| scholarly article | Q13442814 |
| P2093 | author name string | Brian J North | |
| Jianping Guo | |||
| Tao Zhang | |||
| Wenyi Wei | |||
| Xiangpeng Dai | |||
| Ji Cheng | |||
| Kaixiong Tao | |||
| P2860 | cites work | Aberrant membranes and double-membrane structures accumulate in the axons of Atg5-null Purkinje cells before neuronal death | Q81387262 |
| The unravelling of the ubiquitin system | Q87176733 | ||
| DHA improves cognition and prevents dysfunction of entorhinal cortex neurons in 3xTg-AD mice | Q21135531 | ||
| APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain | Q24297668 | ||
| Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice | Q24303752 | ||
| The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production | Q24309767 | ||
| APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein | Q24310276 | ||
| Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism | Q24595310 | ||
| mTOR: from growth signal integration to cancer, diabetes and ageing | Q24633662 | ||
| Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments | Q24633947 | ||
| The ubiquitin proteasomal system: a potential target for the management of Alzheimer's disease | Q26749321 | ||
| It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease | Q26765816 | ||
| Clearance systems in the brain-implications for Alzheimer disease | Q26801541 | ||
| Crosstalk between apoptosis, necrosis and autophagy | Q26829723 | ||
| Drug development in Alzheimer's disease: the path to 2025 | Q27007748 | ||
| Ubiquitylation, neddylation and the DNA damage response | Q28087342 | ||
| Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice | Q28131756 | ||
| Loss of autophagy in the central nervous system causes neurodegeneration in mice | Q28131804 | ||
| CHIP-Hsc70 Complex Ubiquitinates Phosphorylated Tau and Enhances Cell Survival | Q28183470 | ||
| Cell Death Signaling | Q38655649 | ||
| Tau in physiology and pathology | Q38657468 | ||
| Tau and neurodegenerative disease: the story so far. | Q38658752 | ||
| Functional analyses of major cancer-related signaling pathways in Alzheimer's disease etiology | Q38659874 | ||
| Emerging use of everolimus in the treatment of neuroendocrine tumors | Q38661603 | ||
| A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease | Q38672340 | ||
| Regulation of connexins by the ubiquitin system: Implications for intercellular communication and cancer | Q38726000 | ||
| mTOR Signaling in Growth, Metabolism, and Disease. | Q38747508 | ||
| Functional characterization of AMP-activated protein kinase signaling in tumorigenesis | Q38807302 | ||
| Recent advances in SCF ubiquitin ligase complex: Clinical implications | Q38828721 | ||
| Autophagy and Alzheimer's Disease | Q38853431 | ||
| Can 'calpain-cathepsin hypothesis' explain Alzheimer neuronal death? | Q38866092 | ||
| The mTOR signalling cascade: paving new roads to cure neurological disease | Q38875632 | ||
| A fate worse than death: apoptosis as an oncogenic process | Q38882537 | ||
| The unfolded protein response in the therapeutic effect of hydroxy-DHA against Alzheimer's disease. | Q38911653 | ||
| Carboxy terminus heat shock protein 70 interacting protein reduces tau-associated degenerative changes | Q38942375 | ||
| Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis | Q38970279 | ||
| The effects of betulinic acid on neurobehavioral activity, electrophysiology and histological changes in an animal model of the Alzheimer's disease. | Q47747395 | ||
| The roles of ubiquitin modifying enzymes in neoplastic disease | Q47783548 | ||
| A novel RIPK1 inhibitor that prevents retinal degeneration in a rat glaucoma model | Q47803336 | ||
| RIPK1 mediates a disease-associated microglial response in Alzheimer's disease | Q47806841 | ||
| Temsirolimus promotes autophagic clearance of amyloid-β and provides protective effects in cellular and animal models of Alzheimer's disease | Q48017052 | ||
| A systemic view of Alzheimer disease - insights from amyloid-β metabolism beyond the brain | Q48092039 | ||
| A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicity | Q48286007 | ||
| Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation. | Q48354837 | ||
| TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice. | Q48603223 | ||
| Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory | Q48892814 | ||
| Metformin treatment alters memory function in a mouse model of Alzheimer's disease | Q50636567 | ||
| Reactive glia show increased immunoproteasome activity in Alzheimer’s disease | Q51055475 | ||
| Alzheimer's disease | Q55880664 | ||
| Alzheimer's disease | Q60313667 | ||
| FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain | Q77366106 | ||
| Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases | Q38195215 | ||
| Endoplasmic reticulum dysfunction in Alzheimer's disease | Q38203192 | ||
| The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: implications for Alzheimer's disease. | Q38212139 | ||
| The impact of the endoplasmic reticulum protein-folding environment on cancer development | Q38241996 | ||
| Prion-like Mechanisms in Alzheimer's Disease | Q38248456 | ||
| A new prion disease: relationship with central and peripheral amyloidoses | Q38333529 | ||
| Activation of mTOR: a culprit of Alzheimer's disease? | Q38443497 | ||
| Autophagy at the crossroads of catabolism and anabolism | Q38547568 | ||
