| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1046256379 |
| P356 | DOI | 10.1038/ONC.2010.394 |
| P953 | full work available at URL | https://www.nature.com/articles/onc2010394 |
| https://www.nature.com/articles/onc2010394.pdf | ||
| P698 | PubMed publication ID | 20818436 |
| P50 | author | Elisabetta Ferretti | Q38326251 |
| Enrico De Smaele | Q43415796 | ||
| Giuseppe Giannini | Q91254992 | ||
| Lucia Di Marcotullio | Q94543164 | ||
| P2093 | author name string | A. Gulino | |
| I. Screpanti | |||
| M. Moretti | |||
| A. Greco | |||
| P. Infante | |||
| D. Mazzà | |||
| L. Pietrosanti | |||
| S. Coni | |||
| P2860 | cites work | Function of WW domains as phosphoserine- or phosphothreonine-binding modules | Q22008803 |
| Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase | Q24273416 | ||
| U box proteins as a new family of ubiquitin-protein ligases | Q24291397 | ||
| The ubiquitin-protein ligase Itch regulates p73 stability | Q24293071 | ||
| SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response | Q24298620 | ||
| The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice | Q24308721 | ||
| Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins | Q24645749 | ||
| Mechanisms underlying ubiquitination | Q27860656 | ||
| A novel pro-Arg motif recognized by WW domains | Q28140347 | ||
| WW and SH3 domains, two different scaffolds to recognize proline-rich ligands | Q28209648 | ||
| The tight junction-specific protein occludin is a functional target of the E3 ubiquitin-protein ligase itch | Q28215086 | ||
| Modification of proteins by ubiquitin and ubiquitin-like proteins | Q28244250 | ||
| The ubiquitin ligase itch is auto-ubiquitylated in vivo and in vitro but is protected from degradation by interacting with the deubiquitylating enzyme FAM/USP9X | Q28268269 | ||
| Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants | Q28588056 | ||
| The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover | Q28588830 | ||
| Hedgehog antagonist REN(KCTD11) regulates proliferation and apoptosis of developing granule cell progenitors | Q28589954 | ||
| The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20 | Q28593201 | ||
| Ubiquitin and ubiquitin-like proteins as multifunctional signals | Q30014838 | ||
| Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH. | Q31109069 | ||
| The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation | Q33282972 | ||
| Human ITCH E3 ubiquitin ligase deficiency causes syndromic multisystem autoimmune disease. | Q33708589 | ||
| Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain | Q34189079 | ||
| WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation | Q34220865 | ||
| Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change | Q34478754 | ||
| Gli and hedgehog in cancer: tumours, embryos and stem cells. | Q34665999 | ||
| Itchy, a Nedd4 Ubiquitin Ligase, Downregulates Latent Membrane Protein 2A Activity in B-Cell Signaling | Q34975783 | ||
| Asymmetric segregation of Numb: a mechanism for neural specification from Drosophila to mammals | Q35007086 | ||
| The multiple functions of Numb | Q35014902 | ||
| Hedgehog signaling promotes medulloblastoma survival via Bc/II | Q35570435 | ||
| The Nedd4 family of E3 ubiquitin ligases: functional diversity within a common modular architecture | Q35691527 | ||
| Ubiquitin ligases and the immune response | Q35698411 | ||
| WW or WoW: the WW domains in a union of bliss | Q36360723 | ||
| Orchestrating ontogenesis: variations on a theme by sonic hedgehog | Q36626603 | ||
| REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma | Q36987393 | ||
| The coactivator CRTC1 promotes cell proliferation and transformation via AP-1 | Q37083656 | ||
| The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity. | Q37116670 | ||
| Itch: a HECT-type E3 ligase regulating immunity, skin and cancer | Q37191002 | ||
| The HECT family of E3 ubiquitin ligases: multiple players in cancer development | Q37206488 | ||
| Ubiquitin-mediated fluorescence complementation reveals that Jun ubiquitinated by Itch/AIP4 is localized to lysosomes. | Q37570487 | ||
| Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation | Q39750898 | ||
| Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration. | Q39922005 | ||
| The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A | Q40677917 | ||
| MHC class I ubiquitination by a viral PHD/LAP finger protein. | Q40773241 | ||
| Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease | Q40781851 | ||
| Pathways of ubiquitin conjugation | Q41669001 | ||
| Cooperation between GLI and JUN enhances transcription of JUN and selected GLI target genes | Q42449507 | ||
| Gli1 is important for medulloblastoma formation in Ptc1+/- mice | Q42476399 | ||
| Dual degradation signals control Gli protein stability and tumor formation | Q42489576 | ||
| Gli1 induces G2/M arrest and apoptosis in hippocampal but not tumor-derived neural stem cells | Q42524752 | ||
| Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing | Q46834681 | ||
| A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor. | Q47071852 | ||
| A single point mutation in a group I WW domain shifts its specificity to that of group II WW domains | Q48192933 | ||
| Numb is a suppressor of Hedgehog signalling and targets Gli1 for Itch-dependent ubiquitination | Q48364639 | ||
| Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation | Q52545197 | ||
| Structure and function of the WW domain | Q53216103 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 65-76 | |
| P577 | publication date | 2010-09-06 | |
| 2011-01-06 | |||
| P1433 | published in | Oncogene | Q1568657 |
| P1476 | title | Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal | |
| P478 | volume | 30 |
| Q35974696 | A Novel Role of Numb as A Regulator of Pro-inflammatory Cytokine Production in Macrophages in Response to Toll-like Receptor 4 |
| Q90633426 | A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth |
| Q38071943 | A contemporary review of molecular candidates for the development and treatment of childhood medulloblastoma. |
| Q35604264 | A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome |
| Q37609934 | ATM kinase activity modulates ITCH E3-ubiquitin ligase activity. |
| Q36547802 | Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma. |
| Q90446030 | All-trans retinoic acid therapy induces asymmetric division of glioma stem cells from the U87MG cell line |
| Q41790543 | An old friend with new skills: Imiquimod as novel inhibitor of Hedgehog signaling in basal cell carcinoma |
| Q35097063 | Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks |
| Q38059538 | Control of stem cells and cancer stem cells by Hedgehog signaling: Pharmacologic clues from pathway dissection |
| Q36232579 | Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling |
| Q35655451 | Differential expression and clinical significance of three inflammation-related microRNAs in gangliogliomas |
| Q33931827 | Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development |
| Q92153532 | ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP |
| Q98288220 | Expression of Notch pathway components (Numb, Itch, and Siah-1) in colorectal tumors: A clinicopathological study |
| Q50298950 | GLI1 is degraded by the proteasome after ubiquitination by ITCH |
| Q50298947 | GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP |
| Q34981146 | Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors. |
| Q34770115 | Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy |
| Q34118892 | Gli3 repressor controls cell fates and cell adhesion for proper establishment of neurogenic niche |
| Q64226618 | Glycine Regulates Neural Stem Cell Proliferation During Development Lnx1-Dependent Notch Signaling |
| Q35683842 | HECT E3 Ubiquitin Ligase Itch Functions as a Novel Negative Regulator of Gli-Similar 3 (Glis3) Transcriptional Activity. |
| Q99591085 | Hedgehog Signaling and Truncated GLI1 in Cancer |
| Q100633906 | Hepatic stem cell Numb gene is a potential target of Huang Qi Decoction against cholestatic liver fibrosis |
| Q90279272 | ITCH as a potential therapeutic target in human cancers |
| Q33864635 | Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. |
| Q95855995 | Itch attenuates CD4 T cell proliferation in mice by limiting WBP2 protein stability |
| Q27332234 | Itch is required for lateral line development in zebrafish |
| Q52363961 | Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis. |
| Q47166318 | Lithium Suppresses Hedgehog Signaling via Promoting ITCH E3 Ligase Activity and Gli1-SUFU Interaction in PDA Cells |
| Q41335500 | Maml1 acts cooperatively with Gli proteins to regulate sonic hedgehog signaling pathway. |
| Q36676833 | Monoubiquitination of survival motor neuron regulates its cellular localization and Cajal body integrity |
| Q50298948 | NUMB binds ITCH |
| Q37589507 | NUMB inhibition of NOTCH signalling as a therapeutic target in prostate cancer |
| Q59130214 | NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts |
| Q50298949 | NUMB:ITCH bind and ubiquitnate GLI1 |
| Q50298984 | NUMB:ITCH binds GLI1 |
| Q50298985 | NUMB:ITCH ubiquitinates GLI1 |
| Q39611297 | Negative Regulation of the Hippo Pathway by E3 Ubiquitin Ligase ITCH Is Sufficient to Promote Tumorigenicity |
| Q64992804 | Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened. |
| Q59137750 | Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells |
| Q42436142 | Numb Localizes at Endosomes and Controls the Endosomal Sorting of Notch after Asymmetric Division in Drosophila |
| Q90403098 | Numb has distinct function in lung adenocarcinoma and squamous cell carcinoma |
| Q36080257 | Numb regulates the polarized delivery of cyclic nucleotide-gated ion channels in rod photoreceptor cilia |
| Q34541645 | Numb-dependent integration of pre-TCR and p53 function in T-cell precursor development. |
| Q34926779 | Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling |
| Q39098638 | PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress |
| Q36041364 | Regulation of Hedgehog signaling by ubiquitination |
| Q38823123 | Regulation of PTEN degradation and NEDD4-1 E3 ligase activity by Numb |
| Q34518987 | Regulation of Sufu activity by p66β and Mycbp provides new insight into vertebrate Hedgehog signaling |
| Q64246334 | Targeting Hedgehog Signalling through the Ubiquitylation Process: The Multiple Roles of the HECT-E3 Ligase Itch |
| Q38530613 | The E3 ligase Itch in immune regulation and beyond. |
| Q39189628 | The RNA-binding protein Rbfox2: an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion |
| Q24336887 | The antagonistic action of B56-containing protein phosphatase 2As and casein kinase 2 controls the phosphorylation and Gli turnover function of Daz interacting protein 1 |
| Q33752055 | The bantam microRNA acts through Numb to exert cell growth control and feedback regulation of Notch in tumor-forming stem cells in the Drosophila brain |
| Q36962669 | The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint |
| Q53227690 | The intracellular domain of Jagged-1 interacts with Notch1 intracellular domain and promotes its degradation through Fbw7 E3 ligase |
| Q52326270 | The latent geometry of the human protein interaction network. |
| Q50137436 | The ubiquitin ligase ITCH coordinates small intestinal epithelial homeostasis by modulating cell proliferation, differentiation, and migration |
| Q38945828 | The ubiquitin-proteasome system and chromosome 17 in cerebellar granule cells and medulloblastoma subgroups |
| Q35134937 | Tug of war between survival and death: exploring ATM function in cancer |
| Q34480661 | WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response |
| Q90266281 | Wnt, Notch, and TGF-β Pathways Impinge on Hedgehog Signaling Complexity: An Open Window on Cancer |
| Q50298986 | ub-GLI is degraded by the proteasome |
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