Pharmacogenetic testing: Current Evidence of Clinical Utility

scientific article published on August 2013

Pharmacogenetic testing: Current Evidence of Clinical Utility is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1177/2042098613485595
P932PMC publication ID3765014
P698PubMed publication ID24020014

P2093author name stringSusanne B Haga
Jivan Moaddeb
P2860cites workAdverse drug events in hospitalized patients. Excess length of stay, extra costs, and attributable mortality.Q50979176
Validation of warfarin pharmacogenetic algorithms in clinical practice.Q50984731
Influence of cytochrome P-450 CYP2C9 polymorphisms on warfarin sensitivity and risk of over-anticoagulation in patients on long-term treatment.Q52106400
Current use of pharmacogenetic testing: a national survey of thiopurine methyltransferase testing prior to azathioprine prescription.Q53574823
Usefulness of high clopidogrel maintenance dose according to CYP2C19 genotypes in clopidogrel low responders undergoing coronary stenting for non ST elevation acute coronary syndrome.Q54356566
2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report of the American College of CardiolQ55056448
Pharmacogenomic Testing: Knowing More, Doing BetterQ57817766
Frequent distribution of ultrarapid metabolizers of debrisoquine in an ethiopian population carrying duplicated and multiduplicated functional CYP2D6 allelesQ58003139
Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjectsQ60018974
Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complicationsQ63241969
Pharmacogenetic determination of the effects of codeine and prediction of drug interactionsQ71563655
Genetic association between sensitivity to warfarin and expression of CYP2C9*3Q73834859
Drug use during breastfeeding. A survey from the NetherlandsQ75356116
What is clinical utility and why should we care?Q82475827
Discordance between availability of pharmacogenetics studies and pharmacogenetics-based prescribing information for the top 200 drugsQ83089662
Implementation of pharmacogenetics in clinical practice is challengingQ84947101
Academia at the crossroads: education and training in pharmacogenomicsQ88695448
Application of a pharmacogenetic test adoption model to six oncology biomarkersQ88775593
CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research NetworkQ24632735
Evidence-based management of anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice GuidelinesQ24632951
Self-monitoring of oral anticoagulation: systematic review and meta-analysis of individual patient dataQ26865392
Clinical Pharmacogenetics Implementation Consortium Guidelines for CYP2C9 and VKORC1 genotypes and warfarin dosingQ27008360
Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivityQ27650811
Influence of omeprazol on the antiplatelet action of clopidogrel associated to aspirinQ28200091
Clinical significance of the cytochrome P450 2C19 genetic polymorphismQ28201086
Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2Q28242581
Identification of the gene for vitamin K epoxide reductaseQ28242592
Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed motherQ28258937
Codeine intoxication associated with ultrarapid CYP2D6 metabolismQ28300589
Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studiesQ29616299
Physician barriers to incorporating pharmacogenetic treatment strategies for nicotine dependence into clinical practiceQ30226731
Estimation of the warfarin dose with clinical and pharmacogenetic dataQ33410725
When is pharmacogenetic testing for antidepressant response ready for the clinic? A cost-effectiveness analysis based on data from the STAR*D studyQ33459789
Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavirQ33956146
Impact of CYP2C19 variant genotypes on clinical efficacy of antiplatelet treatment with clopidogrel: systematic review and meta-analysisQ33982372
Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) studyQ34009506
Pharmacogenomic biomarker information in drug labels approved by the United States food and drug administration: prevalence of related drug use.Q34013022
Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapyQ34019082
Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavirQ34117815
CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendantsQ34125166
Fatal hydrocodone overdose in a child: pharmacogenetics and drug interactions.Q34137741
