Tau promotes neurodegeneration through global chromatin relaxation

scientific article

Tau promotes neurodegeneration through global chromatin relaxation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NN.3639
P932PMC publication ID4012297
P698PubMed publication ID24464041
P5875ResearchGate publication ID259918471

P50authorBess FrostQ56241080
Martin HembergQ88244360
P2093author name stringMel B Feany
Jada Lewis
P2860cites workUltrafast and memory-efficient alignment of short DNA sequences to the human genomeQ21183894
Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretaseQ24643985
The human genome browser at UCSCQ24672361
HP1 modulates the transcription of cell-cycle regulators in Drosophila melanogasterQ24805861
Tau promotes neurodegeneration via DRP1 mislocalization in vivoQ28119104
A germline-specific class of small RNAs binds mammalian Piwi proteinsQ28244097
Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17Q28274687
Discrete small RNA-generating loci as master regulators of transposon activity in DrosophilaQ28292093
A novel class of small RNAs bind to MILI protein in mouse testesQ28505738
The NIH Roadmap Epigenomics Mapping ConsortiumQ29619856
Neurodegenerative tauopathiesQ29619895
Chromatin proteins: key responders to stressQ31078221
Transcriptional profiling of Alzheimer blood mononuclear cells by microarrayQ33257812
Binding to the minor groove of the double-strand, tau protein prevents DNA from damage by peroxidationQ33348647
Heterochromatic genome stability requires regulators of histone H3 K9 methylationQ33422980
Unlocking the secrets of the genomeQ33745487
The functional organisation of glia in the adult brain of Drosophila and other insects.Q33760874
Clusters of conserved beta cell marker genes for assessment of beta cell phenotypeQ34017831
Genome-wide chromatin state transitions associated with developmental and environmental cuesQ34323419
Selection of candidate housekeeping genes for normalization in human postmortem brain samplesQ35296864
Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylationQ35565682
Heterochromatin structure and functionQ35935655
Tau phosphorylation sites work in concert to promote neurotoxicity in vivoQ36173962
FlyBase: improvements to the bibliographyQ36491607
Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responsesQ36605276
ChromHMM: automating chromatin-state discovery and characterizationQ36625108
Isolation of neuronal chromatin from brain tissueQ36649298
Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensationQ37292399
Uniting germline and stem cells: the function of Piwi proteins and the piRNA pathway in diverse organismsQ37322266
Ribosomal DNA contributes to global chromatin regulation.Q37394429
Amyloid-β and tau--a toxic pas de deux in Alzheimer's diseaseQ37824813
Gene expression profiling in human neurodegenerative diseaseQ38034387
Alzheimer disease in 2020.Q38057724
g:Profiler--a web-based toolset for functional profiling of gene lists from large-scale experimentsQ38302104
p53 is a chromatin accessibility factor for nucleotide excision repair of DNA damageQ39714641
Propagation of tau misfolding from the outside to the inside of a cell.Q39873721
Genome-wide analysis of Polycomb targets in Drosophila melanogasterQ40274308
Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1.Q40694593
Oxidative stress mediates tau-induced neurodegeneration in DrosophilaQ41044662
Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patientsQ41233963
Tau pathology in two Dutch families with mutations in the microtubule-binding region of tauQ42049071
Tau is a candidate gene for chromosome 17 frontotemporal dementiaQ42456776
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau proteinQ42491661
Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protectionQ42811651
Down-regulation of intra-hepatic T-cell signaling associated with GB virus C in a HCV/HIV co-infected group with reduced liver disease.Q43033751
Tauopathy in Drosophila: neurodegeneration without neurofibrillary tanglesQ43642001
Mitochondrial and cytoplasmic thioredoxin reductase variants encoded by a single Drosophila gene are both essential for viabilityQ43858131
Cell cycle activation linked to neuronal cell death initiated by DNA damageQ44774050
TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model.Q46930440
Local caspase activity directs engulfment of dendrites during pruning.Q47071864
Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation.Q48380256
Developmental regulation of heterochromatin-mediated gene silencing in Drosophila.Q52187895
Purification and properties of an ATP-dependent nucleosome remodeling factor.Q52546410
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo.Q52675363
Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila.Q52677007
A neuroprotective role for the DNA damage checkpoint in tauopathy.Q53197946
Visualization of chromatin events associated with repair of ultraviolet light-induced damage by premature chromosome condensation.Q53549933
Tau protein binds single-stranded DNA sequence specifically--the proof obtained in vitro with non-equilibrium capillary electrophoresis of equilibrium mixtures.Q54490742
Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organizationQ83201750
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectneurodegenerationQ1755122
P304page(s)357-366
P577publication date2014-01-26
P1433published inNature NeuroscienceQ1535359
P1476titleTau promotes neurodegeneration through global chromatin relaxation
P478volume17

