Experimental evidence for the age dependence of tau protein spread in the brain

scientific article published on 26 June 2019

Experimental evidence for the age dependence of tau protein spread in the brain is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCIADV.AAW6404
P932PMC publication ID6594764
P698PubMed publication ID31249873

P50authorBradley HymanQ23303113
Susanne WegmannQ87854356
Rachel E BennettQ93091636
Danny McKenzieQ93091640
Molly J KirkQ93091643
Ana C AmaralQ93091645
P2093author name stringEloise Hudry
Zhanyun Fan
Julia Schiantarelli
Nahel Tunio
Louis Delorme
Miwei Hu
Samantha Nicholls
Ashley B Robbins
P2860cites workTransmission and spreading of tauopathy in transgenic mouse brainQ24651334
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Trans-synaptic spread of tau pathology in vivoQ28732288
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Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's diseaseQ29617286
Propagation of tau pathology in a model of early Alzheimer's diseaseQ29620203
Glial contributions to neurodegeneration in tauopathiesQ32173558
Tau promotes neurodegeneration through global chromatin relaxationQ33575083
Proteopathic tau seeding predicts tauopathy in vivo.Q34383788
Chaperones increase association of tau protein with microtubulesQ34470626
A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximityQ34616539
Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathyQ35053727
Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connectionsQ35985428
Transgenic animal models of tauopathiesQ35992159
Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicityQ36394952
Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathyQ36617500
Neuronal activity enhances tau propagation and tau pathology in vivo.Q37127500
Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic miceQ37415258
Protein Quality Control by Molecular Chaperones in NeurodegenerationQ37739093
ECM in brain aging and dementiaQ38269694
2016 Alzheimer's disease facts and figuresQ39444315
Studying tau protein propagation and pathology in the mouse brain using adeno-associated virusesQ40052866
Staging of Alzheimer's disease-related neurofibrillary changesQ40416705
Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.Q40854182
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathiesQ41760966
Expression of Tau Pathology-Related Proteins in Different Brain Regions: A Molecular Basis of Tau PathogenesisQ42288828
The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's DiseaseQ42470207
Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vectorQ45874327
Reduced gliotransmitter release from astrocytes mediates tau-induced synaptic dysfunction in cultured hippocampal neurons.Q48127231
Changes in neuronal DNA content variation in the human brain during agingQ48563741
The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology.Q53215353
Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways.Q55000106
Inert and seed-competent tau monomers suggest structural origins of aggregation.Q55715541
Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structureQ60603641
TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading.Q64928623
Tau impairs neural circuits, dominating amyloid-β effects, in Alzheimer models in vivo.Q64982207
Unconventional Secretion Mediates the Trans-cellular Spreading of TauQ88693640
P4510describes a project that usesImageJQ1659584
P433issue6
P304page(s)eaaw6404
P577publication date2019-06-26
P1433published inScience AdvancesQ19881044
P1476titleExperimental evidence for the age dependence of tau protein spread in the brain
P478volume5

Reverse relations

cites work (P2860)
Q99608983Abnormal Homocysteine Metabolism: An Insight of Alzheimer's Disease from DNA Methylation
Q101135994Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative Phenotypes
Q89598886Curcumin's Nanomedicine Formulations for Therapeutic Application in Neurological Diseases
Q92017756Glycine-alanine dipeptide repeats spread rapidly in a repeat length- and age-dependent manner in the fly brain
Q91647353Klotho Pathways, Myelination Disorders, Neurodegenerative Diseases, and Epigenetic Drugs
Q91971770LRP1 is a master regulator of tau uptake and spread

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