Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

scientific article (publication date: 20 May 2004)

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1056/NEJMOA040938
P3181OpenCitations bibliographic resource ID63134
P698PubMed publication ID15118073

P50authorDavid C. ChristianiQ30069760
Daniel HaberQ5217393
P2093author name stringDaphne W Bell
Raffaella Sordella
Ross A Okimoto
Brian W Brannigan
David N Louis
Jeffrey G Supko
Frank G Haluska
Thomas J Lynch
Patricia L Harris
Sara M Haserlat
Jeff Settleman
Sarada Gurubhagavatula
P2860cites workMutations of the BRAF gene in human cancerQ27860760
P433issue21
P407language of work or nameEnglishQ1860
P921main subjectlung cancerQ47912
P304page(s)2129-39
P577publication date2004-05-20
P1433published inThe New England Journal of MedicineQ582728
P1476titleActivating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
P478volume350

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Q92633975Alleviation of Multidrug Resistance by Flavonoid and Non-Flavonoid Compounds in Breast, Lung, Colorectal and Prostate Cancer
Q38465098Allosteric therapies for lung cancer
Q36973814Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy
Q51072877Alteration of the E-cadherin/β-catenin complex predicts poor response to epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) treatment.
Q36669872Alterations in EGFR and related genes following neo-adjuvant chemotherapy in Chinese patients with non-small cell lung cancer
Q37724576Alterations in VHL as potential biomarkers in renal-cell carcinoma
Q51503951Alterations in cathepsin L expression in lung cancers.
Q33411775Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines
Q42002748Altered trafficking of mutated growth factor receptors and their associated molecules: implication for human cancers
Q34535276Alveolar type II cells possess the capability of initiating lung tumor development
Q54124211Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis.
Q33731181Amphiregulin promotes BAX inhibition and resistance to gefitinib in non-small-cell lung cancers.
Q35964699Amplification of CRKL induces transformation and epidermal growth factor receptor inhibitor resistance in human non-small cell lung cancers
Q24541450Amplification of MET may identify a subset of cancers with extreme sensitivity to the selective tyrosine kinase inhibitor PHA-665752
Q41837923Amplification of chromosome 8 genes in lung cancer
Q48462937Amplification of the epidermal growth factor receptor in astrocytic tumours by chromogenic in situ hybridization: association with clinicopathological features and patient survival.
Q46906937Amplification of the urokinase gene and the sensitivity of prostate cancer cells to urokinase inhibitors.
Q47116010Amylase-Producing Lung Cancer with a Positive Epidermal Growth Factor Receptor Mutation Treated With Gefitinib: A Case Report
Q36228469An Analysis of EGFR Mutations among 1506 Cases of Non-Small Cell Lung Cancer Patients in Guangxi, China.
Q42695763An Architecture for Genomics Analysis in a Clinical Setting Using Galaxy and Docker
Q33890958An EGFR autocrine loop encodes a slow-reacting but dominant mode of mechanotransduction in a polarized epithelium.
Q37137440An Evidence-Based Approach to the Use of Predictive Biomarkers in the Treatment of Non- Small Cell Lung Cancer (NSCLC).
Q47135621An Immunohistochemical Study of Anaplastic Lymphoma Kinase and Epidermal Growth Factor Receptor Mutation in Non-Small Cell Lung Carcinoma
Q64053000An Integrated Next-Generation Sequencing System for Analyzing DNA Mutations, Gene Fusions, and RNA Expression in Lung Cancer
Q39009616An activation of LC3A-mediated autophagy contributes to de novo and acquired resistance to EGFR tyrosine kinase inhibitors in lung adenocarcinoma
Q24293598An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor
Q39684120An anti-Axl monoclonal antibody attenuates xenograft tumor growth and enhances the effect of multiple anticancer therapies
Q53287085An early event of EGFR mutation in pleomorphic carcinoma of the lung.
Q53139955An epidermal growth factor receptor exon 19 mutation in a mucin-producing gastric cancer sample from a Chinese patient.
Q54634908An epidermal growth factor receptor intron 1 polymorphism in healthy women in Poland.
Q36597042An epithelial-mesenchymal transition gene signature predicts resistance to EGFR and PI3K inhibitors and identifies Axl as a therapeutic target for overcoming EGFR inhibitor resistance
Q53158256An evaluation study of EGFR mutation tests utilized for non-small-cell lung cancer in the diagnostic setting.
Q37690880An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models
Q55053711An improved cell membrane chromatography method for the simultaneous screening of two epidermal growth factor receptor antagonists from radix scutellariae.
Q40783190An in silico analytical study of lung cancer and smokers datasets from gene expression omnibus (GEO) for prediction of differentially expressed genes
Q35237394An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
Q35872681An integrated bioinformatics analysis to dissect kinase dependency in triple negative breast cancer
Q48165470An oligoclonal antibody durably overcomes resistance of lung cancer to third-generation EGFR inhibitors
Q53587222An open-label, single-dose, phase 1 study of the absorption, metabolism and excretion of quizartinib, a highly selective and potent FLT3 tyrosine kinase inhibitor, in healthy male subjects, for the treatment of acute myeloid leukemia.
Q44736272An overview of Cancer's special issue on lung cancer in China
Q36043195An overview of lung cancer genomics and proteomics
Q92884879An unbiased in vitro screen for activating epidermal growth factor receptor mutations
Q38077494An update on molecularly targeted therapies in second- and third-line treatment in non-small cell lung cancer: focus on EGFR inhibitors and anti-angiogenic agents
Q34857289Analogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities
Q42551719Analysis of AKT and ERK1/2 protein kinases in extracellular vesicles isolated from blood of patients with cancer.
Q36439434Analysis of BIM (BCL-2 like 11 gene) deletion polymorphism in Chinese non-small cell lung cancer patients
Q46408397Analysis of EGFR gene amplification, protein over-expression and tyrosine kinase domain mutation in recurrent glioblastoma
Q33598423Analysis of EGFR mutation status in tissue and plasma for predicting response to EGFR-TKIs in advanced non-small-cell lung cancer
Q39371891Analysis of EGFR, EML4-ALK, KRAS, and c-MET mutations in Chinese lung adenocarcinoma patients
Q35058437Analysis of Somatic Mutations in Cancer: Molecular Mechanisms of Activation in the ErbB Family of Receptor Tyrosine Kinases
Q39308117Analysis of bypass signaling in EGFR pathway and profiling of bypass genes for predicting response to anticancer EGFR tyrosine kinase inhibitors
Q88729591Analysis of circulating tumor DNA: The next paradigm shift in detection and treatment of lung cancer
Q28472663Analysis of compound synergy in high-throughput cellular screens by population-based lifetime modeling
Q26797471Analysis of different HER-2 mutations in breast cancer progression and drug resistance
Q50936062Analysis of driver mutations in female non-smoker Asian patients with pulmonary adenocarcinoma.
Q34522964Analysis of growth factor signaling in genetically diverse breast cancer lines
Q37702099Analysis of progression-free survival of first-line tyrosine kinase inhibitors in patients with non-small cell lung cancer harboring leu858Arg or exon 19 deletions.
Q37119867Analysis of the benefit of sequential cranial radiotherapy in patients with EGFR mutant non-small cell lung cancer and brain metastasis
Q50947169Analytic inquiry: Molecular testing in lung cancer.
Q41348195Analyzing the Sensitivity of EGFR-L861Q Mutation to TKIs and A Case Report
Q37952236Anaplastic lymphoma kinase as a new target for the treatment of non-small-cell lung cancer.
Q54367113Anaplastic lymphoma kinase gene rearrangements in cytological samples of non-small cell lung cancer: comparison with histological assessment.
Q27851588Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
Q50955739Anaplastic lymphoma kinase translocation is correlated with anaplastic lymphoma kinase expression and mutually exclusive with epidermal growth factor receptor mutation in Taiwanese non-small cell lung cancer.
Q34283623Androgen metabolism in prostate cancer: from molecular mechanisms to clinical consequences
Q36104939Angiogenesis and prostate cancer: important laboratory and clinical findings
Q57023042Ankyrin Repeat Domain 1 Overexpression is Associated with Common Resistance to Afatinib and Osimertinib in EGFR-mutant Lung Cancer
Q35631966Annotation of human cancers with EGFR signaling-associated protein complexes using proximity ligation assays
Q53121293Anti PD-L1 combined with other agents in non-small cell lung cancer: combinations with non-immuno-oncology agents.
Q38832105Anti-EGFR Agents: Current Status, Forecasts and Future Directions.
Q38876644Anti-HER3 monoclonal antibody patritumab sensitizes refractory non-small cell lung cancer to the epidermal growth factor receptor inhibitor erlotinib
Q34088265Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?
Q36321894Anti-epidermal growth factor receptor (EGFR) antibodies overcome resistance of ovarian cancer cells to targeted therapy and natural cytotoxicity
Q37293327Anti-epidermal growth factor receptor strategies for advanced breast cancer
Q28729071Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells
Q41612476Anti-tumor efficacy of theliatinib in esophageal cancer patient-derived xenografts models with epidermal growth factor receptor (EGFR) overexpression and gene amplification
Q38086799Anti-vascular endothelial growth factor therapy in the era of personalized medicine
Q55509033Antibody-assisted target identification reveals afatinib, an EGFR covalent inhibitor, down-regulating ribonucleotide reductase.
Q34132010Antibody-based proteomics: fast-tracking molecular diagnostics in oncology.
Q46836125Antibody-based targeted therapy for gastric cancer
Q40133703Antibody-dependent cellular cytotoxicity of cetuximab against tumor cells with wild-type or mutant epidermal growth factor receptor
Q36466443Anticipating clinical resistance to target-directed agents : the BCR-ABL paradigm
Q36612420Antiestrogen fulvestrant enhances the antiproliferative effects of epidermal growth factor receptor inhibitors in human non-small-cell lung cancer
Q90283381Antitumor Activity of a Novel Tyrosine Kinase Inhibitor AIU2001 Due to Abrogation of the DNA Damage Repair in Non-Small Cell Lung Cancer Cells
Q39980200Antitumor activity of a novel EGFR tyrosine kinase inhibitor against human lung carcinoma in vitro and in vivo
Q36448279Antitumor activity of motesanib alone and in combination with cisplatin or docetaxel in multiple human non-small-cell lung cancer xenograft models
Q36413281Antrodia cinnamomea alleviates cisplatin-induced hepatotoxicity and enhances chemo-sensitivity of line-1 lung carcinoma xenografted in BALB/cByJ mice.
Q64070319Apatinib preferentially inhibits PC9 gefitinib-resistant cancer cells by inducing cell cycle arrest and inhibiting VEGFR signaling pathway
Q37605160Apoptosis and autophagy: BIM as a mediator of tumour cell death in response to oncogene-targeted therapeutics
Q35480110Apoptosis-inducing effects of cetuximab combined with radiotherapy and hypothermia on human nasopharyngeal carcinoma CNE cells
Q27016160Apoptotic agents
Q33235709Application of DETECTER, an evolutionary genomic tool to analyze genetic variation, to the cystic fibrosis gene family
Q37197507Application of PCR methods to evaluate EGFR, KRAS and BRAF mutations in a small number of tumor cells in cytological material from lung cancer patients
Q64099108Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naïve lung adenocarcinoma
Q38170457Application of genotype-guided cancer therapy in solid tumors
Q37204679Applications of genomics in melanoma oncogene discovery
Q36753505Applications of molecular techniques to fine-needle aspiration biopsy
Q33687963Applying new clinicopathological characteristics to prognostication in advanced thyroid carcinoma
Q36900109Applying the discovery of the Philadelphia chromosome
Q36045981Approaches to optimize the use of monoclonal antibodies to epidermal growth factor receptor
Q36502531Appropriate use of tumour biomarkers for treatment with innovative drugs: A retrospective study
Q38989374Approved and Experimental Small-Molecule Oncology Kinase Inhibitor Drugs: A Mid-2016 Overview
Q37564967Are TKIs favourable for the elderly with non-small-cell lung cancer?
Q37351965Are We Making Personalized Cancer Care Less Personalized?
Q37976288Array-based pharmacogenomics of molecular-targeted therapies in oncology.
Q33555207Ascites-derived pancreatic ductal adenocarcinoma primary cell cultures as a platform for personalised medicine
Q35535953Assessing PIK3CA and PTEN in early-phase trials with PI3K/AKT/mTOR inhibitors
Q43061603Assessing the roles of EGFR gene copy number, protein expression and mutation in predicting outcomes in non-small-cell lung cancer after treatment with EGFR inhibitors
Q42204388Assessment of DDR2, BRAF, EGFR and KRAS mutations as therapeutic targets in non-adenocarcinoma lung cancer patients
Q36946796Assessment of cytology based molecular analysis to guide targeted therapy in advanced non-small-cell lung cancer
Q35584933Assessment of epidermal growth factor receptor and K-ras mutation status in cytological stained smears of non-small cell lung cancer patients: correlation with clinical outcomes
Q37121410Assessment of epidermal growth factor receptor mutation/copy number and K-ras mutation in esophageal cancer
Q37052272Assessment of epidermal growth factor receptor status in glioblastomas
Q53126969Assessment of protein expression and gene status of human epidermal growth factor receptor (HER) family molecules in ameloblastomas.
Q55299188Assessment of pulmonary 18F-FDG-PET uptake and cytokine profiles in non-small cell lung cancer patients treated with radiotherapy and erlotinib.
Q37274280Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer
Q53094070Assessment of the clinical application of detecting EGFR, KRAS, PIK3CA and BRAF mutations in patients with non-small cell lung cancer using next-generation sequencing.
Q54965644Assessment of very early response evaluation with 18F-FDG-PET/CT predicts survival in erlotinib treated NSCLC patients-A comparison of methods.
Q28550377Association Study of a Functional Variant on ABCG2 Gene with Sunitinib-Induced Severe Adverse Drug Reaction
Q64983153Association between EGFR mutation and expression of BRCA1 and RAP80 in non-small cell lung cancer.
Q90221713Association between EGFR/KRAS mutation and expression of VEGFA, VEGFR and VEGFR2 in lung adenocarcinoma
Q36526428Association between GABA(A) receptor subunit gene cluster and zolpidem-induced complex sleep behaviors in Han Chinese.
Q40406762Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations
Q43131701Association between epidermal growth factor receptor mutations and the expression of excision repair cross-complementing protein 1 and ribonucleotide reductase subunit M1 mRNA in patients with non-small cell lung cancer
Q83856059Association between vascular-poor area of primary tumors and epidermal growth factor receptor gene status in advanced lung adenocarcinoma
Q54520157Association of ABCB1 polymorphisms with erlotinib pharmacokinetics and toxicity in Japanese patients with non-small-cell lung cancer.
Q37569995Association of BIM Deletion Polymorphism and BIM-γ RNA Expression in NSCLC with EGFR Mutation.
Q89602661Association of Divergent Carcinoembryonic Antigen Patterns and Lung Cancer Progression
Q54310972Association of EGFR mutation or ALK rearrangement with expression of DNA repair and synthesis genes in never-smoker women with pulmonary adenocarcinoma.
Q37641038Association of EGFR mutations with low BRCA1 gene expression in non-small cell lung cancer
Q27851860Association of KRAS and EGFR mutations with survival in patients with advanced lung adenocarcinomas
Q54343399Association of POLK polymorphisms with platinum-based chemotherapy response and severe toxicity in non-small cell lung cancer patients.
Q53269068Association of diffuse, random pulmonary metastases, including miliary metastases, with epidermal growth factor receptor mutations in lung adenocarcinoma.
Q41862336Association of epidermal growth factor receptor and K-Ras mutations with smoking history in non-small cell lung cancer patients
Q40080780Association of genetic variability in enzymes metabolizing chemotherapeutic agents with treatment response in head and neck cancer cases
Q90335241Association with PD-L1 Expression and Clinicopathological Features in 1000 Lung Cancers: A Large Single-Institution Study of Surgically Resected Lung Cancers with a High Prevalence of EGFR Mutation
Q47764617Associations between epidermal growth factor receptor mutations and histological subtypes of lung adenocarcinoma according to the IASLC/ATS/ERS classification in Chinese patients
Q36337437Associations between mutations and histologic patterns of mucin in lung adenocarcinoma: invasive mucinous pattern and extracellular mucin are associated with KRAS mutation
Q43265336Attacking cancer at its foundation
Q58804389Autochthonous murine models for the study of smoker and never-smoker associated lung cancers
Q35583019Autocrine production of amphiregulin predicts sensitivity to both gefitinib and cetuximab in EGFR wild-type cancers
Q38960732Automated objective determination of percentage of malignant nuclei for mutation testing
Q35014385Awakening guardian angels: drugging the p53 pathway
Q37738168B-RAF inhibitors: an evolving role in the therapy of malignant melanoma.
Q104475963BEBT-109, a pan-mutant-selective EGFR inhibitor with potent antitumor activity in EGFR-mutant non-small cell lung cancer
Q37841599BIBW 2992 in non-small cell lung cancer
Q24649935BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
Q37708873BIM deletion polymorphisms in Hispanic patients with non-small cell lung cancer carriers of EGFR mutations
Q35588268BIM expression in treatment-naive cancers predicts responsiveness to kinase inhibitors.
Q28756824BIM mediates EGFR tyrosine kinase inhibitor-induced apoptosis in lung cancers with oncogenic EGFR mutations
Q36413639BRAF mutation testing with a rapid, fully integrated molecular diagnostics system
Q42733647BRAF targeted therapy changes the treatment paradigm in melanoma
Q92284666Barcode sequencing identifies resistant mechanisms to epidermal growth factor receptor inhibitors in circulating tumor DNA of lung cancer patients
Q64913573Basic science of lung cancer.
Q33218734Basics of molecular diagnostics and therapy of malignant tumors
Q50095063Basket Studies: Redefining Clinical Trials in the Era of Genome-Driven Oncology.
Q36011788Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology
Q28740430Benchmarking of mutation diagnostics in clinical lung cancer specimens
Q59808313Better Progression-Free Survival in Elderly Patients with Stage IV Lung Adenocarcinoma Harboring Uncommon Epidermal Growth Factor Receptor Mutations Treated with the First-line Tyrosine Kinase Inhibitors
Q92218750Bevacizumab and CCR2 Inhibitor Nanoparticles Induce Cytotoxicity-Mediated Apoptosis in Doxorubicin-Treated Hepatic and Non-Small Lung Cancer Cells
Q47142558Bevacizumab and gefitinib enhanced whole-brain radiation therapy for brain metastases due to non-small-cell lung cancer
Q36832129Bevacizumab in the treatment of non-small-cell lung cancer
Q37001902Bevacizumab to combat EGFR-TKI resistance in a patient with advanced non-small cell lung cancer harboring an EGFR mutation: A case report
Q35025931Bexarotene plus erlotinib suppress lung carcinogenesis independent of KRAS mutations in two clinical trials and transgenic models
Q46512789Beyond ALK and ROS1: RET, NTRK, EGFR and BRAF gene rearrangements in non-small cell lung cancer
Q38569159Beyond genetics in personalized cancer treatment: assessing dynamics and heterogeneity of tumor responses.
Q33560928Beyond histology: translating tumor genotypes into clinically effective targeted therapies
Q40340043Beyond the TRIBUTE trial: integrating HER1/EGFR tyrosine kinase inhibitors with chemotherapy in advanced NSCLC.
Q50288609Binding of GRB2:GAB1 complex to ligand-responsive p-6Y-EGFR mutants
Q50288599Binding of GRB2:SOS1 complex to phosphorylated ligand-responsive EGFR mutants
Q46963924Binding of gefitinib, an inhibitor of epidermal growth factor receptor-tyrosine kinase, to plasma proteins and blood cells: in vitro and in cancer patients
Q38386392Biobanking for Personalized Medicine
Q37665845Biochemical mechanisms of resistance to small-molecule protein kinase inhibitors
Q59335693Biodegradable Nanoparticles Mediated Co-delivery of Erlotinib (ELTN) and Fedratinib (FDTN) Toward the Treatment of ELTN-Resistant Non-small Cell Lung Cancer (NSCLC) via Suppression of the JAK2/STAT3 Signaling Pathway
Q35885829Bioinformatics and cancer target discovery
Q81367068Biologic staging of non-small-cell lung cancer: prospect or proposal?
Q37242685Biologic therapies for advanced pancreatic cancer
Q36521850Biological agents versus chemotherapy in the treatment of colorectal cancer
Q36540571Biological and clinical implications of EGFR mutations in lung cancer.
Q45965455Biological characteristics and epidermal growth factor receptor tyrosine kinase inhibitors efficacy of EGFR mutation and its subtypes in lung adenocarcinoma.
Q34094855Biomarker analysis of cetuximab plus oxaliplatin/leucovorin/5-fluorouracil in first-line metastatic gastric and oesophago-gastric junction cancer: results from a phase II trial of the Arbeitsgemeinschaft Internistische Onkologie (AIO).
Q34248282Biomarker testing for breast, lung, and gastroesophageal cancers at NCI designated cancer centers
Q34023414Biomarkers That Currently Affect Clinical Practice in Lung Cancer: EGFR, ALK, MET, ROS-1, and KRAS
Q39181810Biomarkers and Immunotherapeutic Targets in Glioblastoma
Q36260477Biomarkers and targeted systemic therapies in advanced non-small cell lung cancer
Q37988924Biomarkers and transcriptome profiling of lung cancer
Q37692666Biomarkers in bronchopulmonary cancer
Q28278305Biomarkers in cancer staging, prognosis and treatment selection
Q37006905Biomarkers in drug discovery and development
Q37371586Biomarkers in early cancer drug development: limited utility
Q34094906Biomarkers of acute lung injury: worth their salt?
Q39569308Biomarkers of cancer metastasis through the lymphovascular system: future perspectives
Q35108419Biomarkers of clinical benefit for anti-epidermal growth factor receptor agents in patients with non-small-cell lung cancer
Q26766535Biomarkers predicting resistance to epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer with wild-type KRAS
Q36040606Biomarkers that currently affect clinical practice: EGFR, ALK, MET, KRAS
Q47110241Biomarkers/Molecular Targets, Immunotherapy, and Treatments for Non-Small Cell Lung Cancer.
Q37388387Biopsy and mutation detection strategies in non-small cell lung cancer
Q90697012Biopsy on progression in patients with EGFR mutation-positive advanced non-small-cell lung cancer-a Canadian experience
Q37236777BlackOPs: increasing confidence in variant detection through mappability filtering
Q36842495Blood-brain barrier transport of non-viral gene and RNAi therapeutics
Q36477753Body mass index and exon 19 mutation as factors predicting the therapeutic efficacy of gefitinib in patients with epidermal growth factor receptor mutation-positive non-small cell lung cancer
Q35154082Bombesin receptor subtype-3 agonists stimulate the growth of lung cancer cells and increase EGF receptor tyrosine phosphorylation
Q33989444Bortezomib induces apoptosis in esophageal squamous cell carcinoma cells through activation of the p38 mitogen-activated protein kinase pathway
Q36224108Braf and erbB2 mutations correlate with smoking status in lung cancer patients
Q48569495Brain metastases from non-small-cell lung cancer: is there room for improvement?
Q38233149Brain metastases in non-small-cell lung cancer: better outcomes through current therapies and utilization of molecularly targeted approaches
Q64071943Brain metastases in resected non-small cell lung cancer: The impact of different tyrosine kinase inhibitors
Q41846992Brain metastasis effectively treated with erlotinib following the acquisition of resistance to gefitinib: a case report
Q48044475Brain metastasis features and association with tumor epidermal growth factor receptor mutation in patients with adenocarcinoma of the lung
Q50949344Brain-derived neurotrophic factor/tropomyosin-related kinase B signaling pathway contributes to the aggressive behavior of lung squamous cell carcinoma.
Q37028777Broad, Hybrid Capture-Based Next-Generation Sequencing Identifies Actionable Genomic Alterations in Lung Adenocarcinomas Otherwise Negative for Such Alterations by Other Genomic Testing Approaches
Q60097206Broken genes in solid tumours
Q41643045Bronchioloalveolar neoplasia.
Q39941747Bronchoscopic Re-biopsy for Mutational Analysis of Non-small Cell Lung Cancer
Q36929987Building a personalized medicine infrastructure at a major cancer center
Q38385958Building the foundation for genomics in precision medicine
Q35176335By downregulating Ku80, hsa-miR-526b suppresses non-small cell lung cancer
Q37421439Bypass mechanisms of resistance to receptor tyrosine kinase inhibition in lung cancer
Q34031219C4.4A as a biomarker in pulmonary adenocarcinoma and squamous cell carcinoma
Q35962454CCR 20th Anniversary Commentary: RAS as a Biomarker for EGFR--Targeted Therapy for Colorectal Cancer-From Concept to Practice
Q34342934CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma
Q55072491CDKN2A(p16) and HRAS are frequently mutated in vulvar squamous cell carcinoma.
Q54673900CHFR hypermethylation and EGFR mutation are mutually exclusive and exhibit contrastive clinical backgrounds and outcomes in non-small cell lung cancer.
Q35778685CI-988 Inhibits EGFR Transactivation and Proliferation Caused by Addition of CCK/Gastrin to Lung Cancer Cells
Q27310110CIP4 promotes lung adenocarcinoma metastasis and is associated with poor prognosis.
Q46979383CNS response after erlotinib therapy in a patient with metastatic NSCLC with an EGFR mutation
Q38924458CRE: a cost effective and rapid approach for PCR-mediated concatenation of KRAS and EGFR exons: Rapid way to detect EGFR and KRAS mutations.
Q33808203CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance.
