| scholarly article | Q13442814 |
| P50 | author | Dung-Fang Lee | Q55283602 |
| P2093 | author name string | J Xu | |
| C Li | |||
| B W O'Malley | |||
| J Fu | |||
| J Ao | |||
| D Lonard | |||
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| Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases | Q27657740 | ||
| Sequence and characterization of a coactivator for the steroid hormone receptor superfamily | Q27860465 | ||
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| The ubiquitin system | Q27860803 | ||
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| Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu | Q28241103 | ||
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| Steroid Receptor Coactivator-1 Coactivates Activating Protein-1-mediated Transactivations through Interaction with the c-Jun and c-Fos Subunits | Q28274783 | ||
| Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice | Q28506102 | ||
| The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development | Q28509946 | ||
| Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved | Q28585804 | ||
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| The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function | Q29547918 | ||
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| Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression | Q30493310 | ||
| Mutation analysis of the BRCA1 gene in 23 families with cases of cancer of the breast, ovary, and multiple other sites | Q33677871 | ||
| Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. | Q33707732 | ||
| Phosphorylation and regulation of beta-catenin by casein kinase I epsilon | Q34157748 | ||
| Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer | Q34181456 | ||
| ACTR/AIB1 functions as an E2F1 coactivator to promote breast cancer cell proliferation and antiestrogen resistance | Q34345868 | ||
| Dynamics of Cullin-RING Ubiquitin Ligase Network Revealed by Systematic Quantitative Proteomics | Q34433677 | ||
| Regulation of somatic growth by the p160 coactivator p/CIP | Q35567773 | ||
| Specific amino acid residues in the basic helix-loop-helix domain of SRC-3 are essential for its nuclear localization and proteasome-dependent turnover | Q35641931 | ||
| An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response | Q35781606 | ||
| Role of the Steroid Receptor Coactivator SRC-3 in Cell Growth | Q36138723 | ||
| Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1. | Q36540639 | ||
| Candidate target genes for loss of heterozygosity on human chromosome 17q21 | Q36694309 | ||
| The AIB1 oncogene promotes breast cancer metastasis by activation of PEA3-mediated matrix metalloproteinase 2 (MMP2) and MMP9 expression | Q36898979 | ||
| Essential phosphatases and a phospho-degron are critical for regulation of SRC-3/AIB1 coactivator function and turnover | Q37001705 | ||
| Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer. | Q37373844 | ||
| KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta | Q37406535 | ||
| Nuclear receptor coregulators in cancer biology | Q37618468 | ||
| Allelotyping of ductal carcinoma in situ of the breast: deletion of loci on 8p, 13q, 16q, 17p and 17q. | Q38480342 | ||
| Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by the generation of phosphatidylinositol 5-phosphate. | Q40020862 | ||
| Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway | Q40115992 | ||
| SRC-3 coactivator functional lifetime is regulated by a phospho-dependent ubiquitin time clock | Q40118969 | ||
| Steroid receptor coactivator-3 and activator protein-1 coordinately regulate the transcription of components of the insulin-like growth factor/AKT signaling pathway | Q40207965 | ||
| Identification of substrates for F-box proteins | Q40341917 | ||
| SRC-3 is required for prostate cancer cell proliferation and survival | Q40377741 | ||
| BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. | Q40633677 | ||
| AIB1 enhances estrogen-dependent induction of cyclin D1 expression | Q40805226 | ||
| Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle | Q42829071 | ||
| AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice | Q44783912 | ||
| Proto-oncogene ACTR/AIB1 promotes cancer cell invasion by up-regulating specific matrix metalloproteinase expression | Q46787346 | ||
| The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase. | Q47069071 | ||
| Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases | Q50337002 | ||
| The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways | Q51568474 | ||
| BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase | Q53633362 | ||
| High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene | Q57165894 | ||
| 17q21-q25 aberrations in breast cancer: combined allelotyping and CGH analysis reveals 5 regions of allelic imbalance among which two correspond to DNA amplification | Q57287554 | ||
| RAC-3 is a NF-kappa B coactivator | Q73230918 | ||
| P433 | issue | 42 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | proteolysis | Q33123 |
| P304 | page(s) | 4350-4364 | |
| P577 | publication date | 2011-05-16 | |
| P1433 | published in | Oncogene | Q1568657 |
| P1476 | title | Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1 | |
| P478 | volume | 30 |
| Q24336527 | Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase |
| Q42153553 | Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer. |
| Q38122011 | Androgen receptors in hormone-dependent and castration-resistant prostate cancer |
| Q91497063 | CRL3-SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling |
| Q54942210 | Chromatin-Bound Cullin-Ring Ligases: Regulatory Roles in DNA Replication and Potential Targeting for Cancer Therapy. |
| Q34775572 | Constitutive activity of the androgen receptor |
| Q26747274 | Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications |
| Q35651231 | Cullin 3 mediates SRC-3 ubiquitination and degradation to control the retinoic acid response |
| Q47284253 | Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation. |
| Q41613690 | Decreased expression of speckle-type POZ protein for the prediction of poor prognosis in patients with non-small cell lung cancer |
| Q53510860 | Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants |
| Q35181646 | Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutants |
