| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Jacques Hugon | Q63142903 |
| P2093 | author name string | Jin-Jing Pei | |
| P2860 | cites work | mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery | Q24302549 |
| Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control | Q24314363 | ||
| Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease | Q24685592 | ||
| TOR signaling in growth and metabolism | Q27860757 | ||
| Molecular organization of target of rapamycin complex 2. | Q27932791 | ||
| A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin | Q28238996 | ||
| Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau | Q28255422 | ||
| mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease | Q28256208 | ||
| Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease | Q28261987 | ||
| Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer's disease brain | Q28267027 | ||
| An RNA-dependent protein kinase is involved in tunicamycin-induced apoptosis and Alzheimer's disease | Q31041277 | ||
| Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner | Q33195730 | ||
| Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. | Q33292443 | ||
| Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron | Q34402849 | ||
| mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo | Q34542438 | ||
| RTP801 is elevated in Parkinson brain substantia nigral neurons and mediates death in cellular models of Parkinson's disease by a mechanism involving mammalian target of rapamycin inactivation. | Q34569422 | ||
| The two TORCs and Akt. | Q34617423 | ||
| Tor signalling in bugs, brain and brawn | Q35058522 | ||
| Okadaic-acid-induced inhibition of protein phosphatase 2A produces activation of mitogen-activated protein kinases ERK1/2, MEK1/2, and p70 S6, similar to that in Alzheimer's disease | Q35791980 | ||
| Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect? | Q35825892 | ||
| Regulation of serine protease activity by aluminum: implications for Alzheimer disease | Q36085876 | ||
| The growing role of mTOR in neuronal development and plasticity. | Q36739424 | ||
| Role of mTOR in physiology and pathology of the nervous system | Q36959417 | ||
| Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology | Q37296372 | ||
| Translational control of gene expression in the human brain | Q38663452 | ||
| Global translational responses to oxidative stress impact upon multiple levels of protein synthesis. | Q39348564 | ||
| Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A. | Q39967325 | ||
| Parallel increase in p70 kinase activation and tau phosphorylation (S262) with Abeta overproduction | Q40037612 | ||
| MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis | Q40049797 | ||
| The immunosuppressant rapamycin exacerbates neurotoxicity of Abeta peptide | Q40235082 | ||
| Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease | Q40297179 | ||
| P70 S6 kinase mediates tau phosphorylation and synthesis | Q40338655 | ||
| Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells. | Q40457386 | ||
| Regulation of elongation factor-2 kinase by pH. | Q40692268 | ||
| The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain. | Q40789796 | ||
| Activation of a PP2A-like phosphatase and dephosphorylation of tau protein characterize onset of the execution phase of apoptosis | Q41039578 | ||
| Alzheimer's disease-associated reduction of polysomal mRNA translation | Q42075712 | ||
| FK506 antagonizes apoptosis and c-jun protein expression in neuronal cultures | Q42540899 | ||
| Global gene expression profiling reveals widespread yet distinctive translational responses to different eukaryotic translation initiation factor 2B-targeting stress pathways | Q42590201 | ||
| In situ hybridization of calcium/calmodulin dependent protein kinase II and tau mRNAs: species differences and relative preservation in Alzheimer's disease | Q43726718 | ||
| Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degeneration | Q44220290 | ||
| BAD and Bcl-2 regulation are early events linking neuronal endoplasmic reticulum stress to mitochondria-mediated apoptosis | Q44280749 | ||
| Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice | Q44587906 | ||
| Homodirectional changes in transcriptome composition and mRNA translation induced by rapamycin and heat shock | Q44649321 | ||
| Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats | Q44776053 | ||
| Acute anoxia induces tau dephosphorylation in rat brain slices and its possible underlying mechanisms | Q46578528 | ||
| Ribosome dysfunction is an early event in Alzheimer's disease. | Q46738279 | ||
| TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model. | Q46930440 | ||
| Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity | Q47624762 | ||
| Overexpression of four-repeat tau mRNA isoforms in progressive supranuclear palsy but not in Alzheimer's disease | Q48115922 | ||
| Peripheral p70S6k levels and emotional memory in patients with Alzheimer's disease | Q48371906 | ||
| Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease | Q48419985 | ||