Q36525874CRISPR/Cas-mediated genome editing to treat EGFR-mutant lung cancer: a personalized molecular surgical therapy
Q38614582CRISPR/Cas9: molecular tool for gene therapy to target genome and epigenome in the treatment of lung cancer
Q41751613CT Radiogenomic Characterization of EGFR, K-RAS, and ALK Mutations in Non-Small Cell Lung Cancer
Q60301839CT Slice Thickness and Convolution Kernel Affect Performance of a Radiomic Model for Predicting EGFR Status in Non-Small Cell Lung Cancer: A Preliminary Study
Q41997242CT characteristics in pulmonary adenocarcinoma with epidermal growth factor receptor mutation
Q100416116CT features and disease spread patterns in ROS1-rearranged lung adenocarcinomas: comparison with those of EGFR-mutant or ALK-rearranged lung adenocarcinomas
Q89116459CT features of HER2-mutant lung adenocarcinomas
Q35086187CT tumor volume measurement in advanced non-small-cell lung cancer: Performance characteristics of an emerging clinical tool
Q36615733CYFRA 21-1 level predicts survival in non-small-cell lung cancer patients receiving gefitinib as third-line therapy
Q37352553CYP2C19 genotype-based phase I studies of a c-Met inhibitor tivantinib in combination with erlotinib, in advanced/metastatic non-small cell lung cancer
Q61806215Can CT radiomic analysis in NSCLC predict histology and EGFR mutation status?
Q35537522Can EGFR mutation status be reliably determined in pre-operative needle biopsies from adenocarcinomas of the lung?
Q36427587Can EGFR-TKIs be used in first line treatment for advanced non-small cell lung cancer based on selection according to clinical factors? - A literature-based meta-analysis
Q26999304Can microRNAs improve the management of lung cancer patients? A clinician's perspective
Q34986181Can systems biology understand pathway activation? Gene expression signatures as surrogate markers for understanding the complexity of pathway activation
Q53243032Cancer Genomics.
Q35999625Cancer Phenotype Diagnosis and Drug Efficacy within Japanese Health Care
Q37153533Cancer as a system failure
Q37810056Cancer biology and genomics: translating discoveries, transforming pathology
Q36561609Cancer biomarkers: a systems approach
Q42968372Cancer biomarkers: closer to delivering on their promise
Q27010961Cancer concepts and principles: primer for the interventional oncologist-part II
Q34002709Cancer driver mutations in protein kinase genes
Q36111899Cancer drug discovery through collaboration.
Q37399404Cancer epigenomics: implications of DNA methylation in personalized cancer therapy
Q28275089Cancer genes and the pathways they control
Q36481954Cancer genes in lung cancer: racial disparities: are there any?
Q38180646Cancer genomics and inherited risk
Q34301519Cancer genomics and pathology: all together now.
Q63018119Cancer genomics: from discovery science to personalized medicine
Q35583180Cancer immunology--analysis of host and tumor factors for personalized medicine
Q36822291Cancer pharmacogenomics
Q26741009Cancer pharmacogenomics, challenges in implementation, and patient-focused perspectives
Q24289309Cancer pharmacogenomics: strategies and challenges
Q90372559Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2
Q36359653Cancer survivorship--genetic susceptibility and second primary cancers: research strategies and recommendations
Q38028798Cancer treatment according to BRCA1 and BRCA2 mutations
Q44574128Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins
Q44960549Cancer: understanding the target
Q36385644Carcinoembryonic antigen-related cell adhesion molecules as surrogate markers for EGFR inhibitor sensitivity in human lung adenocarcinoma
Q36092823Carcinogenesis, cancer therapy and chemoprevention
Q33249923Carcinosarcoma of the colon: report of a case with morphological, ultrastructural and molecular analysis
Q37061596Cardiac toxicity: old and new issues in anti-cancer drugs.
Q33807542Cardio-Oncology: Cancer Therapy-related Cardiovascular Complications in a Molecular Targeted Era: New Concepts and Perspectives
Q93203400Case of Proteinuria, Worsening Hypertension, and Glomerular Endotheliosis With Erlotinib and Gefitinib
Q53631481Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas.
Q39205831Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells.
Q35219426Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
Q38268502Catalytic mechanisms and regulation of protein kinases
Q91805218Cell Model Passports-a hub for clinical, genetic and functional datasets of preclinical cancer models
Q24598357Cell signaling by receptor tyrosine kinases
Q52361534Cell signaling heterogeneity is modulated by both cell-intrinsic and -extrinsic mechanisms: An integrated approach to understanding targeted therapy.
Q41431886Cell-Free DNA Next-Generation Sequencing in Pancreatobiliary Carcinomas.
Q34789161Cell-based Models for Discovery of Pharmacogenomic Markers of Anticancer Agent Toxicity.
Q81939291Cell-free DNA resuscitated for tumor testing
Q38263419Cell-free circulating tumor DNA in plasma/serum of non-small cell lung cancer
Q36003118Cellular responses to EGFR inhibitors and their relevance to cancer therapy
Q38214154Ceritinib for treatment of ALK-rearranged advanced non-small-cell lung cancer
Q36171281Cetuximab and biomarkers in non-small-cell lung carcinoma
Q35023512Cetuximab for the treatment of advanced bronchioloalveolar carcinoma (BAC): an Eastern Cooperative Oncology Group phase II study (ECOG 1504).
Q36668224Cetuximab in the treatment of head and neck cancer
Q46261715Cetuximab plus carboplatin and paclitaxel with or without bevacizumab versus carboplatin and paclitaxel with or without bevacizumab in advanced NSCLC (SWOG S0819): a randomised, phase 3 study
Q41894424Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization
Q36832116Cetuximab, a chimeric human mouse anti-epidermal growth factor receptor monoclonal antibody, in the treatment of human colorectal cancer.
Q98292342Cetuximab-Triptolide Conjugate Suppresses the Growth of EGFR-Overexpressing Lung Cancers through Targeting RNA Polymerase II
Q44948356Cetuximab: an IgG(1) monoclonal antibody for the treatment of epidermal growth factor receptor-expressing tumours
Q88790405Challenges and opportunities of pharmacogenetics in drug development
Q34608597Challenges in Implementing Personalized Medicine for Lung Cancer within a National Healthcare System
Q37220383Challenges in initiating and conducting personalized cancer therapy trials: perspectives from WINTHER, a Worldwide Innovative Network (WIN) Consortium trial
Q38947180Challenges in molecular testing in non-small-cell lung cancer patients with advanced disease
Q37177604Challenges of detecting EGFR T790M in gefitinib/erlotinib-resistant tumours
Q35179046Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease
Q34225871Change or die: targeting adaptive signaling to kinase inhibition in cancer cells
Q26774513Changing strategies for target therapy in gastric cancer
Q36849676Changing the paradigm: the potential for targeted therapy in laryngeal squamous cell carcinoma
Q34778365Characteristics of CD8+ T cell subsets in Chinese patients with chronic HIV infection during initial ART.
Q28706226Characteristics of lung cancers harboring NRAS mutations
Q51661151Characteristics of neoplastic cardiac tamponade and prognosis after pericardiocentesis: a single-center study of 113 consecutive cancer patients.
Q55317607Characterization of Covalent-Reversible EGFR Inhibitors.
Q36389868Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer
Q58786657Characterization of Factors Affecting the Detection Limit of EGFR p.T790M in Circulating Tumor DNA
Q36248587Characterization of a highly effective protein substrate for analysis of JAK2(V617F) Activity
Q92164128Characterization of cancer omics and drug perturbations in panels of lung cancer cells
Q47139649Characterization of the efficacies of osimertinib and nazartinib against cells expressing clinically relevant epidermal growth factor receptor mutations
Q43056671Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas
Q27317429Characterizing tyrosine phosphorylation signaling in lung cancer using SH2 profiling
Q37004639Chasing targets for EGFR tyrosine kinase inhibitors in non-small-cell lung cancer: Asian perspectives
Q64058283Chasing the FOXO3: Insights into Its New Mitochondrial Lair in Colorectal Cancer Landscape
Q36185641Chemoprevention of lung cancer: concepts and strategies
Q46936682Chemopreventive effects of cyclooxygenase-2 inhibitor and epidermal growth factor-receptor kinase inhibitor on rat urinary bladder carcinogenesis
Q36989648Chemoradiation for definitive, preoperative, or postoperative therapy of locally advanced non-small cell lung cancer
Q37799220Chemotherapy and signaling: How can targeted therapies supercharge cytotoxic agents?
Q37614566Chemotherapy for lung cancer: the state of the art in 2009.
Q40375603Chemotherapy for metastatic NSCLC: current status and future direction
Q38237655Chemotherapy in Metastatic NSCLC - New Regimens (Pemetrexed, Nab-Paclitaxel)
Q38838014Chemotherapy remains an essential element of personalized care for persons with lung cancers
Q30940337Chemotherapy versus tyrosine kinase inhibitor in EGFR unselected population advanced non-small cell lung cancer still matter of debate?-An update incorporating the DELTA trial data
Q82297408Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas
Q35217204Chloroquine enhances gefitinib cytotoxicity in gefitinib-resistant nonsmall cell lung cancer cells
Q39869486Chromogenic in situ hybridization analysis of Epidermal Growth Factor Receptor gene/chromosome 7 numerical aberrations in hepatocellular carcinoma based on tissue microarrays
Q34198721Chromogenic in situ hybridization to detect EGFR gene copy number in cell blocks from fine-needle aspirates of non small cell lung carcinomas and lung metastases from colo-rectal cancer
Q36223578Chromosomal aberrations in squamous cell carcinomas of the upper aerodigestive tract: biologic insights and clinical opportunities
Q33781119Chromosomal and genomic changes in lung cancer
Q41487356Chromosome 7 Multiplication in EGFR-positive Lung Carcinomas Based on Tissue Microarray Analysis
Q42453112Chromosome 7 aneusomy in metaplastic breast carcinomas with chondroid, squamous, and spindle-cell differentiation
Q35837368Chronic Obstructive Pulmonary Disease-Related Non-Small-Cell Lung Cancer Exhibits a Low Prevalence of EGFR and ALK Driver Mutations
Q37641586Chronic exposure to cigarette smoke leads to activation of p21 (RAC1)-activated kinase 6 (PAK6) in non-small cell lung cancer cells
Q36287400Chronic treatment of non-small-cell lung cancer cells with gefitinib leads to an epigenetic loss of epithelial properties associated with reductions in microRNA-155 and -200c
Q52640291Cigarette smoke enhances oncogene addiction to c-MET and desensitizes EGFR-expressing non-small cell lung cancer to EGFR TKIs.
Q35207885Cigarette smoke induces aberrant EGF receptor activation that mediates lung cancer development and resistance to tyrosine kinase inhibitors.
Q36309536Cigarette smoking impairs the response of EGFR-TKIs therapy in lung adenocarcinoma patients by promoting EGFR signaling and epithelial-mesenchymal transition
Q38232303Ciliated muconodular papillary tumor of the lung: a newly defined peripheral pulmonary tumor with conspicuous mucin pool mimicking colloid adenocarcinoma: a case report and review of literature
Q36834331Circulating DNA addresses cancer monitoring in non small cell lung cancer patients for detection and capturing the dynamic changes of the disease
Q37635310Circulating Tumor DNA Analysis for Liver Cancers and Its Usefulness as a Liquid Biopsy
Q37780014Circulating endothelial and endothelial progenitor cells in non-small-cell lung cancer.
Q33640472Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages.
Q28077340Circulating tumor cells versus circulating tumor DNA in lung cancer-which one will win?
Q37673460Circulating tumor cells: a window into cancer biology and metastasis
Q24631347Circulating tumor cells: approaches to isolation and characterization
Q37000646Circulating tumour DNA profiling reveals heterogeneity of EGFR inhibitor resistance mechanisms in lung cancer patients.
Q39169544Cisplatin influences acquisition of resistance to molecular-targeted agents through epithelial-mesenchymal transition-like changes
Q38043495Citation classics: Top 50 cited articles in 'respiratory system'.
Q38262804Class act: safety comparison of approved tyrosine kinase inhibitors for non-small-cell lung carcinoma.
Q50050455Classification and regression tree analysis of patients with non-small-cell lung cancer treated with gefitinib after chemotherapy.
Q35654703Classification of Epidermal Growth Factor Receptor Gene Mutation Status Using Serum Proteomic Profiling Predicts Tumor Response in Patients with Stage IIIB or IV Non-Small-Cell Lung Cancer
Q38574971Classification of different patterns of pulmonary adenocarcinomas.
Q52888052Clinical Characteristics and Continued Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Administration in EGFR-mutated Non-Small Cell Lung Cancer with Skeletal Metastasis.
Q47168748Clinical Implications of the Autophagy Core Gene Variations in Advanced Lung Adenocarcinoma Treated with Gefitinib
Q36613044Clinical Next Generation Sequencing for Precision Medicine in Cancer
Q57214546Clinical Outcomes of EGFR Exon 20 Insertion Mutations in Advanced Non-small Cell Lung Cancer in Korea
Q36238822Clinical Significance of ErbB Receptor Family in Urothelial Carcinoma of the Bladder: A Systematic Review and Meta-Analysis
Q27853182Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer
Q38270195Clinical Utility of Circulating Tumor Cells in ALK-Positive Non-Small-Cell Lung Cancer
Q38519252Clinical activity of afatinib in patients with advanced non-small-cell lung cancer harbouring uncommon EGFR mutations: a combined post-hoc analysis of LUX-Lung 2, LUX-Lung 3, and LUX-Lung 6.
Q43195843Clinical activity of the mutant-selective EGFR inhibitor AZD9291 in patients with EGFR inhibitor-resistant non-small cell lung cancer
Q37455251Clinical and Molecular Characteristics of NF1-Mutant Lung Cancer.
Q29615475Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers
Q64098526Clinical and computed tomography characteristics of non-small cell lung cancer with ALK gene rearrangement: Comparison with EGFR mutation and ALK/EGFR-negative lung cancer
Q38042709Clinical and economic review of erlotinib in non-small-cell lung cancer
Q34952066Clinical and epidemiological study of EGFR mutations and EML4-ALK fusion genes among Indian patients with adenocarcinoma of the lung
Q46815372Clinical and molecular predictors of response to EGFR tyrosine kinase inhibitors in non-small cell lung cancer
Q55003763Clinical and radiographic response following targeting of BCAN-NTRK1 fusion in glioneuronal tumor.
Q40048521Clinical application of a cancer genomic profiling assay to guide precision medicine decisions
Q38402811Clinical application of amplicon-based next-generation sequencing to therapeutic decision making in lung cancer
Q38065062Clinical applications for microRNAs in cancer
Q36111249Clinical applications for targeted therapy in bladder cancer
Q36311991Clinical applications of genomics in head and neck cancer
Q38504491Clinical approaches to treat patients with non-small cell lung cancer and epidermal growth factor receptor tyrosine kinase inhibitor acquired resistance.
Q36628704Clinical aspects of epidermal growth factor receptor inhibitors: benefit and risk
Q46446185Clinical benefit in NSCLC: advanced-stage patients require symptom-improving palliation. Experiences from the 'Iressa' expanded access program
Q33279462Clinical benefit of readministration of gefitinib for initial gefitinib-responders with non-small cell lung cancer.
Q37523898Clinical biomarkers in oncology: focus on colorectal cancer
Q37815145Clinical cancer genomics: how soon is now?
Q38253280Clinical cancer research: the past, present and the future
Q34610381Clinical characteristics and course of 63 patients with BRAF mutant lung cancers
Q41920066Clinical characteristics of brain metastases from lung cancer according to histological type: Pretreatment evaluation and survival following whole-brain radiotherapy
Q54109548Clinical characteristics of non-small cell lung cancer harboring mutations in exon 20 of EGFR or HER2.
Q35023498Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations
Q42780600Clinical definition of acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
Q36031642Clinical development of gefitinib in non-small-cell lung cancer and the Iressa Survival Evaluation in Lung Cancer trial
Q35566234Clinical development of phosphatidylinositol-3 kinase pathway inhibitors
Q64055605Clinical development of targeted and immune based anti-cancer therapies
Q44634377Clinical development of targeted moledular cancer drugs
Q33742964Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines
Q46552225Clinical effects for patients with recurrent advanced non-small cell lung cancer treated with icotinib hydrochloride
Q49720695Clinical efficacy and safety of afatinib in the treatment of non-small-cell lung cancer in Chinese patients.
Q90353311Clinical evaluation of dacomitinib for the treatment of metastatic non-small cell lung cancer (NSCLC): current perspectives
Q48422999Clinical factors affecting acquired resistance to gefitinib in previously treated Japanese patients with advanced nonsmall cell lung cancer.
Q35681021Clinical features and mutation status of EGFR, KRAS, BRAF, EML4-ALK and ROS1 between surgical resection samples and non surgical resection samples in lung cancer
Q29615472Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
Q33779181Clinical features and treatment outcome of non-small cell lung cancer (NSCLC) patients with uncommon or complex epidermal growth factor receptor (EGFR) mutations
Q37220488Clinical features reflect exon sites of EGFR mutations in patients with resected non-small-cell lung cancer
Q53303546Clinical impact of amphiregulin expression in patients with epidermal growth factor receptor (EGFR) wild-type nonsmall cell lung cancer treated with EGFR-tyrosine kinase inhibitors.
Q37317171Clinical impact of high-throughput gene expression studies in lung cancer
Q38270567Clinical impact of the new IASLC/ATS/ERS lung adenocarcinoma classification for chest surgeons
Q26823978Clinical implementation of comprehensive strategies to characterize cancer genomes: opportunities and challenges
Q27851527Clinical implications of KRAS mutations in lung cancer patients treated with tyrosine kinase inhibitors: an important role for mutations in minor clones
Q37581276Clinical implications of genetic heterogeneity in multifocal pulmonary adenocarcinomas
Q36519876Clinical implications of genetic polymorphisms on stomach cancer drug therapy
Q34267563Clinical implications of novel activating EGFR mutations in malignant peritoneal mesothelioma
Q34488700Clinical implications of the cancer genome
Q36565941Clinical implications of the mechanism of epidermal growth factor receptor inhibitors
Q91596373Clinical importance of long non‑coding RNA LINC00460 expression in EGFR‑mutant lung adenocarcinoma
Q27024235Clinical investigation of receptor and non-receptor tyrosine kinase inhibitors for the treatment of epithelial ovarian cancer
Q47548020Clinical management and outcome of patients with advanced NSCLC carrying EGFR mutations in Spain
Q49930825Clinical mutational profiling of 1006 lung cancers by next generation sequencing.
Q50629732Clinical mutational profiling of bone metastases of lung and colon carcinoma and malignant melanoma using next-generation sequencing.
Q54313342Clinical next-generation sequencing in patients with non-small cell lung cancer.
Q31158651Clinical outcome according to the level of preexisting epidermal growth factor receptor T790M mutation in patients with lung cancer harboring sensitive epidermal growth factor receptor mutations
Q54118554Clinical outcome study of crizotinib in immunohistochemistry-proven echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase fusion gene among Indian patients with adenocarcinoma lung.
Q37750786Clinical outcomes in non-small-cell lung cancer in relation to expression of predictive and prognostic biomarkers
Q37334996Clinical outcomes in non-small-cell lung cancer patients with EGFR mutations: pooled analysis
Q39457284Clinical outcomes in patients with advanced EGFR-mutated non-small cell lung cancer in South Western Sydney Local Health District.
Q36715107Clinical outcomes of EGFR-TKI treatment and genetic heterogeneity in lung adenocarcinoma patients with EGFR mutations on exons 19 and 21.
Q43272211Clinical outcomes of advanced non-small cell lung cancer patients screened for epidermal growth factor receptor gene mutations
Q38019974Clinical outcomes with erlotinib in patients with epidermal growth factor receptor mutation.
Q34029615Clinical pharmacogenomic testing of KRAS, BRAF and EGFR mutations by high resolution melting analysis and ultra-deep pyrosequencing
Q37873453Clinical pharmacokinetics of tyrosine kinase inhibitors: focus on 4-anilinoquinazolines.
Q36316009Clinical potential of gene mutations in lung cancer
Q36212891Clinical potential of inhibitors of survival pathways and activators of apoptotic pathways in treatment of cervical cancer: changing the apoptotic balance.
Q36345960Clinical relevance of ion channels for diagnosis and therapy of cancer
Q34500155Clinical responses to EGFR-tyrosine kinase inhibitor retreatment in non-small cell lung cancer patients who benefited from prior effective gefitinib therapy: a retrospective analysis
Q33873653Clinical sequencing using a next-generation sequencing-based multiplex gene assay in patients with advanced solid tumors.
Q34041761Clinical significance of BIM deletion polymorphism in non-small-cell lung cancer with epidermal growth factor receptor mutation
Q47118266Clinical significance of cripto-1 expression in lung adenocarcinoma
Q34582813Clinical significance of gefitinib antitumor activity in patients with lung adenocarcinoma
Q42745155Clinical significance of pretreatment C-reactive protein in patients with advanced nonsquamous, non-small cell lung cancer who received gefitinib
Q46351405Clinical significance of pretreatment serum amphiregulin and transforming growth factor-alpha, and an epidermal growth factor receptor somatic mutation in patients with advanced non-squamous, non-small cell lung cancer
Q90403153Clinical significance of repeat rebiopsy in detecting the EGFR T790M secondary mutation in patients with non-small cell lung cancer
Q84584265Clinical significance of serum hepatocyte growth factor and epidermal growth factor gene somatic mutations in patients with non-squamous non-small cell lung cancer receiving gefitinib or erlotinib
Q38041563Clinical testing for molecular targets for personalized treatment in lung cancer.
Q31128049Clinical translation of genotyping and haplotyping data: implementation of in vivo pharmacology experience leading drug prescription to pharmacotyping
Q37196395Clinical trials of novel and targeted therapies: endpoints, trial design, and analysis
Q24630466Clinical use of crizotinib for the treatment of non-small cell lung cancer
Q47704888Clinical usefulness of KRAS, BRAF, and PIK3CA mutations as predictive markers of cetuximab efficacy in irinotecan- and oxaliplatin-refractory Japanese patients with metastatic colorectal cancer
Q35180028Clinical usefulness of gefitinib for non-small-cell lung cancer with a double epidermal growth factor receptor mutation
Q92025240Clinical utility of SMARCA4 testing by immunohistochemistry in rare ovarian tumours
Q34011705Clinical utility of erlotinib for the treatment of non-small-cell lung cancer in Japanese patients: current evidence
Q35107524Clinical validation of a PCR assay for the detection of EGFR mutations in non-small-cell lung cancer: retrospective testing of specimens from the EURTAC trial.
Q33633606Clinical value of the new International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification of lung adenocarcinoma
Q37539427Clinical-molecular factors predicting response and survival for tyrosine-kinase inhibitors.
Q38077041Clinically relevant cancer biomarkers and pharmacogenetic assays
Q80100938Clinico-pathological and biological significance of tyrosine kinase domain gene mutations and overexpression of epidermal growth factor receptor for lung adenocarcinoma
Q37693426Clinicopathologic characteristics and outcomes of Chinese patients with non-small-cell lung cancer and BRAF mutation
Q35790161Clinicopathologic characteristics of patients with ROS1 fusion gene in non-small cell lung cancer: a meta-analysis
Q35007886Clinicopathologic features and outcomes of patients with lung adenocarcinomas harboring BRAF mutations in the Lung Cancer Mutation Consortium
Q54980290Clinicopathological Characteristics and Mutations Driving Development of Early Lung Adenocarcinoma: Tumor Initiation and Progression.
Q90217220Clinicopathological and Prognostic Significance of EML4-ALK Rearrangement in Patients with Surgically Resected Lung Adenocarcinoma: A Propensity Score Matching Study
Q31167585Clinicopathological and demographical characteristics of non-small cell lung cancer patients with ALK rearrangements: a systematic review and meta-analysis
Q33633715Clinicopathological and prognostic features of surgically resected pathological stage I lung adenocarcinoma harboring epidermal growth factor receptor and K-ras mutation
Q50738801Clinicopathological and prognostic significances of EGFR, KRAS and BRAF mutations in biliary tract carcinomas in Taiwan.
Q54269790Clinicopathological characteristics of EGFR mutated adenosquamous carcinoma of the lung.
Q34169194Clinicopathological features and EGFR gene mutation status in elderly patients with resected non-small-cell lung cancer
Q64234032Clinicopathological features and clinical efficacy of crizotinib in Chinese patients with -positive non-small cell lung cancer
Q83568242Clinicopathological features of lung adenocarcinoma with KRAS mutations
Q55259571Clinicopathological features of younger (aged ≤ 50 years) lung adenocarcinoma patients harboring the EML4-ALK fusion gene.
Q51607504Clinicopathological predictors of EGFR/KRAS mutational status in primary lung adenocarcinomas.
Q38784576Clinicopathological significance of p14ARF expression in lung cancer: a meta-analysis
Q27027655Clonal evolution in hematological malignancies and therapeutic implications
Q91272209Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers
Q34254343Co-activation of epidermal growth factor receptor and c-MET defines a distinct subset of lung adenocarcinomas
Q40343596Co-active receptor tyrosine kinases mitigate the effect of FGFR inhibitors in FGFR1-amplified lung cancers with low FGFR1 protein expression.
Q45210729Co-expression of receptors of the HER family correlates with clinical outcome in non-small cell lung cancer (NSCLC).
Q92578527Co-occurring genomic alterations in non-small-cell lung cancer biology and therapy
Q42200131Codon bias imposes a targetable limitation on KRAS-driven therapeutic resistance
Q33682941Coexistence of EGFR with KRAS, or BRAF, or PIK3CA somatic mutations in lung cancer: a comprehensive mutation profiling from 5125 Chinese cohorts
Q34658204Coexistence of KRAS mutation with mutant but not wild-type EGFR predicts response to tyrosine-kinase inhibitors in human lung cancer.
