Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease

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Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease is …
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scholarly articleQ13442814

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P819ADS bibcode1995PNAS...9212260P
P356DOI10.1073/PNAS.92.26.12260
P932PMC publication ID40336
P698PubMed publication ID8618881
P5875ResearchGate publication ID14581440

P50authorRémi QuirionQ3456064
P2093author name stringPoirier J
Gauthier S
Farlow M
Nalbantoglu J
Aubert I
Bertrand P
Hui S
Delisle MC
Lahiri D
Gilfix BM
P2860cites workGene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset familiesQ27860677
Apolipoprotein E genotype and Alzheimer's diseaseQ28249303
Evidence for a membrane defect in Alzheimer disease brainQ28343061
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's diseaseQ29614952
Cloning of hippocampal poly(A) RNA sequences that increase after entorhinal cortex lesion in adult ratQ33245492
Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytesQ33360009
Apolipoproteins in human cerebrospinal fluidQ33976139
Synthesis of acetylcholine from choline derived from phosphatidylcholine in a human neuronal cell lineQ34335793
Alzheimer's disease and senile dementia: loss of neurons in the basal forebrainQ34714755
Choline metabolism as a basis for the selective vulnerability of cholinergic neuronsQ35318283
Lipoprotein receptors and cholesterol homeostasisQ40134833
Apolipoprotein E in animal models of CNS injury and in Alzheimer's diseaseQ40397850
Annular and nonannular binding sites for cholesterol associated with the nicotinic acetylcholine receptorQ42214371
Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkeyQ42464648
Nucleus basalis neuronal loss, neuritic plaques and choline acetyltransferase activity in advanced Alzheimer's diseaseQ42526718
A controlled trial of tacrine in Alzheimer's disease. The Tacrine Study GroupQ44110810
The apolipoprotein epsilon 4 allele in patients with Alzheimer's diseaseQ46484800
Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II).Q48164740
Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult ratsQ48256982
Hippocampal membrane alteration in Alzheimer's diseaseQ48287854
Comparative alterations of nicotinic and muscarinic binding sites in Alzheimer's and Parkinson's diseases.Q48533491
Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioningQ48668350
A 30-week randomized controlled trial of high-dose tacrine in patients with Alzheimer's disease. The Tacrine Study Group.Q52026922
Intracellular membranes are more fluid in platelets of Alzheimer's disease patientsQ52048876
Lewy bodies and response to tacrine in Alzheimer's disease.Q53204289
APOE genotype does not modulate age of onset in families with chromosome 14 encoded Alzheimer's disease.Q53205800
Family study of platelet membrane fluidity in Alzheimer's disease.Q53306162
Cerebrospinal fluid apolipoprotein E is reduced in Alzheimer's disease.Q53312352
Tacrine for senile dementia of Alzheimer's or Lewy body type.Q53314602
Apolipoprotein E polymorphism and Alzheimer's disease.Q53316388
Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease.Q53321766
Determination of alpha-tocopherol, free cholesterol, esterified cholesterols and triacylglycerols in human lipoproteins by high-performance liquid chromatographyQ68670479
Platelet membrane properties in Alzheimer and multi-infarct dementiasQ68713768
Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteinsQ68921833
Reinnervation of the hippocampal perforant pathway zone in Alzheimer's diseaseQ69111199
Tacrine slows the rate of ageing of sarin-inhibited acetylcholinesteraseQ69683824
Decreased myelin lipids in Alzheimer's disease and vascular dementiaQ69800363
A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 alleleQ72319861
Predictive value of apolipoprotein E genotyping in Alzheimer's disease: results of an autopsy series and an analysis of several combined studiesQ72903012
A "DIRECT-COLORING" THIOCHOLINE METHOD FOR CHOLINESTERASESQ76898743
P433issue26
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)12260-12264
P577publication date1995-12-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleApolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease
P478volume92

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