Allopurinol pharmacogenetics: assessment of potential clinical usefulnessQ34236067
Point-of-care genetic testing for personalisation of antiplatelet treatment (RAPID GENE): a prospective, randomised, proof-of-concept trialQ34264876
Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivityQ34332730
Statistical design of personalized medicine interventions: the Clarification of Optimal Anticoagulation through Genetics (COAG) trialQ34397841
Effect of VKORC1 haplotypes on transcriptional regulation and warfarin doseQ34423204
The AmpliChip CYP450 genotyping test: Integrating a new clinical toolQ34537662
A population-based study of the drug interaction between proton pump inhibitors and clopidogrelQ34603772
Insurance coverage policies for personalized medicineQ34608654
Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysisQ34624862
The impact of pharmacogenomics research on drug developmentQ37972982
A randomized and clinical effectiveness trial comparing two pharmacogenetic algorithms and standard care for individualizing warfarin dosing (CoumaGen-II).Q38474432
Apnea in a child after oral codeine: a genetic variant - an ultra-rapid metabolizerQ39334234
CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: a prospective randomized controlled study.Q40174813
Cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity.Q40442584
Cost impact of prospective HLA-B*5701-screening prior to abacavir/lamivudine fixed dose combination use in GermanyQ42243458
Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrelQ42646492
Multivariate analysis of the relation between diet and warfarin dose.Q42726687
Prospective evaluation of a pharmacogenetics-guided warfarin loading and maintenance dose regimen for initiation of therapyQ42731228
Proton-pump inhibitors are associated with increased cardiovascular risk independent of clopidogrel use: a nationwide cohort studyQ42882409
Carriage of cytochrome 2C19 polymorphism is associated with risk of high post-treatment platelet reactivity on high maintenance-dose clopidogrel of 150 mg/day: results of the ACCEL-DOUBLE (Accelerated Platelet Inhibition by a Double Dose of ClopidogQ42962304
Warfarin genotyping reduces hospitalization rates results from the MM-WES (Medco-Mayo Warfarin Effectiveness study).Q43104385
Pharmacogenetic testing in the United Kingdom genetics and immunogenetics laboratoriesQ43205615
Cost-effectiveness of genotype-guided warfarin dosing for patients with atrial fibrillationQ43209301
A policy model to evaluate the benefits, risks and costs of warfarin pharmacogenomic testingQ43218793
Codeine, ultrarapid-metabolism genotype, and postoperative deathQ43289451
Should we be applying warfarin pharmacogenetics to clinical practice? No, not now.Q43290533
Codeine and morphine pathwayQ43480688
Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapyQ43942672
Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control studyQ44339918
Postoperative pain in the neonate: age-related differences in morphine requirements and metabolismQ44536335
Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children.Q44727177
Primary care guidelines for the management of persons infected with human immunodeficiency virus: 2009 update by the HIV medicine Association of the Infectious Diseases Society of AmericaQ45382453
Clinical and ethical considerations in pharmacogenetic testing: views of physicians in 3 "early adopting" departments of psychiatryQ45670133
Cost-effectiveness of using pharmacogenetic information in warfarin dosing for patients with nonvalvular atrial fibrillationQ46157298
Effects of pantoprazole and esomeprazole on platelet inhibition by clopidogrelQ46199177
Prospective study of warfarin dosage requirements based on CYP2C9 and VKORC1 genotypesQ46816940
Several-fold increase in risk of overanticoagulation by CYP2C9 mutationsQ46830669
Randomized trial of genotype-guided versus standard warfarin dosing in patients initiating oral anticoagulationQ46910098
Extent of medication use in breastfeeding women.Q46976330
HLA-B*5701 clinical testing: early experience in the United StatesQ46988876
More codeine fatalities after tonsillectomy in North American childrenQ48249814
Dosing clopidogrel based on CYP2C19 genotype and the effect on platelet reactivity in patients with stable cardiovascular diseaseQ34633709
Clopidogrel with or without omeprazole in coronary artery diseaseQ34660303
