HLA-B*5701 screening for hypersensitivity to abacavir

scientific article

HLA-B*5701 screening for hypersensitivity to abacavir is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1056/NEJMOA0706135
P698PubMed publication ID18256392

P50authorElizabeth J. PhillipsQ91133566
Simon A. MallalQ91272953
Jean-Michel MolinaQ108298727
P2093author name stringOleg Kozyrev
David Nolan
Sara Hughes
Phillip Hay
Janez Tomazic
Giampiero Carosi
Eva Jägel-Guedes
Cassy Workman
Arlene Hughes
Sorin Rugina
Alastair Benbow
Daren Thorborn
Juan Flores Cid
Nicholas Fitch
PREDICT-1 Study Team
Susanna Ryan
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectabacavirQ304330
P304page(s)568-579
P577publication date2008-02-01
P1433published inThe New England Journal of MedicineQ582728
P1476titleHLA-B*5701 screening for hypersensitivity to abacavir.
P478volume358

Reverse relations

cites work (P2860)
Q28711804'Sifting the significance from the data' - the impact of high-throughput genomic technologies on human genetics and health care
Q34792068A Genome-Wide Screen for Large-Effect Alloimmunization Susceptibility Loci among Red Blood Cell Transfusion Recipients with Sickle Cell Disease
Q35023821A Prospective Screening of HLA-B*57.01 Allelic Variant for Preventing the Hypersensivity Reaction to Abacavir: Experience from the Laboratory of Molecular Biology of the Infectious Diseases Division at the University Hospital of Salerno
Q36423260A Review of the 2010 WHO Adult Antiretroviral Therapy Guidelines: Implications and Realities of These Changes for Zambia
Q38777644A Systematic Review of Economic Evaluations of Pharmacogenetic Testing for Prevention of Adverse Drug Reactions.
Q38826219A brighter future for the implementation of pharmacogenomic testing
Q34602508A call for accurate pharmacogenetic labeling: telling it like it is
Q24239831A combination drug of abacavir-lamivudine-zidovudine (Trizivir®) for treating HIV infection and AIDS
Q42868757A fluorescence-based sequence-specific primer PCR for the screening of HLA-B(*)57:01.
Q33419319A genome-wide association study of heparin-induced thrombocytopenia using an electronic medical record
Q42966589A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury
Q35783016A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced torsades de pointes
Q34662516A novel Acute Retroviral Syndrome Severity Score predicts the key surrogate markers for HIV-1 disease progression
Q35321693A novel single cDNA amplicon pyrosequencing method for high-throughput, cost-effective sequence-based HLA class I genotyping
Q50518269A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: the TARGET study.
Q38030496A rare but severe pulmonary side effect of cetuximab in two patients.
Q38085220A review of pharmacogenetics of adverse drug reactions in elderly people
Q34778565A review of the pharmacokinetics of abacavir
Q40092386A severe hypersensitivity reaction to abacavir following re-challenge
Q54204422A transgenic mouse model for HLA-B*57:01-linked abacavir drug tolerance and reactivity.
Q38836848A web resource for mining HLA associations with adverse drug reactions: HLA-ADR
Q34215820A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients
Q36370958A world allergy organization international survey on diagnostic procedures and therapies in drug allergy/hypersensitivity
Q38951349Abacavir + dolutegravir + lamivudine for the treatment of HIV.
Q58557819Abacavir Hypersensitivity Reaction Reporting Rates During a Decade of HLA-B*5701 Screening as a Risk Mitigation Measure
Q37636061Abacavir and lamivudine combination
Q37905058Abacavir and lamivudine for the treatment of human immunodeficiency virus
Q37095697Abacavir hypersensitivity reaction: an update
Q37353680Abacavir hypersensitivity: a model system for pharmacogenetic test adoption
Q35737682Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase
Q28538078Abacavir induced T cell reactivity from drug naïve individuals shares features of allo-immune responses
Q34140322Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity
Q27008841Abacavir pharmacogenetics--from initial reports to standard of care
Q49037532Abacavir usage patterns and hypersensitivity reactions in the EuroSIDA cohort.
Q24235506Abacavir versus other nucleoside reverse transcriptase inhibitor (NRTI) backbone therapies for treatment of HIV infection
Q94348239Abacavir versus other nucleoside reverse transcriptase inhibitor (NRTI) backbone therapies for treatment of HIV infection
Q24202180Abacavir-based triple nucleoside regimens for maintenance therapy in patients with HIV
Q40869976Abacavir-induced fulminant hepatic failure in a HIV/HCV co-infected patient
Q40394091Abacavir-induced reaction with fever and severe skin rash in a patient tested human leukocyte antigen-B*5701 negative
Q28543405Abacavir-reactive memory T cells are present in drug naïve individuals
Q33715435Abacavir/lamivudine combination in the treatment of HIV: a review.
Q35233168Abacavir/lamivudine fixed-dose combination antiretroviral therapy for the treatment of HIV.
Q35214141Abacavir/lamivudine versus tenofovir DF/emtricitabine as part of combination regimens for initial treatment of HIV: final results
Q37803527Acceptance of biomarker-based tests for application in clinical practice: criteria and obstacles
Q44858073Accuracy of SNPs to predict risk of HLA alleles associated with drug-induced hypersensitivity events across racial groups
Q36802085Achieving the World Health Organization's vision for clinical pharmacology
Q57177440Active suppression rather than ignorance: tolerance to abacavir-induced HLA-B*57:01 peptide repertoire alteration
Q28547607Acyclovir Has Low but Detectable Influence on HLA-B*57:01 Specificity without Inducing Hypersensitivity
Q43190836Adding the 'medicines' back into personalized medicine to improve cancer treatment outcomes
Q38663764Advances in the Pharmacogenomics of Adverse Drug Reactions.
Q34594695Adverse cutaneous reactions associated with the newest antiretroviral drugs in patients with human immunodeficiency virus infection
Q38723580Adverse events associated with abacavir use in HIV-infected children and adolescents: a systematic review and meta-analysis
Q36242667Adversomics: a new paradigm for vaccine safety and design
Q69682607African Pharmacogenomics Consortium: Consolidating pharmacogenomics knowledge, capacity development and translation in Africa
Q38594891Allopurinol hypersensitivity: investigating the cause and minimizing the risk
Q58875252An Introduction to Pharmacogenomics and Personalized Medicine
Q37613520An Update on Drug-induced Liver Injury
Q35147717An assessment of adverse drug reactions among HIV positive patients receiving antiretroviral treatment in South Africa
Q48230747An effective strategy to prevent allopurinol-induced hypersensitivity by HLA typing.
Q45241984An evaluation of pharmacists' expectations towards pharmacogenomics
Q56888883Analysis of drug-drug interactions among patients receiving antiretroviral regimens using data from a large open-source prescription database
Q30999121Analyzing the potential for incorrect haplotype calls with different pharmacogenomic assays in different populations: a simulation based on 1000 Genomes data
Q57549163Antimicrobial Agents
Q37389754Antimicrobial stewardship's new weapon? A review of antibiotic allergy and pathways to 'de-labeling'.
Q37234729Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2016 Recommendations of the International Antiviral Society-USA Panel
Q38111430Antiretroviral drug-related toxicities - clinical spectrum, prevention, and management.
Q38170576Antiretroviral regimens sparing agents from the nucleoside(tide) reverse transcriptase inhibitor class: a review of the recent literature
Q37910819Antiretroviral therapy 2010 update: current practices and controversies
Q37770721Antiretroviral therapy and management of HIV infection
Q35770848Antiretroviral therapy in Indian setting: when & what to start with, when & what to switch to?
