| scholarly article | Q13442814 |
| P50 | author | Aaron Ciechanover | Q233205 |
| P2093 | author name string | Yong Tae Kwon | |
| P2860 | cites work | Huntington's disease: a clinical review | Q21202876 |
| Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway | Q22008563 | ||
| Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions | Q22010047 | ||
| The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins | Q24290709 | ||
| CHIP protects from the neurotoxicity of expanded and wild-type ataxin-1 and promotes their ubiquitination and degradation | Q24296740 | ||
| Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6 | Q24300029 | ||
| Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons | Q24306619 | ||
| BAG-1 modulates the chaperone activity of Hsp70/Hsc70. | Q24313113 | ||
| A receptor for the selective uptake and degradation of proteins by lysosomes | Q24319797 | ||
| The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors | Q24321690 | ||
| A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins | Q24339606 | ||
| A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons | Q24529893 | ||
| Chaperone-mediated autophagy: a unique way to enter the lysosome world | Q24628159 | ||
| Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS | Q24633692 | ||
| Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory | Q24645499 | ||
| The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane | Q24646454 | ||
| alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies | Q24653247 | ||
| Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway | Q24657529 | ||
| One step at a time: endoplasmic reticulum-associated degradation | Q24658302 | ||
| An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation | Q24678575 | ||
| Expression of the small heat shock protein family in the mouse CNS: differential anatomical and biochemical compartmentalization. | Q54539175 | ||
| Heat Shock Proteins: Cell Protection through Protein Triage | Q55413708 | ||
| NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets | Q57269938 | ||
| Genetics of Alzheimer’s Disease | Q57393344 | ||
| Protein disulfide isomerase-immunopositive inclusions in patients with amyotrophic lateral sclerosis | Q58125527 | ||
| Peptide sequences that target proteins for enhanced degradation during serum withdrawal | Q68328388 | ||
| The ubiquitin-mediated proteolytic system: involvement of molecular chaperones, degradation of oncoproteins, and activation of transcriptional regulators | Q71574287 | ||
| Independence of the chaperone activity of protein disulfide isomerase from its thioredoxin-like active site | Q71891840 | ||
| Amyloid β-Protein Inhibits Ubiquitin-dependent Protein Degradation in Vitro | Q71996662 | ||
| Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70 | Q73182515 | ||
| Small heat shock proteins inhibit in vitro A beta(1-42) amyloidogenesis | Q73879419 | ||
| Age-associated decrease in proteasome content and activities in human dermal fibroblasts: restoration of normal level of proteasome subunits reduces aging markers in fibroblasts from elderly persons | Q80376039 | ||
| The N-end rule pathway and regulation by proteolysis | Q34189152 | ||
| Peptide sequences that target cytosolic proteins for lysosomal proteolysis | Q34229121 | ||
| Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins | Q34241138 | ||
| Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation | Q34289700 | ||
| Mechanisms of protein-folding diseases at a glance | Q27003095 | ||
| Protein quality control in the nucleus | Q27023202 | ||
| ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation | Q27301374 | ||
| Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding | Q27650844 | ||
| K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody | Q27663589 | ||
| Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation | Q27683847 | ||
| Mechanisms underlying ubiquitination | Q27860656 | ||
| The ubiquitin system | Q27860803 | ||
| Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins | Q27930363 | ||
| Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins | Q27931364 | ||
| Degradation-mediated protein quality control in the nucleus | Q27931698 | ||
| Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1 | Q27932129 | ||
| Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. | Q27933653 | ||
| Role of a ribosome-associated E3 ubiquitin ligase in protein quality control | Q27936843 | ||
| Degradation of misfolded protein in the cytoplasm is mediated by the ubiquitin ligase Ubr1. | Q27939178 | ||