| ER stress and the unfolded protein response in neurodegeneration | Q38653861 | ||
| Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium | Q28252389 | ||
| mTOR signaling in tumorigenesis | Q28252695 | ||
| Neuroinflammation in Alzheimer's disease | Q28259238 | ||
| Reconsider Alzheimer's disease by the ‘calpain–cathepsin hypothesis’—A perspective review | Q28287296 | ||
| Spongiform degeneration in mahoganoid mutant mice | Q28506434 | ||
| Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration | Q28509904 | ||
| Gracile axonal dystrophy (GAD), a new neurological mutant in the mouse | Q28512183 | ||
| Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment | Q28565257 | ||
| Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia | Q28589057 | ||
| Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons | Q28590748 | ||
| The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice | Q28591283 | ||
| Overexpression of Atg5 in mice activates autophagy and extends lifespan | Q29038178 | ||
| Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer | Q29248711 | ||
| The role of autophagy in neurodegenerative disease | Q29614834 | ||
| The unfolded protein response: controlling cell fate decisions under ER stress and beyond | Q29615499 | ||
| Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway | Q30532196 | ||
| CSF Aβ1-42 combined with neuroimaging biomarkers in the early detection, diagnosis and prediction of Alzheimer's disease | Q30655060 | ||
| Biomarkers in the Diagnosis and Prognosis of Alzheimer's Disease | Q30871982 | ||
| Alzheimer's Disease Cerebrospinal Fluid and Neuroimaging Biomarkers: Diagnostic Accuracy and Relationship to Drug Efficacy | Q30996799 | ||
| Neural-specific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration | Q33661680 | ||
| Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease | Q33662063 | ||
| Protein neddylation: beyond cullin-RING ligases | Q34042816 | ||
| The cholinergic system in aging and neuronal degeneration | Q34154074 | ||
| Neddylation dysfunction in Alzheimer's disease | Q34288710 | ||
| Molecular chaperone functions in protein folding and proteostasis | Q34349321 | ||
| YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease | Q34447497 | ||
| Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. | Q34450913 | ||
| Early detection of Alzheimer's disease using PiB and FDG PET | Q34483878 | ||
| A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease | Q34493731 | ||
| Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling | Q34506149 | ||
| Heat shock protein 70 in Alzheimer's disease | Q34560571 | ||
| Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress. | Q34572339 | ||
| Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade | Q34598030 | ||
| Taking aim at Alzheimer's disease through the mammalian target of rapamycin | Q34603651 | ||
| The failure in NGF maturation and its increased degradation as the probable cause for the vulnerability of cholinergic neurons in Alzheimer's disease | Q34615200 | ||
| The role of endoplasmic reticulum stress in neurodegenerative disease | Q38999268 | ||
| The activities of amyloids from a structural perspective | Q39004351 | ||
| Molecular interplay between mutant p53 proteins and autophagy in cancer cells. | Q39015946 | ||
| Endoplasmic reticulum-mediated unfolded protein response and mitochondrial apoptosis in cancer | Q39042225 | ||
| Necroptosis in development, inflammation and disease. | Q39044997 | ||
| Chloroethylating nitrosoureas in cancer therapy: DNA damage, repair and cell death signaling. | Q39112300 | ||
| Programmed cell death and the immune system | Q39120700 | ||
| Autophagy as a potential target for sarcoma treatment | Q39153215 | ||
| Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities | Q39171378 | ||
| Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1. | Q39292455 | ||
| PKD at the crossroads of necrosis and autophagy | Q39402239 | ||
| The Endoplasmic Reticulum Unfolded Protein Response in Neurodegenerative Disorders and Its Potential Therapeutic Significance | Q39410246 | ||
| Regulation of Autophagy through TORC1 and mTORC1. | Q39420799 | ||
| Neuronal and glia abnormalities in Tsc1-deficient forebrain and partial rescue by rapamycin. | Q39425768 | ||
| Autophagy in neurodegenerative diseases: pathogenesis and therapy. | Q39432638 | ||
| The spread of prion-like proteins by lysosomes and tunneling nanotubes: Implications for neurodegenerative diseases. | Q39445835 | ||
| Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. | Q39527042 | ||
| Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis | Q40132104 | ||
| Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. | Q40261652 | ||
| IRE1 signaling exacerbates Alzheimer's disease pathogenesis | Q40278876 | ||
| Reactivity of apolipoprotein E4 and amyloid beta peptide: lysosomal stability and neurodegeneration | Q40349274 | ||
| Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease | Q41323064 | ||
| Necrotic cell death and neurodegeneration: The involvement of endocytosis and intracellular trafficking | Q41409358 | ||
| Targeting autophagy in cancer | Q41912265 | ||
| Selective activation of mTORC1 signaling recapitulates microcephaly, tuberous sclerosis, and neurodegenerative diseases. | Q41930140 | ||
| Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice | Q41979914 | ||
| Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. | Q42239487 | ||
| Neuroprotection by Endoplasmic Reticulum Stress-Induced HRD1 and Chaperones: Possible Therapeutic Targets for Alzheimer's and Parkinson's Disease | Q42705597 | ||
| TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease | Q42777333 | ||
| Overexpression of ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) delays Alzheimer's progression in vivo | Q43051937 | ||
| Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease | Q43648215 | ||
| Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome | Q43788870 | ||
| The impact of cholesterol, DHA, and sphingolipids on Alzheimer's disease | Q43988916 | ||
| Aβ secretion and plaque formation depend on autophagy | Q44061458 | ||
| Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both -Amyloid Production and Clearance | Q44328454 | ||
| Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration. | Q44532915 | ||
| TOR-mediated regulation of metabolism in aging | Q45863420 | ||
| Trehalose rescues Alzheimer's disease phenotypes in APP/PS1 transgenic mice | Q46935089 | ||
| Necroptosis activation in Alzheimer's disease | Q46962553 | ||
| TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling. | Q47113110 | ||
| Functional analysis of Cullin 3 E3 ligases in tumorigenesis. | Q47413250 | ||
| Targeting mitochondrial function and proteostasis to mitigate dynapenia | Q47684486 | ||
| Clinical development of mTor inhibitors for renal cancer | Q47737687 | ||
| The Ubiquitin Code in the Ubiquitin-Proteasome System and Autophagy | Q47745372 | ||
| Resveratrol as a therapeutic agent for Alzheimer's disease | Q34667472 | ||
| Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers | Q34682521 | ||
| Age-induced reduction of autophagy-related gene expression is associated with onset of Alzheimer's disease | Q34987490 | ||
| Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies | Q35152946 | ||
| Misfolded proteins in Alzheimer's disease and type II diabetes. | Q35535599 | ||
| Emerging roles of the FBW7 tumour suppressor in stem cell differentiation | Q35634693 | ||
| Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3β (GSK3β) activity: novel mechanism for Pin1 to protect against Alzheimer disease. | Q35801982 | ||
| Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling | Q35886625 | ||
| The autophagy regulators Ambra1 and Beclin 1 are required for adult neurogenesis in the brain subventricular zone. | Q35966210 | ||
| Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-β peptide oligomers. | Q36003808 | ||
| PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia | Q36181284 | ||
| Autophagic and lysosomal defects in human tauopathies: analysis of post-mortem brain from patients with familial Alzheimer disease, corticobasal degeneration and progressive supranuclear palsy | Q36639242 | ||
| Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis | Q36753541 | ||
| Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders | Q36810822 | ||
| Necroptosis: an alternative cell death program defending against cancer. | Q36880241 | ||
| Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease | Q36885492 | ||
| Development and application of Hsp90 inhibitors | Q37055392 | ||
| Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease. | Q37180223 | ||
| The Noncanonical Role of ULK/ATG1 in ER-to-Golgi Trafficking Is Essential for Cellular Homeostasis | Q37194679 | ||
| Biomarkers for Alzheimer disease in cerebrospinal fluid, urine, and blood | Q37273675 | ||
| Inhibition of the ubiquitin-proteasome system in Alzheimer's disease. | Q37387675 | ||
| Evaluating the Effectiveness of GTM-1, Rapamycin, and Carbamazepine on Autophagy and Alzheimer Disease. | Q37659234 | ||
| Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52. | Q37708598 | ||
| Protein Quality Control by Molecular Chaperones in Neurodegeneration | Q37739093 | ||
| InterfERing with endoplasmic reticulum stress | Q37960224 | ||
| Alzheimer's disease and the quest for its biological measures | Q38018485 | ||
| Early-onset familial Alzheimer's disease (EOFAD). | Q38021307 | ||
| Hsp90 modulation for the treatment of Alzheimer's disease | Q38030122 | ||
| Autophagy, apoptosis, mitoptosis and necrosis: interdependence between those pathways and effects on cancer | Q38066407 | ||
| Endoplasmic reticulum dysfunction in neurological disease | Q38067205 | ||
| Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system | Q38093006 | ||
| The cell biology of prion-like spread of protein aggregates: mechanisms and implication in neurodegeneration | Q38101377 | ||
| Targeting the mTOR signaling network for Alzheimer's disease therapy | Q38121524 | ||
| Relationship between amyloid-beta and the ubiquitin-proteasome system in Alzheimer's disease | Q38186753 | ||
| P275 | copyright license | Creative Commons Attribution | Q6905323 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 5 | |
| P921 | main subject | Alzheimer's disease | Q11081 |
| signal transduction | Q828130 | ||
| P304 | page(s) | e12801 | |
| P577 | publication date | 2018-07-10 | |
| 2018-10-01 | |||
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Aging Cell | Q2221073 |
| P1476 | title | The emerging roles of protein homeostasis-governing pathways in Alzheimer's disease | |
| P478 | volume | 17 |
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