Q33877347Antiretroviral therapy in the clinic
Q34085926Antiretroviral therapy: current drugs
Q81917671Antiretroviral therapy: when to start and which drugs to use
Q40470257Antiretroviral treatment for HIV infection: Swedish recommendations 2016.
Q37870932Antiretroviral use during pregnancy for treatment or prophylaxis
Q34075812Antiviral drug allergy.
Q46445488Applicability of pharmacogenetic studies in daily clinical practice
Q40186791Application of pharmacogenomics to investigate adverse drug reactions to the disease-modifying treatments for multiple sclerosis: a case-control study protocol for dimethyl fumarate-induced lymphopenia
Q26864747Application of routine electronic health record databases for pharmacogenetic research
Q47284170Applications of pharmacogenomics in regulatory science: a product life cycle review
Q37695437Approach to the diagnosis of drug hypersensitivity reactions: similarities and differences between Europe and North America.
Q38286229Are drug metabolites able to cause T-cell-mediated hypersensitivity reactions?
Q57697028Are health technology assessments of pharmacogenetic tests feasible? A case study ofCYP2D6testing in the treatment of breast cancer with tamoxifen
Q36998698Are randomized trials obsolete or more important than ever in the genomic era?
Q90461024Assessing the Implementation of Pharmacogenomic Panel-Testing in Primary Care in the Netherlands Utilizing a Theoretical Framework
Q37803526Assessing the clinical utility of diagnostics used in drug therapy
Q26783472Assessing value of innovative molecular diagnostic tests in the concept of predictive, preventive, and personalized medicine
Q40759624Assessment of pharmacogenetic tests: presenting measures of clinical validity and potential population impact in association studies
Q51055927Association between HLA-B*1301 and dapsone-induced hypersensitivity reactions among leprosy patients in China.
Q36723349Association between antiretroviral exposure and renal impairment among HIV-positive persons with normal baseline renal function: the D:A:D study
Q47254975Association of CYP2C9*3 with phenytoin-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: A systematic review and meta-analysis
Q57557226Association of HLA-A*31:01 Screening With the Incidence of Carbamazepine-Induced Cutaneous Adverse Reactions in a Japanese Population
Q36740238Association of human leukocyte antigen alleles and nevirapine hypersensitivity in a Malawian HIV-infected population
Q34763589Association of pharmacogenetic markers with premature discontinuation of first-line anti-HIV therapy: an observational cohort study
Q91659814Associations between human leukocyte antigen polymorphisms and hypersensitivity to antiretroviral therapy in patients with human immunodeficiency virus: a meta-analysis
Q37881950Attitudes of health care professionals toward pharmacogenetic testing
Q38651981Bayesian analysis of genetic association across tree-structured routine healthcare data in the UK Biobank
Q49612005Benefit of pre-emptive pharmacogenetic information on clinical outcome.
Q43274977Beyond debacle and debate: developing solutions in drug safety
Q38155921Bioactivation of drugs in the skin: relationship to cutaneous adverse drug reactions
Q28652448Biobanks and electronic medical records: enabling cost-effective research
Q47928481Biomarkers of adverse drug reactions.
Q57163738Biomarkers of drug-induced liver injury: progress and utility in research, medicine, and regulation
Q38194173Biomarkers: refining diagnosis and expediting drug development - reality, aspiration and the role of open innovation
Q30699715Bringing clinical pharmacogenomics information to pharmacists: A qualitative study of information needs and resource requirements
Q51599376CARD14 mutations may predict response to antitumour necrosis factor-α therapy in psoriasis: a potential further step towards personalized medicine.
Q36930041CYP2C19 drug-drug and drug-gene interactions in ED patients
Q41048998Can antiretroviral therapy be tailored to each human immunodeficiency virus-infected individual? Role of pharmacogenomics
Q38415606Can genomic medicine improve financial sustainability of health systems?
Q34598487Carbamazepine, HLA-B*1502 and risk of Stevens-Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations.
Q35447163Cardiovascular pharmacogenomics
Q38169969Cardiovascular pharmacogenomics: expectations and practical benefits
Q36487290Cardiovascular pharmacogenomics: the future of cardiovascular therapeutics?
Q28533795Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the international encephalitis consortium
Q21563496Chapter 7: Pharmacogenomics
Q46847041Characterisation of the HLA-DRB1*07:01 biomarker for lapatinib-induced liver toxicity during treatment of early-stage breast cancer patients with lapatinib in combination with trastuzumab and/or taxanes
Q37287431Chemical individuality: concept and outlook
Q41045235Classifying ADRs--does dose matter?
Q40117884Clinical Abacavir Hypersensitivity Reaction among Children in India
Q37155053Clinical Application of Pharmacogenetics: Where are We Now?
Q39013613Clinical and regulatory considerations in pharmacogenetic testing.
Q36441517Clinical application of high throughput molecular screening techniques for pharmacogenomics
Q35502326Clinical applications of drug desensitization in the Asia-Pacific region
Q38654435Clinical characteristics and treatment outcome of Stevens-Johnson syndrome and toxic epidermal necrolysis
Q37678037Clinical implementation of genetic testing in medicine: a US regulatory science perspective
Q37775523Clinical implications of new findings in HIV basic research
Q36630680Clinical perspectives on human genetic screening to prevent nevirapine toxicity
Q36029478Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing
Q38541809Clinical pharmacokinetics and pharmacodynamics of dolutegravir used as a single tablet regimen for the treatment of HIV-1 infection
Q34736194Clinical practice guideline for the management of chronic kidney disease in patients infected with HIV: 2014 update by the HIV Medicine Association of the Infectious Diseases Society of America
Q37784777Clinical syndromes and consequences of antiretroviral-related hepatotoxicity
Q24657536Clinical use of pharmacogenomic tests in 2009
Q35126221Closing the gap between knowledge and clinical application: challenges for genomic translation
Q24200188Co-formulated abacavir-lamivudine-zidovudine for initial treatment of HIV infection and AIDS
Q38367106Combination dolutegravir-abacavir-lamivudine in the management of HIV/AIDS: clinical utility and patient considerations
Q35889793Comparative Analysis of Real-Time Polymerase Chain Reaction Methods to Typing HLA-B*57:01 in HIV-1-Positive Patients.
Q41078615Comparative analysis between saliva and buccal swabs as source of DNA: lesson from HLA-B*57:01 testing.
Q36282969Comparison of HLA allelic imputation programs.
Q36762374Comprehensive genome-wide evaluation of lapatinib-induced liver injury yields a single genetic signal centered on known risk allele HLA-DRB1*07:01.
Q38779627Consolidation of molecular testing in clinical virology
Q38182188Contributions of pharmacogenetics and transcriptomics to the understanding of the hypersensitivity drug reactions
Q90678926Controversies in drug allergy: Testing for delayed reactions
Q40381501Correlation, in previously treated HIV-1 positive patients, between hypersensitivity reaction to abacavir and the presence of the HLA-B*5701 allele
Q42243458Cost impact of prospective HLA-B*5701-screening prior to abacavir/lamivudine fixed dose combination use in Germany
Q48314103Cost-effectiveness of HLA-DQB1/HLA-B pharmacogenetic-guided treatment and blood monitoring in US patients taking clozapine.
Q38671676Cost-effectiveness of pharmacogenetic-guided treatment: are we there yet?