Q36671123Coexistence of PIK3CA and other oncogene mutations in lung adenocarcinoma-rationale for comprehensive mutation profiling
Q33206782Coexpression of epidermal growth factor receptor with related factors is associated with a poor prognosis in non-small-cell lung cancer
Q27691448Collaborative Care in NSCLC; the Role of Early Palliative Care
Q27853014Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab
Q37679938Colorectal cancer in review: the role of the EGFR pathway
Q26824877Combating acquired resistance to tyrosine kinase inhibitors in lung cancer
Q38812090Combating trastuzumab resistance by targeting thioredoxin-1/PTEN interaction
Q52588501Combination TS-1 plus EGFR-tyrosine kinase inhibitors (TKIs) for the treatment of non-small cell lung cancer after progression on first-line or further EGFR-TKIs: A phase II, single-arm trial.
Q35043675Combination of EGFR-TKIs and chemotherapy as first-line therapy for advanced NSCLC: a meta-analysis
Q53681935Combination of Pyrosequencing® and Sanger sequencing reveals alleged novel mutation in exon 18 of EGFR.
Q64111464Combination of cetuximab with met inhibitor in control of cetuximab-resistant oral squamous cell carcinoma
Q48352757Combination of chemotherapy and gefitinib as first-line treatment for patients with advanced lung adenocarcinoma and sensitive EGFR mutations: A randomized controlled trial.
Q34318204Combination of phosphorylated and truncated EGFR correlates with higher tumor and nodal stage in head and neck cancer
Q36795322Combination of radiotherapy with EGFR antagonists for head and neck carcinoma
Q38245873Combination of stereotactic ablative body radiation with targeted therapies
Q92530282Combination therapy of brain radiotherapy and EGFR-TKIs is more effective than TKIs alone for EGFR-mutant lung adenocarcinoma patients with asymptomatic brain metastasis
Q39118597Combination therapy with anti-ErbB3 monoclonal antibodies and EGFR TKIs potently inhibits non-small cell lung cancer
Q33658626Combination therapy: intermittent sorafenib with bevacizumab yields activity and decreased toxicity
Q36143394Combinatorial biomarkers: From early toxicology assays to patient population profiling
Q24632064Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
Q39009280Combined EGFR and autophagy modulation impairs cell migration and enhances radiosensitivity in human glioblastoma cells
Q41811594Combined EGFR/MET or EGFR/HSP90 inhibition is effective in the treatment of lung cancers codriven by mutant EGFR containing T790M and MET.
Q39310312Combined Erlotinib and Cetuximab overcome the acquired resistance to epidermal growth factor receptors tyrosine kinase inhibitor in non-small-cell lung cancer
Q35836350Combined MEK and VEGFR inhibition in orthotopic human lung cancer models results in enhanced inhibition of tumor angiogenesis, growth, and metastasis
Q39051337Combined Tumor Suppressor Defects Characterize Clinically Defined Aggressive Variant Prostate Cancers
Q34345154Combined action of the dinuclear platinum compound BBR3610 with the PI3-K inhibitor PX-866 in glioblastoma
Q37111832Combined anti-proliferative and anti-angiogenic strategies for cancer
Q37080964Combined assessment of EGFR pathway-related molecular markers and prognosis of NSCLC patients
Q54977986Combined caveolin-1 and epidermal growth factor receptor expression as a prognostic marker for breast cancer.
Q33881706Combined effects of asbestos and cigarette smoke on the development of lung adenocarcinoma: different carcinogens may cause different genomic changes
Q57736167Combined inhibition of MEK and PI3K pathways overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer
Q36230865Combined inhibition of insulin-like growth factor-1 receptor enhances the effects of gefitinib in a human non-small cell lung cancer resistant cell line
Q37522017Combined therapies for cancer: a review of EGFR-targeted monotherapy and combination treatment with other drugs
Q40167169Combined treatment of bladder cancer cell lines with lapatinib and varying chemotherapy regimens--evidence of schedule-dependent synergy
Q39559565Combined treatment with EGFR inhibitors and arsenite upregulated apoptosis in human EGFR-positive melanomas: a role of suppression of the PI3K-AKT pathway
Q39850353Combined vascular endothelial growth factor receptor and epidermal growth factor receptor (EGFR) blockade inhibits tumor growth in xenograft models of EGFR inhibitor resistance
Q91816037Combing the Cancer Genome for Novel Kinase Drivers and New Therapeutic Targets
Q34104025Combining AKT inhibition with chloroquine and gefitinib prevents compensatory autophagy and induces cell death in EGFR mutated NSCLC cells
Q34206363Combining EGFR and mTOR blockade for the treatment of epithelioid sarcoma
Q41635081Combining PET/CT with serum tumor markers to improve the evaluation of histological type of suspicious lung cancers
Q41892153Combining chemotherapy with epidermal growth factor receptor inhibition in advanced non-small cell lung cancer.
Q34066159Combining erlotinib and cetuximab is associated with activity in patients with non-small cell lung cancer (including squamous cell carcinomas) and wild-type EGFR or resistant mutations
Q57279749Combining genomic analyses with tumour-derived slice cultures for the characterization of an EGFR-activating kinase mutation in a case of glioblastoma
Q26852202Combining targeted agents and hypo- and hyper-fractionated radiotherapy in NSCLC
Q38868047Combining three antibodies nullifies feedback-mediated resistance to erlotinib in lung cancer
Q50056486Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-smallcell Lung Cancer Associated With Poor Prognosis.
Q38335360Common EGFR-mutated subgroups (Del19/L858R) in advanced non-small-cell lung cancer: chasing better outcomes with tyrosine kinase inhibitors
Q57274907Common and Contrasting Genomic Profiles among the Major Human Lung Cancer Subtypes
Q34906960Common and rare EGFR and KRAS mutations in a Dutch non-small-cell lung cancer population and their clinical outcome.
Q35041632Common oncogenic mutations are infrequent in oral squamous cell carcinoma of Asian origin
Q42346456Comparable rate of EGFR kinase domain mutation in lung adenocarcinomas from Chinese male and female never-smokers
Q92662253Comparative Analysis of Two Methods for the Detection of EGFR Mutations in Plasma Circulating Tumor DNA from Lung Adenocarcinoma Patients
Q60046465Comparative Transcriptomics Unravels Prodigiosin's Potential Cancer-Specific Activity Between Human Small Airway Epithelial Cells and Lung Adenocarcinoma Cells
Q45770152Comparative analyses of overall survival in patients with anaplastic lymphoma kinase-positive and matched wild-type advanced nonsmall cell lung cancer
Q24541311Comparative analysis of cancer genes in the human and chimpanzee genomes
Q51667874Comparative analysis of clinicoradiologic characteristics of lung adenocarcinomas with ALK rearrangements or EGFR mutations.
Q44219909Comparative analysis of epidermal growth factor receptor mutations and gene amplification as predictors of gefitinib efficacy in Japanese patients with nonsmall cell lung cancer
Q33927591Comparative analysis of two clinically active BCR-ABL kinase inhibitors reveals the role of conformation-specific binding in resistance
Q36519015Comparative and integrative functional genomics of HCC.
Q36358798Comparative pharmacogenomics of antiretroviral and cytotoxic treatments.
Q35790108Comparing Platforms for Messenger RNA Expression Profiling of Archival Formalin-Fixed, Paraffin-Embedded Tissues
Q34560075Comparing antibody and small-molecule therapies for cancer
Q60922980Comparison of Clinicopathological Features and Prognosis between Rearrangements and Mutations in Surgically Resected Early-stage Lung Adenocarcinoma
Q36660393Comparison of Direct Sequencing, PNA Clamping-Real Time Polymerase Chain Reaction, and Pyrosequencing Methods for the Detection of EGFR Mutations in Non-small Cell Lung Carcinoma and the Correlation with Clinical Responses to EGFR Tyrosine Kinase In
Q36882732Comparison of EGFR and K-RAS gene status between primary tumours and corresponding metastases in NSCLC.
Q89666748Comparison of EML4-ALK fusion gene positive rate in different detection methods and samples of non-small cell lung cancer
Q36148697Comparison of Epidermal Growth Factor Receptor Mutations between Metastatic Lymph Node Diagnosed by EBUS-TBNA and Primary Tumor in Non-Small Cell Lung Cancer
Q34947842Comparison of IHC, FISH and RT-PCR methods for detection of ALK rearrangements in 312 non-small cell lung cancer patients in Taiwan
Q34756451Comparison of KRAS and EGFR gene status between primary non-small cell lung cancer and local lymph node metastases: implications for clinical practice
Q40368173Comparison of Prevalence and Types of Mutations in Lung Cancers Among Black and White Populations
Q49593937Comparison of Thoracic Radiotherapy Efficacy Between Patients With and Without EGFR-mutated Lung Adenocarcinoma.
Q85776063Comparison of adverse events and efficacy between gefitinib and erlotinib in patients with non-small-cell lung cancer: a retrospective analysis
Q47162466Comparison of cross-platform technologies for EGFR T790M testing in patients with non-small cell lung cancer
Q36474664Comparison of different methods for detecting epidermal growth factor receptor mutations in peripheral blood and tumor tissue of non-small cell lung cancer as a predictor of response to gefitinib
Q41709088Comparison of direct sequencing and amplification refractory mutation system for detecting epidermal growth factor receptor mutation in non-small-cell lung cancer patients: a systematic review and meta-analysis
Q54300832Comparison of epidermal growth factor receptor mutation statuses in tissue and plasma in stage I-IV non-small cell lung cancer patients.
Q46195110Comparison of epidermal growth factor receptor mutations between primary and corresponding metastatic tumors in tyrosine kinase inhibitor-naive non-small-cell lung cancer
Q30438089Comparison of global versus epidermal growth factor receptor pathway profiling for prediction of lapatinib sensitivity in bladder cancer
Q89585374Comparison of next-generation sequencing and immunohistochemistry analysis for targeted therapy-related genomic status in lung cancer patients
Q37708814Comparison of outcomes of tyrosine kinase inhibitor in first- or second-line therapy for advanced non-small-cell lung cancer patients with sensitive EGFR mutations
Q54652248Comparison of p53 and epidermal growth factor receptor gene status between primary tumors and lymph node metastases in non-small cell lung cancers.
Q54117313Comparison of plasma ctDNA and tissue/cytology-based techniques for the detection of EGFR mutation status in advanced NSCLC: Spanish data subset from ASSESS.
Q37644815Comparison of small biopsy specimens and surgical specimens for the detection of EGFR mutations and EML4-ALK in non-small-cell lung cancer
Q94453279Comparison of the characteristics of uncommon epidermal growth factor receptor (EGFR) mutations and EGFR-tyrosine kinase inhibitor treatment in patients with non-small cell lung cancer from different ethnic groups
Q54941379Comparison of the effects of the three major tyrosine kinase inhibitors as first-line therapy for non-small-cell lung cancer harboring epidermal growth factor receptor mutations.
Q38091669Comparison of the efficacy and safety of single-agent erlotinib and doublet molecular targeted agents based on erlotinib in advanced non-small cell lung cancer (NSCLC): a systematic review and meta-analysis
Q37204325Comparison of the efficacy of icotinib in patients with non-small-cell lung cancer according to the type of epidermal growth factor receptor mutation
Q40344659Comparison of the epidermal growth factor receptor gene and protein in primary non-small-cell-lung cancer and metastatic sites: implications for treatment with EGFR-inhibitors
Q35541933Comparison of uncommon EGFR exon 21 L858R compound mutations with single mutation.
Q40891431Comparisons of the clinicopathological features and survival outcomes between lung cancer patients with adenocarcinoma and squamous cell carcinoma.
Q36865316Comparisons of tyrosine phosphorylated proteins in cells expressing lung cancer-specific alleles of EGFR and KRAS
Q39378163Competitive allele specific TaqMan PCR for KRAS, BRAF and EGFR mutation detection in clinical formalin fixed paraffin embedded samples.
Q39477372Competitive amplification of differentially melting amplicons (CADMA) enables sensitive and direct detection of all mutation types by high-resolution melting analysis.
Q33723528Complete response in gallbladder cancer to erlotinib plus gemcitabine does not require mutation of the epidermal growth factor receptor gene: a case report
Q42920934Complex Mutations in the Epidermal Growth Factor Receptor Gene in Non-small Cell Lung Cancer
Q34359601Complex mutations & subpopulations of deletions at exon 19 of EGFR in NSCLC revealed by next generation sequencing: potential clinical implications.
Q93051199Compound 15c, a Novel Dual Inhibitor of EGFRL858R/T790M and FGFR1, Efficiently Overcomes Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance of Non-Small-Cell Lung Cancers
Q36491122Compound EGFR mutations and response to EGFR tyrosine kinase inhibitors.
Q94564084Comprehensive Genomic Profiling of Rare Tumors: Routes to Targeted Therapies
Q35712214Comprehensive Molecular Analysis of NSCLC; Clinicopathological Associations
Q92968477Comprehensive analysis of EGFR T790M detection by ddPCR and ARMS-PCR and the effect of mutant abundance on the efficacy of osimertinib in NSCLC patients
Q64075323Comprehensive analysis of age-related somatic mutation profiles in Chinese young lung adenocarcinoma patients
Q28606437Comprehensive assessment of cancer missense mutation clustering in protein structures
Q36608839Comprehensive epidermal growth factor receptor gene analysis from cytological specimens of non-small-cell lung cancers
Q30235944Comprehensive evaluation of published gene expression prognostic signatures for biomarker-based lung cancer clinical studies
Q28274701Comprehensive genomic characterization of squamous cell lung cancers
Q36544077Comprehensive investigation of oncogenic driver mutations in Chinese non-small cell lung cancer patients
Q39449489Comprehensive molecular oncogenomic profiling and miRNA analysis of prostate cancer
Q42587971Comprehensive molecular tumor profiling in radiation oncology: How it could be used for precision medicine
Q37580410Comprehensive profiling and quantitation of oncogenic mutations in non small-cell lung carcinoma using single molecule amplification and re-sequencing technology
Q37671783Comprehensive profiling of EGFR/HER receptors for personalized treatment of gynecologic cancers
Q39293400Comprehensive study of mutational and clinicopathologic characteristics of adenocarcinoma with lepidic pattern in surgical resected lung adenocarcinoma
Q30581942Computational delineation of tyrosyl-substrate recognition and catalytic landscapes by the epidermal growth factor receptor tyrosine kinase domain
Q30374663Computational modeling of structurally conserved cancer mutations in the RET and MET kinases: the impact on protein structure, dynamics, and stability.
Q90541036Computer Aided Nodule Analysis and Risk Yield (CANARY) characterization of adenocarcinoma: radiologic biopsy, risk stratification and future directions
Q47308660Computer-Aided Nodule Assessment and Risk Yield (CANARY) may facilitate non-invasive prediction of EGFR mutation status in lung adenocarcinomas
Q43059180Con: the case for expanded lung cancer research support
Q36418752Concomitance of P-gp/LRP Expression with EGFR Mutations in Exons 19 and 21 in Non-Small Cell Lung Cancers
Q99582766Concomitant genetic alterations are associated with response to EGFR targeted therapy in patients with lung adenocarcinoma
Q37175551Concordant and Discordant EGFR Mutations in Patients With Multifocal Adenocarcinomas: Implications for EGFR-Targeted Therapy
Q64092527Concurrent Driver Gene Mutations as Negative Predictive Factors in Epidermal Growth Factor Receptor-Positive Non-Small Cell Lung Cancer
Q36151764Concurrent oncogene mutation profile in Chinese patients with stage Ib lung adenocarcinoma
Q36546095Concurrent radiotherapy with gefitinib in elderly patients with esophageal squamous cell carcinoma: Preliminary results of a phase II study
Q90074730Conformational Insight on WT- and Mutated-EGFR Receptor Activation and Inhibition by Epigallocatechin-3-Gallate: Over a Rational Basis for the Design of Selective Non-Small-Cell Lung Anticancer Agents
Q50036265Considerations About the Use of Biomarkers in Cancer Clinical Trials.
Q64256027Constitutive activation of EGFR is associated with tumor progression and plays a prominent role in malignant phenotype of chondrosarcoma
Q35832237Constitutive asymmetric dimerization drives oncogenic activation of epidermal growth factor receptor carboxyl-terminal deletion mutants
Q37707704Construction of a novel cell-based assay for the evaluation of anti-EGFR drug efficacy against EGFR mutation
Q47107157Continuation of gefitinib plus chemotherapy prolongs progression-free survival in advanced non-small cell lung cancer patients who get acquired resistance to gefitinib without T790M mutations
Q40670339Continuous epidermal growth factor receptor-tyrosine kinase inhibitor administration in primary lung adenocarcinoma patients harboring favorable mutations with controlled target lung tumors dose not hinder survival benefit despite small new lesions.
Q96126112Contrast-enhanced T1-weighted image radiomics of brain metastases may predict EGFR mutation status in primary lung cancer
Q28547357Contribution of EGFR and ErbB-3 Heterodimerization to the EGFR Mutation-Induced Gefitinib- and Erlotinib-Resistance in Non-Small-Cell Lung Carcinoma Treatments
Q52983736Contribution of ¹⁸Fluorodeoxyglucose positron emission tomography uptake and TTF-1 expression in the evaluation of the EGFR mutation in patients with lung adenocarcinoma.
Q37109227Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways to leukemia.
Q35605425Control of the MYC-eIF4E axis plus mTOR inhibitor treatment in small cell lung cancer
Q64098514Conventional transbronchial needle aspiration is promising for identifying EGFR mutations in lung adenocarcinoma
Q35772768Cooperative Hedgehog-EGFR signaling
Q34489386Cooperative, nanoparticle-enabled thermal therapy of breast cancer
Q36486421Copy number gains in EGFR and copy number losses in PTEN are common events in osteosarcoma tumors
Q33704537Correlation between (18)f-fluorodeoxyglucose uptake and epidermal growth factor receptor mutations in advanced lung cancer
Q33857652Correlation between EGFR mutation status and response to first-line platinum-based chemotherapy in patients with advanced non-small cell lung cancer
Q39652063Correlation between epidermal growth factor receptor-specific nanobody uptake and tumor burden: a tool for noninvasive monitoring of tumor response to therapy
Q47935277Correlation between status of epidermal growth factor receptor mutation and distant metastases of lung adenocarcinoma upon initial diagnosis based on 1063 patients in China
Q34732930Correlation of EGFR mutation and histological subtype according to the IASLC/ATS/ERS classification of lung adenocarcinoma.
Q46171346Correlation of F-18 fluorodeoxyglucose-positron emission tomography maximal standardized uptake value and EGFR mutations in advanced lung adenocarcinoma.
Q64252788Correlation of Thyroid Transcription Factor-1 Expression with Mutations in Non-Small-Cell Lung Cancer: A Meta-Analysis
Q39669033Correlation of activated STAT3 expression with clinicopathologic features in lung adenocarcinoma and squamous cell carcinoma
Q54477690Correlation of immunohistochemical staining p63 and TTF-1 with EGFR and K-ras mutational spectrum and diagnostic reproducibility in non small cell lung carcinoma.
Q33792597Correlation of survival and EGFR mutation with predominant histologic subtype according to the new lung adenocarcinoma classification in stage IB patients
Q36207143Correlations Between the EGFR Mutation Status and Clinicopathological Features of Clinical Stage I Lung Adenocarcinoma.
Q92408657Correlations Study Between 18F-FDG PET/CT Metabolic Parameters Predicting Epidermal Growth Factor Receptor Mutation Status and Prognosis in Lung Adenocarcinoma
Q33290653Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung cancer patients
Q36389901Correlative studies in neuro-oncology trials: should they influence treatment?
Q40575534Cost-effectiveness analysis of EGFR mutation testing in patients with non-small cell lung cancer (NSCLC) with gefitinib or carboplatin-paclitaxel
Q90198180Cost-effectiveness analysis of the first-line EGFR-TKIs in patients with non-small cell lung cancer harbouring EGFR mutations
Q34410131Coupled mutation finder: a new entropy-based method quantifying phylogenetic noise for the detection of compensatory mutations
Q38766833Covalent EGFR Inhibitors: Binding Mechanisms, Synthetic Approaches, and Clinical Profiles
Q48510829Creating incentives for genomic research to improve targeting of therapies.
Q36405628Crizotinib for the treatment of ALK-rearranged non-small cell lung cancer: a success story to usher in the second decade of molecular targeted therapy in oncology
Q26738381Crizotinib resistance: implications for therapeutic strategies
Q53148505Crizotinib-induced toxicity in an experimental rat model.
Q37982440Crizotinib: a drug that crystallizes a unique molecular subset of non-small-cell lung cancer
Q35596686Crizotinib: a novel and first-in-class multitargeted tyrosine kinase inhibitor for the treatment of anaplastic lymphoma kinase rearranged non-small cell lung cancer and beyond
Q33703063Cross-Platform Comparison of Four Leading Technologies for Detecting EGFR Mutations in Circulating Tumor DNA from Non-Small Cell Lung Carcinoma Patient Plasma
Q37335142Cross-talk between the ErbB/HER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer
Q36429474Crossing the rubicon in lung adenocarcinoma: the conundrum of EGFR tyrosine kinase mutations
Q37314768Crosstalk between Aurora-A and p53: frequent deletion or downregulation of Aurora-A in tumors from p53 null mice
Q36365503Crosstalk with cancer-associated fibroblasts induces resistance of non-small cell lung cancer cells to epidermal growth factor receptor tyrosine kinase inhibition
Q90056608Cucurbitacin D Overcomes Gefitinib Resistance by Blocking EGF Binding to EGFR and Inducing Cell Death in NSCLCs
Q34000044Curcumin induces EGFR degradation in lung adenocarcinoma and modulates p38 activation in intestine: the versatile adjuvant for gefitinib therapy
Q26774502Current Challenges in Glioblastoma: Intratumour Heterogeneity, Residual Disease, and Models to Predict Disease Recurrence
Q40076524Current Japanese regulatory situations of pharmacogenomics in drug administration
Q46034707Current Landscape of Targeted Therapy in Lung Cancer.
Q88566793Current Opportunities and Future Vision of Precision Medicine in Radiation Oncology
Q64890663Current Status of Raf Kinase Inhibitor Protein (RKIP) in Lung Cancer: Behind RTK Signaling.
Q39016850Current Trends in Multidrug Optimization
Q38543780Current and future molecular diagnostics in non-small-cell lung cancer.
Q37184167Current aspects of targeted therapy in head and neck tumors
Q37723328Current challenges for the early clinical development of anticancer drugs in the era of molecularly targeted agents
Q38172914Current clinical application of genomic and proteomic profiling in non-small-cell lung cancer
Q34310062Current concepts on the molecular pathology of non-small cell lung carcinoma
Q35583920Current management of gallbladder carcinoma
Q52715754Current outcomes of postrecurrence survival in patients after resection of non-small cell lung cancer.
Q36849663Current practices and guidelines for clinical next-generation sequencing oncology testing
Q36832121Current role of antibody therapy in patients with metastatic colorectal cancer.
Q36452704Current status and perspective of angiogenesis and antivascular therapeutic strategy: non-small cell lung cancer
Q36364973Current status of cetuximab for the treatment of patients with solid tumors.
Q35667739Current status of immunotherapy for the treatment of lung cancer.
Q39298725Current status of research and treatment for non-small cell lung cancer in never-smoking females
Q37790985Current status of vandetanib (ZD6474) in the treatment of non-small cell lung cancer
Q43196880Current tumor pathology. Clinical expectations of pathological diagnosis
Q34276419Customized chemotherapy based on epidermal growth factor receptor mutation status for elderly patients with advanced non-small-cell lung cancer: a phase II trial.
Q33438894Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression
Q35146940Customizing systemic therapy in patients with advanced non-small cell lung cancer
Q37043766Cutaneous metastasis as an initial presentation of lung adenocarcinoma with KRAS mutation: a case report and literature review
Q34684234Cyclic AMP response element-binding protein overexpression: a feature associated with negative prognosis in never smokers with non-small cell lung cancer
Q33932736Cyclooxygenase-2 inhibitors for non-small-cell lung cancer: A phase II trial and literature review
Q34637939Cyclooxygenase-2 transactivates the epidermal growth factor receptor through specific E-prostanoid receptors and tumor necrosis factor-alpha converting enzyme
Q24303022Cytohesins are cytoplasmic ErbB receptor activators
Q52031018Cytokeratin 20 expression identifies a subtype of pancreatic adenocarcinoma with decreased overall survival.
Q39673657Cytokines and Growth Factors Stimulate Hyaluronan Production: Role of Hyaluronan in Epithelial to Mesenchymal-Like Transition in Non-Small Cell Lung Cancer
Q37890996Cytomorphologic features of advanced lung adenocarcinomas tested for EGFR and KRAS mutations: a retrospective review of 50 cases
Q80142942Cytomorphological correlates of epidermal growth factor receptor mutations in lung carcinoma
Q91756360Cytoplasmic ERβ1 expression is associated with survival of patients with Stage IV lung adenocarcinoma and an EGFR mutation at exon 21 L858R subsequent to treatment with EGFR-TKIs
Q54356882Cytoplasmic YAP expression is associated with prolonged survival in patients with lung adenocarcinomas and epidermal growth factor receptor tyrosine kinase inhibitor treatment.
Q50920187Cytosolic PKM2 stabilizes mutant EGFR protein expression through regulating HSP90-EGFR association.
Q38768617Cytotoxicity of Salvia miltiorrhiza Against Multidrug-Resistant Cancer Cells.
Q55028849Cytotoxicity of allitinib, an irreversible anti-EGFR agent, in a large panel of human cancer-derived cell lines: KRAS mutation status as a predictive biomarker.
