SPOP suppresses prostate cancer through regulation of CYCLIN E1 stability

scientific article published on 20 September 2018

SPOP suppresses prostate cancer through regulation of CYCLIN E1 stability is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41418-018-0198-0
P932PMC publication ID6748103
P698PubMed publication ID30237511

P50authorMin WuQ61190852
Y XiaoQ87824523
Xinghuan WangQ89295104
Lei YinQ42762957
P2093author name stringLei Zhang
Yuan Zhu
Xue-Jing Li
Xiang Lin
Qiao-Yun Long
Shan-Bo Tang
Lin-Gao Ju
Lianyun Li
P2860cites workTumor-suppressor role for the SPOP ubiquitin ligase in signal-dependent proteolysis of the oncogenic co-activator SRC-3/AIB1Q24303428
SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancerQ24339492
Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligaseQ24529056
Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancerQ24616117
Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin LigasesQ27657740
Identification of a novel nuclear speckle-type protein, SPOPQ28118699
Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell lineQ28188152
Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradationQ28208407
Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligaseQ28215069
Discovery and saturation analysis of cancer genes across 21 tumour typesQ28305204
Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation.Q51363519
Small-Molecule Targeting of E3 Ligase Adaptor SPOP in Kidney Cancer.Q51513706
BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.Q53633362
Kinase-independent function of cyclin EQ79544656
Kidney cancer: On target - inhibiting SPOP in ccRCCQ88474604
The emerging role of speckle-type POZ protein (SPOP) in cancer developmentQ34430637
Concurrent deletion of cyclin E1 and cyclin-dependent kinase 2 in hepatocytes inhibits DNA replication and liver regeneration in miceQ34537913
Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancerQ34637940
Cyclin E deregulation promotes loss of specific genomic regionsQ35630051
Fbw7α and Fbw7γ collaborate to shuttle cyclin E1 into the nucleolus for multiubiquitylationQ36506569
Global histone modification profiling reveals the epigenomic dynamics during malignant transformation in a four-stage breast cancer modelQ36749346
Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnoverQ36799180
A jekyll and hyde role of cyclin E in the genotoxic stress response: switching from cell cycle control to apoptosis regulationQ36848850
Higher-order oligomerization promotes localization of SPOP to liquid nuclear specklesQ37011857
Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progressionQ37267971
Analysis of Drosophila segmentation network identifies a JNK pathway factor overexpressed in kidney cancer.Q37373844
SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing.Q37577424
An integrated view of cyclin E function and regulationQ37970290
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.Q38626078
Dysregulation of INF2-mediated mitochondrial fission in SPOP-mutated prostate cancerQ38705858
SPOP Promotes Ubiquitination and Degradation of the ERG Oncoprotein to Suppress Prostate Cancer Progression.Q38837458
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses.Q38838244
Similar, not the same: diverse roles and regulation of cyclin Es.Q39388396
Androgen receptor is the key transcriptional mediator of the tumor suppressor SPOP in prostate cancer.Q42153553
Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylationQ42809976
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.Q47071852
Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillanceQ47379536
SPOP-mediated degradation of BRD4 dictates cellular sensitivity to BET inhibitorsQ47435129
Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors.Q47956425
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.Q47956436
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P921main subjectprostate cancerQ181257
P304page(s)1156-1168
P577publication date2018-09-20
P1433published inCell Death & DifferentiationQ2943974
P1476titleSPOP suppresses prostate cancer through regulation of CYCLIN E1 stability
P478volume26