Q37202607Creating and evaluating genetic tests predictive of drug response
Q58774245Critical assessment of approaches for molecular docking to elucidate associations of HLA alleles with adverse drug reactions
Q90859692Cross-ethnicity tagging SNPs for HLA alleles associated with adverse drug reaction
Q37394799Current concepts of mechanisms in drug-induced hepatotoxicity
Q34996898Current progress in pharmacogenetics.
Q43611334Current situation of the pharmacogenetics of immune recovery in treated HIV-infected patients
Q37293999Current trends in screening across ethnicities for hypersensitivity to abacavir
Q42132518Cutaneous drug hypersensitivity: immunological and genetic perspective
Q36059568Cutaneous side effects of antiosteoporosis treatments
Q36885006DILI: New Insights into Diagnosis and Management
Q92190152Dapsone- and nitroso dapsone-specific activation of T cells from hypersensitive patients expressing the risk allele HLA-B*13:01
Q91016148Defining Regional Differences in Drug-Induced Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Tool to Improve Drug Safety?
Q57745295Deflating the Genomic Bubble
Q91126892Demonstrating Heterogeneity of Treatment Effects Among Patients: An Overlooked but Important Step Toward Precision Medicine
Q30758299Detection of HLA-B*57:01 by real-time PCR: implementation into routine clinical practice and additional validation data
Q50624617Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity.
Q33730146Developing pharmacogenetic evidence throughout clinical development
Q64938049Developing pharmacogenetic screening methods for an emergent country: Vietnam.
Q42607208Developing the evidence base for applying pharmacogenomics: proceeds from DIA Workshop IV--Breakout Session 1.
Q40405160Development of a simple genotyping method for the HLA-A*31:01-tagging SNP in Japanese
Q42213787Development of multiplex pyrosequencing for HLA-B*57:01 screening using single nucleotide polymorphism haplotype
Q91639512Development of the PGx-Passport: A Panel of Actionable Germline Genetic Variants for Pre-Emptive Pharmacogenetic Testing
Q90224362Diabetes: Is There a Future for Pharmacogenomics Guided Treatment?
Q47569828Diagnosing and managing patients with drug hypersensitivity
Q38222509Diagnostic accuracy of HLA-B*57:01 screening for the prediction of abacavir hypersensitivity and clinical utility of the test: a meta-analytic review
Q64126362Different roads, same destination
Q41747771Direct PCR: a new pharmacogenetic approach for the inexpensive testing of HLA-B*57:01.
Q37736460Direct-to-consumer genome testing: opportunities for pharmacogenomics research?
Q38097535Disclosure of individual pharmacogenomic results in research projects: when and what kind of information to return to research participants
Q38871356Distribution of HLA-B alleles in a Ugandan HIV-infected adult population: NORA pharmacogenetic substudy of DART.
Q37948858Do genome-wide association scans have potential for translation?
Q47603763Dolutegravir-induced liver injury leading to sub-acute liver failure requiring transplantation: a case report and review of literature.
Q43059203Dosing tacrolimus based on CYP3A5 genotype: will it improve clinical outcome?
Q44842257Drug Hypersensitivity and Anaphylaxis in Cancer and Chronic Inflammatory Diseases: The Role of Desensitizations
Q33839145Drug Hypersensitivity and Desensitizations: Mechanisms and New Approaches
Q55564369Drug Induced Hypersensitivity and the HLA Complex.
Q37349861Drug development: assessment of pharmacogenetic studies by Spanish research ethics committees
Q27679355Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire
Q35094201Drug hypersensitivity in human immunodeficiency virus-infected patient: challenging diagnosis and management
Q89885623Drug hypersensitivity reactions in Asia: regional issues and challenges
Q34701492Drug hypersensitivity: pharmacogenetics and clinical syndromes
Q64241592Drug reaction with eosinophilia and systemic symptoms (DRESS) in children
Q92535756Drug-Induced Liver Injury: Biomarkers, Requirements, Candidates, and Validation
Q33755165Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis
Q52346835Drug-Induced Skin Adverse Reactions: The Role of Pharmacogenomics in Their Prevention.
Q36512441Drug-induced arrhythmia: pharmacogenomic prescribing?
Q39887958Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future
Q37867695Drug-induced liver injury: a summary of recent advances.
Q35210890Drug-induced liver injury: the dawn of biomarkers?
Q37510856Drug-induced liver injury: what was new in 2008?
Q38122461Drug-reaction eosinophilia and systemic symptoms and drug-induced hypersensitivity syndrome
Q38554604Dual antiviral therapy for HIV and hepatitis C - drug interactions and side effects.
Q38736789Early gene expression changes with rush immunotherapy
Q42665272Economic efficiency of genetic screening to inform the use of abacavir sulfate in the treatment of HIV.
Q38095232Effect of the UGT1A1*28 allele on unconjugated hyperbilirubinemia in HIV-positive patients receiving Atazanavir: a systematic review
Q46488949Efficacy and tolerability of darunavir/ritonavir in combination with abacavir/lamivudine: an option in selected HIV-infected patients
Q41696314Efficacy of switching to dolutegravir plus rilpivirine, the small-tablet regimen, in patients with dysphagia: two case reports
Q34976470Epidemiology and risk factors for drug allergy
Q37540608Essential elements of personalized medicine
Q36605131Establishing the characteristics of an effective pharmacogenetic test for clozapine-induced agranulocytosis
Q51620356Estimation strategies for reacting to the identification of an association between the genome and adverse drug reactions.
Q64126594Evaluation of Prospective HLA-B*13:01 Screening to Prevent Dapsone Hypersensitivity Syndrome in Patients With Leprosy
Q41057427Evaluation of cytokine profile and HLA association in benznidazole related cutaneous reactions in patients with Chagas disease.
Q34002440Evaluation of drug interactions in a large sample of psychiatric inpatients: a data interface for mass analysis with clinical decision support software
Q49909599Evaluation of immune-mediated idiosyncratic drug toxicity using chimeric HLA transgenic mice.
Q93080606Evidence to Support Inclusion of Pharmacogenetic Biomarkers in Randomised Controlled Trials
Q26800980Evolving models of the immunopathogenesis of T cell-mediated drug allergy: The role of host, pathogens, and drug response.
Q28648163Extracting research-quality phenotypes from electronic health records to support precision medicine
Q27692095Fever, rash, and systemic symptoms: understanding the role of virus and HLA in severe cutaneous drug allergy.
Q42278364Flow cytometry analysis with a new FITC-conjugated monoclonal antibody-3E12 for HLA-B*57:01 rapid screening in prevention of abacavir hypersensitivity in HIV-1-infected patients
Q52660415Frank Stinchfield Award: Identification of the At-risk Genotype for Development of Pseudotumors Around Metal-on-metal THAs.
Q33775397French 2013 guidelines for antiretroviral therapy of HIV-1 infection in adults
Q43453078Frequencies of immune hypersensitivity reaction-associated HLA class I alleles in healthy South African Indian and mixed ancestry populations determined by a novel real-time PCR assay.
Q35179761Frequency of HLA B*5701 allele carriers in abacavir treated-HIV infected patients and controls from northeastern Brazil
Q37806982From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics
Q83509385From evidence based medicine to mechanism based medicine. Reviewing the role of pharmacogenetics
Q61639626Genetic Basis of Delayed Hypersensitivity Reactions to Drugs in Jewish and Arab Populations
Q90379501Genetic Diversity of HLA Class I and Class II Alleles in Thai Populations: Contribution to Genotype-Guided Therapeutics
Q41389082Genetic Factors Influencing Drug-Induced Liver Injury: Do They Have a Role in Prevention and Diagnosis?