Q36099324DDR2 polymorphisms and mRNA expression in lung cancers of Japanese patients
Q35364690DDX3X induces primary EGFR-TKI resistance based on intratumor heterogeneity in lung cancer cells harboring EGFR-activating mutations
Q37572189DDX59 promotes DNA replication in lung adenocarcinoma
Q36471888DNA Methylation status of Wnt antagonist SFRP5 can predict the response to the EGFR-tyrosine kinase inhibitor therapy in non-small cell lung cancer.
Q53725947DNA Mutations May Not Be the Cause of Cancer.
Q35238487DNA methylation transcriptionally regulates the putative tumor cell growth suppressor ZNF677 in non-small cell lung cancers
Q42755164DNA repair gene polymorphisms and benefit from gefitinib in never-smokers with lung adenocarcinoma
Q35892040DNA-microarray analysis of brain cancer: molecular classification for therapy
Q35047411DOK2 inhibits EGFR-mutated lung adenocarcinoma
Q54981550Dabrafenib in combination with trametinib in the treatment of patients with BRAF V600-positive advanced or metastatic non-small cell lung cancer: clinical evidence and experience.
Q45219658Dacomitinib as first-line treatment in patients with clinically or molecularly selected advanced non-small-cell lung cancer: a multicentre, open-label, phase 2 trial
Q26778318Dacomitinib in lung cancer: a "lost generation" EGFR tyrosine-kinase inhibitor from a bygone era?
Q38273671Dacomitinib versus erlotinib in patients with advanced-stage, previously treated non-small-cell lung cancer (ARCHER 1009): a randomised, double-blind, phase 3 trial.
Q47257690Dacomitinib versus gefitinib as first-line treatment for patients with EGFR-mutation-positive non-small-cell lung cancer (ARCHER 1050): a randomised, open-label, phase 3 trial
Q42355259Dacomitinib, an emerging HER-targeted therapy for non-small cell lung cancer
Q46228962Database of somatic mutations in EGFR with analyses revealing indel hotspots but no smoking-associated signature
Q93545733De la recherche de pointe au patient : un aller-retour?
Q38651333Deciphering mechanisms of acquired T790M mutation after EGFR inhibitors for NSCLC by computational simulations.
Q38609992Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.
Q37285973Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer.
Q44660604Decreased survival in EGFR gene amplified vulvar carcinoma
Q40135901Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling.
Q33671802Defining the blueprint of the cancer genome
Q37834359Defining the cancer master switch
Q42707531Defining the pathogenicity of DNA sequence variation
Q35631635Defining the role of tyrosine kinase inhibitors in early stage non-small cell lung cancer.
Q36088163Degradation of epidermal growth factor receptor mediates dasatinib-induced apoptosis in head and neck squamous cell carcinoma cells
Q47314182Deguelin induces PUMA-mediated apoptosis and promotes sensitivity of lung cancer cells (LCCs) to doxorubicin (Dox).
Q33779169Deguelin inhibits non-small cell lung cancer via down-regulating Hexokinases II-mediated glycolysis
Q43518666Delivery of chemotherapy and antibodies across the blood-brain barrier and the role of chemoprotection, in primary and metastatic brain tumors: report of the Eleventh Annual Blood-Brain Barrier Consortium meeting
Q58408122DeltaN TP63 reactivation, epithelial phenotype maintenance, and survival in lung squamous cell carcinoma
Q58697688Demographic Composition of Select Oncologic New Molecular Entities Approved by the FDA Between 2008 and 2017
Q36690711Dendrimer nanoscaffolds for potential theranostics of prostate cancer with a focus on radiochemistry
Q89867948Depletion of histone methyltransferase KMT9 inhibits lung cancer cell proliferation by inducing non-apoptotic cell death
Q64059776Deregulation of a Network of mRNA and miRNA Genes Reveals That CK2 and MEK Inhibitors May Synergize to Induce Apoptosis KRAS-Active NSCLC
Q33588217Design and Development of Fluorescent Vemurafenib Analogs for In Vivo Imaging
Q54642118Design and generation of MLPA probe sets for combined copy number and small-mutation analysis of human genes: EGFR as an example.
Q33936934Design and inference for cancer biomarker study with an outcome and auxiliary-dependent subsampling
Q47623485Design, Synthesis, and Antitumor Activity of Novel Quinazoline Derivatives.
Q35132338Designing a high-throughput somatic mutation profiling panel specifically for gynaecological cancers
Q82215956Designing prospective clinical pharmacogenomic (PG) trials: meeting report on drug development strategies to enhance therapeutic decision making
Q91286819Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies
Q99350140Destabilizing single chain major histocompatibility complex class I protein for repurposed enterokinase proteolysis
Q34092187Detecting ALK, ROS1 and RET Fusion Genes in Cell Block Samples
Q58695640Detecting EGFR mutations in patients with non-small cell lung cancer
Q34589493Detection and clinical significance of intratumoral EGFR mutational heterogeneity in Chinese patients with advanced non-small cell lung cancer.
Q36866974Detection of E2A-PBX1 fusion transcripts in human non-small-cell lung cancer
Q43246506Detection of EGFR T790M Mutation in Pericardial Effusion from a Non-Small Cell Lung Cancer Patient with Erlotinib Therapy
Q37313331Detection of EGFR gene mutations in non-small cell lung cancer: lessons from a single-institution routine analysis of 1,403 tumor samples
Q35038358Detection of EGFR mutation in supernatant, cell pellets of pleural effusion and tumor tissues from non-small cell lung cancer patients by high resolution melting analysis and sequencing
Q38398139Detection of EGFR mutations and EML4-ALK rearrangements in lung adenocarcinomas using archived cytological slides.
Q33582524Detection of EGFR mutations in plasma and biopsies from non-small cell lung cancer patients by allele-specific PCR assays.
Q34467915Detection of EGFR mutations with mutation-specific antibodies in stage IV non-small-cell lung cancer
Q36787803Detection of EML4-ALK fusion gene and features associated with EGFR mutations in Chinese patients with non-small-cell lung cancer
Q44509483Detection of EML4-ALK fusion genes in non-small cell lung cancer patients with clinical features associated with EGFR mutations
Q37141952Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping
Q47879384Detection of an EGFR mutation in cytological specimens of lung adenocarcinoma.
Q37709234Detection of circulating tumor DNA in patients with advanced non-small cell lung cancer
Q36755219Detection of drug-sensitizing EGFR exon 19 deletion mutations in salivary gland carcinoma
Q35787132Detection of epidermal growth factor receptor mutation in lung cancer by droplet digital polymerase chain reaction
Q36278010Detection of epidermal growth factor receptor mutation in plasma as a biomarker in Chinese patients with early-stage non-small cell lung cancer
Q39437297Detection of epidermal growth factor receptor mutations in a few cancer cells from transbronchial cytologic specimens by reverse transcriptase-polymerase chain reaction
Q36835257Detection of epidermal growth factor receptor mutations in formalin fixed paraffin embedded biopsies in Malaysian non-small cell lung cancer patients.
Q47093966Detection of epidermal growth factor receptor mutations in lung adenocarcinoma cytological specimens by immunocytochemistry
Q42907464Detection of epidermal growth factor receptor mutations in non-small cell lung cancer tumor specimens from various ways by denaturing high-performance liquid chromatography
Q39531710Detection of low-level EGFR T790M mutation in lung cancer tissues
Q35789640Detection of mutant BRAF alleles in the plasma of patients with metastatic melanoma.
Q29615033Detection of mutations in EGFR in circulating lung-cancer cells
Q40251398Detection of oncogenic mutations in the EGFR gene in lung adenocarcinoma with differential sensitivity to EGFR tyrosine kinase inhibitors
Q36138364Detection of rearrangement of anaplastic lymphoma kinase (ALK) and mutation of epidermal growth factor receptor (EGFR) in primary pulmonary lymphoepithelioma-like carcinoma
Q46609599Detection of response-predicting mutations in the kinase domain of the epidermal growth factor receptor gene in cholangiocarcinomas
Q36497457Detection of tumor PIK3CA status in metastatic breast cancer using peripheral blood
Q33525226Detection of tumor epidermal growth factor receptor pathway dependence by serum mass spectrometry in cancer patients
Q37146779Determinants of survival in advanced non--small-cell lung cancer in the era of targeted therapies
Q36085452Determination of EGFR and KRAS mutational status in Greek non-small-cell lung cancer patients
Q34799198Determination of EGFR mutations in single cells microdissected from enriched lung tumor cells in peripheral blood.
Q39129178Determining EGFR-TKI sensitivity of G719X and other uncommon EGFR mutations in non-small cell lung cancer: Perplexity and solution (Review).
Q54272422Determining the profiles and parameters for gene amplification testing of growth factor receptors in lung cancer.
Q97567723Development and validation of a predictive model for estimating EGFR mutation probabilities in patients with non-squamous non-small cell lung cancer in New Zealand
Q91344944Development and validation of a targeted gene sequencing panel for application to disparate cancers
Q35612289Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms
Q35968389Development of TGF-beta signalling inhibitors for cancer therapy
Q39319196Development of a RNA-Seq Based Prognostic Signature in Lung Adenocarcinoma.
Q38717500Development of a gene panel for next-generation sequencing of clinically relevant mutations in cell-free DNA from cancer patients.
Q50246515Development of a skin rash within the first week and the therapeutic effect in afatinib monotherapy for EGFR-mutant non-small cell lung cancer (NSCLC): Okayama Lung Cancer Study Group experience.
Q49802373Development of a targeted sequencing approach to identify prognostic, predictive and diagnostic markers in paediatric solid tumours.
Q37630493Development of anaplastic lymphoma kinase (ALK) inhibitors and molecular diagnosis in ALK rearrangement-positive lung cancer
Q34393558Development of central nervous system metastases in patients with advanced non-small cell lung cancer and somatic EGFR mutations treated with gefitinib or erlotinib
Q38792120Development of crizotinib, a rationally designed tyrosine kinase inhibitor for non-small cell lung cancer
Q38793056Development of indication criteria for preoperative examination in lung cancer
Q37833005Development of molecularly targeted therapies in biliary tract cancers: reassessing the challenges and opportunities
Q38956309Development of personalized treatments in lung cancer: focusing on the EGFR mutations and beyond.
Q38930336Diagnosis and Molecular Classification of Lung Cancer
Q33737293Diagnostic and Therapeutic Potential of MicroRNAs in Lung Cancer
Q46624082Diagnostic value of a novel fully automated immunochemistry assay for detection of ALK rearrangement in primary lung adenocarcinoma
Q35244225Diagnostic value of mutation-specific antibodies for immunohistochemical detection of epidermal growth factor receptor mutations in non-small cell lung cancer: a meta-analysis
Q52903547Diamond: immunohistochemistry versus sequencing in EGFR analysis of lung adenocarcinomas.
Q37324081Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis.
Q49166137Diethylnitrosamine induces lung adenocarcinoma in FVB/N mouse.
Q47118230Difference in Postsurgical Prognostic Factors between Lung Adenocarcinoma and Squamous Cell Carcinoma
Q37177513Differences among lesions with exon 19, exon 21 EGFR mutations and wild types in surgically resected non-small cell lung cancer
Q37269571Differences in EGFR and KRAS mutation spectra in lung adenocarcinoma of never and heavy smokers
Q52145217Different EGFR Gene Mutations in Exon 18, 19 and 21 as Prognostic and Predictive Markers in NSCLC: A Single Institution Analysis.
Q40016506Different spatial distributions of brain metastases from lung cancer by histological subtype and mutation status of epidermal growth factor receptor.
Q39277085Different treatment orders achieved similar clinical results: a retrospective study for retreatment of epidermal growth factor receptor tyrosine kinase inhibitors in 120 patients with non-small-cell lung cancer
Q35434274Differential Effects of Tyrosine Kinase Inhibitors on Normal and Oncogenic EGFR Signaling and Downstream Effectors
Q90427149Differential Gene Expression in Erlotinib-Treated Fibroblasts
Q58772425Differential MicroRNA Expression between EGFR T790M and L858R Mutated Lung Cancer
Q90411020Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins
Q41930710Differential contribution to neuroendocrine tumorigenesis of parallel egfr signaling in cancer cells and pericytes
Q40384212Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations
Q36121683Differential efficacy of docetaxel according to non-small cell lung cancer histology and the therapeutic effect of epidermal growth factor receptor tyrosine kinase inhibitors
Q45848152Differential expression and activation of epidermal growth factor receptor 1 (EGFR1), ERK, AKT, STAT3, and TWIST1 in nonsmall cell lung cancer (NSCLC).
Q33733522Differential expression of CRKL and AXL genes in lung adenocarcinoma subtypes according to the epidermal growth factor receptor and anaplastic lymphoma kinase gene status
Q41213157Differential expression of bone morphogenetic protein 5 in human lung squamous cell carcinoma and adenocarcinoma.
Q39032624Differential parsing of EGFR endocytic flux among parallel internalization pathways in lung cancer cells with EGFR-activating mutations
Q37708836Differential protein stability of EGFR mutants determines responsiveness to tyrosine kinase inhibitors
Q39430288Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide
Q43200792Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII.
Q35967385Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors
Q90193852Diffuse Lung Metastases in EGFR-Mutant Non-Small Cell Lung Cancer
Q47208190Diffusion-Weighted Imaging of Brain Metastasis from Lung Cancer: Correlation of MRI Parameters with the Histologic Type and Gene Mutation Status.
Q42131816Diminished functional role and altered localization of SHP2 in non-small cell lung cancer cells with EGFR-activating mutations
Q64120213Direct activation of PP2A for the treatment of tyrosine kinase inhibitor-resistant lung adenocarcinoma
Q36855852Direct interaction of avermectin with epidermal growth factor receptor mediates the penetration resistance in Drosophila larvae
Q42652187Direct resequencing of the complete ERBB2 coding sequence reveals an absence of activating mutations in ERBB2 amplified breast cancer
Q39478075Direct sequencing in cytological specimens as a useful strategy for detecting EGFR mutations in non-small cell lung cancer patients.
Q38202550Discoidin domain receptors: a proteomic portrait
Q36847104Discordance of Mutation Statuses of Epidermal Growth Factor Receptor and K-ras between Primary Adenocarcinoma of Lung and Brain Metastasis
Q50050248Discordance of epidermal growth factor receptor mutations between primary tumors and corresponding mediastinal nodal metastases in patients operated on for stage N2 non-small cell lung cancer.
Q38605171Discovering novel pharmacogenomic biomarkers by imputing drug response in cancer patients from large genomics studies.
Q34152841Discovering tumor suppressor genes through genome-wide copy number analysis
Q64075678Discovery Stories of RET Fusions in Lung Cancer: A Mini-Review
Q39781895Discovery and Biological Evaluation of Novel Dual EGFR/c-Met Inhibitors
Q30664020Discovery and Validation of Predictive Biomarkers of Survival for Non-small Cell Lung Cancer Patients Undergoing Radical Radiotherapy: Two Proteins With Predictive Value
Q33566948Discovery and characterization of a novel irreversible EGFR mutants selective and potent kinase inhibitor CHMFL-EGFR-26 with a distinct binding mode
Q93083358Discovery of JND3229 as a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy
Q38829629Discovery of a dual-targeting organometallic ruthenium complex with high activity inducing early stage apoptosis of cancer cells
Q38702793Discovery of a potent dual ALK and EGFR T790M inhibitor
Q34701319Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation
Q99584571Discrete dynamic network modeling of oncogenic signaling: Mechanistic insights for personalized treatment of cancer
Q37421181Disease diversity and FLT3 mutations
Q44331655Disease flare after EGFR tyrosine kinase inhibitor cessation predicts poor survival in patients with non-small cell lung cancer
Q96950911Disease-related cellular protein networks differentially affected under different EGFR mutations in lung adenocarcinoma
Q37078736Disruption of the EGFR E884-R958 ion pair conserved in the human kinome differentially alters signaling and inhibitor sensitivity
Q60933000Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer
Q36547770Dissecting cancer pathways and vulnerabilities with RNAi
Q27851628Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
Q37285302Distinct biological roles for the notch ligands Jagged-1 and Jagged-2.
Q28537922Distinct clinical outcomes of non-small cell lung cancer patients with epidermal growth factor receptor (EGFR) mutations treated with EGFR tyrosine kinase inhibitors: non-responders versus responders
Q36427883Distinct effects of β1 integrin on cell proliferation and cellular signaling in MDA-MB-231 breast cancer cells
Q42484909Distinctive activation patterns in constitutively active and gefitinib-sensitive EGFR mutants
Q46456054Distribution according to histologic type and outcome by gender and age group in Taiwanese patients with lung carcinoma.
Q37328516Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.
Q51214174Diversity of epidermal growth factor receptor-mediated activation of downstream molecules in human lung carcinomas.
Q37314999Divide and conquer: progress in the molecular stratification of cancer
Q53792939Do EGFR tyrosine kinase inhibitors (TKIs) still have a role in EGFR wild-type pre-treated advanced non-small cell lung cancer (NSCLC)?-the shifting paradigm of therapeutics.
Q55387219Docetaxel plus ramucirumab with primary prophylactic pegylated-granulocyte-colony stimulating factor for pretreated non-small cell lung cancer.
Q42145859Does lung cancer mutation status and targeted therapy predict for outcomes and local control in the setting of brain metastases treated with radiation?
Q39205689Does the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor differ according to the type of EGFR mutation in non-small cell lung cancer?
Q35200480Does the order of factors affect the product? Lessons learned from the TORCH trial
Q51576856Dose effect of cigarette smoking on frequency and spectrum of epidermal growth factor receptor gene mutations in Korean patients with non-small cell lung cancer.
Q37709570Dosing to rash: a phase II trial of the first-line erlotinib for patients with advanced non-small-cell lung cancer an Eastern Cooperative Oncology Group Study (E3503).
Q28237711Double-stranded DNA in exosomes: a novel biomarker in cancer detection
Q53556638Down Expression of FBP1 Is a Negative Prognostic Factor for Non-Small-Cell Lung Cancer.
Q53622918Down-regulation of ERK1/2 and AKT-mediated X-ray repair cross-complement group 1 protein (XRCC1) expression by Hsp90 inhibition enhances the gefitinib-induced cytotoxicity in human lung cancer cells.
Q24307767Downregulation and growth inhibitory role of FHL1 in lung cancer
Q39510460Downregulation of Mig-6 in nonsmall-cell lung cancer is associated with EGFR signaling
Q35227386Downregulation of ubiquitin inhibits the proliferation and radioresistance of non-small cell lung cancer cells in vitro and in vivo
Q39048792Dramatic antitumor effects of the dual MET/RON small-molecule inhibitor LY2801653 in non-small cell lung cancer
Q36498413Driven to metastasize: Kinases as potential therapeutic targets in prostate cancer
Q37815607Driver mutations and differential sensitivity to targeted therapies: a new approach to the treatment of lung adenocarcinoma
Q36179400Driver mutations determine survival in smokers and never-smokers with stage IIIB/IV lung adenocarcinomas
Q59080774Drivers and passengers
Q48263037Droplet digital PCR-based EGFR mutation detection with an internal quality control index to determine the quality of DNA.
Q37282274Drug Insight: cetuximab in the treatment of recurrent and metastatic squamous cell carcinoma of the head and neck
Q37174391Drug Insight: panitumumab, a human EGFR-targeted monoclonal antibody with promising clinical activity in colorectal cancer
Q37634419Drug Resistance Mechanisms in Non-Small Cell Lung Carcinoma
Q36834883Drug Resistance to EGFR Inhibitors in Lung Cancer
Q39390532Drug Sensitivity Assays of Human Cancer Organoid Cultures
Q35827606Drug development in oncology: classical cytotoxics and molecularly targeted agents
Q37970537Drug development to overcome resistance to EGFR inhibitors in lung and colorectal cancer
Q39493552Drug efficacy testing in mice
Q36893554Drug insight: advances in renal cell carcinoma and the role of targeted therapies
Q36040613Drug resistance and its significance for treatment decisions in non-small-cell lung cancer
Q37008882Drug resistance in cancer - searching for mechanisms, markers and therapeutic agents
Q94317317Drug resistance in lung cancer
Q28537830Drug resistance missense mutations in cancer are subject to evolutionary constraints
Q36801208Drug screening and grouping by sensitivity with a panel of primary cultured cancer spheroids derived from endometrial cancer
Q45327788Drug screening to target nuclear orphan receptor NR4A2 for cancer therapeutics
Q38664437Drug-diagnostic co-development: challenges and issues
Q36735178Drug-sensitive FGFR2 mutations in endometrial carcinoma
Q33564782Drug-sensitive FGFR3 mutations in lung adenocarcinoma
Q28079559Drugging the addict: non-oncogene addiction as a target for cancer therapy
Q28254233Drugging the cancer kinome: progress and challenges in developing personalized molecular cancer therapeutics
Q33860674Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells
Q36258125Dual HER2/PIK3CA Targeting Overcomes Single-Agent Acquired Resistance in HER2-Amplified Uterine Serous Carcinoma Cell Lines In Vitro and In Vivo
Q34122718Dual inhibition of EGFR and mTOR pathways in small cell lung cancer.
Q37520544Dual inhibition of ErbB1 and ErbB2 in cancer by recombinant human prolidase mutant hPEPD-G278D.
Q39091696Dual inhibition of MEK1/2 and EGFR synergistically induces caspase-3-dependent apoptosis in EGFR inhibitor-resistant lung cancer cells via BIM upregulation
Q37382669Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations
Q33759715Dual specificity phosphatase 6 (DUSP6) is an ETS-regulated negative feedback mediator of oncogenic ERK signaling in lung cancer cells
Q37363050Dual targeting of EGFR can overcome a major drug resistance mutation in mouse models of EGFR mutant lung cancer
Q36273532Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype
Q37126666DxS Ltd.
Q41694055Dynamic circulating tumor DNA quantificaton for the individualization of non-small-cell lung cancer patients treatment.
Q24294659Dynamic profiling of the post-translational modifications and interaction partners of epidermal growth factor receptor signaling after stimulation by epidermal growth factor using Extended Range Proteomic Analysis (ERPA)
Q42362771Dynamics of EGFR mutations in plasma recapitulates the clinical response to EGFR-TKIs in NSCLC patients
Q36670951Dynamics of biological systems: role of systems biology in medical research
Q36746250Dynamics of circulating tumor DNA represented by the activating and resistant mutations in epidermal growth factor receptor tyrosine kinase inhibitor treatment
Q55334265Dynamics of multiple resistance mechanisms in plasma DNA during EGFR-targeted therapies in non-small cell lung cancer.
Q44323391EFHD2 promotes epithelial-to-mesenchymal transition and correlates with postsurgical recurrence of stage I lung adenocarcinoma
Q37438426EGF Induced RET Inhibitor Resistance in CCDC6-RET Lung Cancer Cells
Q38951627EGF potentiation of VEGF production is cell density dependent in H292 EGFR wild type NSCLC cell line
Q24561953EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
Q37799824EGF receptor in lung cancer: a successful story of targeted therapy
Q38034817EGF receptor-targeted therapy in non-small-cell lung cancer: role of germline polymorphisms in outcome and toxicity
Q29619032EGF-ERBB signalling: towards the systems level
Q40235641EGF-independent activation of cell-surface EGF receptors harboring mutations found in gefitinib-sensitive lung cancer
Q37043503EGF-receptor targeting with monoclonal antibodies in colorectal carcinomas: rationale for a pharmacogenomic approach
Q57032248EGFR Amplification and Sensitizing Mutations Correlate with Survival in Lung Adenocarcinoma Patients Treated with Erlotinib (MutP-CLICaP)
Q36044399EGFR Exon 18 Mutations in East Asian Patients with Lung Adenocarcinomas: A Comprehensive Investigation of Prevalence, Clinicopathologic Characteristics and Prognosis
Q36971209EGFR Fusions as Novel Therapeutic Targets in Lung Cancer
Q37240726EGFR Inhibition in the Treatment of Non-Small Cell Lung Cancer
Q36244968EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib
Q30397503EGFR L858M/L861Q cis Mutations Confer Selective Sensitivity to Afatinib
Q35606916EGFR Mutant Structural Database: computationally predicted 3D structures and the corresponding binding free energies with gefitinib and erlotinib.
Q49959764EGFR Mutation Status in Lung Adenocarcinoma-Associated Malignant Pleural Effusion and Efficacy of EGFR Tyrosine Kinase Inhibitors.
Q93183634EGFR Mutation Testing: Changing Patterns of Molecular Testing in Brazil
Q36687288EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors
Q33859707EGFR Mutations in Latinos From the United States and Latin America.
Q91637156EGFR Polymorphism and Survival of NSCLC Patients Treated with TKIs: A Systematic Review and Meta-Analysis
Q46411995EGFR R497K polymorphism is a favorable prognostic factor for advanced lung cancer
Q34627605EGFR Signaling in Colorectal Carcinoma
Q35040888EGFR T790M mutation as a possible target for immunotherapy; identification of HLA-A*0201-restricted T cell epitopes derived from the EGFR T790M mutation
Q47836622EGFR T790M mutation testing of non-small cell lung cancer tissue and blood samples artificially spiked with circulating cell-free tumor DNA: results of a round robin trial.
Q42701535EGFR T790M: revealing the secrets of a gatekeeper
Q45886897EGFR TKI as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer
Q39167752EGFR TKI combination with immunotherapy in non-small cell lung cancer
Q99728118EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer
Q36048238EGFR and HER2 genomic gain in recurrent non-small cell lung cancer after surgery: impact on outcome to treatment with gefitinib and association with EGFR and KRAS mutations in a Japanese cohort
Q36733618EGFR and HER2 signaling in breast cancer brain metastasis
Q54495025EGFR and HER2-Akt-mTOR signaling pathways are activated in subgroups of salivary gland carcinomas.