| Protein disaggregation mediated by heat-shock protein Hsp104. | Q27940314 | ||
| Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion | Q27973919 | ||
| Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis | Q28115951 | ||
| Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis | Q28131805 | ||
| Heat shock proteins in human cancer | Q28143188 | ||
| Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity | Q28143597 | ||
| Cooperation of a ubiquitin domain protein and an E3 ubiquitin ligase during chaperone/proteasome coupling | Q28202126 | ||
| Alpha-synuclein and neurodegenerative diseases | Q28204386 | ||
| Neurodegenerative disorders of protein aggregation | Q28212108 | ||
| Chaperonins are cell-signalling proteins: the unfolding biology of molecular chaperones | Q28213199 | ||
| Mammalian HSP60 is quickly sorted into the mitochondria under conditions of dehydration | Q28215605 | ||
| Binding of ATP to heat shock protein 90: evidence for an ATP-binding site in the C-terminal domain | Q28216259 | ||
| A molecular chaperone complex at the lysosomal membrane is required for protein translocation | Q28216426 | ||
| The activity of hsp90 alpha promoter is regulated by NF-kappa B transcription factors | Q28242458 | ||
| Interaction of the molecular chaperone DNAJB6 with growing amyloid-beta 42 (Aβ42) aggregates leads to sub-stoichiometric inhibition of amyloid formation | Q28247808 | ||
| Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice | Q28251779 | ||
| The ubiquitin-proteasome system and its role in inflammatory and autoimmune diseases | Q28263960 | ||
| Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis | Q28264387 | ||
| Metazoan Hsp70 machines use Hsp110 to power protein disaggregation | Q34300523 | ||
| Withaferin A induces proteasome inhibition, endoplasmic reticulum stress, the heat shock response and acquisition of thermotolerance | Q34316709 | ||
| Heat shock proteins: endogenous modulators of apoptotic cell death | Q34340472 | ||
| Molecular chaperone functions in protein folding and proteostasis | Q34349321 | ||
| Role of ubiquitin-proteasome-mediated proteolysis in nervous system disease | Q34372681 | ||
| Heat‐shock protein 70 modulates toxic extracellular α‐synuclein oligomers and rescues trans‐synaptic toxicity | Q34421765 | ||
| Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation | Q34488383 | ||
| Molecular chaperones: assisting assembly in addition to folding | Q34529216 | ||
| Protein aggregation in crowded environments. | Q34532811 | ||
| Triad3A regulates ubiquitination and proteasomal degradation of RIP1 following disruption of Hsp90 binding | Q34565587 | ||
| Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties | Q34581749 | ||
| Consequences of the selective blockage of chaperone-mediated autophagy | Q34596028 | ||
| Impaired neurogenesis and cardiovascular development in mice lacking the E3 ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. | Q34597362 | ||
| Protein misassembly: macromolecular crowding and molecular chaperones | Q34598310 | ||
| Chaperoning Anfinsen: the steric foldases. | Q34628177 | ||
| Monitoring the prevention of amyloid fibril formation by alpha-crystallin. Temperature dependence and the nature of the aggregating species | Q34713919 | ||
| Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins | Q34719259 | ||
| Molecular chaperones antagonize proteotoxicity by differentially modulating protein aggregation pathways | Q34979557 | ||
| Varying intertrial interval reveals temporally defined memory deficits and enhancements in NTAN1-deficient mice | Q35040572 | ||
| Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies | Q35152946 | ||
| Binding of the molecular chaperone αB-crystallin to Aβ amyloid fibrils inhibits fibril elongation | Q35246361 | ||
| Polypeptide transfer from Hsp40 to Hsp70 molecular chaperones | Q35623822 | ||
| Proteasome and peptidase function in MHC-class-I-mediated antigen presentation | Q35634031 | ||
| Ubiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stability | Q35672223 | ||
| Heat shock transcription factor 1-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones | Q35674426 | ||
| BAG-1--a nucleotide exchange factor of Hsc70 with multiple cellular functions | Q35675549 | ||
| Molecular chaperones in Parkinson's disease--present and future | Q35688796 | ||
| Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils | Q35753373 | ||
| CHIP: a link between the chaperone and proteasome systems | Q35759085 | ||