Q26768628Genetic Markers of the Host in Persons Living with HTLV-1, HIV and HCV Infections
Q52588359Genetic Testing in Clinical Settings.
Q37931275Genetic association studies in drug-induced liver injury
Q37389496Genetic association studies to detect adverse drug reactions: abacavir hypersensitivity as an example
Q89747408Genetic associations with clozapine-induced myocarditis in patients with schizophrenia
Q38095989Genetic characterization to improve interpretation and clinical management of hepatotoxicity caused by tyrosine kinase inhibitors.
Q37264559Genetic factors that confer sensitivity to HAART in HIV-infected subjects: implication of a benefit of an earlier initiation of HAART.
Q89155792Genetic markers of severe cutaneous adverse reactions
Q34389768Genetic screening for metabolic and age-related complications in HIV-infected persons
Q24202114Genetic testing for prevention of severe drug-induced skin rash
Q37430324Genetic tests and genomic biomarkers: regulation, qualification and validation
Q34072196Genetic variants of APOC3 promoter and HLA-B genes in an HIV infected cohort in northern South Africa: a pilot study
Q34400003Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity
Q33693846Genetic-based prediction of disease traits: prediction is very difficult, especially about the future
Q37396981Genetics and the general physician: insights, applications and future challenges
Q38207944Genetics of immune-mediated adverse drug reactions: a comprehensive and clinical review
Q37714294Genome-wide association studies in pharmacogenomics.
Q35288691Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols
Q50680426Genomic medicine implementation: learning by example.
Q38114005Genomic medicine: a decade of successes, challenges, and opportunities
Q40086462Genomic testing as a tool to optimise drug therapy
Q35252277Genomics and drug response
Q36393911Genotype-based clinical trials in cardiovascular disease
Q38233757Genotype-guided drug prescribing: a systematic review and meta-analysis of randomized control trials
Q33582530Genotyping for severe drug hypersensitivity
Q96341703Global frequencies of clinically important HLA alleles and their implications for the cost-effectiveness of preemptive pharmacogenetic testing
Q43500764Guidance for pharmacogenomic biomarker testing in labels of FDA-approved drugs
Q22241321HIV Treatment Adherence, Drug Resistance, Virologic Failure: Evolving Concepts
Q83813731HIV as a chronic disease
Q58085173HIV control: Is getting there the same as staying there?
Q57096915HIV infection
Q40628462HIV infection : Test and treatment
Q37988776HIV therapies and the kidney: some good, some not so good?
Q37272625HLA B*5701 status, disease progression, and response to antiretroviral therapy
Q37963995HLA alleles and drug hypersensitivity reactions
Q37444410HLA and infectious diseases
Q38037649HLA and pharmacogenetics of drug hypersensitivity.
Q33666857HLA associations and clinical implications in T-cell mediated drug hypersensitivity reactions: an updated review.
Q47148549HLA genotyping by next-generation sequencing of complementary DNA.
Q50502052HLA polymorphisms influence the development of skin rash arising from treatment with EGF receptor inhibitors.
Q34172669HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans
Q34999573HLA-B allele and haplotype diversity among Thai patients identified by PCR-SSOP: evidence for high risk of drug-induced hypersensitivity
Q46238859HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis
Q93091889HLA-B*35:01 Allele Is a Potential Biomarker for Predicting Polygonum multiflorum-Induced Liver Injury in Humans
Q57273952HLA-B*38:02:01predicts carbimazole/methimazole-induced agranulocytosis
Q99608520HLA-B*39:01:01 is a novel risk factor for antithyroid drug-induced agranulocytosis in Japanese population
Q37667333HLA-B*57 Allele Is Associated with Concomitant Anti-tuberculosis and Antiretroviral Drugs Induced Liver Toxicity in Ethiopians
Q46445494HLA-B*5701 and hypersensitivity reactions to abacavir. Study methods and clinical relevance
Q42759515HLA-B*5701 frequency in Chilean HIV-infected patients and in general population
Q37514235HLA-B*5701 screening prior to abacavir prescription: clinical and laboratory aspects
Q33768961HLA-B*5701 testing to predict abacavir hypersensitivity
Q36343650HLA-B*57:01 allele prevalence in HIV-infected North American subjects and the impact of allele testing on the incidence of abacavir-associated hypersensitivity reaction in HLA-B*57:01-negative subjects
Q89997697HLA-B*57:01 allele prevalence in treatment-Naïve HIV-infected patients from Colombia
Q61447461HLA-B*57:01 screening and hypersensitivity reaction to abacavir between 1999 and 2016 in the OPERA observational database: a cohort study
Q91599524HLA-C*12:02 is strongly associated with Xuesaitong-induced cutaneous adverse drug reactions
Q52837404HLA-DQ allele-restricted activation of nitroso sulfamethoxazole-specific CD4-positive T lymphocytes from patients with cystic fibrosis.
Q47572304HLA-DQA1-HLA-DRB1 polymorphism is a major predictor of azathioprine-induced pancreatitis in patients with inflammatory bowel disease
Q42704205HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants.
Q92432175HLA-DRB1*07:01 and lapatinib-induced hepatotoxicity: a systematic review and meta-analysis
Q47826173HLA-associated drug hypersensitivity and the prediction of adverse drug reactions.
Q38949927HLADR: a database system for enhancing the discovery of biomarkers for predicting human leukocyte antigen-mediated idiosyncratic adverse drug reactions.
Q47320133HLAs: Key regulators of T-cell-mediated drug hypersensitivity.
Q37635191Harms from medicines: inevitable, in error or intentional.
Q27335598Harvesting candidate genes responsible for serious adverse drug reactions from a chemical-protein interactome
Q48861311Health regulatory communications of well-established safety-related pharmacogenomics associations in six developed countries: an evaluation of alignment.
Q38542198Hepatotoxicity of New Oral Anticoagulants (NOACs).
Q95272476High-Resolution HLA Typing of HLA-A, -B, -C, -DRB1, and -DQB1 in Kinh Vietnamese by Using Next-Generation Sequencing
Q99711638High-Throughput Sequencing to Investigate Associations Between HLA Genes and Metamizole-Induced Agranulocytosis
Q33575664Host genetic determinants of human immunodeficiency virus infection and disease progression in children
Q36872470Host genomic influences on HIV/AIDS.
Q40097257Human Leukocyte Antigen (HLA) and Immune Regulation: How Do Classical and Non-Classical HLA Alleles Modulate Immune Response to Human Immunodeficiency Virus and Hepatitis C Virus Infections?
Q30238992Human leucocyte antigen-adverse drug reaction associations: from a perspective of ethnicity.
Q38285818Human leukocyte antigen genetic risk factors of drug-induced liver toxicology
Q41918861Hypersensitivity Reaction Associated with Abacavir Therapy in an Indian HIV Patient - A Case Report
Q34976463Hypersensitivity reactions to HIV therapy
Q58804798Hypertension genomics and cardiovascular prevention
Q92509274Identification of drug-specific public TCR driving severe cutaneous adverse reactions
Q37702844Identifying predictive markers for personalized treatment selection
Q83258983Identifying who is at risk of drug-induced liver injury: is human leukocyte antigen specificity the key?
