| scholarly article | Q13442814 |
| P2093 | author name string | Brian J North | |
| Jianping Guo | |||
| Wenyi Wei | |||
| Xiangpeng Dai | |||
| Zhiwei Wang | |||
| Ji Cheng | |||
| Kaixiong Tao | |||
| P2860 | cites work | Preclinical evidences toward the use of triterpenoid CDDO-Me for solid cancer prevention and treatment | Q21245749 |
| Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells | Q22010574 | ||
| Hallmarks of Cancer: The Next Generation | Q22252312 | ||
| Acetylation-dependent regulation of Skp2 function | Q24292805 | ||
| K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking | Q24295450 | ||
| Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway | Q24296695 | ||
| CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity. | Q24296919 | ||
| Breast cancer metastasis suppressor 1 (BRMS1) is destabilized by the Cul3-SPOP E3 ubiquitin ligase complex | Q24297410 | ||
| A CK2-dependent mechanism for degradation of the PML tumor suppressor | Q24298158 | ||
| The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 | Q24300456 | ||
| UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids | Q24300880 | ||
| Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1 | Q24303428 | ||
| Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension | Q24304929 | ||
| Ubiquitin-dependent regulation of COPII coat size and function | Q24305964 | ||
| The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses | Q24306576 | ||
| KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron | Q24307394 | ||
| A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells | Q24307672 | ||
| The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation | Q24315972 | ||
| The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells | Q24317195 | ||
| Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement | Q24318748 | ||
| Control of rapsyn stability by the CUL-3-containing E3 ligase complex | Q24318969 | ||
| Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover | Q24319707 | ||
| Translational homeostasis via the mRNA cap-binding protein, eIF4E | Q24320659 | ||
| Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer | Q38705858 | ||
| Management of menopausal symptoms in women with gynecologic cancers | Q38720569 | ||
| SPOP promotes SIRT2 degradation and suppresses non-small cell lung cancer cell growth | Q38722041 | ||
| Cullin 3SPOP ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6. | Q38733838 | ||
| Melatonin and the von Hippel-Lindau/HIF-1 oxygen sensing mechanism: A review | Q38743052 | ||
| Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate | Q38746625 | ||
| SPOP promotes tumor progression via activation of β-catenin/TCF4 complex in clear cell renal cell carcinoma | Q38749330 | ||
| Cutting Edge: A Cullin-5-TRAF6 Interaction Promotes TRAF6 Polyubiquitination and Lipopolysaccharide Signaling. | Q38768063 | ||
| A review of gigaxonin mutations in giant axonal neuropathy (GAN) and cancer | Q38792675 | ||
| FoxO3 inactivation promotes human cholangiocarcinoma tumorigenesis and chemoresistance through Keap1-Nrf2 signaling | Q38795542 | ||
| A mechanism for the suppression of homologous recombination in G1 cells | Q38813207 | ||
| Recent advances in SCF ubiquitin ligase complex: Clinical implications | Q38828721 | ||
| SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein | Q38834625 | ||
| The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update | Q38837451 | ||
| SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression. | Q38837458 | ||
| Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination | Q38852414 | ||
| Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension | Q24321928 | ||
| A Cullin3-KLHL20 Ubiquitin Ligase-Dependent Pathway Targets PML to Potentiate HIF-1 Signaling and Prostate Cancer Progression | Q24322269 | ||
| Ubiquitylation-dependent localization of PLK1 in mitosis | Q24322683 | ||
| Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase | Q24336527 | ||
| The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis | Q24336860 | ||
| Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4 | Q24338315 | ||
| Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival | Q24338406 | ||
| SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer | Q24339492 | ||
| Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase | Q24529056 | ||
| Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex | Q24559743 | ||
| Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 | Q24563807 | ||
| Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity | Q24567626 | ||
| Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain | Q24609907 | ||
| Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells | Q24632871 | ||
| Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy | Q24652502 | ||
| BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase | Q24652896 | ||
| Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis | Q24680360 | ||
| Cullin-RING ligases in regulation of autophagy | Q26746956 | ||
| NRF2, a Key Regulator of Antioxidants with Two Faces towards Cancer | Q26747249 | ||
| Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications | Q26747274 | ||
| Redox Modulating NRF2: A Potential Mediator of Cancer Stem Cell Resistance | Q26774916 | ||
| Cullin family proteins and tumorigenesis: genetic association and molecular mechanisms | Q26822657 | ||
| RBR E3 ubiquitin ligases: new structures, new insights, new questions | Q26828565 | ||
| Targeting the ubiquitin pathway for cancer treatment | Q26866185 | ||
| Building and remodelling Cullin-RING E3 ubiquitin ligases | Q27027816 | ||
| Cortical dynamics during cell motility are regulated by CRL3(KLHL21) E3 ubiquitin ligase | Q27325699 | ||
| Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility | Q27355584 | ||
| Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases | Q27657740 | ||
| Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP | Q27685443 | ||
| DBC2/RhoBTB2 functions as a tumor suppressor protein via Musashi-2 ubiquitination in breast cancer | Q33721211 | ||
| Dimerization of CUL7 and PARC is not required for all CUL7 functions and mouse development | Q33862965 | ||
| Identification and characterization of KCASH2 and KCASH3, 2 novel Cullin3 adaptors suppressing histone deacetylase and Hedgehog activity in medulloblastoma. | Q33864635 | ||
| Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation | Q33868529 | ||
| Genetic analysis of cytoprotective functions supported by graded expression of Keap1 | Q33877576 | ||
| Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells | Q33906824 | ||
| KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling | Q33914111 | ||
| Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy | Q33944189 | ||
| Nedd8 on cullin: building an expressway to protein destruction. | Q33976667 | ||
| Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation | Q34043797 | ||
| Cul4A is essential for spermatogenesis and male fertility | Q34162380 | ||
| Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells | Q34181353 | ||
| The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesis | Q34188318 | ||
| Evidence for molecular differences in prostate cancer between African American and Caucasian men | Q34205227 | ||
| SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer. | Q34233538 | ||
| Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental development | Q34273850 | ||
| Identification of causal genetic drivers of human disease through systems-level analysis of regulatory networks. | Q34324288 | ||
| KLHL2 interacts with and ubiquitinates WNK kinases | Q34356315 | ||
| Estrogen-related receptor α decreases RHOA stability to induce orientated cell migration | Q34408834 | ||
| The emerging role of speckle-type POZ protein (SPOP) in cancer development | Q34430637 | ||
| 2004 WHO classification of the renal tumors of the adults | Q34488979 | ||
| Identification of a novel germline SPOP mutation in a family with hereditary prostate cancer | Q34502671 | ||
| The mouse: genetics meets behaviour | Q34522821 | ||
| Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. | Q34627230 | ||
| Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer | Q34637940 | ||
| Sézary syndrome is a unique cutaneous T-cell lymphoma as identified by an expanded gene signature including diagnostic marker molecules CDO1 and DNM3. | Q34717463 | ||
| Peroxiredoxin 1 controls prostate cancer growth through Toll-like receptor 4-dependent regulation of tumor vasculature | Q34793013 | ||
| Cytoplasmic CUL9/PARC Ubiquitin Ligase Is a Tumor Suppressor and Promotes p53-Dependent Apoptosis | Q34942236 | ||
| Gene expression network analysis of ETV1 reveals KCTD10 as a novel prognostic biomarker in gastrointestinal stromal tumor | Q34974255 | ||
| Roles of F-box proteins in cancer | Q35012352 | ||
| PDZ-RhoGEF ubiquitination by Cullin3-KLHL20 controls neurotrophin-induced neurite outgrowth | Q35047461 | ||
| Overexpression of Nrf2 protects against microcystin-induced hepatotoxicity in mice | Q35131144 | ||
| Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3 | Q35140143 | ||
| Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutants | Q35181646 | ||
| Protection against phalloidin-induced liver injury by oleanolic acid involves Nrf2 activation and suppression of Oatp1b2. | Q35243790 | ||
| Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover | Q35274529 | ||
| KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8. | Q35378646 | ||
| G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L | Q35574621 | ||
| PLZF, a tumor suppressor genetically lost in metastatic castration-resistant prostate cancer, is a mediator of resistance to androgen deprivation therapy | Q35612095 | ||