| Q38993298 | Differential expression of speckled POZ protein, SPOP: putative regulation by miR-145. |
| Q38705858 | Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancer |
| Q35274529 | Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover |
| Q34205227 | Evidence for molecular differences in prostate cancer between African American and Caucasian men |
| Q24616117 | Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer |
| Q36447819 | Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes |
| Q30388270 | Exome-Scale Discovery of Hotspot Mutation Regions in Human Cancer Using 3D Protein Structure |
| Q47413250 | Functional analysis of Cullin 3 E3 ligases in tumorigenesis. |
| Q57116830 | Functional roles of Speckle-Type Poz (SPOP) Protein in Genomic stability |
| Q34793424 | GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex |
| Q34502671 | Identification of a novel germline SPOP mutation in a family with hereditary prostate cancer |
| Q34536832 | Identification of speckle-type POZ protein somatic mutations in African American prostate cancer |
| Q92410949 | Interplay Among PI3K/AKT, PTEN/FOXO and AR Signaling in Prostate Cancer |
| Q27022288 | Interplay between genomic alterations and androgen receptor signaling during prostate cancer development and progression |
| Q38186042 | Links between oestrogen receptor activation and proteolysis: relevance to hormone-regulated cancer therapy. |
| Q90240271 | LncRNA ADAMTS9-AS2 suppresses the proliferation of gastric cancer cells and the tumorigenicity of cancer stem cells through regulating SPOP |
| Q38190362 | Maintaining and reprogramming genomic androgen receptor activity in prostate cancer |
| Q35725904 | Mastermind-Like 1 Is Ubiquitinated: Functional Consequences for Notch Signaling |
| Q38151036 | Molecular pathology and prostate cancer therapeutics: from biology to bedside |
| Q34365632 | Molecular pathways and targets in prostate cancer |
| Q85630948 | Mutational and expressional analyses of SPOP, a candidate tumor suppressor gene, in prostate, gastric and colorectal cancers |
| Q51032285 | Next-Generation Sequencing |
| Q38384489 | Next-generation sequencing technology in prostate cancer diagnosis, prognosis, and personalized treatment |
| Q24337070 | PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha |
| Q38869756 | Properties and Clinical Relevance of Speckle-Type POZ Protein in Human Colorectal Cancer |
| Q51363519 | Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation |
| Q36799180 | Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover |
| Q34637940 | Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer |
| Q40656637 | RNA interference-mediated silencing of speckle-type POZ protein promotes apoptosis of renal cell cancer cells |
| Q57108205 | Recent advances in prostate cancer research: large-scale genomic analyses reveal novel driver mutations and DNA repair defects |
| Q35128269 | Role of the nuclear receptor coactivator AIB1-Delta4 splice variant in the control of gene transcription |
| Q38837458 | SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression. |
| Q40758288 | SPOP Regulates Endometrial Stromal Cell Decidualization in Mice |
| Q91828572 | SPOP Regulates The Biological Mechanism Of Ovarian Cancer Cells Through The Hh Signaling Pathway |
| Q91713061 | SPOP and cancer: a systematic review |
| Q99241388 | SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation |
| Q24339492 | SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer |
| Q38834625 | SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein |
| Q91598898 | SPOP suppresses prostate cancer through regulation of CYCLIN E1 stability |
| Q34233538 | SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer. |
| Q37577424 | SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing. |
| Q47435129 | SPOP-mediated degradation of BRD4 dictates cellular sensitivity to BET inhibitors |
| Q39044222 | Somatic Mutations in Prostate Cancer: Closer to Personalized Medicine. |
| Q51011096 | Somatic mutation ofSPOPtumor suppressor gene is rare in breast, lung, liver cancers, and acute leukemias |
| Q37002758 | Speckle-type POZ (pox virus and zinc finger protein) protein gene deletion in ovarian cancer: Fluorescence in situ hybridization analysis of a tissue microarray |
| Q60936355 | Speckle-type POZ protein functions as a tumor suppressor in non-small cell lung cancer due to DNA methylation |
| Q52661725 | Speckle-type POZ protein is negatively associated with malignancies and inhibits cell proliferation and migration in liver cancer. |
| Q41836192 | Speckle-type POZ protein, SPOP, is involved in the DNA damage response. |
| Q36808705 | Steroid receptor coactivator-3 as a potential molecular target for cancer therapy |
| Q37546043 | Steroid receptor coactivators as therapeutic targets in the female reproductive system |
| Q27685443 | Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP |
| Q51586225 | TMPRSS2-ERG gene fusion is rare compared to PTEN deletions in stage T1a prostate cancer |
| Q38109474 | The Genomic Landscape of Prostate Cancer |
| Q37731299 | The Phosphorylation of PDX-1 by Protein Kinase CK2 Is Crucial for Its Stability |
| Q94474488 | The diverse roles of SPOP in prostate cancer and kidney cancer |
| Q37163747 | The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications. |
| Q92413024 | The emerging role of SPOP protein in tumorigenesis and cancer therapy |
| Q34430637 | The emerging role of speckle-type POZ protein (SPOP) in cancer development |
| Q33729031 | The levels of RAC3 expression are up regulated by TNF in the inflammatory response |
| Q36423878 | The role of AIB1 in breast cancer |
| Q90093670 | The role of ubiquitination in tumorigenesis and targeted drug discovery |
| Q54981709 | Therapeutic Targeting of Sunitinib-Induced AR Phosphorylation in Renal Cell Carcinoma. |
| Q37093164 | Tripartite motif containing 28 (TRIM28) promotes breast cancer metastasis by stabilizing TWIST1 protein. |
| Q36309431 | Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells |
| Q53078772 | Uterine function in the mouse requires speckle-type poz protein. |
| Q35897588 | miR-137 Targets p160 Steroid Receptor Coactivators SRC1, SRC2, and SRC3 and Inhibits Cell Proliferation |
| Q58729558 | miRNA-543 promotes cell migration and invasion by targeting SPOP in gastric cancer |
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