Q26824391Idiosyncratic adverse drug reactions: current concepts
Q38145274Idiosyncratic drug-induced liver injury: an update on the 2007 overview
Q92377615Immune mechanisms of idiosyncratic drug-induced liver injury
Q37510953Immune mediation of hypersensitivity adverse drug reactions: implications for therapy
Q27681301Immune self-reactivity triggered by drug-modified HLA-peptide repertoire
Q63728479Immunity and mental illness: findings from a Danish population-based immunogenetic study of seven psychiatric and neurodevelopmental disorders
Q37786631Immunological aspects of nonimmediate reactions to beta-lactam antibiotics
Q37991389Immunomodulatory effects of antimicrobial agents. Part I: antibacterial and antiviral agents
Q26787099Impact of New Genomic Technologies on Understanding Adverse Drug Reactions
Q34147916Implementation and utilization of genetic testing in personalized medicine
Q39062032Implementing Pharmacogenomics in Europe: Design and Implementation Strategy of the Ubiquitous Pharmacogenomics Consortium.
Q39034897Implementing Precision Medicine: The Ethical Challenges
Q49999241Implementing pharmacogenomics decision support across seven European countries: The Ubiquitous Pharmacogenomics (U-PGx) project.
Q47274350Improved Diagnosis and Care for Rare Diseases through Implementation of Precision Public Health Framework
Q34316771In silico analysis of HLA associations with drug-induced liver injury: use of a HLA-genotyped DNA archive from healthy volunteers
Q54364218In the NEWS A QUICK ROUNDUP OF NEWS AND INFORMATION FROM OUR COMMUNITY.
Q26741420In vitro Models to Evaluate Drug-Induced Hypersensitivity: Potential Test Based on Activation of Dendritic Cells
Q39909074In vitro tests for drug hypersensitivity reactions: an ENDA/EAACI Drug Allergy Interest Group position paper
Q34484483Incidence and predictors of regimen-modification from first-line antiretroviral therapy in Thailand: a cohort study
Q39022892Incidence and risk estimate of drug-induced agranulocytosis in Hong Kong Chinese. A population-based case-control study.
Q89040497Increased risk of strontium ranelate-related SJS/TEN is associated with HLA
Q36441423Individualization of antiretroviral therapy
Q38040697Individualization of drug therapy: history, present state, and opportunities for the future
Q33443448Influence of human leukocyte antigen (HLA) alleles and killer cell immunoglobulin-like receptors (KIR) types on heparin-induced thrombocytopenia (HIT).
Q92320730Influence of tissue context on gene prioritization for predicted transcriptome-wide association studies
Q37715735Inhibition of human endogenous retrovirus-K by antiretroviral drugs
Q57415259Initiating allopurinol therapy: do we need to know the patient's human leucocyte antigen status?
Q36599112Integrating electronic health record genotype and phenotype datasets to transform patient care
Q37715400Integrating pharmacogenetic information and clinical decision support into the electronic health record
Q92102522Integrating pharmacogenetic testing into primary care
Q42672191Interethnic comparisons of important pharmacology genes using SNP databases: potential application to drug regulatory assessments
Q43447907Interlaboratory measurement differences in intracellular carbovir triphosphate concentrations in HIV-infected patients: sources of variability in processing, shipping, and quantitation
Q81236984Is personalized medicine finally arriving?
Q37500009Italian consensus statement on management of HIV-infected individuals with advanced disease naïve to antiretroviral therapy.
Q35567805Key role of human leukocyte antigen in modulating human immunodeficiency virus progression: An overview of the possible applications
Q38045377Latest advances in predicting DILI in human subjects: focus on biomarkers
Q42782253Learning from product labels and label changes: how to build pharmacogenomics into drug-development programs
Q37708018Leveraging Genomic Factors to Improve Benefit-Risk
Q36370325Leveraging genomic data in smoking cessation trials in the era of Precision Medicine: Why and how.
Q38852184Liver involvement in human immunodeficiency virus infection
Q36163437Looking to the future: incorporating genomic information into disparities research to reduce measurement error and selection bias
Q33779389Loss-of-function CYP2C9 variants: finding the correct clinical role for Type 2 diabetes pharmacogenetic testing
Q35977574Low prevalence of human leukocyte antigen-B*5701 in HIV-1-infected Chinese subjects: a prospective epidemiological investigation
Q35188723Management of HIV infection in treatment-naive patients: a review of the most current recommendations
Q57302639Mechanisms of Adverse Drug Reactions
Q34169362Mechanisms of drug-induced liver injury: from bedside to bench
Q64241600Mechanisms of hypersensitivity reactions induced by drugs
Q97549977Mechanistic insights into antiretroviral drug-induced liver injury
Q30808861Medical genomics: Gather and use genetic data in health care
Q47277590Medical histories
Q37937051Metabolic activation in drug-induced liver injury
Q37757136Methodological and statistical issues in pharmacogenomics
Q26744637MinION: A Novel Tool for Predicting Drug Hypersensitivity?
Q36426953Modifying Antiretroviral Therapy in Virologically Suppressed HIV-1-Infected Patients
Q36089652Molecular docking to identify associations between drugs and class I human leukocyte antigens for predicting idiosyncratic drug reactions.
Q38248679Molecular mechanisms for contribution of MHC molecules to autoimmune diseases
Q37617319Multiphenotype association study of patients randomized to initiate antiretroviral regimens in AIDS Clinical Trials Group protocol A5202.
Q36419326N-terminal valine adduct from the anti-HIV drug abacavir in rat haemoglobin as evidence for abacavir metabolism to a reactive aldehyde in vivo
Q44357874NAVAGATE: a rubric to move from pharmacogenomics science to pharmacogenomics practice
Q39533858NRTI backbone in HIV treatment: will it remain relevant?
Q33378483Natural variation in immune responses to neonatal Mycobacterium bovis Bacillus Calmette-Guerin (BCG) Vaccination in a Cohort of Gambian infants
Q35167944Nephrotoxicity of HAART
Q40092748Nevirapine patch testing in Thai human immunodeficiency virus infected patients with nevirapine drug hypersensitivity
Q47140255New Insights into Drug Reaction with Eosinophilia and Systemic Symptoms Pathophysiology
Q48012091New Rodent Population Models May Inform Human Health Risk Assessment and Identification of Genetic Susceptibility to Environmental Exposures
Q26800973New approaches for predicting T cell-mediated drug reactions: A role for inducible and potentially preventable autoimmunity
Q44117548New approaches to drug safety: a pharmacovigilance tool kit.
Q26800976New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity
Q90334944New genetic predictors for abacavir tolerance in HLA-B*57:01 positive individuals
Q41876196Novel Concepts for Drug Hypersensitivity Based on the Use of Long-Time Scale Molecular Dynamic Simulation
Q64269386Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity
Q36173814Novel rare variants in congenital cardiac arrhythmia genes are frequent in drug-induced torsades de pointes.
Q44393316Novel sensitive, specific and rapid pharmacogenomic test for the prediction of abacavir hypersensitivity reaction: HLA-B*57:01 detection by real-time PCR.
Q92953588Older HIV-infected adults. Complex patients (III): Polypharmacy
Q36477760Omics Screening for Pharmaceutical Efficacy and Safety in Clinical Practice
Q39644558On pharmacogenomics in pharmacy benefit management
Q34976284Once-Daily, Single-Tablet Regimens For the Treatment of HIV-1 Infection
Q46544844Once-daily abacavir/lamivudine and ritonavir-boosted atazanavir for the treatment of HIV-1 infection in antiretroviral-naïve patients: a 48-week pilot study
Q88487480Opportunities and Challenges in Cardiovascular Pharmacogenomics: From Discovery to Implementation
Q37202877Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotyping
Q37100793Other side of the coin for personalised medicine and healthcare: content analysis of 'personalised' practices in the literature
Q41505058Paediatric European Network for Treatment of AIDS (PENTA) guidelines for treatment of paediatric HIV-1 infection 2015: optimizing health in preparation for adult life
Q35219662Paediatric drug development: are population models predictive of pharmacokinetics across paediatric populations?
