
Q58697838Fibroblast Growth Factor 10 in Pancreas Development and Pancreatic Cancer
Q92773787Immune-related somatic mutation genes are enriched in PDACs with diabetes
Q92383002In silico identification of EP400 and TIA1 as critical transcription factors involved in human hepatocellular carcinoma relapse
Q90375389LOTUS: A single- and multitask machine learning algorithm for the prediction of cancer driver genes
Q98906859MYEOV increases HES1 expression and promotes pancreatic cancer progression by enhancing SOX9 transactivity
Q89848838Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer
Q99634411Roles for MDC1 in cancer development and treatment
Q60909293SOX9 is a dose-dependent metastatic fate determinant in melanoma
Q91838151The impact of TP53BP1 and MLH1 on metastatic capability in cases of locally advanced prostate cancer and their usefulness in clinical practice
Q64063248miR-1-3p suppresses proliferation of hepatocellular carcinoma through targeting SOX9

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