| Activated mTOR and PKR kinases in lymphocytes correlate with memory and cognitive decline in Alzheimer's disease | Q48428585 | ||
| Genetic complexity of Alzheimer's disease: successes and challenges. | Q48445023 | ||
| Assessments of the accumulation severities of amyloid beta-protein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains | Q48630091 | ||
| Alzheimer's disease brain: alterations in RNA levels and in a ribonuclease-inhibitor complex | Q48632716 | ||
| Cultured neurons expressing phosphorylated tau are more resistant to apoptosis induced by NMDA or serum deprivation | Q48747792 | ||
| Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias | Q48868584 | ||
| The relation between p70S6k expression in lymphocytes and the decline of cognitive test scores in patients with Alzheimer disease. | Q51987233 | ||
| Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease | Q53181393 | ||
| Expression of tau mRNA and soluble tau isoforms in affected and non-affected brain areas in Alzheimer's disease. | Q53264751 | ||
| Phosphorylated eukaryotic translation factor 4E is elevated in Alzheimer brain. | Q53366814 | ||
| Lactate and pH in the brain: association and dissociation in different pathophysiological states | Q69696498 | ||
| Phosphorylation of human microtubule-associated protein tau by protein kinases of the AGC subfamily | Q80356160 | ||
| Increased autophagy in transgenic mice with a G93A mutant SOD1 gene | Q80774356 | ||
| Increased mTORC1 signaling UPRegulates stress | Q80877075 | ||
| P433 | issue | 6B | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cell biology | Q7141 |
| Alzheimer's disease | Q11081 | ||
| enzyme | Q8047 | ||
| signal transduction | Q828130 | ||
| P304 | page(s) | 2525-32 | |
| P577 | publication date | 2008-12-01 | |
| P1433 | published in | Journal of Cellular and Molecular Medicine | Q1524063 |
| P1476 | title | mTOR-dependent signalling in Alzheimer's disease | |
| P478 | volume | 12 |
| Q102075390 | A meta-analysis of the effect of binge drinking on the oral microbiome and its relation to Alzheimer's disease |
| Q101410046 | A transition to degeneration triggered by oxidative stress in degenerative disorders |
| Q90337790 | APOE genotype-dependent pharmacogenetic responses to rapamycin for preventing Alzheimer's disease |
| Q38443497 | Activation of mTOR: a culprit of Alzheimer's disease? |
| Q36388420 | Activation of the macroautophagic system in scrapie-infected experimental animals and human genetic prion diseases |
| Q64076827 | Alzheimer's Disease and Cancer: When Two Monsters Cannot Be Together |
| Q26778149 | Alzheimer's Disease: Mechanism and Approach to Cell Therapy |
| Q36539459 | Analysis of Proteins That Rapidly Change Upon Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC) |
| Q38853431 | Autophagy and Alzheimer's Disease |
| Q46451525 | Beneficial effects of rapamycin in a Drosophila model for hereditary spastic paraplegia |
| Q59335039 | Blood-Based Kinase Assessments in Alzheimer's Disease |
| Q47658721 | Both decreased Akt expression and mTOR phosphorylation are related to decreased neuronal differentiation in the hippocampal alveus of aged mice |
| Q48873897 | Brain-Specific Basal and Novelty-Induced Alternations in PI3K-Akt and MAPK/ERK Signaling in a Middle-Aged AβPP/PS1 Mouse Model of Alzheimer's Disease |
| Q37585461 | Cerebral mTOR signal and pro-inflammatory cytokines in Alzheimer's disease rats |
| Q41973704 | Chronic hypoxia impairs murine hippocampal development and depletes the postnatal progenitor pool by attenuating mammalian target of rapamycin signaling |
| Q34344867 | Concerted perturbation observed in a hub network in Alzheimer's disease |
| Q27025904 | Consolidation and translation regulation |
| Q37662094 | Consumption of pomegranates improves synaptic function in a transgenic mice model of Alzheimer's disease |
| Q33938047 | Cotinine halts the advance of Alzheimer's disease-like pathology and associated depressive-like behavior in Tg6799 mice |
| Q37180223 | Dysfunction of the mTOR pathway is a risk factor for Alzheimer's disease. |
| Q38978791 | Dysregulated mTORC1-Dependent Translational Control: From Brain Disorders to Psychoactive Drugs |
| Q36218608 | Effect of treadmill exercise on PI3K/AKT/mTOR, autophagy, and Tau hyperphosphorylation in the cerebral cortex of NSE/htau23 transgenic mice |
| Q34350366 | Elucidating the role of DEPTOR in Alzheimer's disease |
| Q65002070 | Everolimus, a mammalian target of rapamycin inhibitor, ameliorated streptozotocin-induced learning and memory deficits via neurochemical alterations in male rats. |
| Q34490371 | Finding undetected protein associations in cell signaling by belief propagation |
| Q35014198 | Frontier of epilepsy research - mTOR signaling pathway |
| Q33707896 | Genetic reduction of mammalian target of rapamycin ameliorates Alzheimer's disease-like cognitive and pathological deficits by restoring hippocampal gene expression signature |
| Q54979703 | Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease. |