Q36417380Parsing interindividual drug variability: an emerging role for systems pharmacology
Q26784638Pathogenesis and diagnosis of delayed-type drug hypersensitivity reactions, from bedside to bench and back
Q38546782Pathogenesis of drug allergy--current concepts and recent insights
Q49617664Patient ethnicity and the risk of immune-mediated adverse drug reactions.
Q37816389Pediatric antiretroviral therapy
Q64241572Pediatric drug hypersensitivity: which diagnostic tests?
Q40149092Penicillin Allergy Is Not Necessarily Forever.
Q24339559Peptide-binding motifs and characteristics for HLA -B*13:01 molecule
Q34772602Perceptions of genetic testing and genomic medicine among drug users
Q64354468Personalised Medicine: The Odyssey from Hope to Practice
Q87675152Personalised medicine, disease prevention, and the inverse care law: more harm than benefit?
Q38976521Personalized learning: From neurogenetics of behaviors to designing optimal language training
Q42793934Personalized medicine and tobacco-related health disparities: is there a role for genetics?
Q57223243Personalized medicine for HLA-associated drug-hypersensitivity reactions
Q44620260Personalized medicine in sepsis: the coming of age.
Q36336007Personalized medicine: is it a pharmacogenetic mirage?
Q35107992Personalized sequencing and the future of medicine: discovery, diagnosis and defeat of disease.
Q39190869Personalizing carbamazepine therapy
Q34938911Personalizing health care: feasibility and future implications
Q38731079Personalizing supportive care in oncology patients using pharmacogenetic-driven treatment pathways
Q35895922Perspective: Does personalized medicine hold the future for medicine?
Q26853274Perspectives on pharmacogenomics of antiretroviral medications and HIV-associated comorbidities
Q33819062PharmGKB summary: abacavir pathway
Q35168561PharmGKB summary: very important pharmacogene information for human leukocyte antigen B.
Q92410147Pharmacist-Initiated Pre-Emptive Pharmacogenetic Panel Testing with Clinical Decision Support in Primary Care: Record of PGx Results and Real-World Impact
Q58799157Pharmacogenetic Markers of Drug Hypersensitivity in a Thai Population
Q97883055Pharmacogenetic Testing for Prevention of Severe Cutaneous Adverse Drug Reactions
Q35812195Pharmacogenetic allele nomenclature: International workgroup recommendations for test result reporting.
Q38214388Pharmacogenetic biomarkers for predicting drug response.
Q100723198Pharmacogenetic information in Swiss drug labels - a systematic analysis
Q38391340Pharmacogenetic testing in idiosyncratic drug-induced liver injury: current role in clinical practice
Q57475451Pharmacogenetic testing in oncology: a Brazilian perspective
Q33815409Pharmacogenetic testing through the direct-to-consumer genetic testing company 23andMe
Q37151528Pharmacogenetic testing: Current Evidence of Clinical Utility
Q37867481Pharmacogenetic testing: time for clinical practice guidelines
Q57302658Pharmacogenetic tests: the need for a level playing field
Q42965039Pharmacogenetics
Q47786696Pharmacogenetics and Pharmacogenomics in Moderate-to-Severe Psoriasis
Q37772183Pharmacogenetics and human genetic polymorphisms
Q44315373Pharmacogenetics and pharmacogenomics: adverse drug reactions
Q46402808Pharmacogenetics and rational drug use around the world
Q26797938Pharmacogenetics as a tool to tailor antiretroviral therapy: A review
Q40165805Pharmacogenetics at 50: genomic personalization comes of age.
Q34343365Pharmacogenetics in clinical practice: how far have we come and where are we going?
Q37275470Pharmacogenetics in drug discovery and development: a translational perspective
Q37532571Pharmacogenetics in heart failure: promises and challenges
Q37956206Pharmacogenetics in psychiatry: translating research into clinical practice.
Q37657531Pharmacogenetics in reproductive and perinatal medicine
Q64968253Pharmacogenetics in the Treatment of Cardiovascular Diseases and Its Current Progress Regarding Implementation in the Clinical Routine.
Q35840645Pharmacogenetics in type 2 diabetes: potential implications for clinical practice
Q57302675Pharmacogenetics of Adverse Drug Reactions
Q57302676Pharmacogenetics of Adverse Drug Reactions
Q36970927Pharmacogenetics of Potassium Channel Blockers
Q38221179Pharmacogenetics of antiretroviral therapy
Q37845914Pharmacogenetics of cutaneous adverse drug reactions
Q34118186Pharmacogenetics of drug hypersensitivity
Q37770487Pharmacogenetics of drug-induced liver injury
Q37969220Pharmacogenetics of drug-metabolizing enzymes: the prodrug hypothesis.
Q37107177Pharmacogenetics of hypersensitivity to abacavir: from PGx hypothesis to confirmation to clinical utility
Q37251569Pharmacogenetics of nucleoside reverse-transcriptase inhibitor-associated peripheral neuropathy
Q28083449Pharmacogenetics predictive of response and toxicity in acute lymphoblastic leukemia therapy
Q23919667Pharmacogenetics, pharmacogenomics, and individualized medicine
Q47776901Pharmacogenetics: a general review on progress to date
Q34171192Pharmacogenetics: from bench to byte--an update of guidelines
Q37430384Pharmacogenetics: implementing personalized medicine
Q52702236Pharmacogenomic Advances in the Prediction and Prevention of Cutaneous Idiosyncratic Drug Reactions.
Q47357309Pharmacogenomic Biomarkers for Improved Drug Therapy-Recent Progress and Future Developments
Q38364391Pharmacogenomic information in drug labels: European Medicines Agency perspective.
Q33910107Pharmacogenomic knowledge gaps and educational resource needs among physicians in selected specialties.
Q41764396Pharmacogenomic substudies of randomized controlled trials: consideration of safety outcomes.
Q35985374Pharmacogenomic test that predicts response to inhaled corticosteroids in adults with asthma likely to be cost-saving
Q46518961Pharmacogenomic testing and response to warfarin
Q92506521Pharmacogenomics
Q38607878Pharmacogenomics and Implications for Nursing Practice
Q37791154Pharmacogenomics and active surveillance for serious adverse drug reactions in children.
Q37658586Pharmacogenomics and patient care: one size does not fit all.
Q33762268Pharmacogenomics and personalized medicine: lost in translation?
Q38983589Pharmacogenomics and pharmacogenetics for the intensive care unit: a narrative review.
Q43450646Pharmacogenomics and the prevention of mother-to-child transmission of HIV.
Q64109702Pharmacogenomics in dermatology: tools for understanding gene-drug associations
Q28274686Pharmacogenomics in diabetes mellitus: insights into drug action and drug discovery
Q36001208Pharmacogenomics in early-phase clinical development
Q37933413Pharmacogenomics in the assessment of therapeutic risks versus benefits: inside the United States Food and Drug Administration
Q26782786Pharmacogenomics in the clinic
Q99630610Pharmacogenomics of COVID-19 therapies
Q35878413Pharmacogenomics of HIV therapy: summary of a workshop sponsored by the National Institute of Allergy and Infectious Diseases
Q27015820Pharmacogenomics of adverse drug reactions
Q34987138Pharmacogenomics of adverse drug reactions: practical applications and perspectives
Q34977413Pharmacogenomics of antimicrobial agents
Q30400366Pharmacogenomics of off-target adverse drug reactions
Q44807614Pharmacogenomics of severe cutaneous adverse reactions
Q34342305Pharmacogenomics of severe cutaneous adverse reactions and drug-induced liver injury
Q34976915Pharmacogenomics: the genetics of variable drug responses
Q37272534Pharmacogenomics: the promise of personalized medicine for CNS disorders.
