Pharmacogenetics, pharmacogenomics, and individualized medicine

journal article published in 2011

Pharmacogenetics, pharmacogenomics, and individualized medicine is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1124/PR.110.003533
P2880NIOSHTIC-2 ID20038682
P3181OpenCitations bibliographic resource ID1523536
P698PubMed publication ID21436344
P5875ResearchGate publication ID50850736

P50authorQiang MaQ79935556
P2093author name stringA. Y. H. Lu
P2860cites workOrigins of individual variability in P4501A inductionQ23919659
From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directionsQ60670847
Common allelic variants of cytochrome P4503A4 and their prevalence in different populationsQ63241958
The efficacy and six-week tolerability of simvastatin 80 and 160 mg/dayQ73048669
MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjectsQ77133730
Hypothesis: comparisons of inter- and intra-individual variations can substitute for twin studies in drug researchQ77221152
CYP2C19 genotype status and effect of omeprazole on intragastric pH in humansQ77788807
Genetic control of isoniazid metabolism in manQ79227074
Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatmentQ79826393
Pharmacogenomics of MRP transporters (ABCC1-5) and BCRP (ABCG2)Q81235097
Pharmacogenomics of 4-hydroxycoumarin anticoagulantsQ81235099
Warfarin pharmacogeneticsQ81887452
The challenges of dealing with promiscuous drug-metabolizing enzymes, receptors and transportersQ25112732
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinibQ27861059
A common polymorphism associated with antibiotic-induced cardiac arrhythmiaQ28138550
Genetic lesions of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler-Najjar and Gilbert syndromes: correlation of genotype to phenotypeQ28140057
Human UDP-glucuronosyltransferases: metabolism, expression, and diseaseQ28145608
Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarctionQ28168881
Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokineticsQ28179830
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphismsQ28203288
Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-AmericansQ28209488
Pharmacogenomics of human UDP-glucuronosyltransferases and irinotecan toxicityQ28218156
Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectivesQ28222158
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2Q28242581
Identification of the gene for vitamin K epoxide reductaseQ28242592
Medical genetics: a marker for Stevens-Johnson syndromeQ28254047
HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillinQ29417159
Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor geneQ29614892
SLCO1B1 variants and statin-induced myopathy--a genomewide studyQ29619028
Some statistical data on atypical cholinesterase of human serumQ30874133
Cytochrome P450 2C9 polymorphisms: a comprehensive review of the in-vitro and human data.Q32072529
Irinotecan-induced diarrhea: functional significance of the polymorphic ABCC2 transporter proteinQ33267448
Apixaban metabolism and pharmacokinetics after oral administration to humansQ33373622
Estimation of the warfarin dose with clinical and pharmacogenetic dataQ33410725
Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer diseaseQ33662063
Pharmacogenomics: translating functional genomics into rational therapeuticsQ33751829
TNFalpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients.Q33941873
N-acetyltransferase 2 and bladder cancer: an overview and consideration of the evidence for gene-environment interactionQ33985340
A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirements in African AmericansQ34085379
Pharmacogenetics and adverse drug reactionsQ34088287
Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavirQ34117815
Results of a prospective study of acute liver failure at 17 tertiary care centers in the United StatesQ34165115
Inheritance and drug responseQ34175608
Pharmacogenomics--drug disposition, drug targets, and side effectsQ34175616
Pharmacogenomics: unlocking the human genome for better drug therapyQ34192677
Interindividual variability in inhibition and induction of cytochrome P450 enzymesQ34192754
Pharmacogenetic study of statin therapy and cholesterol reductionQ44938097
Diflomotecan pharmacokinetics in relation to ABCG2 421C>A genotypeQ44960521
CYP2C19 polymorphism is a major predictor of treatment failure in white patients by use of lansoprazole-based quadruple therapy for eradication of Helicobacter pyloriQ45062165
High risk of cerebral-vein thrombosis in carriers of a prothrombin-gene mutation and in users of oral contraceptivesQ45887974
ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.Q45993642
Apixaban, an oral, direct, selective factor Xa inhibitor, in combination with antiplatelet therapy after acute coronary syndrome: results of the Apixaban for Prevention of Acute Ischemic and Safety Events (APPRAISE) trial.Q45995789
Comparative metabolism of 14C-labeled apixaban in mice, rats, rabbits, dogs, and humans.Q46023319
Defective activity of recombinant cytochromes P450 3A4.2 and 3A4.16 in oxidation of midazolam, nifedipine, and testosteroneQ46453447
Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokineticsQ46551880
