Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation

scientific article published on 22 October 2016

Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.CANLET.2016.10.021
P932PMC publication ID5148662
P698PubMed publication ID27780719

P2093author name stringMin Li
Wenyi Wei
Xiangpeng Dai
Fei Wu
Lixin Wan
Qiang Ding
Jinfang Zhang
Nicholas Mitsiades
Wenjian Gan
P2860cites workTumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1Q24303428
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damageQ24303577
Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly.Q42128896
Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer.Q42153553
E2F transcription factors and digestive system malignancies: how much do we know?Q42772377
Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphataseQ42779085
Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain.Q45086646
APC/CCdh1-dependent degradation of Cdc20 requires a phosphorylation on CRY-box by Polo-like kinase-1 during somatic cell cycleQ45383374
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.Q47071852
Gene expression profiling in glioblastoma and immunohistochemical evaluation of IGFBP-2 and CDC20.Q48863501
Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome DegradationQ50938485
Overexpression of Cdc20 in clinically localized prostate cancer: Relation to high Gleason score and biochemical recurrence after laparoscopic radical prostatectomy.Q52884318
BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligaseQ53633362
CDC20, a potential cancer therapeutic target, is negatively regulated by p53.Q55467766
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugationQ24314520
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancerQ24339492
Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligaseQ24529056
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancerQ24616117
The genomic complexity of primary human prostate cancerQ24617949
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancerQ24648025
Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesisQ26998944
Genetically engineered mouse models for functional studies of SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligasesQ27027897
Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin LigasesQ27657740
Function and regulation of cullin-RING ubiquitin ligasesQ28131707
How proteolysis drives the cell cycleQ28297983
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancerQ29616732
Ubiquitin ligases: cell-cycle control and cancerQ29617992
The anaphase promoting complex/cyclosome: a machine designed to destroyQ29618398
Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.Q30596621
Cdc20: a potential novel therapeutic target for cancer treatmentQ33584460
Identification and validation of genes involved in cervical tumourigenesisQ33825832
APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destructionQ33842900
Activity of the APC(Cdh1) form of the anaphase-promoting complex persists until S phase and prevents the premature expression of Cdc20pQ34516234
Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancerQ34637940
Cdc20: a WD40 activator for a cell cycle degradation machineQ34646331
Preparing to read the ubiquitin code: a middle-out strategy for characterization of all lysine-linked diubiquitins.Q34650330
The Molecular Taxonomy of Primary Prostate CancerQ34674332
Roles of F-box proteins in cancerQ35012352
Destruction of full-length androgen receptor by wild-type SPOP, but not prostate-cancer-associated mutantsQ35181646
Targeting Cdc20 as a novel cancer therapeutic strategyQ35688708
SPOP E3 Ubiquitin Ligase Adaptor Promotes Cellular Senescence by Degrading the SENP7 deSUMOylaseQ36278928
Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnoverQ36799180
The emerging family of CULLIN3-RING ubiquitin ligases (CRL3s): cellular functions and disease implications.Q37163747
Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligaseQ37482039
MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapyQ38026589
Tissue array analysis of expression microarray candidates identifies markers associated with tumor grade and outcome in serous epithelial ovarian cancerQ38314637
SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.Q38837458
Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPAQ39451627
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectprotein ubiquitinationQ3547638
P304page(s)207-214
P577publication date2016-10-22
P1433published inCancer LettersQ326372
P1476titleProstate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation
P478volume385

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cites work (P2860)
Q90279283APC/C ubiquitin ligase: Functions and mechanisms in tumorigenesis
Q49584310Cell division cycle 20 promotes cell proliferation and invasion and inhibits apoptosis in osteosarcoma cells
Q38733838Cullin 3SPOP ubiquitin E3 ligase promotes the poly-ubiquitination and degradation of HDAC6.
Q47413250Functional analysis of Cullin 3 E3 ligases in tumorigenesis.
Q57116830Functional roles of Speckle-Type Poz (SPOP) Protein in Genomic stability
Q47098821Identification of SPOP related metabolic pathways in prostate cancer
Q91713061SPOP and cancer: a systematic review
Q99241388SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation
Q55618243SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression.
Q38834625SPOP regulates prostate epithelial cell proliferation and promotes ubiquitination and turnover of c-MYC oncoprotein
Q92487025SPOP regulates the DNA damage response and lung adenocarcinoma cell response to radiation
Q91598898SPOP suppresses prostate cancer through regulation of CYCLIN E1 stability
Q92651169The Anaphase Promoting Complex/Cyclosome (APC/C): A Versatile E3 Ubiquitin Ligase
Q94474488The diverse roles of SPOP in prostate cancer and kidney cancer
Q92413024The emerging role of SPOP protein in tumorigenesis and cancer therapy
Q53078772Uterine function in the mouse requires speckle-type poz protein.

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