Q41829016EGFR and K-RAS mutations and ERCC1, TUBB3, TYMS, RRM1 and EGFR mRNA expression in non-small cell lung cancer: Correlation with clinical response to gefitinib or chemotherapy
Q34346624EGFR and K-Ras mutations in women with lung adenocarcinoma: implications for treatment strategy definition
Q36419182EGFR and K-ras gene mutation status in squamous cell anal carcinoma: a role for concurrent radiation and EGFR inhibitors?
Q37790671EGFR and KRAS in colorectal cancer
Q34096414EGFR and KRAS mutation analysis in cytologic samples of lung adenocarcinoma enabled by laser capture microdissection.
Q47780922EGFR and KRAS mutations do not enrich for the activation of IL-6, JAK1 or phosphorylated STAT3 in resected lung adenocarcinoma.
Q38391135EGFR and KRAS mutations in Turkish non-small cell lung cancer patients: a pilot study
Q53238557EGFR and KRAS mutations in lung carcinoma: molecular testing by using cytology specimens.
Q37205334EGFR and KRAS mutations in patients with adenocarcinoma of the lung
Q38160089EGFR and KRAS mutations, and ALK fusions: current developments and personalized therapies for patients with advanced non-small-cell lung cancer.
Q80647736EGFR and gastrointestinal stromal tumor: an immunohistochemical and FISH study of 82 cases
Q46039810EGFR dinucleotide repeat polymorphism as a prognostic indicator in non-small cell lung cancer.
Q33576802EGFR endocytosis is a novel therapeutic target in lung cancer with wild-type EGFR.
Q37021792EGFR exon 20 insertion mutations in lung adenocarcinomas: prevalence, molecular heterogeneity, and clinicopathologic characteristics.
Q33963199EGFR exon 20 insertion mutations in non-small-cell lung cancer: preclinical data and clinical implications
Q62127975EGFR exon mutation distribution and outcome in non-small-cell lung cancer: a Portuguese retrospective study
Q33372792EGFR expression in gallbladder carcinoma in North America
Q46513909EGFR gene amplification in breast cancer: correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations
Q27851658EGFR gene amplification is related to adverse clinical outcomes in cervical squamous cell carcinoma, making the EGFR pathway a novel therapeutic target
Q53249127EGFR gene copy number gain is related to high tumor SUV and frequent relapse after adjuvant chemotherapy in resected lung adenocarcinoma.
Q40378678EGFR gene copy number heterogeneity in fine-needle aspiration cytology from breast carcinomas determined by chromogenic in situ hybridization
Q38796569EGFR gene mutation in gastrointestinal stromal tumours.
Q44690866EGFR gene mutations in patients with adenosquamous lung carcinoma.
Q48014727EGFR heterogeneity and implications for therapeutic intervention in glioblastoma
Q37180302EGFR inhibition in non-small cell lung cancer: current evidence and future directions
Q24794815EGFR inhibition in non-small cell lung cancer: resistance, once again, rears its ugly head
Q38257898EGFR inhibitors and autophagy in cancer treatment
Q38120309EGFR inhibitors as the first-line systemic treatment for advanced non-small-cell lung cancer.
Q43849261EGFR inhibitors for wild-type EGFR NSCLC: to use or not to use?
Q37767383EGFR inhibitors in non-small cell lung cancer (NSCLC): the emerging role of the dual irreversible EGFR/HER2 inhibitor BIBW 2992.
Q36306259EGFR inhibitors: what have we learned from the treatment of lung cancer?
Q34008570EGFR isoforms and gene regulation in human endometrial cancer cells
Q36772144EGFR kinase domain mutation positive lung cancers are sensitive to intrapleural perfusion with hyperthermic chemotherapy (IPHC) complete treatment.
Q36758325EGFR kinase domain mutations - functional impact and relevance for lung cancer therapy
Q37709182EGFR kinase inhibitors and gastric acid suppressants in EGFR-mutant NSCLC: a retrospective database analysis of potential drug interaction.
Q38554153EGFR kinase-dependent and kinase-independent roles in clear cell renal cell carcinoma
Q37191983EGFR lung cancer mutants get specialized
Q46717312EGFR mRNA is upregulated, but somatic mutations of the gene are hardly found in renal cell carcinoma in Japanese patients.
Q41065727EGFR modulates monounsaturated fatty acid synthesis through phosphorylation of SCD1 in lung cancer
Q53538486EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy.
Q46055656EGFR mutation analysis in non-small-cell lung cancer : Experience from routine diagnostics
Q46853023EGFR mutation in gefitinib-responsive small-cell lung cancer
Q46484941EGFR mutation in kidney carcinoma confers sensitivity to gefitinib treatment: a case report.
Q35164306EGFR mutation is a better predictor of response to tyrosine kinase inhibitors in non-small cell lung carcinoma than FISH, CISH, and immunohistochemistry
Q80100696EGFR mutation of tumor and serum in gefitinib-treated patients with chemotherapy-naive non-small cell lung cancer
Q34992513EGFR mutation status and survival after diagnosis of brain metastasis in nonsmall cell lung cancer
Q58793364EGFR mutation status in Tunisian non-small-cell lung cancer patients evaluated by mutation-specific immunohistochemistry
Q38053963EGFR mutation status in brain metastases of non-small cell lung carcinoma.
Q36611944EGFR mutation status in tumour-derived DNA from pleural effusion fluid is a practical basis for predicting the response to gefitinib
Q64109081EGFR mutation subtypes and response to immune checkpoint blockade treatment in non-small cell lung cancer
Q38061599EGFR mutation testing in lung cancer: a review of available methods and their use for analysis of tumour tissue and cytology samples
Q45243918EGFR mutation testing practice in advanced non-small cell lung cancer
Q38379393EGFR mutation testing using archival-stained smears in non-small cell lung carcinoma.
Q36135844EGFR mutation: Significance as a stratification factor in the era of molecular-targeted therapy
Q30664830EGFR mutational status in a large series of Caucasian European NSCLC patients: data from daily practice
Q46236872EGFR mutations and HER2/3 protein expression and clinical outcome in Chinese advanced non-small cell lung cancer patients treated with gefitinib
Q98938383EGFR mutations and ROS1 and ALK rearrangements in a large series of non-small cell cancer in South India
Q83093506EGFR mutations and molecularly targeted therapy: a new era in the treatment of lung cancer
Q37434212EGFR mutations are detected comparably in cytologic and surgical pathology specimens of nonsmall cell lung cancer
Q46263820EGFR mutations are more frequent in well-differentiated than in poor-differentiated lung adenocarcinomas
Q26852507EGFR mutations as a prognostic and predictive marker in non-small-cell lung cancer
Q43238274EGFR mutations cause a lethal syndrome of epithelial dysfunction with progeroid features
Q34688967EGFR mutations in Indian lung cancer patients: clinical correlation and outcome to EGFR targeted therapy
Q54112709EGFR mutations in early-stage and advanced-stage lung adenocarcinoma: Analysis based on large-scale data from China.
Q36579633EGFR mutations in lung adenocarcinomas: clinical testing experience and relationship to EGFR gene copy number and immunohistochemical expression
Q38515822EGFR mutations in lung cancer: from tissue testing to liquid biopsy
Q35800614EGFR mutations in patients with brain metastases from lung cancer: association with the efficacy of gefitinib.
Q37566609EGFR mutations in patients with lung adenocarcinoma in southwest China: are G719S/A and L861Q more likely detected in tumors derived from smokers?
Q34167004EGFR mutations in patients with non-small cell lung cancer from mainland China and their relationships with clinicopathological features: a meta-analysis
Q37421036EGFR mutations in surgically resected fresh specimens from 697 consecutive Chinese patients with non-small cell lung cancer and their relationships with clinical features.
Q54117532EGFR mutations subset in Chinese lung squamous cell carcinoma patients.
Q55502873EGFR overexpression is not common in patients with head and neck cancer. Cell lines are not representative for the clinical situation in this indication.
Q51794333EGFR point mutation in non-small cell lung cancer is occasionally accompanied by a second mutation or amplification.
Q36348040EGFR polymorphism as a predictor of clinical outcome in advanced lung cancer patients treated with EGFR-TKI.
Q46653404EGFR polymorphisms, hormone replacement therapy and lung adenocarcinoma risk: analysis from a genome-wide association study in never-smoking women
Q51744466EGFR protein overexpression and gene copy number increases in oral tongue squamous cell carcinoma.
Q46054209EGFR protein overexpression and mutation in areca quid-associated oral cavity squamous cell carcinoma in Taiwan
Q38171032EGFR signaling and autophagy dependence for growth, survival, and therapy resistance
Q46677125EGFR somatic doublets in lung cancer are frequent and generally arise from a pair of driver mutations uncommonly seen as singlet mutations: one-third of doublets occur at five pairs of amino acids
Q38552978EGFR targeted therapies and radiation: Optimizing efficacy by appropriate drug scheduling and patient selection
Q24652337EGFR targeted therapy in non-small cell lung cancer: potential role of cetuximab
Q34618994EGFR targeting drugs in the treatment of head and neck squamous cell carcinoma
Q36557678EGFR testing and clinical management of advanced NSCLC: a Galician Lung Cancer Group study (GGCP 048-10)
Q28243483EGFR testing in lung cancer is ready for prime time
Q37177600EGFR tyrosine kinase inhibitors for the treatment of NSCLC in East Asia: present and future
Q46837947EGFR tyrosine kinase inhibitors in non-small cell lung cancer: report of a 3-year compassionate use experience with gefitinib in stage IIIB/IV outpatients
Q37393940EGFR tyrosine kinase inhibitors versus chemotherapy as first-line therapy for non-small cell lung cancer patients with the L858R point mutation
Q38089244EGFR tyrosine kinase inhibitors: a therapy for a few, for the majority or for all non-small cell lung cancer patients?
Q38106905EGFR tyrosine kinase inhibitors: difference in efficacy and resistance
Q39362508EGFR tyrosine kinase mutation testing in the treatment of non-small-cell lung cancer
Q39538057EGFR upregulates inflammatory and proliferative responses in human lung adenocarcinoma cell line (A549), induced by lower dose of cadmium chloride
Q42731684EGFR with TKI-sensitive mutations in exon 19 is highly expressed and frequently detected in Chinese patients with lung squamous carcinoma
Q37561771EGFR(S) inhibitors in the treatment of gastro-intestinal cancers: what's new?
Q36741251EGFR, ALK, RET, KRAS and BRAF alterations in never-smokers with non-small cell lung cancer
Q35893808EGFR, CD10 and proliferation marker Ki67 expression in ameloblastoma: possible role in local recurrence
Q36947038EGFR, HER2 and VEGF pathways: validated targets for cancer treatment
Q33727426EGFR, PIK3CA, KRAS and BRAF mutations in meningiomas
Q38807586EGFR-GRB2 Protein Colocalization Is a Prognostic Factor Unrelated to Overall EGFR Expression or EGFR Mutation in Lung Adenocarcinoma
Q90224747EGFR-Specific Tyrosine Kinase Inhibitor Modifies NK Cell-Mediated Antitumoral Activity against Ovarian Cancer Cells
Q36285611EGFR-T790M is a rare lung cancer susceptibility allele with enhanced kinase activity
Q40562646EGFR-TKI rechallenge with bevacizumab in EGFR-mutant non-small cell lung cancer
Q53698558EGFR-TKI resistance and MAP17 are associated with cancer stem cell like properties.
Q30871237EGFR-TKI therapy for patients with brain metastases from non-small-cell lung cancer: a pooled analysis of published data
Q57485837EGFR-TKI-sensitive mutations in lung carcinomas: are they related to clinical features and CT findings?
Q37538757EGFR-directed therapies to treat non-small-cell lung cancer
Q24335999EGFR-mediated Beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance
Q60449321EGFR-mutant lung adenocarcinoma in a patient with Li-Fraumeni syndrome
Q24606177EGFR-mutant lung adenocarcinomas treated first-line with the novel EGFR inhibitor, XL647, can subsequently retain moderate sensitivity to erlotinib
Q34406334EGFR-mutated lung cancer: a paradigm of molecular oncology
Q37160173EGFR-targeted therapies in lung cancer: predictors of response and toxicity
Q36619212EGFR-targeted therapy for non-small cell lung cancer: focus on EGFR oncogenic mutation
Q37682778EGFR-targeted therapy results in dramatic early lung tumor regression accompanied by imaging response and immune infiltration in EGFR mutant transgenic mouse models
Q36826056EGFR-tyrosine kinase inhibitor treatment in a patient with advanced non-small cell lung cancer and concurrent exon 19 and 21 EGFR mutations: A case report and review of the literature
Q37206247EGFR/HER2 in breast cancer: a biological approach for molecular diagnosis and therapy
Q46640557EGFR/KRAS mutations and gefitinib therapy in Chinese NSCLC patients
Q35619241EGFR: The Paradigm of an Oncogene-Driven Lung Cancer
Q80100754EGFR: a prognostic and/or a predictive marker?
Q35078031EGFRvIII mediates hepatocellular carcinoma cell invasion by promoting S100 calcium binding protein A11 expression
Q55457200EGFRvIII-Stat5 Signaling Enhances Glioblastoma Cell Migration and Survival.
Q34356008EGFs and ERBBs--brief history and prospects
Q35730962EML4-ALK fusion gene in Korean non-small cell lung cancer
Q46113744EML4-ALK lung cancers are characterized by rare other mutations, a TTF-1 cell lineage, an acinar histology, and young onset.
Q24645724EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues
Q36335816EML4-ALK translocation is associated with early onset of disease and other clinicopathological features in Chinese female never-smokers with non-small-cell lung cancer
Q54727452EML4-ALK: honing in on a new target in non-small-cell lung cancer.
Q39220097EMP-1 promotes tumorigenesis of NSCLC through PI3K/AKT pathway
Q37589341EORTC Elderly Task Force and Lung Cancer Group and International Society for Geriatric Oncology (SIOG) experts' opinion for the treatment of non-small-cell lung cancer in an elderly population.
Q38805633EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer
Q35532215EPMA position paper in cancer: current overview and future perspectives
Q36355962ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma
Q29619520ERBB receptors and cancer: the complexity of targeted inhibitors
Q33601653ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics
Q90101145ERBB3 mutations in cancer: biological aspects, prevalence and therapeutics
Q38919117ERBB3-independent activation of the PI3K pathway in EGFR-mutant lung adenocarcinomas
Q37337542ERBBs in the gastrointestinal tract: recent progress and new perspectives
Q85303113ERCC1 and the efficacy of cisplatin in patients with resected non-small cell lung cancer
Q99419149EREG-driven oncogenesis of Head and Neck Squamous Cell Carcinoma exhibits higher sensitivity to Erlotinib therapy
Q52649612ERK inhibition represses gefitinib resistance in non-small cell lung cancer cells.
Q37661108ERK1/2 blockade prevents epithelial-mesenchymal transition in lung cancer cells and promotes their sensitivity to EGFR inhibition
Q28741454EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas
Q33392707Early detection of erlotinib treatment response in NSCLC by 3'-deoxy-3'-[F]-fluoro-L-thymidine ([F]FLT) positron emission tomography (PET).
Q33947163Early growth response-1 induces and enhances vascular endothelial growth factor-A expression in lung cancer cells
Q54113607Early radiological response as predictor of overall survival in non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor mutations.
Q35571704Eastern Cooperative Oncology Group Phase II Trial of lapatinib in men with biochemically relapsed, androgen dependent prostate cancer
Q36439557Echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase rearrangement and epidermal growth factor receptor mutation coexisting in Chinese patients with lung adenocarcinoma
Q26747510Ectopic Expression of Testis Germ Cell Proteins in Cancer and Its Potential Role in Genomic Instability
Q58545847Effect Sizes of Somatic Mutations in Cancer
Q64109900Effect of Cetuximab and Small Interfering RNA Combination Treatment in NSCLC Cell Lines with Wild Type and Use of as a Possible Biomarker for Treatment Responsiveness
Q64072904Effect of EGFR gene polymorphism on efficacy of chemotherapy combined with targeted therapy for non-small cell lung cancer in Chinese patients
Q79782947Effect of ERCC1 polymorphisms and the modification by smoking on the survival of non-small cell lung cancer patients
Q53519220Effect of Sustained Elevated Gastric pH Levels on Gefitinib Exposure.
Q40337329Effect of adding gefitinib to neoadjuvant chemotherapy in estrogen receptor negative early breast cancer in a randomized phase II trial
Q36524729Effect of hydrothorax EGFR gene mutation and EGFR-TKI targeted therapy on advanced non-small cell lung cancer patients
Q37090804Effect of lapatinib on the development of estrogen receptor-negative mammary tumors in mice
Q92298178Effect of miR-140-5p on the regulation of proliferation and apoptosis in NSCLC and its underlying mechanism
Q35221485Effect of phosphorylation on EGFR dimer stability probed by single-molecule dynamics and FRET/FLIM.
Q35699603Effect of sialylation on EGFR phosphorylation and resistance to tyrosine kinase inhibition
Q38634910Effect of smoking status on progression-free and overall survival in non-small cell lung cancer patients receiving erlotinib or gefitinib: a meta-analysis
Q54973430Effective osimertinib treatment in a patient with discordant T790 M mutation detection between liquid biopsy and tissue biopsy.
Q54979668Effectiveness of afatinib after ineffectiveness of gefitinib in an advanced lung adenocarcinoma patient with a single EGFR exon 20 S768I mutation: a case report.
Q34041701Effectiveness of gefitinib against non-small-cell lung cancer with the uncommon EGFR mutations G719X and L861Q.
Q38956327Effectiveness of maintenance treatments for nonsmall cell lung cancer
Q36036046Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell lung cancer cell lines
Q37389605Effects of epidermal growth factor receptor-tyrosine kinase inhibitors alone on EGFR-mutant non-small cell lung cancer with brain metastasis
Q37000538Effects of erlotinib in EGFR mutated non-small cell lung cancers with resistance to gefitinib
Q54356532Effects of icotinib on advanced non-small cell lung cancer with different EGFR phenotypes.
Q36733598Effects of icotinib on early-stage non-small-cell lung cancer as neoadjuvant treatment with different epidermal growth factor receptor phenotypes
Q36967631Effects of oncogenic mutations on the conformational free-energy landscape of EGFR kinase
Q89092109Efficacy and Safety of Afatinib for EGFR-mutant Non-small Cell Lung Cancer, Compared with Gefitinib or Erlotinib
Q36631504Efficacy and safety of icotinib as first-line therapy in patients with advanced non-small-cell lung cancer
Q36924484Efficacy and safety of icotinib in patients with brain metastases from lung adenocarcinoma
Q54210501Efficacy of EGFR tyrosine kinase inhibitors for non-adenocarcinoma lung cancer patients harboring EGFR-sensitizing mutations in China.
Q54347207Efficacy of S-1 plus nedaplatin compared to standard second-line chemotherapy in EGFR-negative lung adenocarcinoma after failure of first-line chemotherapy.
Q34050239Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): a double-blind, placebo-controlled, phase 3 trial
Q36247866Efficacy of bronchoscopic biopsy for the detection of epidermal growth factor receptor mutations and anaplastic lymphoma kinase gene rearrangement in lung adenocarcinoma
Q46008308Efficacy of depatuxizumab mafodotin (ABT-414) monotherapy in patients with EGFR-amplified, recurrent glioblastoma: results from a multi-center, international study.
Q36616462Efficacy of epidermal growth factor receptor-targeted molecular therapy in anaplastic thyroid cancer cell lines
Q41099007Efficacy of erlotinib in previously treated patients with advanced non-small cell lung cancer: analysis of the Chinese subpopulation in the TRUST study
Q52893820Efficacy of icotinib in lung squamous-cell cancer: A real-world experience from single institution.
Q35233470Efficacy of increased-dose erlotinib for central nervous system metastases in non-small cell lung cancer patients with epidermal growth factor receptor mutation
Q36351290Efficacy of irreversible EGFR-TKIs for the uncommon secondary resistant EGFR mutations L747S, D761Y, and T854A.
Q33485003Efficacy of sorafenib on metastatic renal cell carcinoma in Asian patients: results from a multicenter study
Q34785940Efficacy of third-line pemetrexed monotherapy versus pemetrexed combination with bevacizumab in patients with advanced EGFR mutation-positive lung adenocarcinoma
Q51296848Efficacy, safety, and survival factors for sorafenib treatment in Japanese patients with advanced hepatocellular carcinoma.
Q36438421Elderly male smokers with right lung tumors are viable candidates for KRAS mutation screening
Q36116287Electrical detection of cancer biomarker using aptamers with nanogap break-junctions
Q92134578Elemental and mutational analysis of lung tissue in lung adenocarcinoma patients
Q35064133Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells
Q39971699Elevated CRAF as a potential mechanism of acquired resistance to BRAF inhibition in melanoma
Q39828170Elevated integrin α6β4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancer.
Q37099888Elevated neutrophil gelatinase-associated lipocalin contributes to erlotinib resistance in non-small cell lung cancer
Q39473591Elevated progesterone receptor membrane component 1/sigma-2 receptor levels in lung tumors and plasma from lung cancer patients
Q43261058Elevated serum levels of TPS and CYFRA 21-1 predict poor prognosis in advanced non-small-cell lung cancer patients treated with gefitinib
Q35948915Elevated β-catenin pathway as a novel target for patients with resistance to EGF receptor targeting drugs
Q79886528Elevation of soluble interleukin-2 receptor in patients with non-small cell lung cancer treated with gefitinib
Q37691441Emerging MEK inhibitors.
Q37588717Emerging Raf inhibitors.
Q98944239Emerging Therapies in Thoracic Malignancies-Immunotherapy, Targeted Therapy, and T-Cell Therapy in Non-Small Cell Lung Cancer
Q38623361Emerging anti-cancer antibodies and combination therapies targeting HER3/ERBB3.
Q36758593Emerging drugs for mesothelioma
Q36944022Emerging drugs for targeted therapy of bladder cancer.
Q35914897Emerging insights into the molecular and cellular basis of glioblastoma
Q37848663Emerging molecular biomarkers--blood-based strategies to detect and monitor cancer
Q36084718Emerging molecular classification in renal cell carcinoma: implications for drug development
Q38642455Emerging molecular targets and therapy for cholangiocarcinoma
Q37269316Emerging options for the management of non-small cell lung cancer
Q37249366Emerging paradigms in the development of resistance to tyrosine kinase inhibitors in lung cancer
Q45216006Emerging role of erlotinib (OSI-774) in non-small-cell lung cancer.
Q33892582Emerging role of gefitinib in the treatment of non-small-cell lung cancer (NSCLC).
Q28078928Emerging roles of Nrf2 signal in non-small cell lung cancer
Q35988130Emerging strategies and applications of pharmacogenomics
Q35008971Emerging tactical strategies for fighting the war on cancer based on the genetic landscape
Q28070165Emerging therapeutic agents for lung cancer
Q37030800Emerging therapies for malignant glioma
Q64089193Emerging therapies for non-small cell lung cancer
Q34483953Emerging treatment for advanced lung cancer with EGFR mutation
Q36228352Emerging treatment options for patients with recurrent advanced thymic epithelial tumors
Q36519807Emerging treatments for choroidal metastases
Q46071509Emerging uses of biomarkers in lung cancer management: molecular mechanisms of resistance
Q39841334Emodin enhances gefitinib-induced cytotoxicity via Rad51 downregulation and ERK1/2 inactivation
Q42869980Endocytosis and cancer
Q37549617Endocytosis and signalling: a meeting with mathematics
Q38892107Endothelial PAS domain-containing protein 1 confers TKI-resistance by mediating EGFR and MET pathways in non-small cell lung cancer cells
Q37129376Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR
Q46424042Endothelin causes transactivation of the EGFR and HER2 in non-small cell lung cancer cells
Q35051626Enhanced anti-angiogenic effect of E7820 in combination with erlotinib in epidermal growth factor receptor-tyrosine kinase inhibitor-resistant non-small-cell lung cancer xenograft models
Q39124519Enhanced antitumor activity of erlotinib in combination with the Hsp90 inhibitor CH5164840 against non-small-cell lung cancer
Q27305848Enhanced dimerization drives ligand-independent activity of mutant epidermal growth factor receptor in lung cancer
Q36484536Enhancement of the antitumor activity of ionising radiation by nimotuzumab, a humanised monoclonal antibody to the epidermal growth factor receptor, in non-small cell lung cancer cell lines of differing epidermal growth factor receptor status
Q33648864Epidemiological features of lung giant cell carcinoma and therapy for patients with EGFR mutations based on case reports and the surveillance, epidemiology, and end results (SEER) database
Q39363203Epidemiological profile and prognostic factors in patients with lung cancer
Q36337982Epidemiology informing clinical practice: from bills of mortality to population laboratories
Q90150760Epidermal Growth Factor Receptor (EGFR) Gene Mutation Analysis in Adenocarcinoma of Lung, the First Report from Iran
Q47261688Epidermal Growth Factor Receptor (EGFR) Kinase Inhibitors and Non-Small Cell Lung Cancer (NSCLC) - Advances in Molecular Diagnostic Techniques to Facilitate Targeted Therapy.