Q37978619Pharmacogenomics: what is next?
Q38217626Pharmacogenovigilance: a pharmacogenomics pharmacovigilance program
Q28069383Pharmacokinetic, Pharmacogenetic, and Other Factors Influencing CNS Penetration of Antiretrovirals
Q43238013Pharmacology: A false sense of non-self
Q35408073Phenome-wide Association Study Relating Pretreatment Laboratory Parameters With Human Genetic Variants in AIDS Clinical Trials Group Protocols
Q38793657Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants.
Q34264876Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trial
Q34806335Polymorphisms of Pyrimidine Pathway Enzymes Encoding Genes and HLA-B*40∶01 Carriage in Stavudine-Associated Lipodystrophy in HIV-Infected Patients
Q38051400Potential effect of pharmacogenetics on maternal, fetal and infant antiretroviral drug exposure during pregnancy and breastfeeding.
Q35604133Practical ethics: establishing a pathway to benefit for complex pharmacogenomic tests
Q47597667Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics
Q89658254Precision Medicine in Non-Communicable Diseases
Q39103035Precision medicine in allergic disease-food allergy, drug allergy, and anaphylaxis-PRACTALL document of the European Academy of Allergy and Clinical Immunology and the American Academy of Allergy, Asthma and Immunology
Q92838639Predicting (side) effects for patients with inflammatory bowel disease: The promise of pharmacogenetics
Q30793085Predicting HLA alleles from high-resolution SNP data in three Southeast Asian populations
Q37771029Predicting and preventing acute drug-induced liver injury: what's new in 2010?
Q38161564Prediction of hypersensitivity to antibiotics: what factors need to be considered?
Q44442043Predictive ability of direct-to-consumer pharmacogenetic testing: when is lack of evidence really lack of evidence?
Q38031096Predictive genetic testing for drug-induced liver injury: considerations of clinical utility
Q63241927Preempting and preventing drug-induced liver injury
Q101217454Prevalence and types of inconsistencies in clinical pharmacogenetic recommendations among major U.S. sources
Q37077485Prevalence of HLA-B*5701 and Its Relationship with Abacavir Hypersensitivity Reaction in Iranian HIV-Infected Patients
Q41000900Prevalence of HLA-B*57:01 allele in Argentinean HIV-1 infected patients
Q91655284Prevalence of abacavir-associated hypersensitivity syndrome and HLA-B*5701 allele in a Portuguese HIV-positive population
Q37638863Prevalence of human leukocyte antigen-B*5701 among HIV-infected children in Thailand and Cambodia: implications for abacavir use.
Q64285801Prevention and Diagnosis of Severe T-Cell-Mediated Adverse Drug Reactions: Are We There Yet?
Q28083100Progress in understanding the genomic basis for adverse drug reactions: a comprehensive review and focus on the role of ethnicity
Q37506497Promise of pharmacogenomics for drug discovery, treatment and prevention of Parkinson's disease. A perspective
Q37082500Promises and challenges of pharmacogenetics: an overview of study design, methodological and statistical issues
Q45966834Prospective-retrospective biomarker analysis for regulatory consideration: white paper from the industry pharmacogenomics working group.
Q38043095Prostate cancer: germline prediction for a commonly variable malignancy.
Q92642094Rapid Detection of HLA-B*57:01-Expressing Cells Using a Label-Free Interdigitated Electrode Biosensor Platform for Prevention of Abacavir Hypersensitivity in HIV Treatment
Q43734275Rapid screening for the detection of HLA-B57 and HLA-B58 in prevention of drug hypersensitivity
Q50071892Rare disease prevention and treatment: the need for a level playing field.
Q34131354Realities and expectations of pharmacogenomics and personalized medicine: impact of translating genetic knowledge into clinical practice
Q38753644Recent advances in biomarkers and therapeutic interventions for hepatic drug safety - false dawn or new horizon?
Q38931289Recent advances in the understanding of severe cutaneous adverse reactions
Q38457053Recent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms
Q64061836Recent developments in genetic/genomic medicine
Q34408357Recommendations for HLA-B*15:02 and HLA-A*31:01 genetic testing to reduce the risk of carbamazepine-induced hypersensitivity reactions.
Q42366705Regional Experience of Abacavir: Valuable but Still has Unanswered Question.
Q57697208Removing barriers to a clinical pharmacogenetics service
Q34126724Renal function declines more in tenofovir- than abacavir-based antiretroviral therapy in low-body weight treatment-naïve patients with HIV infection
Q48160261Reply to: Medication contaminants as a potential cause of anaphylaxis to vincristine: What about drug specific antigens?
Q26800964Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy
Q42533914Responding to the clopidogrel warning by the US food and drug administration: real life is complicated
Q41756168Returning pharmacogenetic secondary findings from genome sequencing: let's not put the cart before the horse.
Q37871623Review article: Drug-induced liver injury--its pathophysiology and evolving diagnostic tools
Q35168108Risk factors for idiosyncratic drug-induced liver injury
Q37859373Risk modeling strategies for pharmacogenetic studies
Q38396234Role of dermatology in pharmacogenomics: drug-induced skin injury.
Q38941642Role of pharmacogenetics in public health and clinical health care: a SWOT analysis
Q35898538Role of the Pharmacist in Caring for Patients with HIV/AIDS: Clinical Practice Guidelines
Q50115047SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation.
Q90466306SJS/TEN 2019: From science to translation
Q44483899Safe and effective medicines for all: is personalized medicine the answer?
Q34503452Safety analysis of Epzicom® (lamivudine/abacavir sulfate) in post-marketing surveillance in Japan
Q34503521Safety analysis of Ziagen® (abacavir sulfate) in postmarketing surveillance in Japan
Q42259925Safety and Efficacy of Ziagen (Abacavir Sulfate) in HIV-Infected Korean Patients
Q43027653Safety and efficacy of a 36-week induction regimen of abacavir/lamivudine and ritonavir-boosted atazanavir in HIV-infected patients
Q92649408Screening HLA to Prevent Severe Drug Reactions-A Devil's Advocate Perspective
Q88160211Severe Cutaneous Adverse Drug Reactions: Presentation, Risk Factors, and Management
Q28076600Severe Cutaneous Adverse Reactions: The Pharmacogenomics from Research to Clinical Implementation
Q39291741Severe Delayed Cutaneous and Systemic Reactions to Drugs: A Global Perspective on the Science and Art of Current Practice
Q41927200Severe Delayed Drug Reactions: Role of Genetics and Viral Infections.
Q55060097Severe cutaneous adverse reactions to drugs.
Q37992545Severe drug eruptions revisited
Q43118505Severe skin rash associated with atazanavir
Q91599716Single-Tablet Regimens in the Treatment of HIV-1 Infection
Q90415524Single-cell transcriptomics reveal polyclonal memory T-cell responses in skin with positive abacavir patch test results
Q35679980Smoking cessation pharmacogenetics: analysis of varenicline and bupropion in placebo-controlled clinical trials
Q35185164Statistical Optimization of Pharmacogenomics Association Studies: Key Considerations from Study Design to Analysis
Q38164730Stevens-Johnson syndrome / toxic epidermal necrolysis: an Asia-Pacific perspective
Q38689568Structural Elements Recognized by Abacavir-Induced T Cells
Q38080040Studies on abacavir-induced hypersensitivity reaction: a successful example of translation of pharmacogenetics to personalized medicine
Q33954585Successes achieved and challenges ahead in translating biomarkers into clinical applications
Q37436365Successful translation of pharmacogenetics into the clinic: the abacavir example
Q35737580Survival and HLA-B*57 in HIV/HCV Co-Infected Patients on Highly Active Antiretroviral Therapy (HAART).