Reverse relations

cites work (P2860)
Q39270980A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies
Q47402222A Conserved Cytoskeletal Signaling Cascade Mediates Neurotoxicity of FTDP-17 Tau Mutations In Vivo.
Q57036609A Novel Mutation in Brain Tumor Causes Both Neural Over-Proliferation and Neurodegeneration in Adult
Q64245708A walk through tau therapeutic strategies
Q36591506Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss
Q52798973Age-related change in γH2AX of Drosophila muscle: its significance as a marker for muscle damage and longevity.
Q47578572Age-related epigenetic changes in hippocampal subregions of four animal models of Alzheimer's disease.
Q50279747Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the Ribosome.
Q38831862Alzheimer's disease: An acquired neurodegenerative laminopathy
Q46240783Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies.
Q100316542An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease
Q34688159Are there roles for brain cell senescence in aging and neurodegenerative disorders?
Q89859049Awakening the dark side: retrotransposon activation in neurodegenerative disorders
Q41475139Axonal Degeneration during Aging and Its Functional Role in Neurodegenerative Disorders
Q41440551Bar-coding neurodegeneration: identifying subcellular effects of human neurodegenerative disease proteins using Drosophila leg neurons.
Q89873864Betaine restores epigenetic control and supports neuronal mitochondria in the cuprizone mouse model of multiple sclerosis
Q60938313Centromere and Pericentromere Transcription: Roles and Regulation … in Sickness and in Health
Q38820198Changes in Methionine Metabolism and Histone H3 Trimethylation Are Linked to Mitochondrial Defects in Multiple Sclerosis
Q38676090Chromatin Changes Associated with Neuronal Maintenance and Their Pharmacological Application
Q91692887Chromatin Regulation in Complex Brain Disorders
Q38234538Chromatin regulators in neurodevelopment and disease: Analysis of fly neural circuits provides insights: Networks of chromatin regulators and transcription factors underlie Drosophila neurogenesis and cognitive defects in intellectual disability and
Q46563937Chromatin-state discovery and genome annotation with ChromHMM.
Q30829185Co-expression of truncated and full-length tau induces severe neurotoxicity
Q104459100Comparative proteomic analysis highlights metabolic dysfunction in α-synucleinopathy
Q26996848Connecting the dots between tau dysfunction and neurodegeneration
Q89977186Contributions of DNA Damage to Alzheimer's Disease
Q39355455Date Palm Tree (Phoenix dactylifera L.): Natural Products and Therapeutic Options.
Q91786451Deconstructing and targeting the genomic architecture of human neurodegeneration
Q39021778Defective Phagocytic Corpse Processing Results in Neurodegeneration and Can Be Rescued by TORC1 Activation
Q30835928Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models
Q92355676Diseases of the nERVous system: retrotransposon activity in neurodegenerative disease
Q38605280Dissecting the role of Engrailed in adult dopaminergic neurons--Insights into Parkinson disease pathogenesis
Q33862621Dissecting the role of non-coding RNAs in the accumulation of amyloid and tau neuropathologies in Alzheimer's disease.
Q58716431Divergent brain gene expression patterns associate with distinct cell-specific tau neuropathology traits in progressive supranuclear palsy
Q47929663Diversity of astroglial responses across human neurodegenerative disorders and brain aging
Q41071847Dysregulation of Microtubule Stability Impairs Morphofunctional Connectivity in Primary Neuronal Networks
Q26770475Epigenetic Alterations in Alzheimer's Disease
Q28075559Epigenetic Changes in Neurodegenerative Diseases
Q89050478Epigenetic Regulation in Neurodegenerative Diseases
Q45874743Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice
Q97570185Epigenetic mechanisms in Alzheimer's disease
Q35340073Epigenetic mechanisms underlying the pathogenesis of neurogenetic diseases
Q28080633Epigenetics and therapeutic targets mediating neuroprotection
Q64947677Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains.
Q93091651Experimental evidence for the age dependence of tau protein spread in the brain
Q53116855Genome instability in Alzheimer disease.
Q57469396Genome-wide identification of genic and intergenic neuronal DNA regions bound by Tau protein under physiological and stress conditions
Q26765365Glial Tau Pathology in Tauopathies: Functional Consequences
Q61444197Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer's disease in old Bmi1+/- mice
Q55348325Heterochromatin protects retinal pigment epithelium cells from oxidative damage by silencing p53 target genes.
Q27324109Heterochromatin remodeling by CDK12 contributes to learning in Drosophila.
Q57471207Histone Hyperacetylation as a Response to Global Brain Ischemia Associated with Hyperhomocysteinemia in Rats
Q37347856Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns.
Q41335857Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau.
Q57816597Hyperphosphorylation of Tau Associates With Changes in Its Function Beyond Microtubule Stability
Q92068848Identification of Methylated Gene Biomarkers in Patients with Alzheimer's Disease Based on Machine Learning