A vitamin K epoxide reductase complex subunit-1 (VKORC1) mutation in a patient with vitamin K antagonist resistanceQ46566220
Genetic testing for warfarin dosing? Not yet ready for prime timeQ46787525
Prasugrel compared with high loading- and maintenance-dose clopidogrel in patients with planned percutaneous coronary intervention: the Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Activation and Aggregation-Thrombolysis in MyocQ46868498
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expressionQ46906576
Characterization of the UDP glucuronosyltransferase activity of human liver microsomes genotyped for the UGT1A1*28 polymorphismQ46980000
Association between angiotensin-converting enzyme gene polymorphisms and regression of left ventricular hypertrophy in patients treated with angiotensin-converting enzyme inhibitorsQ48206347
Richard Weinshilboum: Pharmacogenetics: The future is here!Q48351049
Treatment outcome of tacrine therapy depends on apolipoprotein genotype and gender of the subjects with Alzheimer's disease.Q50899702
Contrasting Genetic Influence of CCR2 and CCR5 Variants on HIV-1 Infection and Disease ProgressionQ56607621
Digoxin pharmacokinetics and MDR1 genetic polymorphismsQ57314091
Role of BCRP 421C>A polymorphism on rosuvastatin pharmacokinetics in healthy Chinese malesQ57500331
SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acidQ57825144
Angiotensin converting enzyme gene polymorphism and ACE inhibition in diabetic nephropathyQ59489273
Corticosteroid pharmacogenetics: association of sequence variants in CRHR1 with improved lung function in asthmatics treated with inhaled corticosteroidsQ34318910
CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatmentQ34381754
Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivityQ34400003
Common VKORC1 and GGCX polymorphisms associated with warfarin doseQ34417386
Effect of VKORC1 haplotypes on transcriptional regulation and warfarin doseQ34423204
Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashesQ34477526
Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene clusterQ34502235
Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.Q34502241
HLA-B*5701 screening for hypersensitivity to abacavirQ34747145
Association of warfarin dose with genes involved in its action and metabolismQ35633802
Moving towards individualized medicine with pharmacogenomicsQ35784527
Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratiosQ35860313
Pharmacogenomics and individualized drug therapyQ36366823
Genetic determinants of dose and clinical outcomes in patients receiving oral anticoagulantsQ36525260
The pharmocogenomics of warfarin: closing in on personalized medicineQ36588832
Pharmacogenomics: challenges and opportunitiesQ36658763
Pharmacokinetic and pharmacodynamic variability: a daunting challenge in drug therapyQ36737738
Pharmacogenetics of warfarin: regulatory, scientific, and clinical issuesQ36956360
Clinical pharmacogenetics and potential application in personalized medicineQ37294099
Translation of the Philadelphia chromosome into therapy for CML.Q37344094
Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variantQ37356747
A regulatory science perspective on warfarin therapy: a pharmacogenetic opportunityQ37380399
Targeted cancer therapies in the twenty-first century: lessons from imatinibQ37710963
CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activityQ38315596
Pharmacogenetic perspectives gained from twin and family studiesQ38628447
Can personalized drug therapy be achieved? A closer look at pharmaco-metabonomicsQ40284428
Impact of genetic polymorphisms of the beta2-adrenergic receptor on albuterol bronchodilator pharmacodynamics.Q40812511
A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injuryQ42966589
Use of pharmaco-metabonomics for early prediction of acetaminophen-induced hepatotoxicity in humansQ43150806
ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatinQ43174441
Personalized medicine, pharmacogenetics, and clopidogrel: unraveling variability of response.Q43177405
In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studiesQ43235385
A possible mechanism for the differences in efficiency and variability of active metabolite formation from thienopyridine antiplatelet agents, prasugrel and clopidogrel.Q43286781
Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomesQ43445863
The effect of common polymorphisms of the beta2-adrenergic receptor on agonist-mediated vascular desensitizationQ43756517
Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimusQ44579589
Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kineticsQ44872799
The influence of pharmacogenetics on the time to achieve target tacrolimus concentrations after kidney transplantation.Q44899003
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmanufacturingQ187939
geneQ7187
toxicologyQ7218
pharmacogenomicsQ1152227
diseaseQ12136
P5008on focus list of Wikimedia projectWikimedia–NIOSH collaborationQ104416361
P304page(s)437-459
P577publication date2011-03-24
P1433published inPharmacological ReviewsQ2085079
P859sponsorNIOSH Health Effects Laboratory DivisionQ123344455
P1476titlePharmacogenetics, pharmacogenomics, and individualized medicine
P478volume63

Reverse relations

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