Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover

scientific article

Endometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/CDDIS.2015.47
P932PMC publication ID4385925
P698PubMed publication ID25766326
P5875ResearchGate publication ID273786672

P2093author name stringP Zhang
Y Zhang
H Huang
J Ma
L Yu
X Jin
Y Tang
J Peng
C Wang
K Gao
J An
Y Dong
Q Yan
R Wumaier
P2860cites workThe antiestrogen ICI 182780 disrupts estrogen receptor nucleocytoplasmic shuttlingQ52514375
BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligaseQ53633362
Whole abdominal radiotherapy in the adjuvant treatment of patients with stage III and IV endometrial cancer: a gynecologic oncology group studyQ81780938
Tumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1Q24303428
Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligaseQ24336527
Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligaseQ24529056
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancerQ24616117
Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin LigasesQ27657740
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008Q27860674
Integrated genomic characterization of endometrial carcinomaQ28289962
Steroid hormone receptors: many actors in search of a plotQ29618397
The emerging genomic landscape of endometrial cancerQ34026976
Estrogen receptor: current understanding of its activation and modulationQ34120680
Identification of molecular pathway aberrations in uterine serous carcinoma by genome-wide analyses.Q34393919
Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutantsQ35181646
Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genesQ36447819
Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinomaQ36637663
Proteasome-dependent degradation of the human estrogen receptorQ37160826
The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications.Q37163747
Pin1 modulates ERα levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradationQ37274658
Rational management of endocrine resistance in breast cancer: a comprehensive review of estrogen receptor biology, treatment options, and future directions.Q37279990
Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer.Q37373844
Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligaseQ37482039
SPOP mutations in prostate cancer across demographically diverse patient cohorts.Q37584305
Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnoverQ37599824
Links between oestrogen receptor activation and proteolysis: relevance to hormone-regulated cancer therapy.Q38186042
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)e1687
P577publication date2015-03-12
P1433published inCell Death and DiseaseQ2197222
P1476titleEndometrial cancer-associated mutants of SPOP are defective in regulating estrogen receptor-α protein turnover
P478volume6

Reverse relations

cites work (P2860)
Q91497063CRL3-SPOP ubiquitin ligase complex suppresses the growth of diffuse large B-cell lymphoma by negatively regulating the MyD88/NF-κB signaling
Q26747274Cullin 3 Ubiquitin Ligases in Cancer Biology: Functions and Therapeutic Implications
Q38733838Cullin 3SPOP ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6.
Q28086796Dysregulation of ubiquitin ligases in cancer
Q36556179Effects of 8-Prenylnaringenin and Whole-Body Vibration Therapy on a Rat Model of Osteopenia
Q47413250Functional analysis of Cullin 3 E3 ligases in tumorigenesis.
Q37011857Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles
Q45848384Moving forward with actionable therapeutic targets and opportunities in endometrial cancer: NCI clinical trials planning meeting report on identifying key genes and molecular pathways for targeted endometrial cancer trials
Q51032285Next-Generation Sequencing
Q40758288SPOP Regulates Endometrial Stromal Cell Decidualization in Mice
Q91828572SPOP Regulates The Biological Mechanism Of Ovarian Cancer Cells Through The Hh Signaling Pathway
Q91713061SPOP and cancer: a systematic review
Q90781287SPOP suppresses pancreatic cancer progression by promoting the degradation of NANOG
Q92481994SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer
Q47435129SPOP-mediated degradation of BRD4 dictates cellular sensitivity to BET inhibitors
Q60936355Speckle-type POZ protein functions as a tumor suppressor in non-small cell lung cancer due to DNA methylation
Q36009016Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles
Q92413024The emerging role of SPOP protein in tumorigenesis and cancer therapy
Q36309431Tumor suppressor SPOP mediates the proteasomal degradation of progesterone receptors (PRs) in breast cancer cells
Q33906824Tumor suppressor SPOP ubiquitinates and degrades EglN2 to compromise growth of prostate cancer cells
Q53078772Uterine function in the mouse requires speckle-type poz protein.

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