Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease.

scientific article published on 08 May 2013

Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1008947287
P356DOI10.1186/2051-5960-1-3
P932PMC publication ID3776211
P698PubMed publication ID24252508
P5875ResearchGate publication ID257103989

P50authorSharon C YatesQ59694396
P2093author name stringZsuzsanna Nagy
A David Smith
Margaret M Esiri
Roy Bicknell
Paul Hubbard
Gordon Wilcock
Sharon Christie
Sarah Durant
Amen Zafar
Sheila Nagy
P2860cites workControl of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway.Q46843629
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Rapamycin is a neuroprotective treatment for traumatic brain injury.Q48290046
The cell division cycle and the pathophysiology of Alzheimer's diseaseQ48382381
Genome wide profiling of altered gene expression in the neocortex of Alzheimer's diseaseQ48398994
Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's diseaseQ48428585
Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer diseaseQ48751082
P53-mediated G(1)/S checkpoint dysfunction in lymphocytes from Alzheimer's disease patients.Q53305818
Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain.Q53366814
MCI is a clinically useful concept.Q53380350
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's diseaseQ21136406
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairmentsQ24633947
Cluster analysis and display of genome-wide expression patternsQ24644463
mTOR signaling: at the crossroads of plasticity, memory and diseaseQ24647655
Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's diseaseQ24685592
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Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brainQ28267027
mTOR-dependent signalling in Alzheimer's diseaseQ28308319
Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injuryQ28571240
The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsyQ28579751
Molecular mechanisms of mTOR-mediated translational controlQ29615529
A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer diseaseQ33297839
Impact of RNA degradation on gene expression profiling.Q33652966
Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's diseaseQ33700331
Developing Antiepileptogenic Drugs for Acquired Epilepsy: Targeting the Mammalian Target of Rapamycin (mTOR) PathwayQ33805859
Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organizationQ34142269
Gene expression reveals overlap between normal aging and Alzheimer's disease genesQ34154632
Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticityQ35612500
Alzheimer's disease and the amyloid cascade hypothesis: a critical reviewQ35855587
The last neuronal division: a unifying hypothesis for the pathogenesis of Alzheimer's disease.Q36275654
Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responsesQ36605276
Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticityQ36712611
Role of mTOR in physiology and pathology of the nervous systemQ36959417
Regulation of cell death and epileptogenesis by the mammalian target of rapamycin (mTOR): a double-edged sword?Q37603072
Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growthQ37645017
Neuroimaging results impose new views on Alzheimer's disease--the role of amyloid revisedQ37971458
Microarray gene expression analysis of fixed archival tissue permits molecular classification and identification of potential therapeutic targets in diffuse large B-cell lymphoma.Q38404561
Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's diseaseQ38504815
The immunosuppressant rapamycin exacerbates neurotoxicity of Abeta peptideQ40235082
P70 S6 kinase mediates tau phosphorylation and synthesisQ40338655
Staging of Alzheimer's disease-related neurofibrillary changesQ40416705
Rapamycin blocks IL-2-driven T cell cycle progression while preserving T cell survivalQ40805846
Cell cycle kinesis in lymphocytes in the diagnosis of Alzheimer's diseaseQ43832582
P921main subjectAlzheimer's diseaseQ11081
risk factorQ1475848
P304page(s)3
P577publication date2013-05-08
P1433published inActa Neuropathologica CommunicationsQ27724912
P1476titleDysfunction of the mTOR pathway is a risk factor for Alzheimer's disease
P478volume1

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cites work (P2860)
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Q36539459Analysis of Proteins That Rapidly Change Upon Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC)
Q48547364AβPP/PS1 Transgenic Mice Show Sex Differences in the Cerebellum Associated with Aging
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