| Overexpression of S100B, TM4SF4, and OLFM4 genes is correlated with liver metastasis in Taiwanese colorectal cancer patients | Q35635170 | ||
| A Non-Canonical Function of Gβ as a Subunit of E3 Ligase in Targeting GRK2 Ubiquitylation | Q35690591 | ||
| Cullin-3 regulates late endosome maturation. | Q35735068 | ||
| Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities | Q35754537 | ||
| Peptide and small molecule inhibitors of the Keap1-Nrf2 protein-protein interaction. | Q35836115 | ||
| Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis | Q35839406 | ||
| Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy | Q27685461 | ||
| CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling | Q27697991 | ||
| Systematic approaches to identify E3 ligase substrates | Q28068398 | ||
| Utilization of Dimethyl Fumarate and Related Molecules for Treatment of Multiple Sclerosis, Cancer, and Other Diseases | Q28078742 | ||
| Distinct and overlapping functions of the cullin E3 ligase scaffolding proteins CUL4A and CUL4B | Q28086765 | ||
| KCTD10 is involved in the cardiovascular system and Notch signaling during early embryonic development | Q28117817 | ||
| Identification of a novel nuclear speckle‐type protein, SPOP | Q28118699 | ||
| Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection | Q28118714 | ||
| Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesis | Q28262931 | ||
| DBC2 significantly influences cell-cycle, apoptosis, cytoskeleton and membrane-trafficking pathways | Q28303625 | ||
| Nrf2 is essential for protection against acute pulmonary injury in mice | Q28343659 | ||
| Cytoprotection "gone astray": Nrf2 and its role in cancer | Q28393784 | ||
| Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E | Q28504517 | ||
| Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice | Q28506102 | ||
| CUL4A abrogation augments DNA damage response and protection against skin carcinogenesis | Q28508809 | ||
| REN: a novel, developmentally regulated gene that promotes neural cell differentiation | Q28510059 | ||
| MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein | Q28511797 | ||
| Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway | Q28579883 | ||
| Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved | Q28585804 | ||
| Cul4A is required for hematopoietic stem-cell engraftment and self-renewal | Q28587021 | ||
| Two conserved domains in PCIF1 mediate interaction with pancreatic transcription factor PDX-1 | Q28591307 | ||
| Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis | Q28591483 | ||
| The BTB-kelch protein KLHL6 is involved in B-lymphocyte antigen receptor signaling and germinal center formation | Q28592532 | ||
| Cul4A targets p27 for degradation and regulates proliferation, cell cycle exit, and differentiation during erythropoiesis | Q28593723 | ||
| CUL-4A is critical for early embryonic development | Q28594730 | ||
| Cell-fate determination by ubiquitin-dependent regulation of translation | Q28975777 | ||
| An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer | Q29616732 | ||
| Physiological functions of the HECT family of ubiquitin ligases | Q29617293 | ||
| Ubiquitin ligases: cell-cycle control and cancer | Q29617992 | ||
| Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation | Q29618051 | ||
| Conserved properties of Drosophila Insomniac link sleep regulation and synaptic function | Q31704640 | ||
| Frequent concerted genetic mechanisms disrupt multiple components of the NRF2 inhibitor KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex in thyroid cancer | Q33591232 | ||
| ATP5H/KCTD2 locus is associated with Alzheimer's disease risk. | Q33652534 | ||
| Kelch-like ECT2-interacting protein KLEIP regulates late-stage pulmonary maturation via Hif-2α in mice | Q33677228 | ||
| E3 Ubiquitin Ligases Neurobiological Mechanisms: Development to Degeneration | Q33705444 | ||
| Properties and Clinical Relevance of Speckle-Type POZ Protein in Human Colorectal Cancer | Q38869756 | ||
| KLHL39 suppresses colon cancer metastasis by blocking KLHL20-mediated PML and DAPK ubiquitination | Q38916626 | ||
| SCP phosphatases suppress renal cell carcinoma by stabilizing PML and inhibiting mTOR/HIF signaling | Q38949865 | ||
| The genomic landscape of hepatoblastoma and their progenies with HCC-like features | Q38964756 | ||
| The Cohesive Metastasis Phenotype in Human Prostate Cancer | Q38966462 | ||
| Early use of chemotherapy in metastatic prostate cancer | Q38976473 | ||
| Knockdown of TNFAIP1 inhibits growth and induces apoptosis in osteosarcoma cells through inhibition of the nuclear factor-κB pathway | Q38980730 | ||
| Enhanced LPS-induced peritonitis in mice deficiency of cullin 4B in macrophages | Q38988311 | ||
| Nrf2 signaling pathway: Pivotal roles in inflammation. | Q39003225 | ||
| Downregulated RhoBTB2 Expression Contributes to Poor Outcome in Osteosarcoma Patients | Q39138028 | ||
