Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility

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Human X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1009335368
P356DOI10.1038/SREP20227
P932PMC publication ID4735749
P698PubMed publication ID26832838
P5875ResearchGate publication ID292946471

P50authorChun-Yu ChenQ91509592
P2093author name stringShu-Wha Lin
Chien-Yu Lin
I-Shing Yu
Pao-Lin Kuo
Ying-Hung Lin
June-Tai Wu
Shu-Rung Lin
Chih-Hsiang Yu
Jui-Ching Wu
P2860cites workUbiquitin-dependent proteolysis in mammalian spermatogenesis, fertilization, and sperm quality control: killing three birds with one stoneQ23919482
CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesisQ24306088
Small-molecule inhibition of BRDT for male contraceptionQ24616901
The expression level of septin12 is critical for spermiogenesisQ24656517
A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly.Q27936513
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damageQ28238604
Essential role of the CUL4B ubiquitin ligase in extra-embryonic tissue development during mouse embryogenesisQ28262931
Expression profiling of purified male germ cells: stage-specific expression patterns related to meiosis and postmeiotic development.Q52033926
Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strainQ52099750
Cullin3 is a KLHL10-interacting protein preferentially expressed during late spermiogenesisQ53657294
Inhibition of Cullin RING Ligases by Cycle Inhibiting Factor: Evidence for Interference with Nedd8-Induced Conformational ControlQ58096387
Protamine 3'-untranslated sequences regulate temporal translational control and subcellular localization of growth hormone in spermatids of transgenic miceQ69650700
Male contraceptionQ78613040
Deletion of the CUL4B gene in a boy with mental retardation, minor facial anomalies, short stature, hypogonadism, and ataxiaQ82258329
[WHO Laboratory Manual for the Examination and Processing of Human Semen: its applicability to andrology laboratories in China]Q83227094
Molecular control of rodent spermatogenesisQ37988312
Chromatin dynamics during spermiogenesis.Q38148897
Mass spectrometry-based, label-free quantitative proteomics of round spermatids in miceQ38474009
CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1/DNMT3A in DNA methylation-based epigenetic silencingQ39051578
Global identification of modular cullin-RING ligase substratesQ39462405
Mutations in Cullin 4B result in a human syndrome associated with increased camptothecin-induced topoisomerase I-dependent DNA breaksQ39621855
Cullin4B/E3-ubiquitin ligase negatively regulates beta-cateninQ40063695
Dioxin receptor is a ligand-dependent E3 ubiquitin ligaseQ40152793
CRL4(RBBP7) is required for efficient CENP-A deposition at centromeres.Q41185795
Cellular source and mechanisms of high transcriptome complexity in the mammalian testisQ42773838
Fixation of testes and eyes using a modified Davidson's fluid: comparison with Bouin's fluid and conventional Davidson's fluidQ44109100
Remodeling of the actin cytoskeleton during mammalian sperm capacitation and acrosome reactionQ44327274
CRL4DCAF1 is required in activated oocytes for follicle maintenance and ovulationQ48591740
Rescue of the genetically engineered Cul4b mutant mouse as a potential model for human X-linked mental retardationQ28270351
Mutations in CUL4B, which encodes a ubiquitin E3 ligase subunit, cause an X-linked mental retardation syndrome associated with aggressive outbursts, seizures, relative macrocephaly, central obesity, hypogonadism, pes cavus, and tremorQ28284058
Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradationQ28284798
Sertoli-Sertoli and Sertoli-germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesisQ28286295
Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardationQ28286574
A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase δ in response to DNA damage and during the S phaseQ28295980
CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteinsQ28586529
RNF8-dependent histone modifications regulate nucleosome removal during spermatogenesisQ28589254
Contribution of the two genes encoding histone variant h3.3 to viability and fertility in miceQ28591185
CRL4-DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation.Q30663393
Cul4B regulates neural progenitor cell growthQ31095156
Male infertility caused by spermiogenic defects: lessons from gene knockoutsQ33708260
Replacement variant histone genes contain intervening sequencesQ34048209
Cul4A is essential for spermatogenesis and male fertilityQ34162380
The E3 ubiquitin ligase Cullin 4A regulates meiotic progression in mouse spermatogenesisQ34188318
Lack of Cul4b, an E3 ubiquitin ligase component, leads to embryonic lethality and abnormal placental developmentQ34273850
Histone H3 variants specify modes of chromatin assemblyQ34444033
RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesisQ34829400
Mouse models of male infertility.Q34932076
Deciphering the pathways of germ cell apoptosis in the testisQ35207734
Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathwayQ35863296
Transcription in haploid male germ cellsQ35893757
Role of actin cytoskeleton in mammalian sperm capacitation and the acrosome reactionQ36062995
Understanding cullin-RING E3 biology through proteomics-based substrate identificationQ36455676
New approaches to male non-hormonal contraceptionQ36487259
The mammalian acrosome as a secretory lysosome: new and old evidence.Q36559411
Meiotic sex chromosome inactivationQ36747812
Caspase signalling pathways in human spermatogenesis.Q36815637
CRL4s: the CUL4-RING E3 ubiquitin ligasesQ37440298
Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression.Q37446146
Integrated transcriptome analysis of mouse spermatogenesisQ37532346
From meiosis to postmeiotic events: the secrets of histone disappearance.Q37656482
CUL4B-deficiency in humans: understanding the clinical consequences of impaired Cullin 4-RING E3 ubiquitin ligase functionQ37847269
Functions of water channels in male and female reproductive systems.Q37985354
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectdisabilityQ12131
disability affecting intellectual abilitiesQ3317827
X-linked intellectual disabilityQ8041560
P304page(s)20227
P577publication date2016-02-02
P1433published inScientific ReportsQ2261792
P1476titleHuman X-linked Intellectual Disability Factor CUL4B Is Required for Post-meiotic Sperm Development and Male Fertility
P478volume6

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cites work (P2860)
Q55363927Deletion of DDB1- and CUL4- associated factor-17 (Dcaf17) gene causes spermatogenesis defects and male infertility in mice.
Q47927250Function of RAD6B and RNF8 in spermatogenesis
Q47413250Functional analysis of Cullin 3 E3 ligases in tumorigenesis.
Q29871128Identification of KIAA1210 as a novel X-chromosome-linked protein that localizes to the acrosome and associates with the ectoplasmic specialization in testes.
Q47603216Nuclear organization during in vitro differentiation of porcine mesenchymal stem cells (MSCs) into adipocytes

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