Q37814401Systematic review of pharmacoeconomic studies of pharmacogenomic tests
Q79701040Systems biology and functional genomics approaches for the identification of cellular responses to drug toxicity
Q26824166Systems pharmacology: network analysis to identify multiscale mechanisms of drug action
Q34971993T cell-mediated hypersensitivity reactions to drugs
Q26747638T-cell-mediated drug hypersensitivity: immune mechanisms and their clinical relevance
Q53395242TNF-α genetic polymorphism -308G/A and antituberculosis drug-induced hepatitis.
Q47431684Tag SNPs for HLA-B alleles that are associated with drug response and disease risk in the Chinese Han population
Q37518294The 2013 Clinical Guidelines for the Diagnosis and Treatment of HIV/AIDS in HIV-Infected Koreans
Q26781379The 2015 Clinical Guidelines for the Diagnosis and Treatment of HIV/AIDS in HIV-Infected Koreans
Q64103074The 2018 Clinical Guidelines for the Diagnosis and Treatment of HIV/AIDS in HIV-Infected Koreans
Q38637036The 3 Cs of Antibiotic Allergy-Classification, Cross-Reactivity, and Collaboration
Q87796110The 8th International Congress on Cutaneous Adverse Drug Reactions, Taiwan, 2013: focus on severe cutaneous adverse reactions
Q39123582The Application of Genomics in Diabetes: Barriers to Discovery and Implementation
Q37776403The Application of Metabonomics to Predict Drug-Induced Liver Injury
Q93015537The Contribution of Major Histocompatibility Complex Class II Genes to an Association with Autoimmune Diseases
Q46442936The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir
Q28080256The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity
Q26772999The Need for Biomarkers in Diagnosis and Prognosis of Drug-Induced Liver Disease: Does Metabolomics Have Any Role?
Q36794572The Outlier in All of Us: Why Implementing Pharmacogenomics Could Matter for Everyone
Q28748224The application of mass-spectrometry-based protein biomarker discovery to theragnostics
Q38651282The chemical, genetic and immunological basis of idiosyncratic drug-induced liver injury.
Q37111658The cost-effectiveness of HLA-B*5701 genetic screening to guide initial antiretroviral therapy for HIV.
Q59352293The dawn of precision medicine in HIV: state of the art of pharmacotherapy
Q38369889The emerging science of precision medicine and pharmacogenomics for Parkinson's disease
Q35023687The evolution of three decades of antiretroviral therapy: challenges, triumphs and the promise of the future.
Q38621727The evolving story of human leukocyte antigen and the immunogenetics of peanut allergy
Q38257150The first steps towards the era of personalised vaccinology: predicting adverse reactions
Q38773033The genetics of drug efficacy: opportunities and challenges
Q38040150The glory of guidelines and the twilight of reality: controversies and challenges in the prevention and treatment of HIV in children
Q89983773The hepatotoxicity of Polygonum multiflorum: The emerging role of the immune-mediated liver injury
Q38151546The impact of germline mutations on targeted therapy
Q64903516The impact of pharmacogenetics in the treatment of allergic disease and asthma.
Q37405140The impact of pharmacogenetics on HIV therapy
Q36441470The implications of pharmacogenomics in the treatment of HIV-1-infected patients of African descent.
Q37299239The medical and economic roles of pipeline pharmacogenetics: Alzheimer's disease as a model of efficacy and HLA-B(*)5701 as a model of safety
Q50504777The personalized medicine revolution: getting it right for children.
Q38088942The potential use of expression profiling: implications for predicting treatment response in rheumatoid arthritis
Q38075076The practice of pre-marketing safety assessment in drug development
Q84443544The promises of personalized medicine
Q38805500The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction.
Q49356419The rise of the genome and personalised medicine.
Q39427540The role of HLA genes in pharmacogenomics: unravelling HLA associated adverse drug reactions
Q37430412The role of pharmacogenetics and pharmacogenomics in improving translational medicine.
Q38163945The role of pharmacogenetics in the disposition of and response to tacrolimus in solid organ transplantation.
Q34121303The rules remain the same for genomic medicine: the case against "reverse genetic exceptionalism".
Q38050483The structural basis of HLA-associated drug hypersensitivity syndromes
Q36203536The success of pharmacogenomics in moving genetic association studies from bench to bedside: study design and implementation of precision medicine in the post-GWAS era.
Q83005846The vaccine adverse event reporting system and vaccine safety research in the genomics era
Q43196823Thiopurine S- methyltransferase [corrected] testing in idiopathic pulmonary fibrosis: a pharmacogenetic cost-effectiveness analysis
Q28385221Tilting at quixotic trait loci (QTL): an evolutionary perspective on genetic causation
Q44684432Time (again) for a randomized trial of pharmacogenetics of antiretroviral therapy
Q33688133Towards the clinical implementation of pharmacogenetics in bipolar disorder.
Q38596576Toxic Epidermal Necrolysis Like Reaction due to Low-dose Methotrexate in a Case of Cutaneous Lupus Erythematosus: A Rare Occurrence
Q36954711Toxicity-related antiretroviral drug treatment modifications in individuals starting therapy: a cohort analysis of time patterns, sex, and other risk factors
Q34561910Toxicogenetics: population-based testing of drug and chemical safety in mouse models
Q38177342Toxicophores, reactive metabolites and drug safety: when is it a cause for concern?
Q35992621Translational research in infectious disease: current paradigms and challenges ahead
Q39712911Treating HIV-1 Infection: What Might the Future Hold?
Q37634509Treatment of HIV infection: Swedish recommendations 2009.
Q37634345Treatment of osteoporosis: recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivity
Q44470116Trofile HIV co-receptor usage assay.
Q45919628Unboosted atazanavir plus co-formulated lamivudine/abacavir as a ritonavir-sparing simplification strategy in routine clinical practice.
Q36134088Understanding and predicting binding between human leukocyte antigens (HLAs) and peptides by network analysis
Q36085404Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study
Q34982530Use of biological knowledge to inform the analysis of gene-gene interactions involved in modulating virologic failure with efavirenz-containing treatment regimens in ART-naïve ACTG clinical trials participants.
Q37102523Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients
Q37264536Use of plasmid-derived external quality control samples in pharmacogenetic testing
Q57646588User considerations in assessing pharmacogenomic tests and their clinical support tools
Q37621615Using systems approaches to address challenges for clinical implementation of pharmacogenomics.
Q53135190Validation of a rapid test for HLA-B*58:01/57:01 allele screening to detect individuals at risk for drug-induced hypersensitivity.
Q37335127Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus
Q52927417Vertical Integration of Pharmacogenetics in Population PK/PD Modeling: A Novel Information Theoretic Method
Q30391322What's new for antiretroviral treatment in women with HIV
Q47744582Whole genome sequencing in critically ill children
Q57839685Whole-Genome Sequencing: The New Standard of Care?
Q37826340Why, when, and how should pharmacogenetics be applied in clinical studies?: current and future approaches to study designs
Q81743327[General concepts and study methods in pharmacogenetics]
Q83162303[HIV infection]
Q53782071[The HLA system in the Moroccan population: General review].

Search more.