| Activation of protein kinase CK2 attenuates FOXO3a functioning in a PML-dependent manner: implications in human prostate cancer | Q39181098 | ||
| Nrf2-induced antiapoptotic Bcl-xL protein enhances cell survival and drug resistance | Q39217937 | ||
| Ubiquitin Ligases: Structure, Function, and Regulation. | Q39219103 | ||
| BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs. | Q39255572 | ||
| Enzyme-substrate relationships in the ubiquitin system: approaches for identifying substrates of ubiquitin ligases | Q39271396 | ||
| The KEAP1-NRF2 System in Cancer | Q39317112 | ||
| Regulation of various DNA repair pathways by E3 ubiquitin ligases | Q39393655 | ||
| ROS-modulated therapeutic approaches in cancer treatment. | Q39396774 | ||
| The Ubiquitin System, Autophagy, and Regulated Protein Degradation | Q39400672 | ||
| Nrf2 as a target for prevention of age-related and diabetic cataracts by against oxidative stress | Q39443773 | ||
| KLHL12-mediated ubiquitination of the dopamine D4 receptor does not target the receptor for degradation | Q39748131 | ||
| Histone deacetylase and Cullin3-REN(KCTD11) ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation | Q39750898 | ||
| Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish | Q39755467 | ||
| The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction | Q39986392 | ||
| Repression of transcriptional activity of estrogen receptor alpha by a Cullin3/SPOP ubiquitin E3 ligase complex | Q39991661 | ||
| Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by the generation of phosphatidylinositol 5-phosphate. | Q40020862 | ||
| PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex | Q40219081 | ||
| RhoBTB2 is a substrate of the mammalian Cul3 ubiquitin ligase complex | Q40563288 | ||
| BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. | Q40633677 | ||
| RNA interference-mediated silencing of speckle-type POZ protein promotes apoptosis of renal cell cancer cells | Q40656637 | ||
| SPOP Regulates Endometrial Stromal Cell Decidualization in Mice | Q40758288 | ||
| CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation | Q41060304 | ||
| Disruption of the PHRF1 Tumor Suppressor Network by PML-RARα Drives Acute Promyelocytic Leukemia Pathogenesis | Q41433578 | ||
| RhoBTB2 (DBC2) functions as a multifunctional tumor suppressor in thyroid cancer cells via mitochondrial apoptotic pathway. | Q41642489 | ||
| KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3. | Q41728387 | ||
| The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension. | Q41774507 | ||
| Speckle-type POZ protein, SPOP, is involved in the DNA damage response. | Q41836192 | ||
| KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants | Q41865879 | ||
| Monomethyl fumarate augments NK cell lysis of tumor cells through degranulation and the upregulation of NKp46 and CD107a | Q42138439 | ||
| Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer. | Q42153553 | ||
| The CUL3-KLHL18 ligase regulates mitotic entry and ubiquitylates Aurora-A | Q42162215 | ||
| Spatiotemporal 16p11.2 protein network implicates cortical late mid-fetal brain development and KCTD13-Cul3-RhoA pathway in psychiatric diseases | Q42164701 | ||
| The CUL3-SPOP-DAXX axis is a novel regulator of VEGFR2 expression in vascular endothelial cells | Q42320699 | ||
| Dual targeting of androgen receptor and mTORC1 by salinomycin in prostate cancer | Q42321600 | ||
| Repurposing Tecfidera for cancer | Q42341715 | ||
| Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages | Q35946350 | ||
| Aberrant regulation of hematopoiesis by T cells in BAZF-deficient mice | Q35950048 | ||
| Phosphorylation-dependent regulation of Notch1 signaling: the fulcrum of Notch1 signaling | Q36078480 | ||
| Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia | Q36159459 | ||
| KLHL21, a novel gene that contributes to the progression of hepatocellular carcinoma | Q36171505 | ||
| Inhibition of SALL4 suppresses carcinogenesis of colorectal cancer via regulating Gli1 expression | Q36261279 | ||
| SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylase | Q36278928 | ||
| Bardoxolone methyl decreases megalin and activates nrf2 in the kidney | Q36280389 | ||
| Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells | Q36309431 | ||
| Cullin-3 regulates vascular smooth muscle function and arterial blood pressure via PPARγ and RhoA/Rho-kinase. | Q36328405 | ||
| Monomethyl fumarate promotes Nrf2-dependent neuroprotection in retinal ischemia-reperfusion | Q36393675 | ||
| Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension | Q36414701 | ||
| Selective proteasomal degradation of the B'β subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15 | Q36481737 | ||
| Prognostic role of Gli1 expression in solid malignancies: a meta-analysis | Q36602649 | ||
| Cell Autonomous and Nonautonomous Function of CUL4B in Mouse Spermatogenesis | Q36727406 | ||
| Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover | Q36799180 | ||
| Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination | Q36848348 | ||
| Modest loss of peripheral axons, muscle atrophy and formation of brain inclusions in mice with targeted deletion of gigaxonin exon 1 | Q36853945 | ||
| REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma | Q36987393 | ||
| Speckle-type POZ (pox virus and zinc finger protein) protein gene deletion in ovarian cancer: Fluorescence in situ hybridization analysis of a tissue microarray | Q37002758 | ||
| The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus | Q37036376 | ||
| Gut bacteria and cancer | Q37082877 | ||
| Rho GTPases of the RhoBTB subfamily and tumorigenesis | Q37094102 | ||
| Cullin 3 as a novel target in diverse pathologies | Q37133559 | ||
| Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha | Q37140410 | ||
| The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications. | Q37163747 | ||
| The integrated landscape of driver genomic alterations in glioblastoma | Q37237987 | ||
| Proliferation defects and genome instability in cells lacking Cul4A. | Q37249694 | ||
| Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression | Q37267971 | ||
| Association of KCTD10, MVK, and MMAB polymorphisms with dyslipidemia and coronary heart disease in Han Chinese population | Q37311144 | ||
| Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. | Q37343015 | ||
| Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice | Q37369378 | ||
| Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. | Q37373844 | ||
| KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta | Q37406535 | ||
| The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells | Q42396446 | ||
| KCTD10 is critical for heart and blood vessel development of zebrafish | Q42652702 | ||
| KCTD11 tumor suppressor gene expression is reduced in prostate adenocarcinoma. | Q42728434 | ||
| A novel PDIP1-related protein, KCTD10, that interacts with proliferating cell nuclear antigen and DNA polymerase delta | Q42813188 | ||
| Distinct functional surface regions on ubiquitin | Q43635274 | ||
| Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development. | Q46619920 | ||
| Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice | Q46975887 | ||
| Silencing Aurora A leads to re-sensitization of breast cancer cells to Taxol through downregulation of SRC-mediated ERK and mTOR pathways | Q46976280 | ||
| Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors. | Q47956425 | ||
| Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. | Q47956436 | ||
| Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain. | Q48153883 | ||
| KCTD2, an adaptor of Cullin3 E3 ubiquitin ligase, suppresses gliomagenesis by destabilizing c-Myc | Q48369262 | ||
| Decreased expression of the SPOP gene is associated with poor prognosis in glioma | Q48472889 | ||
| Squamous cell carcinoma-related oncogene (SCCRO) neddylates Cul3 protein to selectively promote midbody localization and activity of Cul3KLHL21 protein complex during abscission. | Q48594712 | ||
| Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport. | Q48604760 | ||
| Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases | Q50337002 | ||
| Somatic mutation ofSPOPtumor suppressor gene is rare in breast, lung, liver cancers, and acute leukemias | Q51011096 | ||
| Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice. | Q51054878 | ||
| Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord. | Q51056272 | ||
| cMyBP-C was decreased via KLHL3-mediated proteasomal degradation in congenital heart diseases | Q51094580 | ||
| Lack of CUL4B in Adipocytes Promotes PPARγ-Mediated Adipose Tissue Expansion and Insulin Sensitivity. | Q51296743 | ||
| Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation | Q51363519 | ||
| Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer | Q51513706 | ||
| NF-E2-related factor 2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice | Q51757585 | ||
| Speckle-type POZ protein is negatively associated with malignancies and inhibits cell proliferation and migration in liver cancer. | Q52661725 | ||
| Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants | Q53510860 | ||
| Genetic analysis of the DBC2 gene in gastric cancer | Q53561030 | ||
| BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase | Q53633362 | ||
| Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex | Q54346071 | ||
| DBC2 gene is silenced by promoter methylation in bladder cancer. | Q54523712 | ||
| Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice. | Q54527911 | ||
| Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination. | Q55033836 | ||
| The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment. | Q55041021 | ||
| Expanding the Ubiquitin Code | Q57269871 | ||
| Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E | Q58236966 | ||