Q36322658Epidermal Growth Factor Receptor (EGFR) Pathway Biomarkers in the Randomized Phase III Trial of Erlotinib Versus Observation in Ovarian Cancer Patients with No Evidence of Disease Progression after First-Line Platinum-Based Chemotherapy
Q92454757Epidermal Growth Factor Receptor (EGFR) Pathway, Yes-Associated Protein (YAP) and the Regulation of Programmed Death-Ligand 1 (PD-L1) in Non-Small Cell Lung Cancer (NSCLC)
Q33803406Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer
Q33737298Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways
Q47614764Epidermal Growth Factor Receptor Expression Predicts Time and Patterns of Recurrence in Patients with Glioblastoma After Radiotherapy and Temozolomide
Q58567008Epidermal Growth Factor Receptor Gene in Non-Small-Cell Lung Cancer: The Importance of Promoter Polymorphism Investigation
Q36040002Epidermal Growth Factor Receptor Mutation (EGFR) Testing for Prediction of Response to EGFR-Targeting Tyrosine Kinase Inhibitor (TKI) Drugs in Patients with Advanced Non-Small-Cell Lung Cancer: An Evidence-Based Analysis
Q38460428Epidermal Growth Factor Receptor Mutation Status in the Treatment of Non-small Cell Lung Cancer: Lessons Learned
Q80393070Epidermal growth factor (EGF) activates nuclear factor-kappaB through IkappaBalpha kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IkappaBalpha
Q36239648Epidermal growth factor inhibition in solid tumours
Q57692990Epidermal growth factor ligand/receptor loop and downstream signaling activation pattern in completely resected nonsmall cell lung cancer
Q40212739Epidermal growth factor receptor (EGFR) antibody down-regulates mutant receptors and inhibits tumors expressing EGFR mutations
Q33302191Epidermal growth factor receptor (EGFR) gene copy number detection in non-small-cell lung cancer; a comparison of fluorescence in situ hybridization and chromogenic in situ hybridization.
Q36485352Epidermal growth factor receptor (EGFR) high gene copy number and activating mutations in lung adenocarcinomas are not consistently accompanied by positivity for EGFR protein by standard immunohistochemistry.
Q35667627Epidermal growth factor receptor (EGFR) in lung cancer: an overview and update
Q36458742Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy
Q39828582Epidermal growth factor receptor (EGFR) mutation and p-EGFR expression in resected non-small cell lung cancer
Q28284519Epidermal growth factor receptor (EGFR) mutation and personalized therapy in advanced nonsmall cell lung cancer (NSCLC)
Q34781380Epidermal growth factor receptor (EGFR) mutations are exceptionally rare in thyroid transcription factor (TTF-1)-negative adenocarcinomas of the lung.
Q54361563Epidermal growth factor receptor (EGFR) mutations as biomarker for head and neck squamous cell carcinomas (HNSCC).
Q82500381Epidermal growth factor receptor (EGFR) mutations in a series of non-small-cell lung cancer (NSCLC) patients and response rate to EGFR-specific tyrosine kinase inhibitors (TKIs)
Q30850656Epidermal growth factor receptor (EGFR) mutations in lung cancer: preclinical and clinical data.
Q39254692Epidermal growth factor receptor (EGFR): A rising star in the era of precision medicine of lung cancer.
Q44740671Epidermal growth factor receptor R521K polymorphism shows favorable outcomes in KRAS wild-type colorectal cancer patients treated with cetuximab-based chemotherapy
Q47116265Epidermal growth factor receptor T790M mutation as a prognostic factor in EGFR-mutant non-small cell lung cancer patients that acquired resistance to EGFR tyrosine kinase inhibitors
Q36014004Epidermal growth factor receptor abnormalities in the pathogenesis and progression of lung adenocarcinomas
Q27865182Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain
Q42818168Epidermal growth factor receptor activation in prostate cancer by three novel missense mutations
Q33575439Epidermal growth factor receptor and K-RAS status in two cohorts of squamous cell carcinomas
Q35549063Epidermal growth factor receptor and K-Ras in non-small cell lung cancer-molecular pathways involved and targeted therapies
Q36907221Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors
Q35956330Epidermal growth factor receptor and KRAS mutations in Brazilian lung cancer patients
Q54494664Epidermal growth factor receptor and Kras gene expression: reliability of mutational analysis on cytological samples.
Q38995524Epidermal growth factor receptor and anaplastic lymphoma kinase testing and mutation prevalence in patients with advanced non-small cell lung cancer in Switzerland: A comprehensive evaluation of real world practices
Q37790320Epidermal growth factor receptor and mammalian target of rapamycin as therapeutic targets in malignant glioma: current clinical status and perspectives
Q28080187Epidermal growth factor receptor and notch signaling in non-small-cell lung cancer
Q36653667Epidermal growth factor receptor as a major anticancer drug target
Q34195184Epidermal growth factor receptor copy number in potentially malignant oral disorders and oral squamous cell carcinoma: a short communication and preliminary study.
Q46679323Epidermal growth factor receptor domain II, IV, and kinase domain mutations in human solid tumors
Q40448827Epidermal growth factor receptor double targeting by a tyrosine kinase inhibitor (Iressa) and a monoclonal antibody (Cetuximab). Impact on cell growth and molecular factors.
Q36728450Epidermal growth factor receptor exon 20 insertions in advanced lung adenocarcinomas: Clinical outcomes and response to erlotinib
Q36503084Epidermal growth factor receptor exon 20 p.S768I mutation in non-small cell lung carcinoma: A case report combined with a review of the literature and investigation of clinical significance
Q46371923Epidermal growth factor receptor expression analysis in chemotherapy-naive patients with advanced non-small-cell lung cancer treated with gefitinib or placebo in combination with platinum-based chemotherapy
Q40332214Epidermal growth factor receptor expression and activation in neuroendocrine tumours
Q34411696Epidermal growth factor receptor expression and gene amplification in colorectal carcinoma: an immunohistochemical and chromogenic in situ hybridization study
Q42052616Epidermal growth factor receptor expression and gene copy number analysis in gastric carcinoma samples from Chinese patients
Q39335663Epidermal growth factor receptor expression in acute myelogenous leukaemia is associated with clinical prognosis
Q33691211Epidermal growth factor receptor expression in breast cancer association with biologic phenotype and clinical outcomes
Q81414066Epidermal growth factor receptor expression in renal cell carcinoma: rationale for therapy with sidling blockade
Q92134583Epidermal growth factor receptor first generation tyrosine-kinase inhibitors
Q44485092Epidermal growth factor receptor gene amplification and gefitinib sensitivity in patients with recurrent lung cancer
Q33942092Epidermal growth factor receptor gene amplification in atypical adenomatous hyperplasia of the lung.
Q34557318Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer
Q40756893Epidermal growth factor receptor gene mutation as risk factor for recurrence in patients with surgically resected lung adenocarcinoma: a matched-pair analysis
Q54538613Epidermal growth factor receptor gene mutation, amplification and protein expression in malignant pleural mesothelioma.
Q80584656Epidermal growth factor receptor gene mutations in atypical adenomatous hyperplasias of the lung
Q57075013Epidermal growth factor receptor gene mutations in non-small-cell lung cancer cells are associated with increased radiosensitivity in vitro
Q44051250Epidermal growth factor receptor gene mutations in papillary thyroid carcinoma
Q35164907Epidermal growth factor receptor gene mutations in patients with lung adenocarcinoma differ by frequency and type between Uighur and Han ethnic groups in Xinjiang Autonomous Region
Q37476827Epidermal growth factor receptor genomic variation in NSCLC patients receiving tyrosine kinase inhibitor therapy: a systematic review and meta-analysis
Q28084216Epidermal growth factor receptor immunohistochemistry: new opportunities in metastatic colorectal cancer
Q54416267Epidermal growth factor receptor in adrenocortical tumors: analysis of gene sequence, protein expression and correlation with clinical outcome.
Q35642677Epidermal growth factor receptor in breast carcinoma: association between gene copy number and mutations.
Q34105339Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance
Q28088636Epidermal growth factor receptor in non-small cell lung cancer
Q37132640Epidermal growth factor receptor in pancreatic cancer.
Q37634598Epidermal growth factor receptor in relation to tumor development: EGFR gene and cancer
Q35013457Epidermal growth factor receptor in relation to tumor development: EGFR-targeted anticancer therapy
Q36504349Epidermal growth factor receptor inhibition and non-small cell lung cancer
Q36071392Epidermal growth factor receptor inhibition in lung cancer: the evolving role of individualized therapy
Q28475894Epidermal growth factor receptor inhibition modulates the microenvironment by vascular normalization to improve chemotherapy and radiotherapy efficacy
Q36482542Epidermal growth factor receptor inhibitors and antiangiogenic agents for the treatment of non-small cell lung cancer
Q36157284Epidermal growth factor receptor inhibitors and their role in non-small-cell lung cancer
Q36429442Epidermal growth factor receptor inhibitors in cancer treatment.
Q34382797Epidermal growth factor receptor inhibitors in colorectal cancer treatment: what's new?
Q36830108Epidermal growth factor receptor inhibitors in non-small cell lung cancer
Q38088756Epidermal growth factor receptor inhibitors in non-small-cell lung cancer
Q36302860Epidermal growth factor receptor inhibitors in the treatment of non-small cell lung cancer
Q35222011Epidermal growth factor receptor is a critical mediator of ultraviolet B irradiation-induced signal transduction in immortalized human keratinocyte HaCaT cells
Q43555541Epidermal growth factor receptor is associated with the onset of skeletal related events in non-small cell lung cancer
Q37123445Epidermal growth factor receptor kinase domain mutations are rare in salivary gland carcinomas
Q37252270Epidermal growth factor receptor kinase domain mutations in esophageal and pancreatic adenocarcinomas
Q35812818Epidermal growth factor receptor mutation analysis in cytological specimens and responsiveness to gefitinib in advanced non-small cell lung cancer patients
Q37719929Epidermal growth factor receptor mutation and diverse tumors: case report and concise literature review
Q37265114Epidermal growth factor receptor mutation in adenocarcinoma lung in a North Indian population: Prevalence and relation with different clinical variables
Q33824203Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity
Q37102688Epidermal growth factor receptor mutation in lung adenocarcinoma in India: A single center study
Q34676580Epidermal growth factor receptor mutation status and clinicopathological features of combined small cell carcinoma with adenocarcinoma of the lung
Q50096967Epidermal growth factor receptor mutation status is strongly associated with smoking status in patients undergoing surgical resection for lung adenocarcinoma.
Q44669701Epidermal growth factor receptor mutation subtypes and geographical distribution among Indian non-small cell lung cancer patients
Q45272652Epidermal growth factor receptor mutation, but not sex and smoking, is independently associated with favorable prognosis of gefitinib-treated patients with lung adenocarcinoma
Q54569001Epidermal growth factor receptor mutation-guided treatment for lung cancers: Where are we now?
Q54395887Epidermal growth factor receptor mutation-specific immunohistochemical antibodies in lung adenocarcinoma.
Q33617464Epidermal growth factor receptor mutations and anaplastic lymphoma kinase rearrangements in lung cancer with nodular ground-glass opacity
Q34575299Epidermal growth factor receptor mutations and susceptibility to targeted therapy in lung cancer
Q37232048Epidermal growth factor receptor mutations and the clinical outcome in male smokers with squamous cell carcinoma of lung
Q51491538Epidermal growth factor receptor mutations as a prognostic factor in Korean patients with advanced lung adenocarcinoma who had not been treated with received epidermal growth factor receptor tyrosine kinase inhibitors.
Q84409820Epidermal growth factor receptor mutations detected by denaturing high-performance liquid chromatography in nonsmall cell lung cancer: impact on response to therapy with epidermal growth factor receptor-tyrosine kinase inhibitors
Q58082495Epidermal growth factor receptor mutations in Chinese patients with laryngeal squamous cell carcinoma
Q54179471Epidermal growth factor receptor mutations in East European non-small cell lung cancer patients.
Q38174770Epidermal growth factor receptor mutations in lung adenocarcinoma
Q29615474Epidermal growth factor receptor mutations in lung cancer
Q36817294Epidermal growth factor receptor mutations in lung cancers.
Q39918647Epidermal growth factor receptor mutations in non-small cell lung cancer influence downstream Akt, MAPK and Stat3 signaling
Q36662504Epidermal growth factor receptor mutations in nonsmall cell lung carcinoma patients in Kuwait
Q53270990Epidermal growth factor receptor mutations in patients with oral cavity cancer in a betel nut chewing-prevalent area.
Q36429519Epidermal growth factor receptor mutations predict sensitivity to gefitinib in patients with non-small-cell lung cancer
Q40190070Epidermal growth factor receptor overexpression is common and not correlated to gene copy number in ependymoma
Q53564370Epidermal growth factor receptor polymorphisms and clinical outcomes in non-small-cell lung cancer patients treated with gefitinib.
Q33996096Epidermal growth factor receptor polymorphisms and risk for toxicity in paediatric patients treated with gefitinib
Q43407740Epidermal growth factor receptor protein expression and genomic alterations in renal cell carcinoma
Q39739616Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1alpha in non-small cell lung cancer cells
Q39752055Epidermal growth factor receptor signaling in nonsmall cell lung cancer
Q34561698Epidermal growth factor receptor signaling synergizes with Hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway
Q38207484Epidermal growth factor receptor signalling in keratinocyte biology: implications for skin toxicity of tyrosine kinase inhibitors
Q49468021Epidermal growth factor receptor somatic mutation analysis in 354 Chinese patients with non-small cell lung cancer.
Q36014238Epidermal growth factor receptor status in anaplastic thyroid carcinoma
Q33315034Epidermal growth factor receptor structural alterations in gastric cancer
Q34159125Epidermal growth factor receptor targeted therapy of squamous cell carcinoma of the head and neck
Q39165055Epidermal growth factor receptor tyrosine kinase inhibition up-regulates interleukin-6 in cancer cells and induces subsequent development of interstitial pneumonia
Q36660669Epidermal growth factor receptor tyrosine kinase inhibitor-resistant disease
Q34031229Epidermal growth factor receptor tyrosine kinase inhibitors for non-small cell lung cancer
Q38763111Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of central nervous system metastases from non-small cell lung cancer: the present and the future
Q24653036Epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small-cell lung cancer: results and open issues
Q37431620Epidermal growth factor receptor tyrosine kinase inhibitors in elderly or poor performance status patients with advanced non-small cell lung cancer
Q38594474Epidermal growth factor receptor tyrosine kinase inhibitors in elderly patients with non-small cell lung cancer
Q35290807Epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer: a decade of progress and hopeful future
Q38701670Epidermal growth factor receptor tyrosine kinase inhibitors in previously treated advanced non-small-cell lung cancer with wild-type EGFR.
Q36402837Epidermal growth factor receptor tyrosine kinase inhibitors with conventional chemotherapy for the treatment of non-small cell lung cancer
Q38168795Epidermal growth factor receptor tyrosine-kinase inhibitor treatment resistance in non-small cell lung cancer: biological basis and therapeutic strategies
Q34589789Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors
Q36493232Epidermal growth factor receptor-targeted agents for lung cancer
Q40038133Epidermal growth factor receptor-targeted therapy.
Q36119978Epidermal growth factor receptor-targeted treatment for advanced colorectal carcinoma
Q38888532Epidermal growth factor receptor-tyrosine kinase inhibitor therapy is especially beneficial to patients with exon 19 deletion compared with exon 21 L858R mutation in non-small-cell lung cancer: Systematic review and meta analysis
Q54329048Epidermal growth factor receptor-tyrosine kinase inhibitors in advanced squamous cell carcinoma of the lung: a meta-analysis.
Q90886378Epidermal growth factor receptor: Structure-function informing the design of anticancer therapeutics
Q33779882Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalized
Q36042698Epidermal growth factor signals regulate dihydropyrimidine dehydrogenase expression in EGFR-mutated non-small-cell lung cancer.
Q36938216Epigenetic Therapy in Lung Cancer - Role of microRNAs
Q38150749Epistatic interactions and drug response
Q82917858Epithelial growth factor receptor status in primary and recurrent ovarian cancer
Q24535592Epithelial membrane protein-1 is a biomarker of gefitinib resistance.
Q37977436Epithelial mesenchymal transition and lung cancer
Q36399326Epithelial-mesenchymal transition in lung cancer: is tobacco the "smoking gun"?
Q34095970Epithelioid sarcoma expresses epidermal growth factor receptor but gene amplification and kinase domain mutations are rare.
Q38729111ErbB Family Signalling: A Paradigm for Oncogene Addiction and Personalized Oncology
Q37668848ErbB Proteins as Molecular Target of Dietary Phytochemicals in Malignant Diseases
Q37970020ErbB family receptor inhibitors as therapeutic agents in breast cancer: current status and future clinical perspective
Q36545883ErbB receptor negative regulatory mechanisms: implications in cancer
Q36677496ErbB receptors and epithelial-cadherin-catenin complex in human carcinomas
Q24683709ErbB receptors: from oncogenes to targeted cancer therapies
Q33928631ErbB-3 mediates phosphoinositide 3-kinase activity in gefitinib-sensitive non-small cell lung cancer cell lines
Q37249978ErbBs in lung cancer
Q37419295Eribulin sensitizes oral squamous cell carcinoma cells to cetuximab via induction of mesenchymal-to-epithelial transition.
Q35263024Erlotinib 'dosing-to-rash': a phase II intrapatient dose escalation and pharmacologic study of erlotinib in previously treated advanced non-small cell lung cancer
Q40161836Erlotinib (OSI-774)-induced inhibition of transitional cell carcinoma of bladder cell line growth is enhanced by interferon-alpha
Q38245038Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study
Q38841850Erlotinib and gefitinib responsiveness in head and neck cancer cell lines--a comparing analysis with cetuximab.
Q33945734Erlotinib at a dose of 25 mg daily for non-small cell lung cancers with EGFR mutations
Q24685474Erlotinib effectively inhibits JAK2V617F activity and polycythemia vera cell growth
Q54616855Erlotinib efficacy and cerebrospinal fluid concentration in patients with lung adenocarcinoma developing leptomeningeal metastases during gefitinib therapy.
Q36425173Erlotinib eradicates brain metastases from epidermal growth factor receptor mutant non-small cell lung cancer
Q36224756Erlotinib has better efficacy than gefitinib in adenocarcinoma patients without EGFR-activating mutations, but similar efficacy in patients with EGFR-activating mutations.
Q43955796Erlotinib hydrochloride
Q34266864Erlotinib in African Americans with advanced non-small cell lung cancer: a prospective randomized study with genetic and pharmacokinetic analyses.
Q36161290Erlotinib in non-small cell lung cancer: a review
Q36968183Erlotinib in non-small-cell lung cancer
Q48597941Erlotinib in patients with advanced lung squamous cell carcinoma.
Q35628121Erlotinib in the treatment of advanced non-small cell lung cancer: an update for clinicians
Q37307567Erlotinib in the treatment of advanced pancreatic cancer
Q36284485Erlotinib in the treatment of non-small cell lung cancer
Q37290401Erlotinib in wild type epidermal growth factor receptor non-small cell lung cancer: A systematic review
Q39975225Erlotinib induces mitochondrial-mediated apoptosis in human H3255 non-small-cell lung cancer cells with epidermal growth factor receptorL858R mutation through mitochondrial oxidative phosphorylation-dependent activation of BAX and BAK.
Q33275026Erlotinib inhibits growth of a patient-derived chordoma xenograft
Q35558557Erlotinib is a viable treatment for tumors with acquired resistance to cetuximab
Q36228534Erlotinib is effective in pancreatic cancer with epidermal growth factor receptor mutations: a randomized, open-label, prospective trial
Q36151475Erlotinib plus capecitabine as first-line treatment for older Chinese patients with advanced adenocarcinoma of the lung (C-TONG0807): an open-label, single arm, multicenter phase II study
Q39121775Erlotinib resistance in EGFR-amplified glioblastoma cells is associated with upregulation of EGFRvIII and PI3Kp110δ.
Q42017054Erlotinib resistance in mouse models of epidermal growth factor receptor-induced lung adenocarcinoma
Q34134464Erlotinib response in an NSCLC patient with a novel compound G719D+L861R mutation in EGFR.
Q35996048Erlotinib therapy after initial platinum doublet therapy in patients with EGFR wild type non-small cell lung cancer: results of a combined patient-level analysis of the NCIC CTG BR.21 and SATURN trials
Q34657690Erlotinib usage after prior treatment with gefitinib in advanced non-small cell lung cancer: A clinical perspective and review of published literature
Q46542092Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): a randomised controlled trial
Q27851712Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial
Q35152542Erlotinib-cisplatin combination inhibits growth and angiogenesis through c-MYC and HIF-1α in EGFR-mutated lung cancer in vitro and in vivo
Q37754925Erlotinib: an EGF receptor tyrosine kinase inhibitor in non-small-cell lung cancer treatment
Q36839754Erlotinib: success of a molecularly targeted agent for the treatment of advanced pancreatic cancer
Q38970911Esophageal carcinoma cell line with high EGFR polysomy is responsive to gefitinib
Q38694441Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
Q36834539Establishment and characterization of a human intrahepatic cholangiocarcinoma cell line derived from an Italian patient.
Q35921330Establishment of a patient-derived intrahepatic cholangiocarcinoma xenograft model with KRAS mutation
Q37028611Establishment of patient-derived non-small cell lung cancer xenograft models with genetic aberrations within EGFR, KRAS and FGFR1: useful tools for preclinical studies of targeted therapies
Q41672200Estimation of age-related DNA degradation from formalin-fixed and paraffin-embedded tissue according to the extraction methods
Q35051314Estrogen adversely affects the prognosis of patients with lung adenocarcinoma.
Q38434138Estrogen receptor signaling pathways in human non-small cell lung cancer
Q33561588Estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 (HER2), and epidermal growth factor receptor expression and benefit from lapatinib in a randomized trial of paclitaxel with lapatinib or placebo as first-line treatme
Q34657570Estrogen receptors as the novel therapeutic biomarker in non-small cell lung cancer
Q41171803Ethics of mandatory research biopsy for correlative end points within clinical trials in oncology
Q37399540Ethnic differences and functional analysis of MET mutations in lung cancer
Q35943089Ethnicity affects EGFR and KRAS gene alterations of lung adenocarcinoma
Q61455095Eukaryotic translation initiation factor 3 subunit C is associated with acquired resistance to erlotinib in non-small cell lung cancer
Q47099044Evaluating the Prognostic Value of ERCC1 and Thymidylate Synthase Expression and the Epidermal Growth Factor Receptor Mutation Status in Adenocarcinoma Non-Small-Cell Lung Cancer
Q37432535Evaluation of 7q31 region improves the accuracy of EGFR FISH assay in non small cell lung cancer.
Q38753542Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis
Q53306420Evaluation of PTEN and Mcl-1 expressions in NSCLC expressing wild-type or mutated EGFR.
Q38686009Evaluation of concurrent chemoradiotherapy for locally advanced NSCLC according to EGFR mutation status
Q51319681Evaluation of crizotinib absolute bioavailability, the bioequivalence of three oral formulations, and the effect of food on crizotinib pharmacokinetics in healthy subjects.
Q41973777Evaluation of current methods to detect the mutations of epidermal growth factor receptor in non-small cell lung cancer patients
Q79346134Evaluation of denaturing high-performance liquid chromatography as a rapid detection method for identification of epidermal growth factor receptor mutations in nonsmall-cell lung cancer
Q33379967Evaluation of efficacy and safety of gefitinib as monotherapy in Chinese patients with advanced non-small cell lung cancer and very poor performance status
Q36611204Evaluation of epidermal growth factor receptor mutation status in serum DNA as a predictor of response to gefitinib (IRESSA).
Q36966128Evaluation of epidermal growth factor receptor mutations based on mutation specific immunohistochemistry in non-small cell lung cancer: A preliminary study.
Q40977709Evaluation of erlotinib for the treatment of patients with non-small cell lung cancer with epidermal growth factor receptor wild type
Q51700829Evaluation of gefitinib efficacy according to body surface area in patients with non-small cell lung cancer harboring an EGFR mutation.
Q36523502Evaluation of gefitinib for treatment of refractory solid tumors and central nervous system malignancies in pediatric patients
Q41994944Evaluation of immunohistochemistry using two different antibodies and procedures for primary lung adenocarcinoma harboring anaplastic lymphoma kinase rearrangement
Q39716869Evaluation of modified PEG-anilinoquinazoline derivatives as potential agents for EGFR imaging in cancer by small animal PET.
Q37883964Evaluation of molecular prognostic and predictive factors: an important step towards personalised treatment in non small cell lung cancer
Q36582547Evaluation of phosphatidylinositol-3-kinase catalytic subunit (PIK3CA) and epidermal growth factor receptor (EGFR) gene mutations in pancreaticobiliary adenocarcinoma
Q43846394Evaluation of statistical designs in phase I expansion cohorts: the Dana-Farber/Harvard Cancer Center experience.
Q39308716Evaluation of the efficacy and safety of anti-PD-1 and anti-PD-L1 antibody in the treatment of non-small cell lung cancer (NSCLC): a meta-analysis
Q50674470Evaluation of the new IASLC/ATS/ERS proposed classification of adenocarcinoma based on lepidic pattern in patients with pathological stage IA pulmonary adenocarcinoma.
Q38844092Evidence for efficient phosphorylation of EGFR and rapid endocytosis of phosphorylated EGFR via the early/late endocytic pathway in a gefitinib-sensitive non-small cell lung cancer cell line.
Q91729686Evolution of Small Molecule Kinase Drugs
Q47816379Evolution of early phase clinical trials in oncology
Q58613175Evolution of platinum resistance in high-grade serous ovarian cancer
Q33557413Evolution of systemic therapy for advanced pancreatic cancer
Q35591358Evolutionary modeling of combination treatment strategies to overcome resistance to tyrosine kinase inhibitors in non-small cell lung cancer
Q36327195Evolvable signaling networks of receptor tyrosine kinases: relevance of robustness to malignancy and to cancer therapy
Q40228498Evolving '-omics' technologies in the drug development process.
Q30398030Evolving health care through personal genomics
Q34529131Evolving landscape of tumor molecular profiling for personalized cancer therapy: a comprehensive review.
Q37349280Excerpts from the 1st international NTNU symposium on current and future clinical biomarkers of cancer: innovation and implementation, June 16th and 17th 2016, Trondheim, Norway
Q83106750Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer
Q37255147Existing and emerging technologies for tumor genomic profiling
Q28743468Exome sequencing reveals comprehensive genomic alterations across eight cancer cell lines
Q37416668Exome sequencing reveals germline gain-of-function EGFR mutation in an adult with Lhermitte-Duclos disease.