| Q27320372 | Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease |
| Q34669340 | Hot topics in aging research: protein translation and TOR signaling, 2010 |
| Q34043165 | Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits |
| Q112337950 | Inhibiting Autophagy Pathway of PI3K/AKT/mTOR Promotes Apoptosis in SK-N-SH Cell Model of Alzheimer's Disease |
| Q38027944 | Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer's disease. |
| Q33569701 | Interaction of double-stranded RNA-dependent protein kinase (PKR) with the death receptor signaling pathway in amyloid beta (Abeta)-treated cells and in APPSLPS1 knock-in mice |
| Q57723328 | Interplay between glycogen synthase kinase-3β and tau in the cerebellum of Hsp27 transgenic mouse |
| Q30412891 | Mammalian target of rapamycin (mTor) mediates tau protein dyshomeostasis: implication for Alzheimer disease |
| Q37680075 | Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology |
| Q37985671 | Mammalian target of rapamycin: a valid therapeutic target through the autophagy pathway for Alzheimer's disease? |
| Q90114589 | Mitochondria Targeted Therapeutics for Alzheimer's Disease: The Good. The Bad. The Potential |
| Q37587126 | Mitophagy and Parkinson's disease: the PINK1-parkin link. |
| Q39555156 | Modulation of oxidative stress and tau phosphorylation by the mTOR activator phosphatidic acid in SH-SY5Y cells |
| Q24633947 | Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-beta, and Tau: effects on cognitive impairments |
| Q37856779 | Molecular mechanisms linking diabetes mellitus and Alzheimer disease: beta-amyloid peptide, insulin signaling, and neuronal function |
| Q24595310 | Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism |
| Q37310632 | PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease |
| Q46489201 | PPAR Gamma Coactivator 1 Beta (PGC-1β) Reduces Mammalian Target of Rapamycin (mTOR) Expression via a SIRT1-Dependent Mechanism in Neurons |
| Q35893701 | Phospholipase D in brain function and Alzheimer's disease. |
| Q48802243 | Pro-neurogenesis and anti-dementia properties of tetradecyl 2,3-dihydroxybenzoate through TrkA receptor-mediated signalling pathways |
| Q38820173 | Pushing the threshold: How NMDAR antagonists induce homeostasis through protein synthesis to remedy depression. |
| Q42092288 | Radiosynthesis of [18F]ATPFU: a potential PET ligand for mTOR. |
| Q37636226 | Rapamycin Loaded Solid Lipid Nanoparticles as a New Tool to Deliver mTOR Inhibitors: Formulation and in Vitro Characterization. |
| Q37707528 | Rapamycin inhibits lipopolysaccharide-induced neuroinflammation in vitro and in vivo |
| Q92715084 | Revealing brain mechanisms of mTOR-mediated translational regulation: Implications for chronic pain |
| Q41116590 | Role of mammalian target of rapamycin signaling in autophagy and the neurodegenerative process using a senescence accelerated mouse-prone 8 model |
| Q37988399 | Roles of AMP-activated protein kinase in Alzheimer's disease. |
| Q21563497 | Rule-based cell systems model of aging using feedback loop motifs mediated by stress responses |
| Q38558121 | Screening the Molecular Framework Underlying Local Dendritic mRNA Translation. |
| Q58693255 | Senescence-Accelerated Mice P8: A Tool to Study Brain Aging and Alzheimer's Disease in a Mouse Model |
| Q27015640 | Shedding new light on neurodegenerative diseases through the mammalian target of rapamycin |
| Q90049715 | Targeting Autophagy for the Treatment of Alzheimer's Disease: Challenges and Opportunities |
| Q38815881 | Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies |
| Q27027415 | Tau and tauopathies |
| Q38184783 | The dark sides of amyloid in Alzheimer's disease pathogenesis |
| Q38028872 | The mTOR signaling pathway in the brain: focus on epilepsy and epileptogenesis |
| Q26824286 | The neurology of mTOR |
| Q28256247 | The role of mTOR signaling in Alzheimer disease |
| Q28730954 | The zinc dyshomeostasis hypothesis of Alzheimer's disease |
| Q37565965 | Treatment of intermittent hypoxia increases phosphorylated tau in the hippocampus via biological processes common to aging |
| Q64094060 | Urolithin A attenuates memory impairment and neuroinflammation in APP/PS1 mice |
| Q58694801 | Widespread Genotype-Phenotype Correlations in Intellectual Disability |
| Q36823796 | mTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring rats |
| Q47953822 | mTOR in Down syndrome: Role in Aß and tau neuropathology and transition to Alzheimer disease-like dementia |
| Q39298436 | mTOR referees memory and disease through mRNA repression and competition |
| Q50674022 | mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice. |
| Q58795101 | mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases |
| Q33736580 | mTORC1 Is a Local, Postsynaptic Voltage Sensor Regulated by Positive and Negative Feedback Pathways |
| Q47140692 | mTORC2 (Rictor) in Alzheimer's Disease and Reversal of Amyloid-β Expression-Induced Insulin Resistance and Toxicity in Rat Primary Cortical Neurons |
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