Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma.

scientific article

Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1593/NEO.101630
P932PMC publication ID3071086
P698PubMed publication ID21472142
P5875ResearchGate publication ID51031424

P50authorElisabetta FerrettiQ38326251
Enrico De SmaeleQ43415796
P2093author name stringAlberto Gulino
Isabella Screpanti
Danilo Cucchi
Maria Anna Occhione
Lucia Di Marcotullio
Roberto Bei
Gianluca Canettieri
Sonia Coni
Marta Moretti
Azzura Greco
Marella Maroder
Marianna Pelloni
Laura Pietrosanti
Paola Infante
Jelena Todorovic
P2860cites workHDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcriptionQ24292915
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HEF1-dependent Aurora A activation induces disassembly of the primary ciliumQ24647111
Modification of proteins by ubiquitin and ubiquitin-like proteinsQ28244250
Medulloblastoma: developmental mechanisms out of controlQ28302377
Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitorsQ28589954
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancerQ29615649
Hedgehog: functions and mechanismsQ29619190
Signaling pathways in medulloblastomaQ30446635
Hedgehog-Gli signalling and the growth of the brain.Q34514462
Histone deacetylase inhibitors in cancer therapyQ34659283
Chromosome 17p deletion in human medulloblastoma: a missing checkpoint in the Hedgehog pathwayQ35910352
An integrated approach identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated genes in developing cerebellum and medulloblastomaQ36405493
Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapyQ36559283
Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural developmentQ36599922
Born to bind: the BTB protein-protein interaction domain.Q36660566
Hedgehog signaling pathway in neural development and disease.Q36873897
REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastomaQ36987393
Medulloblastoma in childhood: new biological advancesQ37010548
Cerebellar granule cells: insights into proliferation, differentiation, and role in medulloblastoma pathogenesisQ37255423
Pathological and molecular heterogeneity of medulloblastoma.Q37289156
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockadeQ37291730
Medulloblastoma: role of developmental pathways, DNA repair signaling, and other players.Q37595542
Vismodegib, a small-molecule inhibitor of the hedgehog pathway for the treatment of advanced cancersQ37760113
Protected from the inside: Endogenous histone deacetylase inhibitors and the road to cancerQ37833362
Alternative splicing of the ErbB-4 cytoplasmic domain and its regulation by hedgehog signaling identify distinct medulloblastoma subsets.Q38311063
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stressQ38828331
Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylationQ39750898
Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes.Q41438658
Deconstructing the hedgehog pathway in development and diseaseQ41844372
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449Q42031842
The tumor suppressor gene KCTD11REN is regulated by Sp1 and methylation and its expression is reduced in tumorsQ42601921
Medulloblastoma growth inhibition by hedgehog pathway blockadeQ44119270
Molecular organization of the cullin E3 ligase adaptor KCTD11.Q54372064
Multiple genomic alterations including N-myc amplification in a primary large cell medulloblastoma.Q55475292
Molecular genetic studies of chromosome 11 and chromosome 22q DNA sequences in pediatric medulloblastomas.Q55476296
Targeting the Hedgehog pathway in cancerQ79397666
P433issue4
P921main subjectmedulloblastomaQ1333608
cullin family protein bindingQ21096356
Potassium channel tetramerization domain containing 6Q21096446
Potassium channel tetramerization domain containing 21Q21113532
P304page(s)374-385
P577publication date2011-04-01
P1433published inNeoplasiaQ2962042
P1476titleIdentification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma
P478volume13

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