Q35669012Exon 19 deletion of epidermal growth factor receptor is associated with prolonged survival in brain metastases from non-small-cell lung cancer
Q33621754Exons 19 and 21 of epidermal growth factor receptor are highly conserved in squamous cell cancer of the head and neck
Q43195723Expanding options for EGFR targeting in lung cancer
Q34359274Experience with afatinib in patients with non-small cell lung cancer progressing after clinical benefit from gefitinib and erlotinib
Q38524526Experience with erlotinib in the treatment of non-small cell lung cancer
Q26799390Expert Consensus on the Management of Adverse Events from EGFR Tyrosine Kinase Inhibitors in the UK
Q39288360Exploiting Synthetic Lethality and Network Biology to Overcome EGFR Inhibitor Resistance in Lung Cancer.
Q29615120Exploiting the PI3K/AKT pathway for cancer drug discovery
Q58802587Exploiting vulnerabilities in cancer signalling networks to combat targeted therapy resistance
Q37818230Exploration of synthetic lethal interactions as cancer drug targets
Q41920903Exploratory study on the correlation between 14 lung cancer-related gene expression and specific clinical characteristics of NSCLC patients
Q54319566Exploring microRNA-mediated alteration of EGFR signaling pathway in non-small cell lung cancer using an mRNA:miRNA regression model supported by target prediction databases.
Q52688847Expression and copy number gains of the RET gene in 631 early and mid stage non-small cell lung cancer cases.
Q83855416Expression and genomic status of EGFR and ErbB-2 in alveolar and embryonal rhabdomyosarcoma
Q36341754Expression biomarkers for clinical efficacy and outcome prediction in cancer
Q39144184Expression level of CRKL and AXL combined with exon 19 deletion in EGFR and ALK status confer differential prognosis of lung adenocarcinoma subtypes
Q35218145Expression levels of estrogen receptor beta in conjunction with aromatase predict survival in non-small cell lung cancer
Q36774633Expression of E-cadherin and KRAS mutation may serve as biomarkers of cetuximab-based therapy in metastatic colorectal cancer
Q38329982Expression of EGF-family receptors and amphiregulin in multiple myeloma. Amphiregulin is a growth factor for myeloma cells
Q36010179Expression of EGFR Is Closely Related to Reduced 3-Year Survival Rate in Chinese Female NSCLC
Q34745805Expression of NRG1 and its receptors in human bladder cancer
Q40117486Expression of Rab5a in hepatocellular carcinoma: Possible involvement in epidermal growth factor signaling
Q35238466Expression of sulfotransferase SULT1A1 in cancer cells predicts susceptibility to the novel anticancer agent NSC-743380
Q80587761Expression of syndecan-1 and expression of epidermal growth factor receptor are associated with survival in patients with nonsmall cell lung carcinoma
Q35036471Expression of the mismatch repair gene hMLH1 is enhanced in non-small cell lung cancer with EGFR mutations
Q37457741Expression of the receptor for hyaluronic acid mediated motility (RHAMM) is associated with poor prognosis and metastasis in non-small cell lung carcinoma
Q30009050Expression pattern of FGFR2, Grb2 and Plcγ1 acts as a novel prognostic marker of recurrence recurrence-free survival in lung adenocarcinoma
Q38296583Expression signatures in lung cancer reveal a profile for EGFR-mutant tumours and identify selective PIK3CA overexpression by gene amplification
Q37291399FAIM2, as a novel diagnostic maker and a potential therapeutic target for small-cell lung cancer and atypical carcinoid
Q91982178FAM83A and FAM83B as Prognostic Biomarkers and Potential New Therapeutic Targets in NSCLC
Q42059865FAM83A and FAM83B: candidate oncogenes and TKI resistance mediators
Q24296333FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice
Q35073348FAM83B is a novel biomarker for diagnosis and prognosis of lung squamous cell carcinoma
Q47307357FDA Benefit-Risk Assessment of Osimertinib for the Treatment of Metastatic Non-Small Cell Lung Cancer Harboring Epidermal Growth Factor Receptor T790M Mutation
Q53089675FDG PET/CT metabolic tumor volume and total lesion glycolysis predict prognosis in patients with advanced lung adenocarcinoma.
Q38234978FDG-PET/CT response evaluation during EGFR-TKI treatment in patients with NSCLC.
Q39297937FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma
Q38966912FGFR1 activation is an escape mechanism in human lung cancer cells resistant to afatinib, a pan-EGFR family kinase inhibitor
Q36406190FGFR1 amplification in squamous cell carcinoma of the lung
Q47260594FLNa negatively regulated proliferation and metastasis in lung adenocarcinoma A549 cells via suppression of EGFR.
Q36251184FLT3 tyrosine kinase inhibitors
Q40371743FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance.
Q61813957FOSB⁻PCDHB13 Axis Disrupts the Microtubule Network in Non-Small Cell Lung Cancer
Q35745004FS-93, an Hsp90 inhibitor, induces G2/M arrest and apoptosis via the degradation of client proteins in oncogene addicted and derived resistant cancer cells
Q39281214Factors associated with efficacy of first-generation epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancer
Q28252845Factors underlying sensitivity of cancers to small-molecule kinase inhibitors
Q39809931Fast and sensitive pretargeted labeling of cancer cells through a tetrazine/trans-cyclooctene cycloaddition
Q35073353Favorable effect of the combination of vinorelbine and dihydropyrimidine dehydrogenase‑inhibitory fluoropyrimidine in EGFR‑mutated lung adenocarcinoma: retrospective and in vitro studies
Q43101561Favorable response to icotinib in a lung cancer patient with a special mutation at exon 19 of epidermal growth factor receptor
Q36439363Feasibility of computed tomography-guided core needle biopsy in producing state-of-the-art clinical management in Chinese lung cancer.
Q54977963Feasibility of continuing crizotinib therapy after RECIST-PD in advanced non-small cell lung cancer patients with ALK/ROS-1 mutations.
Q37427038Feasibility of imaging of epidermal growth factor receptor expression with ZEGFR:2377 affibody molecule labeled with 99mTc using a peptide-based cysteine-containing chelator.
Q55363718Feasibility study of cancer genome alterations identified by next generation sequencing: ABC study.
Q41729710Feedback control of ErbB2 via ERK-mediated phosphorylation of a conserved threonine in the juxtamembrane domain.
Q37831109Feedback regulation of EGFR signalling: decision making by early and delayed loops.
Q64931081Fibrinogen is associated with EGFR mutation status and lymphatic metastasis in non-small cell lung cancer.
Q24658237Fibroblast growth factor (FGF) and FGF receptor-mediated autocrine signaling in non-small-cell lung cancer cells
Q90616691Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer
Q36924414Fibroblast-secreted hepatocyte growth factor mediates epidermal growth factor receptor tyrosine kinase inhibitor resistance in triple-negative breast cancers through paracrine activation of Met
Q37639588Final overall survival in JO22903, a phase II, open-label study of first-line erlotinib for Japanese patients with EGFR mutation-positive non-small-cell lung cancer
Q60918185Finding the Right Way to Target EGFR in Glioblastomas; Lessons from Lung Adenocarcinomas
Q54246031Finding the missing links in EGFR.
Q93382354Fine-needle aspiration cytology of non-small cell lung carcinoma: A paradigm shift
Q60921601First- and Second-Generation EGFR-TKIs Are All Replaced to Osimertinib in Chemo-Naive Mutation-Positive Non-Small Cell Lung Cancer?
Q48004901First-Line Carboplatin, Pemetrexed, and Panitumumab in Patients with Advanced Non-Squamous KRAS Wild Type (WT) Non-Small-Cell Lung Cancer (NSCLC).
Q41569372First-line gefitinib for elderly patients with advanced NSCLC harboring EGFR mutations. A combined analysis of North-East Japan Study Group studies
Q34386915First-line gefitinib in Caucasian EGFR mutation-positive NSCLC patients: a phase-IV, open-label, single-arm study.
Q43639934First-line gefitinib therapy for elderly patients with non-small cell lung cancer harboring EGFR mutation: Central Japan Lung Study Group 0901.
Q47763039First-line icotinib versus cisplatin/pemetrexed plus pemetrexed maintenance therapy for patients with advanced EGFR mutation-positive lung adenocarcinoma (CONVINCE): a phase 3, open-label, randomized study
Q38088215First-line management of EGFR-mutated advanced lung adenocarcinoma: recent developments
Q37625444First-line systemic treatment of advanced stage non-small-cell lung cancer in Asia: consensus statement from the Asian Oncology Summit 2009.
Q38221293First-line therapeutic options for advanced non-small-cell lung cancer in the molecular medicine era.
Q38032437First-line therapy of mutated non-small cell lung cancer: an update
Q54186267First-line treatment in NSCLC harboring EGFR common mutations: EGFR TKI in monotherapy or in combination with anti-VEGF?
Q36283596First-line treatment of EGFR-mutant non-small-cell lung cancer: the role of erlotinib and other tyrosine kinase inhibitors
Q64228070First-line tyrosine kinase inhibitors in EGFR mutation-positive non-small-cell lung cancer: a network meta-analysis
Q34591159Five microRNAs in plasma as novel biomarkers for screening of early-stage non-small cell lung cancer
Q37164590Five-Year Survival in EGFR-Mutant Metastatic Lung Adenocarcinoma Treated with EGFR-TKIs
Q50876305Flavonoids and Tannins from Smilax china L. Rhizome Induce Apoptosis Via Mitochondrial Pathway and MDM2-p53 Signaling in Human Lung Adenocarcinoma Cells.
Q39284284Flexible lab-tailored cut-offs for suitability of formalin-fixed tumor samples for diagnostic mutational analyses
Q55030214Flipped script for gefitinib: A reapproved tyrosine kinase inhibitor for first-line treatment of epidermal growth factor receptor mutation positive metastatic nonsmall cell lung cancer.
Q41965926Fluorescent signatures for variable DNA sequences
Q36939898Flying under the radar: the new wave of BCR-ABL inhibitors
Q28550689Focal Adhesion Kinase Inhibitors in Combination with Erlotinib Demonstrate Enhanced Anti-Tumor Activity in Non-Small Cell Lung Cancer
Q38089600Focus on the potential role of ficlatuzumab in the treatment of non-small cell lung cancer
Q35845580Focused molecular analysis of small cell lung cancer: feasibility in routine clinical practice
Q42368437Folliculin Interacts with Rab35 to Regulate EGF-Induced EGFR Degradation
Q35200424Following the crumbs: from tissue samples, to pharmacogenomics, to NSCLC therapy
Q34669260Fool's gold, lost treasures, and the randomized clinical trial
Q39528185Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks
Q83230378Formation of Neu/ErbB2-induced mammary tumors is unaffected by loss of ErbB4
Q37698293Four-dimensional dynamics of MAPK information processing systems.
Q40929491Frequencies of EGFR single nucleotide polymorphisms in non-small cell lung cancer patients and healthy individuals in the Republic of Serbia: a preliminary study
Q92798844Frequency and clinical features of BRAF mutations among patients with stage III/IV lung adenocarcinoma without EGFR/ALK aberrations
Q27851448Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma
Q34673282Frequency and type of epidermal growth factor receptor mutations in African Americans with non-small cell lung cancer
Q35915133Frequency of EGFR and KRAS mutations in lung adenocarcinomas in African Americans
Q37110396Frequency of EGFR and KRAS mutations in patients with non small cell lung cancer by racial background: do disparities exist?
Q35016912Frequency of EGFR mutations in 907 lung adenocarcioma patients of Indian ethnicity
Q35871742Frequency of driver mutations in lung adenocarcinoma from female never-smokers varies with histologic subtypes and age at diagnosis
Q46607446Frequency of epidermal growth factor receptor mutations in Bangladeshi patients with adenocarcinoma of the lung
Q54284515Frequent alterations of HER2 through mutation, amplification, or overexpression in pleomorphic lobular carcinoma of the breast.
Q27851615Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer.
Q38489488Frequent central nervous system failure after clinical benefit with epidermal growth factor receptor tyrosine kinase inhibitors in Korean patients with nonsmall-cell lung cancer.
Q46738962Frequent mutations in the neurotrophic tyrosine receptor kinase gene family in large cell neuroendocrine carcinoma of the lung
Q80173694From bench to bedside and back again?
Q28533949From bench to bedside: lessons learned in translating preclinical studies in cancer drug development
Q50123361From biology to therapy: Improvements of therapeutic options in Lung cancer.
Q24621007From combinatorial peptide selection to drug prototype (II): targeting the epidermal growth factor receptor pathway
Q92302884From discovery of tyrosine phosphorylation to targeted cancer therapies: The 2018 Tang Prize in Biopharmaceutical Science
Q37551148From drug discovery to biomarker-driven clinical trials in lymphoma
Q37003218From genotype to phenotype: Are there imaging characteristics associated with lung adenocarcinomas harboring RET and ROS1 rearrangements?
Q26830811From modules to medicine: How modular domains and their associated networks can enable personalized medicine
Q55093479From mono- to bivalent: improving theranostic properties of target modules for redirection of UniCAR T cells against EGFR-expressing tumor cells in vitro and in vivo.
Q46560311From nihilism to individualism: the evolution of lung cancer therapy
Q37236447From oncogene to network addiction: the new frontier of cancer genomics and therapeutics
Q28385559From single-gene to multiplex analysis in lung cancer, challenges and accomplishments: a review of a single institution's experience
Q35117568From the bench to bedside: biological and methodology considerations for the future of companion diagnostics in nonsmall cell lung cancer
Q26864637From tissue to molecular phenotyping: pre-analytical requirements heidelberg experience
Q90612116Frontiers of ctDNA, targeted therapies, and immunotherapy in non-small-cell lung cancer
Q34094224Frontline gefitinib in advanced non-small cell lung cancer: Meta-analysis of published randomized trials
Q93337424Fully automated real-time PCR for EGFR testing in non-small cell lung carcinoma
Q36120023Functional analysis of cancer-associated EGFR mutants using a cellular assay with YFP-tagged EGFR intracellular domain
Q37732019Functional analysis of polymorphisms in the COX-2 gene and risk of lung cancer
Q36221780Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2.
Q51739953Functional characterization of an activating TEK mutation in acute myeloid leukemia: a cellular context-dependent activating mutation.
Q33838325Functional characterization of human cancer-derived TRKB mutations
Q34423170Functional consequences of somatic mutations in cancer using protein pocket-based prioritization approach
Q54977360Functional cooperation between HIF-1α and c-Jun in mediating primary and acquired resistance to gefitinib in NSCLC cells with activating mutation of EGFR.
Q33368629Functional copy-number alterations in cancer
Q37999073Functional drug-gene interactions in lung cancer.
Q45933675Functional evaluation of therapeutic response of HCC827 lung cancer to bevacizumab and erlotinib targeted therapy using dynamic contrast-enhanced and diffusion-weighted MRI.
Q85001306Functional mutation analysis of EGFR family genes and corresponding lymph node metastases in head and neck squamous cell carcinoma
Q48013156Functional precision cancer medicine-moving beyond pure genomics
Q37269270Functional role of eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) in NSCLC
Q36895812Future of molecular profiling of human hepatocellular carcinoma
Q35404376Fuzheng Kang'ai decoction combined with gefitinib in advanced non-small cell lung cancer patients with epidermal growth factor receptor mutations: study protocol for a randomized controlled trial
Q42702662GAB2 Amplification in Squamous Cell Lung Cancer of Non-Smokers.
Q49789981GRK5 functions as an oncogenic factor in non-small-cell lung cancer.
Q61804215GSK-3β regulates the endothelial-to-mesenchymal transition via reciprocal crosstalk between NSCLC cells and HUVECs in multicellular tumor spheroid models
Q55070732Gain of copy number and amplification of the RET gene in lung cancer.
Q35067654Galectin-4, a novel predictor for lymph node metastasis in lung adenocarcinoma
Q40161268Gastrin-releasing peptide activates Akt through the epidermal growth factor receptor pathway and abrogates the effect of gefitinib
Q34768400Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells
Q54719163Gastrointestinal toxicities of novel agents in cancer therapy.
Q33265628Gefitinib (IRESSA) sensitive lung cancer cell lines show phosphorylation of Akt without ligand stimulation
Q39400141Gefitinib (ZD1839) increases the efficacy of cisplatin in ovarian cancer cells
Q36135604Gefitinib (ZD1839, Iressa) in non-small-cell lung cancer: a review of clinical trials from a daily practice perspective.
Q64969430Gefitinib Plus Bevacizumab vs. Gefitinib Alone for EGFR Mutant Non-squamous Non-small Cell Lung Cancer.
Q28485309Gefitinib analogue V1801 induces apoptosis of T790M EGFR-harboring lung cancer cells by up-regulation of the BH-3 only protein Noxa
Q54564062Gefitinib and chemotherapy combination studies in five novel human non small cell lung cancer xenografts. Evidence linking EGFR signaling to gefitinib antitumor response.
Q35345489Gefitinib and erlotinib in metastatic non-small cell lung cancer: a meta-analysis of toxicity and efficacy of randomized clinical trials.
Q36740873Gefitinib as first line therapy in Malaysian patients with EGFR mutation-positive non-small-cell lung cancer: A single-center retrospective study
Q46333966Gefitinib first or gefitinib second: is timing everything in the treatment of EGFR mutant non-small cell lung cancer?
Q36612517Gefitinib for non-small-cell lung cancer patients with epidermal growth factor receptor gene mutations screened by peptide nucleic acid-locked nucleic acid PCR clamp
Q37929795Gefitinib for non-small-cell lung cancer treatment
Q88123698Gefitinib for oesophageal cancer: a cog in need of a wheel?
Q37357287Gefitinib for the treatment of non-small-cell lung cancer
Q37738913Gefitinib for the treatment of non-small-cell lung cancer.
Q36512046Gefitinib in Selected Patients with Pre-Treated Non-Small-Cell Lung Cancer: Results from a Phase IV, Multicenter, Non-Randomized Study (SELINE)
Q35031807Gefitinib in non small cell lung cancer
Q36161284Gefitinib in non-small cell lung cancer
Q36610166Gefitinib in patients with progressive high-grade gliomas: a multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO).
Q37449013Gefitinib in the treatment of advanced non-small-cell lung cancer
Q26739096Gefitinib in the treatment of nonsmall cell lung cancer with activating epidermal growth factor receptor mutation
Q54321696Gefitinib induces cytoplasmic translocation of the CDK inhibitor p27 and its binding to a cleaved intermediate of caspase 8 in non-small cell lung cancer cells.
Q28534577Gefitinib inhibits invasive phenotype and epithelial-mesenchymal transition in drug-resistant NSCLC cells with MET amplification
Q36155335Gefitinib is more effective in never-smokers with non-small-cell lung cancer: experience among Asian patients
Q50506376Gefitinib plus Fuzheng Kang'ai Formula () in patients with advanced non-small cell lung cancer with epidermal growth factor receptor mutation: A randomized controlled trial.
Q29620605Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
Q36065216Gefitinib radiosensitizes non-small cell lung cancer cells by suppressing cellular DNA repair capacity
Q34114278Gefitinib radiosensitizes non-small cell lung cancer cells through inhibition of ataxia telangiectasia mutated
Q33231452Gefitinib response of erlotinib-refractory lung cancer involving meninges--role of EGFR mutation
Q36615832Gefitinib treatment affects androgen levels in non-small-cell lung cancer patients
Q53513542Gefitinib treatment in patients with postoperative recurrent non-small-cell lung cancer harboring epidermal growth factor receptor gene mutations.
Q44679030Gefitinib treatment is highly effective in non-small-cell lung cancer patients failing previous chemotherapy in Taiwan: a prospective phase II study
Q29619975Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
Q46232500Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial.
Q30544631Gefitinib versus placebo in completely resected non-small-cell lung cancer: results of the NCIC CTG BR19 study
Q42328764Gefitinib with pemetrexed as first-line therapy in patients with advanced nonsquamous non-small cell lung cancer with activating epidermal growth factor receptor mutations
Q37419104Gefitinib, Fluorouracil, Oxaliplatin, and Leucovorin (IFOX) Regimen for Colorectal Cancer
Q45169148Gefitinib--a novel targeted approach to treating cancer
Q28469345Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics
Q35580846Gefitinib-mediated reactive oxygen specie (ROS) instigates mitochondrial dysfunction and drug resistance in lung cancer cells
Q36661222Gefitinib-resistance is related to BIM expression in non-small cell lung cancer cell lines
Q43042819Gefitinib: a consideration of cost
Q38338492Gefitinib: a review of its use in adults with advanced non-small cell lung cancer
Q33207883Gefitinib: a review of its use in the management of advanced non-small-cell lung cancer
Q33915997Gemcitabine for the treatment of advanced nonsmall cell lung cancer
Q64238805Gene Expression Profiling Reveals Distinct Molecular Subtypes of Esophageal Squamous Cell Carcinoma in Asian Populations
Q37221902Gene Expression of the EGF System-a Prognostic Model in Non-Small Cell Lung Cancer Patients Without Activating EGFR Mutations
Q94603193Gene Signature for Sorafenib Susceptibility in Hepatocellular Carcinoma: Different Approach with a Predictive Biomarker
Q36755676Gene amplification of EGFR, HER2, FGFR2 and MET in esophageal squamous cell carcinoma
Q83139511Gene amplification, mutation, and protein expression of EGFR and mutations of ERBB2 in serous ovarian carcinoma
Q46465639Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study
Q41714879Gene copy number gain of EGFR is a poor prognostic biomarker in gastric cancer: evaluation of 855 patients with bright-field dual in situ hybridization (DISH) method
Q38378815Gene expression of MAGE-A3 and PRAME tumor antigens and EGFR mutational status in Taiwanese non-small cell lung cancer patients
Q33263277Gene expression patterns that predict sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer cell lines and human lung tumors
Q40141195Gene expression profiling of epidermal growth factor receptor/KRAS pathway activation in lung adenocarcinoma
Q39312152Gene expression-based chemical genomics identifies heat-shock protein 90 inhibitors as potential therapeutic drugs in cholangiocarcinoma.
Q24809183Gene mutations in lung cancer: promising predictive factors for the success of molecular therapy
Q34994030Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer
Q39159155Gene silencing of c-Met leads to brain metastasis inhibitory effects
Q28397345Gene-Lifestyle Interactions in Complex Diseases: Design and Description of the GLACIER and VIKING Studies
Q34566773Gene-guided gefitinib switch maintenance therapy for patients with advanced EGFR mutation-positive non-small cell lung cancer: an economic analysis
Q33829488Generation of lung cancer cell lines harboring EGFR T790M mutation by CRISPR/Cas9-mediated genome editing
Q54114243Genetic Association of Drug Response to Erlotinib in Chinese Advanced Non-small Cell Lung Cancer Patients.
Q38198930Genetic Interactions of STAT3 and Anticancer Drug Development
Q40498334Genetic Modifiers of Progression-Free Survival in Never-Smoking Lung Adenocarcinoma Patients Treated with First-Line Tyrosine Kinase Inhibitors
Q35898597Genetic abnormalities of the EGFR pathway in African American Patients with non-small-cell lung cancer
Q36695240Genetic alterations and protein expression of KIT and PDGFRA in serous ovarian carcinoma
Q36524569Genetic alterations in lung adenocarcinoma with a micropapillary component
Q40040928Genetic alterations in the tyrosine kinase transcriptome of human cancer cell lines
Q36393012Genetic alterations in urothelial bladder carcinoma: an updated review
Q34674319Genetic and epigenetic analysis of erbB signaling pathway genes in lung cancer
Q34125003Genetic and expression analysis of HER-2 and EGFR genes in salivary duct carcinoma: empirical and therapeutic significance
Q33520794Genetic and proteomic features associated with survival after treatment with erlotinib in first-line therapy of non-small cell lung cancer in Eastern Cooperative Oncology Group 3503.
Q36115735Genetic changes in squamous cell lung cancer: a review
Q37899883Genetic determinants of anticancer drug activity: towards a global approach to personalized cancer medicine.
Q35897344Genetic heterogeneity of actionable genes between primary and metastatic tumor in lung adenocarcinoma
Q37977835Genetic insight and therapeutic targets in squamous-cell lung cancer
Q34832117Genetic modifiers of EGFR dependence in non-small cell lung cancer
Q37113682Genetic predictors of MEK dependence in non-small cell lung cancer
Q34658903Genetic variations of the A13/A14 repeat located within the EGFR 3' untranslated region have no oncogenic effect in patients with colorectal cancer
Q33693846Genetic-based prediction of disease traits: prediction is very difficult, especially about the future
Q37765099Genetics of biliary tract cancers and emerging targeted therapies
Q36344243Genetics of drug resistance
Q39872383Genistein enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitors and inhibits nuclear factor kappa B in nonsmall cell lung cancer cell lines
Q28391355Genome stability pathways in head and neck cancers
Q28385454Genome wide SNP comparative analysis between EGFR and KRAS mutated NSCLC and characterization of two models of oncogenic cooperation in non-small cell lung carcinoma
Q33598001Genome-wide analysis of gynecologic cancer: The Cancer Genome Atlas in ovarian and endometrial cancer
Q37037246Genome-wide association study of genetic predictors of overall survival for non-small cell lung cancer in never smokers
Q34354428Genome-wide identification of significant aberrations in cancer genome.
Q82452891Genome-wide single-nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in the PI3-kinase pathway
Q37028708Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets
Q35671373Genomic Characterization of Non-Small-Cell Lung Cancer in African Americans by Targeted Massively Parallel Sequencing
Q92555522Genomic Medicine-Progress, Pitfalls, and Promise
Q55457466Genomic Profiling on an Unselected Solid Tumor Population Reveals a Highly Mutated Wnt/β-Catenin Pathway Associated with Oncogenic EGFR Mutations.