Q34202948Integrated multi-cohort transcriptional meta-analysis of neurodegenerative diseases.
Q51763074Into the Fourth Dimension: Dysregulation of Genome Architecture in Aging and Alzheimer's Disease.
Q37714956KDM4B histone demethylase and G9a regulate expression of vascular adhesion proteins in cerebral microvessels
Q42118631Lamin Dysfunction Mediates Neurodegeneration in Tauopathies.
Q36174462Lifespan and Stress Resistance in Drosophila with Overexpressed DNA Repair Genes
Q64078047Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons
Q37239971Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatin
Q53606806Mechanisms of Evolutionary Innovation Point to Genetic Control Logic as the Key Difference Between Prokaryotes and Eukaryotes.
Q28082451Modeling the complex pathology of Alzheimer's disease in Drosophila
Q64245316Neurodegeneration, Heterochromatin, and Double-Stranded RNA
Q42690788Neuroepigenetic mechanisms in disease
Q26765693Neuroprotective Transcription Factors in Animal Models of Parkinson Disease
Q39095474Nuclear Dynamics of Heterochromatin Repair.
Q26769950Nuclear Tau and Its Potential Role in Alzheimer's Disease
Q41312269Oxidative Stress Modifies the Levels and Phosphorylation State of Tau Protein in Human Fibroblasts.
Q42123491Oxidative stress signaling to chromatin in health and disease.
Q91987091PIWI Proteins and piRNAs in the Nervous System
Q57938232PIWIL1 protein power targets tau therapy
Q36639646Parkinson disease and progressive supranuclear palsy: protein expression in skin.
Q57406604Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies
Q90192013Perinuclear Lamin A and Nucleoplasmic Lamin B2 Characterize Two Types of Hippocampal Neurons through Alzheimer's Disease Progression
Q90349337Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models
Q26797972Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage response
Q54978673Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn.
Q64271899REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease
Q98778468RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
Q28396013Repression of the Antioxidant NRF2 Pathway in Premature Aging
Q47281403Retiring the term FTDP-17 as MAPT mutations are genetic forms of sporadic frontotemporal tauopathies.
Q38669105Review: Spreading the word: precise animal models and validated methods are vital when evaluating prion-like behaviour of alpha-synuclein
Q33559303Roles of tau protein in health and disease
Q38514865Shaping of interphase chromosomes by the microtubule network.
Q47974120Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases.
Q35643397Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease
Q38973220Spatial genome organization and cognition
Q52657416Streamlined histone-based fluorescence lifetime imaging microscopy (FLIM) for studying chromatin organisation.
Q47387588TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling.
Q46576148Targeted Downregulation of dMyc Suppresses Pathogenesis of Human Neuronal Tauopathies in Drosophila by Limiting Heterochromatin Relaxation and Tau Hyperphosphorylation
Q92765086Targeted Downregulation of kdm4a Ameliorates Tau-engendered Defects in Drosophila melanogaster
Q89011157Tau Activates Transposable Elements in Alzheimer's Disease
Q59544017Tau Mutations Serve as a Novel Risk Factor for Cancer
Q95301002Tau affects P53 function and cell fate during the DNA damage response
Q33705540Tau association with synaptic vesicles causes presynaptic dysfunction
Q90157898Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration
Q28070250Tau physiology and pathomechanisms in frontotemporal lobar degeneration
Q47689697Tau-based therapies in neurodegeneration: opportunities and challenges
Q58558860Tau-induced nuclear envelope invagination causes a toxic accumulation of mRNA in Drosophila
Q26768223Tau: The Center of a Signaling Nexus in Alzheimer's Disease
Q93203071Tauopathy and neurodegeneration: A role for stress
Q35800000The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer's Disease
Q52692035The Retrotransposon storm and the dangers of a Collyer's genome.
Q38826595The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism
Q57944749The involvement of tau in nucleolar transcription and the stress response
Q39004340The road to restoring neural circuits for the treatment of Alzheimer's disease
Q39118898Therapeutic Strategies for Restoring Tau Homeostasis
Q27315889Transcriptional control of steroid biosynthesis genes in the Drosophila prothoracic gland by ventral veins lacking and knirps
Q89934165Transcriptional signature of prion-induced neurotoxicity in a Drosophila model of transmissible mammalian prion disease
Q61448737Unraveling Novel Mechanisms of Neurodegeneration Through a Large-Scale Forward Genetic Screen in
Q89506083Untangling the Tauopathy for Alzheimer's disease and parkinsonism
Q28383011Variations in brain DNA
Q37059940Vitamin C alleviates aging defects in a stem cell model for Werner syndrome
Q89752915When function follows form: Nuclear compartment structure and the epigenetic landscape of the aging neuron
Q89763818Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice
Q34753015p53 prevents neurodegeneration by regulating synaptic genes.
Q47911489α-synuclein Induces Mitochondrial Dysfunction through Spectrin and the Actin Cytoskeleton

Search more.