| PLZF expression during colorectal cancer development and in normal colorectal mucosa according to body size, as marker of colorectal cancer risk | Q59034426 | ||
| Clinico-pathological significance of the molecular alterations of the SPOP gene in prostate cancer | Q85281472 | ||
| Mutational and expressional analyses of SPOP, a candidate tumor suppressor gene, in prostate, gastric and colorectal cancers | Q85630948 | ||
| Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism | Q37417507 | ||
| NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer | Q37423465 | ||
| Identifying the Ubiquitin Ligase Complex That Regulates the NF1 Tumor Suppressor and Ras | Q37435516 | ||
| The tumour suppressor Pdcd4: recent advances in the elucidation of function and regulation | Q37438657 | ||
| TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer | Q37443033 | ||
| Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling | Q37534076 | ||
| SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing. | Q37577424 | ||
| SPOP mutations in prostate cancer across demographically diverse patient cohorts. | Q37584305 | ||
| Silencing speckle-type POZ protein by promoter hypermethylation decreases cell apoptosis through upregulating Hedgehog signaling pathway in colorectal cancer | Q37603495 | ||
| The role of SRC-3 in human breast cancer | Q37660904 | ||
| pVHL suppresses kinase activity of Akt in a proline-hydroxylation-dependent manner | Q37666827 | ||
| Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution | Q37830775 | ||
| Cullin-RING Ligases as Attractive Anti-cancer Targets | Q38059746 | ||
| The paradoxical role of Nrf2 in tumor biology | Q38096044 | ||
| BG-12 in Multiple Sclerosis | Q38109572 | ||
| Nrf2, the master redox switch: the Achilles' heel of ovarian cancer? | Q38255734 | ||
| Keap1 regulates the constitutive expression of GST A1 during differentiation of Caco-2 cells. | Q38291034 | ||
| Angiopoietin-1 is regulated by miR-204 and contributes to corneal neovascularization in KLEIP-deficient mice | Q38306468 | ||
| BAZF, a novel component of cullin3-based E3 ligase complex, mediates VEGFR and Notch cross-signaling in angiogenesis | Q38328249 | ||
| Mechanisms regulating glioma invasion | Q38386429 | ||
| Natural Nrf2 activators in diabetes | Q38545531 | ||
| Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation. | Q38626078 | ||
| Nrf2-ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases. | Q38652602 | ||
| The genetic landscape of endometrial clear cell carcinomas. | Q38674086 | ||
| Endoplasmic Reticulum Stress, NRF2 Signalling and Cardiovascular Diseases in a Nutshell | Q38675840 | ||
| Ductal adenocarcinoma of the prostate: Clinical and biological profiles | Q38683009 | ||
| The see-saw of Keap1-Nrf2 pathway in cancer | Q38685723 | ||
| Klhl6 Deficiency Impairs Transitional B Cell Survival and Differentiation. | Q38694939 | ||
| Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma | Q38695950 | ||
| Neuro-oncology in 2015: Progress in glioma diagnosis, classification and treatment | Q38702130 | ||
| Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime? | Q38702248 | ||
| MiR-424 Promotes Non-Small Cell Lung Cancer Progression and Metastasis through Regulating the Tumor Suppressor Gene TNFAIP1. | Q38702526 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 11-28 | |
| P577 | publication date | 2017-11-08 | |
| P1433 | published in | Biochimica et Biophysica Acta: Reviews on Cancer | Q15724442 |
| P1476 | title | Functional analysis of Cullin 3 E3 ligases in tumorigenesis | |
| P478 | volume | 1869 |
| Q100311434 | Control of craniofacial and brain development by Cullin3-RING ubiquitin ligases: Lessons from human disease genetics |
| Q61800494 | Cullin-3/KCTD10 E3 complex is essential for Rac1 activation through RhoB degradation in human epidermal growth factor receptor 2-positive breast cancer cells |
| Q89936646 | De Novo Variants in SPOP Cause Two Clinically Distinct Neurodevelopmental Disorders |
| Q94453485 | Functional Genomic Screening Independently Identifies CUL3 as a Mediator of Vemurafenib Resistance via Src-Rac1 Signaling Axis |
| Q92738485 | KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders |
| Q99241388 | SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation |
| Q93165664 | SPOP inhibits mice pancreatic stellate cell activation by promoting FADD degradation in cerulein-induced chronic pancreatitis |
| Q90781287 | SPOP suppresses pancreatic cancer progression by promoting the degradation of NANOG |
| Q93195753 | The CRL3BTBD9 E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration |
| Q90437578 | The association of speckle-type POZ protein with lymph node metastasis and prognosis in cancer patients: A meta-analysis |
| Q94474488 | The diverse roles of SPOP in prostate cancer and kidney cancer |
| Q89544479 | The emerging roles of protein homeostasis-governing pathways in Alzheimer's disease |
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