| Role of heat shock proteins during polyglutamine neurodegeneration: mechanisms and hypothesis | Q35764321 | ||
| Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding | Q35812368 | ||
| Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies | Q35839667 | ||
| Suppression of protein aggregation by chaperone modification of high molecular weight complexes | Q35888633 | ||
| Protein aggregation and neurodegenerative disease | Q28273600 | ||
| Proteomic data from human cell cultures refine mechanisms of chaperone-mediated protein homeostasis | Q28286034 | ||
| In vivo half-life of a protein is a function of its amino-terminal residue | Q28287702 | ||
| Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains | Q28298487 | ||
| CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70 | Q28303344 | ||
| Formation of toxic oligomeric alpha-synuclein species in living cells | Q28472448 | ||
| A mouse amidase specific for N-terminal asparagine. The gene, the enzyme, and their function in the N-end rule pathway | Q28511918 | ||
| Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment | Q28565257 | ||
| A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins | Q28579745 | ||
| Altered activity, social behavior, and spatial memory in mice lacking the NTAN1p amidase and the asparagine branch of the N-end rule pathway | Q28593574 | ||
| Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly | Q28910341 | ||
| Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species | Q28910363 | ||
| A proteomics approach to understanding protein ubiquitination | Q29547312 | ||
| TPR proteins: the versatile helix | Q29547585 | ||
| Molecular chaperones in protein folding and proteostasis | Q29547715 | ||
| Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy | Q29614178 | ||
| Structure and mechanism of the Hsp90 molecular chaperone machinery | Q29615146 | ||
| The HSP70 chaperone machinery: J proteins as drivers of functional specificity | Q29616140 | ||
| Enhancement of proteasome activity by a small-molecule inhibitor of USP14 | Q29616735 | ||
| HSP90 at the hub of protein homeostasis: emerging mechanistic insights | Q29616824 | ||
| HSP90 and the chaperoning of cancer | Q29617504 | ||
| The small heat shock proteins and their role in human disease. | Q30350852 | ||
| The substrate recognition domains of the N-end rule pathway | Q30437353 | ||
| Dynamics of heat shock protein 90 C-terminal dimerization is an important part of its conformational cycle | Q30496642 | ||
| Role of the ubiquitin proteasome system in Alzheimer's disease | Q33307872 | ||
| Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease | Q33526350 | ||
| Genome-wide RNA interference screen identifies previously undescribed regulators of polyglutamine aggregation | Q33694463 | ||
| Brain-permeable small-molecule inhibitors of Hsp90 prevent alpha-synuclein oligomer formation and rescue alpha-synuclein-induced toxicity | Q33714875 | ||
| Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78 | Q33778232 | ||
| NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation | Q33915312 | ||
| A nucleus-based quality control mechanism for cytosolic proteins | Q33948472 | ||
| The ubiquitin-proteasome pathway and synaptic plasticity | Q33994715 | ||
| The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system | Q34056277 | ||
| RGS4 and RGS5 are in vivo substrates of the N-end rule pathway | Q34085136 | ||
| Identification of a redox-regulated chaperone network | Q34107320 | ||
| Toxic proteins in neurodegenerative disease | Q34133493 | ||
| Heat-shock protein 90, a chaperone for folding and regulation | Q34163660 | ||
| Mapping the road to recovery: the ClpB/Hsp104 molecular chaperone. | Q38015664 | ||
| Interactions of the proteasomal system with chaperones: protein triage and protein quality control | Q38021164 | ||
| Heat shock protein-inducing compounds as therapeutics to restore proteostasis in atrial fibrillation | Q38032035 | ||
| Molecular chaperones, α-synuclein, and neurodegeneration | Q38038121 | ||
| Alzheimer’s disease, cerebrovascular disease, and the β-amyloid cascade. | Q38066233 | ||
| The changing scene of amyotrophic lateral sclerosis | Q38086771 | ||
| Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting | Q38088874 | ||
| The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol | Q38131625 | ||
| Protein rescue from aggregates by powerful molecular chaperone machines | Q38141722 | ||
| Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases | Q38195215 | ||
| Cargo recognition and trafficking in selective autophagy | Q38215949 | ||