HLA-B*5701 screening for hypersensitivity to abacavirQ34747145
Executive summary: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).Q34788509
Criteria influencing the clinical uptake of pharmacogenomic strategiesQ34843224
Genetic determinants of response to clopidogrel and cardiovascular eventsQ34910210
Cytochrome p-450 polymorphisms and response to clopidogrelQ34910228
Drug excretion into breast milk--overviewQ35111467
Genetics informatics trial (GIFT) of warfarin to prevent deep vein thrombosis (DVT): rationale and study designQ35218128
Outcomes with concurrent use of clopidogrel and proton-pump inhibitors: a cohort studyQ35222839
Facilitating clinical implementation of pharmacogenomicsQ35294151
Pharmacogenetics of cytochrome p4502D6: genetic background and clinical implicationQ35594563
Clinical Pharmacogenetics Implementation Consortium guidelines for cytochrome P450-2C19 (CYP2C19) genotype and clopidogrel therapyQ35603072
Introduction to the ninth edition: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice GuidelinesQ35752615
Personalizing medicine with clinical pharmacogeneticsQ35791989
The role of cost-effectiveness analysis in the era of pharmacogenomicsQ35817019
Maternal medications during breastfeedingQ35869959
Warfarin pharmacogenetics: a rising tide for its clinical valueQ35915581
The effect of CYP2D6 polymorphisms on the response to pain treatment for pediatric sickle cell pain crisisQ35994975
Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosingQ36029478
Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19.Q36356462
Interethnic differences in genetic polymorphisms of CYP2D6 in the U.S. population: clinical implicationsQ36395914
Role of cytochrome P450 genotype in the steps toward personalized drug therapyQ36441521
The largest prospective warfarin-treated cohort supports genetic forecastingQ37071087
Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarinQ37087348
High sensitivity of human leukocyte antigen-b*5701 as a marker for immunologically confirmed abacavir hypersensitivity in white and black patientsQ37150304
Influence of CYP2C9 and VKORC1 1173C/T genotype on the risk of hemorrhagic complications in African-American and European-American patients on warfarinQ37195550
Optimizing drug outcomes through pharmacogenetics: a case for preemptive genotypingQ37202877
Drug use during breast-feedingQ37435192
Back to the future: why randomized controlled trials cannot be the answer to pharmacogenomics and personalized medicineQ37551901
Pharmacodynamic effect and clinical efficacy of clopidogrel and prasugrel with or without a proton-pump inhibitor: an analysis of two randomised trialsQ37590925
Clopidogrel pharmacogenomics and risk of inadequate platelet inhibition: US FDA recommendationsQ37627874
Using pharmacogenetics in real time to guide warfarin initiation: a clinician updateQ37965130
CYP2C19 genotype, clopidogrel metabolism, platelet function, and cardiovascular events: a systematic review and meta-analysisQ37971875
P433issue4
P304page(s)155-169
P577publication date2013-08-01
P1433published inTherapeutic advances in drug safetyQ26853818
P1476titlePharmacogenetic testing: Current Evidence of Clinical Utility
P478volume4

Reverse relations

cites work (P2860)
Q92450459Bringing microbiome-drug interaction research into the clinic
Q28072203Cost-Effectiveness of Pharmacogenomic and Pharmacogenetic Test-Guided Personalized Therapies: A Systematic Review of the Approved Active Substances for Personalized Medicine in Germany
Q50117218Developing Pharmacogenomic Reports: Insights from Patients and Clinicians.
Q54935902Disease burden and the role of pharmacogenomics in African populations.
Q92875032Heterogeneity in the distribution of 159 drug-response related SNPs in world populations and their genetic relatedness
Q37063857Personalized Medicine in the U.S. and Germany: Awareness, Acceptance, Use and Preconditions for the Wide Implementation into the Medical Standard.
Q36508972Pharmacogenetics: Using Genetic Information to Guide Drug Therapy
Q50333604Rapid screening for targeted genetic variants via high-resolution melting curve analysis.
Q39833609Rare genetic variants in cellular transporters, metabolic enzymes, and nuclear receptors can be important determinants of interindividual differences in drug response
Q47929031The challenges of implementing pharmacogenomic testing in the clinic.

Search more.