Do SLCO1B3 (T334G) and CYP3A5*3 polymorphisms affect response in Egyptian chronic myeloid leukemia patients receiving imatinib therapy?

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Do SLCO1B3 (T334G) and CYP3A5*3 polymorphisms affect response in Egyptian chronic myeloid leukemia patients receiving imatinib therapy? is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1179/1607845412Y.0000000067
P698PubMed publication ID23394475

P2093author name stringAhmed M L Bedewy
Shereen M El-Maghraby
P2860cites workPharmacogenetics, pharmacogenomics, and individualized medicineQ23919667
Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humansQ28140931
Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8).Q34330241
Evolving concepts in the management of chronic myeloid leukemia: recommendations from an expert panel on behalf of the European LeukemiaNetQ34567629
Clinical pharmacokinetics of imatinibQ36240739
Novel targeted therapies to overcome imatinib mesylate resistance in chronic myeloid leukemia (CML).Q36280662
Pharmacogenomics of human OATP transportersQ36416907
Chronic myelogenous leukemia (CML): resistance to tyrosine kinase inhibitorsQ36612755
Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancerQ36974142
Chronic myeloid leukemia: an update of concepts and management recommendations of European LeukemiaNetQ37163550
Influence of CYP3A5 and drug transporter polymorphisms on imatinib trough concentration and clinical response among patients with chronic phase chronic myeloid leukemiaQ42933358
CYP3A activity influences imatinib response in patients with chronic myeloid leukemia: a pilot study on in vivo CYP3A activityQ43200942
CYP3A5 genotype did not impact on nifedipine disposition in healthy volunteersQ44675164
Clinical relevance of a pharmacogenetic approach using multiple candidate genes to predict response and resistance to imatinib therapy in chronic myeloid leukemia.Q45936706
Inhibition of imatinib transport by uremic toxins during renal failureQ46403767
Imatinib pharmacokinetics and its correlation with response and safety in chronic-phase chronic myeloid leukemia: a subanalysis of the IRIS studyQ46767695
Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expressionQ46906576
Variants in the SLCO1B3 gene: interethnic distribution and association with paclitaxel pharmacokinetics.Q50641149
Genetic polymorphism of CYP3A5 in Indian chronic myeloid leukemia patients.Q53366009
Polymorphisms and linkage disequilibrium of the OATP8 (OATP1B3) gene in Japanese subjects.Q54601398
P433issue4
P921main subjectimatinibQ177094
chronic myeloid leukemiaQ729735
P304page(s)211-216
P577publication date2013-01-31
P1433published inHematologyQ15752084
P1476titleDo SLCO1B3 (T334G) and CYP3A5*3 polymorphisms affect response in Egyptian chronic myeloid leukemia patients receiving imatinib therapy?
P478volume18

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cites work (P2860)
Q99711975Association of the Trough, Peak/Trough Ratio of Imatinib, Pyridine-N-Oxide Imatinib and ABCG2 SNPs 34 G>A and SLCO1B3 334 T>G With Imatinib Response in Egyptian Chronic Myeloid Leukemia Patients
Q87230149Genetic polymorphisms in cytochrome P450 and clinical outcomes of FOLFIRI chemotherapy in patients with metastatic colorectal cancer
Q53803475Impact of CYP3A4*18 and CYP3A5*3 Polymorphisms on Imatinib Mesylate Response Among Chronic Myeloid Leukemia Patients in Malaysia.
Q50261890Influence of CYP3A5*3 and ABCB1 C3435T on clinical outcomes and trough plasma concentrations of imatinib in Nigerians with chronic myeloid leukaemia.
Q38996487Pharmacogenetics of drug transporters in modulating imatinib disposition and treatment outcomes in chronic myeloid leukemia & gastrointestinal stromal tumor patients
Q58588447The significance of enzyme and transporter polymorphisms for imatinib plasma levels and achieving an optimal response in chronic myeloid leukemia patients
Q37663396Uptake carriers and oncology drug safety

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