| Tetratricopeptide repeat motif-mediated Hsc70-mSTI1 interaction. Molecular characterization of the critical contacts for successful binding and specificity | Q38359786 | ||
| The Mechanism and Function of Group II Chaperonins | Q38455984 | ||
| α-Synuclein: Experimental Pathology | Q38915762 | ||
| BiP prevents rod opsin aggregation | Q39303756 | ||
| GRP78 counteracts cell death and protein aggregation caused by mutant huntingtin proteins | Q39366737 | ||
| Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase. | Q39372230 | ||
| HSPB7 is the most potent polyQ aggregation suppressor within the HSPB family of molecular chaperones | Q39655631 | ||
| Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease | Q39686268 | ||
| A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation | Q39738894 | ||
| Clearance of mutant aggregate-prone proteins by autophagy. | Q39990129 | ||
| BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein. | Q40063710 | ||
| Disease-associated prion protein oligomers inhibit the 26S proteasome | Q40139713 | ||
| Histone deacetylase 6 inhibition compensates for the transport deficit in Huntington's disease by increasing tubulin acetylation | Q40152899 | ||
| Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway | Q40267721 | ||
| 17-AAG, an Hsp90 inhibitor, causes kinetochore defects: a novel mechanism by which 17-AAG inhibits cell proliferation | Q40311479 | ||
| Cell type- and brain region-resolved mouse brain proteome. | Q40367891 | ||
| Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function | Q40425170 | ||
| Geldanamycin induces Hsp70 and prevents alpha-synuclein aggregation and toxicity in vitro | Q40517262 | ||
| Saccharomyces cerevisiae Hsp104 enhances the chaperone capacity of human cells and inhibits heat stress-induced proapoptotic signaling | Q40542997 | ||
| Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release | Q40551652 | ||
| Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease. | Q36085373 | ||
| Novel insights into the mechanism of chaperone-assisted protein disaggregation | Q36275416 | ||
| The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system | Q36295481 | ||
| Genomic evidence for independent origins of beta-like globin genes in monotremes and therian mammals | Q36446409 | ||
| Celastrol inhibits polyglutamine aggregation and toxicity though induction of the heat shock response | Q36488831 | ||
| The small heat shock proteins αB-crystallin and Hsp27 suppress SOD1 aggregation in vitro | Q36636450 | ||
| Huntington's disease: pathological mechanisms and therapeutic strategies | Q36822322 | ||
| Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease | Q36835739 | ||
| Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries | Q36857677 | ||
| Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor | Q36884034 | ||
| The mammalian N-end rule pathway: new insights into its components and physiological roles | Q36982121 | ||
| Prefoldin protects neuronal cells from polyglutamine toxicity by preventing aggregation formation | Q37000637 | ||
| Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons | Q37143978 | ||
| Multivalency-assisted control of intracellular signaling pathways: application for ubiquitin- dependent N-end rule pathway | Q37149486 | ||
| Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease | Q37178375 | ||
| Autophagy: a lysosomal degradation pathway with a central role in health and disease | Q37245031 | ||
| Hsp104 and ClpB: protein disaggregating machines | Q37325250 | ||
| Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease | Q37336253 | ||
| Therapeutic strategies within the ubiquitin proteasome system. | Q37531925 | ||
| Stressing the ubiquitin-proteasome system | Q37562694 | ||
| Heat-shock protein 104 expression is sufficient for thermotolerance in yeast | Q37583039 | ||
| Heat shock proteins; an overview | Q37695318 | ||
| Chaperone-assisted degradation: multiple paths to destruction | Q37714916 | ||
| Protein folding sculpting evolutionary change | Q37726611 | ||
| The culprit behind amyloid beta peptide related neurotoxicity in Alzheimer's disease: oligomer size or conformation? | Q37774042 | ||
| Structure, Assembly and Homeostatic Regulation of the 26S Proteasome | Q37798615 | ||
| The role of ubiquitin-proteasome system in ageing. | Q37842831 | ||
| Misfolded protein aggregates: mechanisms, structures and potential for disease transmission | Q37875484 | ||
| Protein aggregate spreading in neurodegenerative diseases: problems and perspectives | Q37882078 | ||
| Epidemiology and etiology of Parkinson's disease: a review of the evidence | Q37882546 | ||
| Alteration of protein folding and degradation in motor neuron diseases: Implications and protective functions of small heat shock proteins. | Q37942467 | ||
| The N-end rule pathway: emerging functions and molecular principles of substrate recognition | Q37947993 | ||
| Roles of extracellular chaperones in amyloidosis | Q37976159 | ||
| Protein homeostasis, aging and Alzheimer's disease | Q37987808 | ||
| Misfolded PrP and a novel mechanism of proteasome inhibition | Q37997568 | ||
| Chaperone networks in protein disaggregation and prion propagation | Q38009622 | ||
| Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity | Q40573441 | ||
| TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation | Q40691639 | ||
| Purification of polyglutamine aggregates and identification of elongation factor-1alpha and heat shock protein 84 as aggregate-interacting proteins. | Q40692086 | ||
| An essential role of N-terminal arginylation in cardiovascular development | Q40720569 | ||
| Decreased levels of proteasome activity and proteasome expression in aging spinal cord | Q40873171 | ||
| Supervising the fold: functional principles of molecular chaperones | Q40949089 | ||
| Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients. | Q41206538 | ||
| Bivalent inhibitor of the N-end rule pathway | Q41671474 | ||
| Genetic suppression of polyglutamine toxicity in Drosophila | Q41724127 | ||
| Chaperone-dependent Neurodegeneration: A Molecular Perspective on Therapeutic Intervention | Q41786144 | ||
| Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events | Q41905072 | ||
| Hul5 HECT ubiquitin ligase plays a major role in the ubiquitylation and turnover of cytosolic misfolded proteins | Q42069478 | ||
| Changes in the proteolytic activities of proteasomes and lysosomes in human fibroblasts produced by serum withdrawal, amino-acid deprivation and confluent conditions | Q42157082 | ||
| Identification of thermolabile Escherichia coli proteins: prevention and reversion of aggregation by DnaK and ClpB. | Q42247311 | ||
| Disorder targets misorder in nuclear quality control degradation: a disordered ubiquitin ligase directly recognizes its misfolded substrates. | Q42564287 | ||
| The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin | Q42826312 | ||
| Regulation of lamp2a levels in the lysosomal membrane | Q42831940 | ||
| Proteins containing peptide sequences related to Lys-Phe-Glu-Arg-Gln are selectively depleted in liver and heart, but not skeletal muscle, of fasted rats | Q42859938 | ||
| The metazoan protein disaggregase and amyloid depolymerase system: Hsp110, Hsp70, Hsp40, and small heat shock proteins | Q42949802 | ||
| Disruption of ionic interactions between the nucleotide binding domain 1 (NBD1) and middle (M) domain in Hsp100 disaggregase unleashes toxic hyperactivity and partial independence from Hsp70. | Q42974776 | ||
| Protein quality control: U-box-containing E3 ubiquitin ligases join the fold | Q44061660 | ||
| Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions | Q44177978 | ||
| Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis | Q44197126 | ||
| Pharmacological prevention of Parkinson disease in Drosophila. | Q44202026 | ||
| Aggregated and monomeric alpha-synuclein bind to the S6' proteasomal protein and inhibit proteasomal function | Q44292891 | ||
| Alzheimer's associated variant ubiquitin causes inhibition of the 26S proteasome and chaperone expression | Q44518998 | ||
| Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila | Q44607268 | ||
| Proteasomal inhibition by alpha-synuclein filaments and oligomers. | Q44719233 | ||
| Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers | Q44904974 | ||
| Analysis of alpha-synuclein-associated proteins by quantitative proteomics | Q44964546 | ||
| BAG-1M is up-regulated in hippocampus of Alzheimer's disease patients and associates with tau and APP proteins | Q44965883 | ||
| Huntingtin: a single bait hooks many species | Q45296265 | ||
| Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein | Q45296862 | ||
| Overexpression of yeast hsp104 reduces polyglutamine aggregation and prolongs survival of a transgenic mouse model of Huntington's disease | Q45298652 | ||
| Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease | Q45304607 | ||
| Hsp104 targets multiple intermediates on the amyloid pathway and suppresses the seeding capacity of Abeta fibrils and protofibrils | Q46318976 | ||
| Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells | Q46442791 | ||
| Celastrol protects against MPTP- and 3-nitropropionic acid-induced neurotoxicity. | Q46644015 | ||
| Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice | Q46739909 | ||
| Hsp70 chaperone machine remodels protein aggregates at the initial step of Hsp70-Hsp100-dependent disaggregation. | Q46895785 | ||
| Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity | Q47241011 | ||
| Lewy bodies are ubiquitinated. A light and electron microscopic immunocytochemical study | Q48131361 | ||
| No global neocortical nerve cell loss in brains from patients with senile dementia of Alzheimer's type | Q48134637 | ||
| The molecular chaperone alphaB-crystallin enhances amyloid beta neurotoxicity | Q48136014 | ||
| Polymorphisms in protein disulfide isomerase are associated with sporadic amyotrophic lateral sclerosis in the Chinese Han population | Q48164274 | ||
| Induction of multiple heat shock proteins and neuroprotection in a primary culture model of familial amyotrophic lateral sclerosis | Q48430053 | ||
| Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity | Q48463677 | ||
| Facilitated stimulus-response associative learning and long-term memory in mice lacking the NTAN1 amidase of the N-end rule pathway | Q49035335 | ||
| Hsp105 reduces the protein aggregation and cytotoxicity by expanded-polyglutamine proteins through the induction of Hsp70. | Q50550445 | ||
| Chaperonin TRiC promotes the assembly of polyQ expansion proteins into nontoxic oligomers. | Q50715387 | ||
| Potential effect of S-nitrosylated protein disulfide isomerase on mutant SOD1 aggregation and neuronal cell death in amyotrophic lateral sclerosis. | Q51779212 | ||
| Cytosolic chaperonin prevents polyglutamine toxicity with altering the aggregation state. | Q52573641 | ||
| Inhibition of α-synuclein aggregation by small heat shock proteins. | Q53322022 | ||
| Heat shock proteins 70 and 90 inhibit early stages of amyloid beta-(1-42) aggregation in vitro. | Q53381705 | ||
| Hsp70 proteins bind Hsp100 regulatory M domains to activate AAA+ disaggregase at aggregate surfaces. | Q54323301 | ||
| The molecular principles of N-end rule recognition. | Q54378101 | ||
| P921 | main subject | molecular chaperones | Q422496 |
| quality control | Q827792 | ||
| neurodegeneration | Q1755122 | ||
| P304 | page(s) | 185 | |
| P577 | publication date | 2017-04-06 | |
| P1433 | published in | Frontiers in Neuroscience | Q2177807 |
| P1476 | title | Protein Quality Control by Molecular Chaperones in Neurodegeneration | |
| P478 | volume | 11 |
| Q92995041 | Abundant neuroprotective chaperone Lipocalin-type prostaglandin D synthase (L-PGDS) disassembles the Amyloid-β fibrils |
| Q93039143 | Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau |
| Q52332679 | Ataxia-Telangiectasia Mutated Kinase in the Control of Oxidative Stress, Mitochondria, and Autophagy in Cancer: A Maestro With a Large Orchestra. |
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| Q52716160 | Bortezomib enhances radiosensitivity in oral cancer through inducing autophagy-mediated TRAF6 oncoprotein degradation. |
| Q41623081 | Chaperone-Based Therapies for Disease Modification in Parkinson's Disease. |
| Q60908088 | Chaperoning the : Current Knowledge and Future Directions |
| Q47302470 | Cilostazol, a phosphodiesterase 3 inhibitor, activates proteasome-mediated proteolysis and attenuates tauopathy and cognitive decline |
| Q91868596 | Common Neurodegeneration-Associated Proteins Are Physiologically Expressed by Human B Lymphocytes and Are Interconnected via the Inflammation/Autophagy-Related Proteins TRAF6 and SQSTM1 |
| Q49649749 | Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules |
| Q93051251 | Could Heat Therapy Be an Effective Treatment for Alzheimer's and Parkinson's Diseases? A Narrative Review |
| Q39457805 | Crosstalk and Interplay between the Ubiquitin-Proteasome System and Autophagy |
| Q49233227 | DnaJ/Hsp40 Family and Parkinson's Disease |
| Q52332790 | Dysfunction of Protein Quality Control in Parkinsonism-Dementia Complex of Guam. |
| Q42334027 | Editorial: Ubiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System |
| Q55489699 | Engineered Hsp70 chaperones prevent Aβ42-induced memory impairments in a Drosophila model of Alzheimer's disease. |
| Q93091651 | Experimental evidence for the age dependence of tau protein spread in the brain |
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