Q33313648Genomic activation of the EGFR and HER2-neu genes in a significant proportion of invasive epithelial ovarian cancers
Q49678076Genomic alterations of ERBB receptors in cancer: clinical implications.
Q37427132Genomic amplification and high expression of EGFR are key targetable oncogenic events in malignant peripheral nerve sheath tumor
Q35079683Genomic analyses across six cancer types identify basal-like breast cancer as a unique molecular entity
Q36195093Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer
Q35873554Genomic and functional analysis identifies CRKL as an oncogene amplified in lung cancer
Q34104493Genomic and genetic characterization of cholangiocarcinoma identifies therapeutic targets for tyrosine kinase inhibitors
Q35036588Genomic and transcriptional alterations in lung adenocarcinoma in relation to EGFR and KRAS mutation status
Q38060203Genomic biomarkers for patient selection and stratification: the cancer paradigm.
Q36851245Genomic landscape of non-small cell lung cancer in smokers and never-smokers
Q38231825Genomic medicine and targeted therapy for solid tumors
Q38114005Genomic medicine: a decade of successes, challenges, and opportunities
Q37269251Genomic profiling of lung adenocarcinoma patients reveals therapeutic targets and confers clinical benefit when standard molecular testing is negative
Q36207381Genomic profiling of multiple sequentially acquired tumor metastatic sites from an "exceptional responder" lung adenocarcinoma patient reveals extensive genomic heterogeneity and novel somatic variants driving treatment response
Q26853507Genomic sequencing in cancer
Q35807322Genomic technology applied to pharmacological traits
Q35252277Genomics and drug response
Q36084693Genomics of lung cancer may change diagnosis, prognosis and therapy
Q92830555Genomics-Enabled Precision Medicine for Cancer
Q37376509Genomics: applications in mechanism elucidation
Q35519172Genotype-dependent sensitivity of uveal melanoma cell lines to inhibition of B-Raf, MEK, and Akt kinases: rationale for personalized therapy
Q35146927Genotype-driven therapies for non-small cell lung cancer: focus on EGFR, KRAS and ALK gene abnormalities
Q27851633Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
Q36660664Genotyping and genomic profiling of non-small-cell lung cancer: implications for current and future therapies
Q33275318Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1
Q33901617Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: a novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma
Q35546231Germline EGFR T790M mutation found in multiple members of a familial cohort
Q40732783Germline mutations causing familial lung cancer
Q33367793Germline polymorphisms as modulators of cancer phenotypes
Q94481864Germline whole exome sequencing of a family with appendiceal mucinous tumours presenting with pseudomyxoma peritonei
Q40116157Glioblastoma cellular cross-talk converges on NF-κB to attenuate EGFR inhibitor sensitivity.
Q38460865Glioblastoma: pathology, molecular mechanisms and markers
Q35089063Global Oct4 target gene analysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer
Q37699154Glucocorticoids may compromise the effect of gefitinib in non-small cell lung cancer
Q30447539Gold nanoparticles: From nanomedicine to nanosensing.
Q34059536Good Clinical Response to Erlotinib in a Non-Small Cell Lung Cancer Patient Harboring Multiple Brain Metastases and a Double Active Somatic Epidermal Growth Factor Gene Mutation
Q27851566Good clinical response to gefitinib in a non-small cell lung cancer patient harboring a rare somatic epidermal growth factor gene point mutation; codon 768 AGC > ATC in exon 20 (S768I).
Q90429716Gossypol Inhibits Non-small Cell Lung Cancer Cells Proliferation by Targeting EGFRL858R/T790M
Q42035610Grand challenge commentary: Informative diagnostics for personalized medicine.
Q46939852Griffipavixanthone from Garcinia oblongifolia champ induces cell apoptosis in human non-small-cell lung cancer H520 cells in vitro
Q49287962Ground-glass opacity heralding invasive lung adenocarcinoma with prodromal dermatomyositis: a case report.
Q37045217Growth factors and oncogenes as targets in melanoma: lost in translation?
Q34064620Growth suppression of lung cancer cells by targeting cyclic AMP response element-binding protein
Q37631021Guideline Recommendations for Testing of ALK Gene Rearrangement in Lung Cancer: A Proposal of the Korean Cardiopulmonary Pathology Study Group.
Q39622232Guidelines for biomarker testing in advanced non-small-cell lung cancer. A national consensus of the Spanish Society of Medical Oncology (SEOM) and the Spanish Society of Pathology (SEAP).
Q90448494HCC-derived EGFR mutants are functioning, EGF-dependent, and erlotinib-resistant
Q37073441HER Receptor Family: Novel Candidate for Targeted Therapy for Gallbladder and Extrahepatic Bile Duct Cancer
Q36734936HER family inhibitors in pancreatic cancer: current status and future directions
Q33699007HER kinase axis receptor dimer partner switching occurs in response to EGFR tyrosine kinase inhibition despite failure to block cellular proliferation
Q36217582HER1/EGFR tyrosine kinase inhibitors for the treatment of glioblastoma multiforme
Q36061145HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy.
Q36322762HER2 amplification: a potential mechanism of acquired resistance to EGFR inhibition in EGFR-mutant lung cancers that lack the second-site EGFRT790M mutation
Q41308137HER2, TOP2A, CCND1, EGFR and C-MYC oncogene amplification in colorectal cancer
Q55045037HER3 expression is enhanced during progression of lung adenocarcinoma without EGFR mutation from stage 0 to IA1.
Q36615002HER3 genomic gain and sensitivity to gefitinib in advanced non-small-cell lung cancer patients
Q39263953HGF induces novel EGFR functions involved in resistance formation to tyrosine kinase inhibitors
Q36822204HIF, hypoxia and the role of angiogenesis in non-small cell lung cancer
Q33586269HPV infection and EGFR activation/alteration in HIV-infected East African patients with conjunctival carcinoma
Q52717015Haploid genetic screens identify genetic vulnerabilities to microtubule-targeting agents.
Q54257595Harnessing massively parallel DNA sequencing for the personalization of cancer management.
Q37411128Harnessing plasma genotyping for precision therapy against lung cancer
Q89634774Harnessing the vulnerabilities of p53 mutants in lung cancer - Focusing on the proteasome: a new trick for an old foe?
Q36249234Have we made progress in pharmacogenomics? The implementation of molecular markers in colon cancer
Q58197295Head and neck cancer: from research to therapy and cure
Q35762499Heat shock protein 90 inhibition in lung cancer
Q38819110Heightening Energetic Stress Selectively Targets LKB1-Deficient Non-Small Cell Lung Cancers
Q46268586Hemorrhagic pericardial effusion and multiple pulmonary nodules in a 37 year old male who has "never smoked"
Q42995833Heparin-binding EGF-like factor augments esophageal epithelial cell proliferation, migration and inhibits TRAIL-mediated apoptosis via EGFR/MAPK signaling.
Q38377273Hepatocyte growth factor and Met in drug discovery
Q36842715Her signaling in pancreatic cancer
Q33747967Her4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro system
Q92163099Heregulin expression and its clinical implication for patients with EGFR-mutant non-small cell lung cancer treated with EGFR-tyrosine kinase inhibitors
Q27853391Heterogeneity of resistance mutations detectable by next-generation sequencing in TKI-treated lung adenocarcinoma
Q38065082Heterogeneity of the EGFR mutation status between the primary tumor and metastatic lymph node and the sensitivity to EGFR tyrosine kinase inhibitor in non-small cell lung cancer
Q42227138Heterozygous mutation (G/G→G/A) at nt 2607 of the EGFR gene is closely associated with increases in EGFR copy number and mRNA half life, but impaired EGFR protein synthesis in squamous cell carcinomas of the head and neck - implication for gefitinib
Q30157152Hierarchical modeling of activation mechanisms in the ABL and EGFR kinase domains: thermodynamic and mechanistic catalysts of kinase activation by cancer mutations
Q36793862High EGFR copy number predicts benefits from tyrosine kinase inhibitor treatment for non-small cell lung cancer patients with wild-type EGFR.
Q53300836High EGFR gene copy number predicts poor outcome in triple-negative breast cancer.
Q36051484High ERK protein expression levels correlate with shorter survival in triple-negative breast cancer patients
Q41708722High PHLPP1 expression levels predicts longer time of acquired resistance to EGFR tyrosine kinase inhibitors in patients with lung adenocarcinoma
Q38776722High expression of EGFR predicts poor survival in patients with resected T3 stage gastric adenocarcinoma and promotes cancer cell survival
Q28304785High frequency of BRAF V600E mutations in ameloblastoma
Q46448637High incidence of disease recurrence in the brain and leptomeninges in patients with nonsmall cell lung carcinoma after response to gefitinib
Q33717222High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886)
Q25257525High resolution genomic analysis of sporadic breast cancer using array-based comparative genomic hybridization
Q33336861High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies
Q33267389High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer.
Q37619902High sensitivity EndoV mutation scanning through real-time ligase proofreading
Q40822344High serum level of C-reactive protein is associated with worse outcome of patients with advanced-stage NSCLC treated with erlotinib.
Q87745890High specificity but low sensitivity of mutation-specific antibodies against EGFR mutations in non-small-cell lung cancer
Q28740553High throughput interrogation of somatic mutations in high grade serous cancer of the ovary
Q37109744High-content analysis of cancer genome DNA alterations
Q36477716High-fidelity of non-small cell lung cancer xenograft models derived from bronchoscopy-guided biopsies
Q38754469High-throughput Phenotyping of Lung Cancer Somatic Mutations
Q45901707High-throughput biochemical kinase selectivity assays: panel development and screening applications.
Q34050186High-throughput genotyping in osteosarcoma identifies multiple mutations in phosphoinositide-3-kinase and other oncogenes
Q39991911High-throughput lung cancer cell line screening for genotype-correlated sensitivity to an EGFR kinase inhibitor
Q36288148High-throughput molecular analysis in lung cancer: insights into biology and potential clinical applications
Q36497083High-throughput mutational analysis of the human cancer genome
Q57693480High-throughput oncogene mutation profiling in human cancer
Q42316845High-throughput screening of rare metabolically active tumor cells in pleural effusion and peripheral blood of lung cancer patients
Q36591388High-throughput sequence analysis of the tyrosine kinome in acute myeloid leukemia
Q40476723Highly Sensitive and Reliable Detection of EGFR Exon 19 Deletions by Droplet Digital Polymerase Chain Reaction.
Q27851714Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer
Q37068513Highly parallel identification of essential genes in cancer cells
Q50465588Highly sensitive EGFR mutation detection by specific amplification of mutant alleles.
Q38164052Histo-cytological diagnostic accuracy in lung cancer
Q48132127Histologic Grade Is Predictive of Incidence of Epidermal Growth Factor Receptor Mutations in Metastatic Lung Adenocarcinoma
Q40109306Histological Transformation to Large Cell Neuroendocrine Carcinoma from Lung Adenocarcinoma Harboring an EGFR Mutation: An Autopsy Case Report.
Q33904760Histological comparison between preoperative and surgical specimens of non-small cell lung cancer for distinguishing between "squamous" and "non-squamous" cell carcinoma
Q48150376Histone Deacetylase Inhibitors Resensitize EGFR/EGFRvIII-Overexpressing, Erlotinib-Resistant Glioblastoma Cells to Tyrosine Kinase Inhibition.
Q37598057Historical Evolution of Second-Line Therapy in Non-Small Cell Lung Cancer
Q42292319Honokiol Induces Apoptosis, G1 Arrest, and Autophagy in KRAS Mutant Lung Cancer Cells
Q38858961Honokiol targets mitochondria to halt cancer progression and metastasis
Q95260313Hormone receptor expression correlates with EGFR gene mutation in lung cancer in patients with simultaneous primary breast cancer
Q37793837How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine
Q37245907How Molecular Understanding Affects to Prescribing Patterns and Clinical Outcome of Gefitinib in Non-small Cell Lung Cancer? 10 Year Experience of Single Institution
Q37588365How and when to use genetic markers for nonsmall cell lung cancer.
Q37065678How genetically engineered mouse tumor models provide insights into human cancers
Q26992045How many molecular subtypes? Implications of the unique tumor principle in personalized medicine
Q48411592How to develop novel treatments for EGFR-mutant lung cancer.
Q37587294How to unleash mitochondrial apoptotic blockades to kill cancers?
Q36429550How will lung cancer be treated in the future?
Q40352167Hsp90 inhibitors cause G2/M arrest associated with the reduction of Cdc25C and Cdc2 in lung cancer cell lines
Q36982771Human Mena+11a isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines
Q27023576Human correlates of provocative questions in pancreatic pathology
Q37538406Humoral immune responses to EGFR-derived peptides predict progression-free and overall survival of non-small cell lung cancer patients receiving gefitinib
Q52655439Hybrid Capture-Based Comprehensive Genomic Profiling Identifies Lung Cancer Patients with Well-Characterized Sensitizing Epidermal Growth Factor Receptor Point Mutations That Were Not Detected by Standard of Care Testing.
Q37379240Hydrogel-based protein array for quantifying epidermal growth factor receptor activity in cell lysates
Q60050105Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells
Q35591083Hypermethylated Epidermal growth factor receptor (EGFR) promoter is associated with gastric cancer
Q89206292Hypoxia Promotes Resistance to EGFR Inhibition in NSCLC Cells via the Histone Demethylases, LSD1 and PLU-1
Q40147314Hypoxia increases the motility of lung adenocarcinoma cell line A549 via activation of the epidermal growth factor receptor pathway
Q39302684Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors.
Q38968478Hypoxia induces resistance to ALK inhibitors in the H3122 non-small cell lung cancer cell line with an ALK rearrangement via epithelial-mesenchymal transition.
Q38659248ICRP Publication 131: Stem Cell Biology with Respect to Carcinogenesis Aspects of Radiological Protection
Q35631086IGDB.NSCLC: integrated genomic database of non-small cell lung cancer
Q39101764IGF-1R/epithelial-to-mesenchymal transition (EMT) crosstalk suppresses the erlotinib-sensitizing effect of EGFR exon 19 deletion mutations
Q35833023IL-8 confers resistance to EGFR inhibitors by inducing stem cell properties in lung cancer.
Q37520432IL-8 signaling is involved in resistance of lung carcinoma cells to erlotinib
Q47773490Icotinib versus gefitinib in previously treated advanced non-small-cell lung cancer (ICOGEN): a randomised, double-blind phase 3 non-inferiority trial
Q38666574Icotinib versus whole-brain irradiation in patients with EGFR-mutant non-small-cell lung cancer and multiple brain metastases (BRAIN): a multicentre, phase 3, open-label, parallel, randomised controlled trial
Q38352862Icotinib, a selective EGF receptor tyrosine kinase inhibitor, for the treatment of non-small-cell lung cancer
Q36843769Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells
Q79448974Identical epidermal growth factor receptor mutations in adenocarcinomatous and squamous cell carcinomatous components of adenosquamous carcinoma of the lung
Q38668707Identification and Validation of Driver Kinases from Next-Generation Sequencing Data
Q36557174Identification and characterization of RET fusions in advanced colorectal cancer
Q30877356Identification and preliminary characterization of novel small molecules that inhibit growth of human lung adenocarcinoma cells
Q24633776Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
Q42646980Identification of 10 Candidate Biomarkers Distinguishing Tuberculous and Malignant Pleural Fluid by Proteomic Methods.
Q34354515Identification of 33 candidate oncogenes by screening for base-specific mutations.
Q98384563Identification of 4-Anilino-6-aminoquinazoline Derivatives as Potential MERS-CoV Inhibitors
Q47100541Identification of Clinically Approved Drugs Indacaterol and Canagliflozin for Repurposing to Treat Epidermal Growth Factor Tyrosine Kinase Inhibitor-Resistant Lung Cancer
Q92350228Identification of Crucial Candidate Genes and Pathways in Glioblastoma Multiform by Bioinformatics Analysis
Q46393465Identification of EGFR kinase domain mutations among lung cancer patients in China: implication for targeted cancer therapy
Q54268313Identification of EGFR mutation, KRAS mutation, and ALK gene rearrangement in cytological specimens of primary and metastatic lung adenocarcinoma.
Q92102263Identification of Epidermal Growth Factor Receptor Tyrosine-Kinase Mutations in Non-small Cell Lung Cancer: Testing Platform Matters
Q91844098Identification of FOS as a Candidate Risk Gene for Liver Cancer by Integrated Bioinformatic Analysis
Q43161186Identification of RET gene fusion by exon array analyses in "pan-negative" lung cancer from never smokers
Q41637034Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma
Q39167915Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo
Q51326919Identification of a new insertion in exon 20 of EGFR in a woman with NSCLC.
Q34887667Identification of an exon 4-deletion variant of epidermal growth factor receptor with increased metastasis-promoting capacity
Q61815055Identification of antiproliferative emodin analogues as inhibitors of epidermal growth factor receptor in cancer
Q28239452Identification of cancer genes by mutational profiling of tumor genomes
Q45030586Identification of driver mutations in lung cancer: first step in personalized cancer
Q54457108Identification of epidermal growth factor receptor (EGFR) exon 20 single nucleotide polymorphism in Chinese squamous cell carcinoma of head and neck (SCCHN).
Q37368954Identification of exon 19 and 21 mutations of EGFR gene in Chinese patients with esophageal squamous cell carcinoma
Q31132212Identification of gefitinib off-targets using a structure-based systems biology approach; their validation with reverse docking and retrospective data mining
Q41623567Identification of microRNAs involved in gefitinib resistance of non-small-cell lung cancer through the insulin-like growth factor receptor 1 signaling pathway
Q37323468Identification of molecular targets in urologic oncology
Q33690276Identification of novel driver mutations of the discoidin domain receptor 2 (DDR2) gene in squamous cell lung cancer of Chinese patients
Q64105070Identification of novel mutations of Insulin Receptor Substrate 1 (IRS1) in tumor samples of non-small cell lung cancer (NSCLC): Implications for aberrant insulin signaling in development of cancer
Q35166315Identification of oncogenic point mutations and hyperphosphorylation of anaplastic lymphoma kinase in lung cancer.
Q91793139Identification of somatic copy number variations in plasma cell free DNA correlating with intrinsic resistances to EGFR targeted therapy in T790M negative non-small cell lung cancer
Q36897470Identification of structural aberrations in cancer by SNP array analysis
Q46557776Identification of the rare EGFR mutation p.G796S as somatic and germline mutation in white patients with squamous cell carcinoma of the head and neck
Q28511622Identification of the scaramanga gene implicates Neuregulin3 in mammary gland specification
Q27851410Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
Q36127636Identifying EGFR mutation-induced drug resistance based on alpha shape model analysis of the dynamics
Q91742348Identifying a wide range of actionable variants using capture-based ultra-deep targeted sequencing in treatment-naive patients with primary lung adenocarcinoma
Q26781810Identifying activating mutations in the EGFR gene: prognostic and therapeutic implications in non-small cell lung cancer
Q34295696Identifying and targeting ROS1 gene fusions in non-small cell lung cancer
Q90610221Identifying epidermal growth factor receptor mutation status in patients with lung adenocarcinoma by three-dimensional convolutional neural networks
Q35264584Identifying erlotinib-sensitive non-small cell lung carcinoma tumors in mice using [(11)C]erlotinib PET.
Q36328508Identifying molecular markers for the early detection of pancreatic neoplasia
Q38420747Identifying novel targets of oncogenic EGF receptor signaling in lung cancer through global phosphoproteomics.
Q89926672Identifying relationships between imaging phenotypes and lung cancer-related mutation status: EGFR and KRAS
Q37889967Identifying responders to trastuzumab therapy in breast cancer
Q55401345Identifying the Causes of Cancer Health Disparities: Biologic and Non Biologic Determinants.
Q37187172Imaging Characteristics in ALK Fusion-Positive Lung Adenocarcinomas by Using HRCT.
Q38137829Imaging EGFR and HER2 by PET and SPECT: a review
Q38852701Imaging in Advanced Non-Small Cell Lung Cancer: A Medical Oncology Perspective.
Q37320501Imaging of EGFR and EGFR tyrosine kinase overexpression in tumors by nuclear medicine modalities.
Q36050371Imaging of lung cancer in the era of molecular medicine
Q36654677Immediate Versus Delayed Treatment with EGFR Tyrosine Kinase Inhibitors after First-line Therapy in Advanced Non-small-cell Lung CANCER
Q38206386Immune regulation of therapy-resistant niches: emerging targets for improving anticancer drug responses
Q37898427Immunochemistry and lung cancer: application in diagnosis, prognosis and targeted therapy
Q38868664Immunohistochemical analysis of EGFR and hyaluronan in tongue cancer and the development of regional recurrence in patients initially diagnosed N0.
Q54399363Immunohistochemical detection of ROS1 is useful for identifying ROS1 rearrangements in lung cancers.
Q34008820Immunohistochemical expression of epidermal growth factor receptor (EGFR) in oral squamous cell carcinoma in relation to proliferation, apoptosis, angiogenesis and lymphangiogenesis
Q34158993Immunohistochemical staining with EGFR mutation-specific antibodies: high specificity as a diagnostic marker for lung adenocarcinoma
Q47140225Immunohistochemistry for predictive biomarkers in non-small cell lung cancer
Q51046274Immunohistochemistry with a novel mutation-specific monoclonal antibody as a screening tool for the EGFR L858R mutational status in primary lung adenocarcinoma.
Q57069991Immunotherapy combined with epidermal growth factor receptor-tyrosine kinase inhibitors in non-small-cell lung cancer treatment
Q38367414Immunotherapy for lung cancer: for whom the bell tolls?
Q51132444Immunotherapy in lung cancer.
Q55312983Immunotherapy in the Asiatic population: any differences from Caucasian population?
Q52624361Immunotherapy in treatment naïve advanced non-small cell lung cancer.
Q36797398Immunotherapy of cancer: from monoclonal to oligoclonal cocktails of anti-cancer antibodies: IUPHAR Review 18.
Q26751473Immunotoxin Therapies for the Treatment of Epidermal Growth Factor Receptor-Dependent Cancers
Q47654457Impact of Concurrent Genomic Alterations Detected by Comprehensive Genomic Sequencing on Clinical Outcomes in East-Asian Patients with EGFR-Mutated Lung Adenocarcinoma.
Q39957730Impact of EGFR gene polymorphisms on anticancer drug cytotoxicity in vitro
Q34339890Impact of EGFR inhibitor in non-small cell lung cancer on progression-free and overall survival: a meta-analysis
Q38937520Impact of EGFR mutations and KRAS amino acid substitution on the response to radiotherapy for brain metastasis of non-small-cell lung cancer.
Q50853655Impact of EGFR tyrosine kinase inhibitors versus chemotherapy on the development of leptomeningeal metastasis in never smokers with advanced adenocarcinoma of the lung.
Q34028470Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib
Q35852269Impact of Pre-Analytical Variables on Cancer Targeted Gene Sequencing Efficiency.
Q36534696Impact of Precision Medicine in Diverse Cancers: A Meta-Analysis of Phase II Clinical Trials
Q42949033Impact of Serum Hepatocyte Growth Factor on Treatment Response to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Patients with Non–Small Cell Lung Adenocarcinoma
Q50321656Impact of Weight Loss at Presentation on Survival in Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR-TKI) Sensitive Mutant Advanced Non-small Cell Lung Cancer (NSCLC) Treated with First-line EGFR-TKI.
Q37471822Impact of active smoking on survival of patients with metastatic lung adenocarcinoma harboring an epidermal growth factor receptor (EGFR) mutation
Q92646422Impact of age on EGFR mutations in never-smoking female lung adenocarcinoma patients with malignant pleural effusion
Q37742492Impact of biomarkers on non-small cell lung cancer treatment
Q40876078Impact of body surface area on survival in EGFR-mutant non-small cell lung cancer patients treated with gefitinib monotherapy: observational study of the Okayama Lung Cancer Study Group 0703.
Q97538360Impact of concurrent genomic alterations in epidermal growth factor receptor (EGFR)-mutated lung cancer
Q41612456Impact of country of birth on genetic testing of metastatic lung adenocarcinomas in France: African women exhibit a mutational spectrum more similar to Asians than to Caucasians
Q42167271Impact of epidermal growth factor receptor (EGFR) kinase mutations, EGFR gene amplifications, and KRAS mutations on survival of pancreatic adenocarcinoma
Q24625201Impact of epidermal growth factor receptor and KRAS mutations on clinical outcomes in previously untreated non-small cell lung cancer patients: results of an online tumor registry of clinical trials
Q53597217Impact of genetic diagnostics on drug development strategy.
Q80845931Impact of genetic polymorphisms in DNA repair enzymes on drug resistance in lung cancer
Q89543321Impact of somatic mutations on prognosis in resected non-small-cell lung cancer: The Japan Molecular Epidemiology for lung cancer study
Q85515558Impact of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification of stage IA adenocarcinoma of the lung: Correlation between computed tomography images and EGFR and KRAS gene
Q41879278Impact of thymidylate synthase protein expression on efficacy of chemotherapy in advanced lung cancer patients
Q92334155Impact of tumor microenvironment on the efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors in patients with EGFR-mutant non-small cell lung cancer
Q35560129Impact of upfront cellular enrichment by laser capture microdissection on protein and phosphoprotein drug target signaling activation measurements in human lung cancer: Implications for personalized medicine.
Q62512297Impact ofABCG2polymorphisms on the clinical outcome and toxicity of gefitinib in non-small-cell lung cancer patients
Q37186795Impact on disease-free survival of adjuvant erlotinib or gefitinib in patients with resected lung adenocarcinomas that harbor EGFR mutations
Q39712642Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations
Q39045171Implementation of a Precision Pathology Program Focused on Oncology-Based Prognostic and Predictive Outcomes.
Q34163458Implementation of biomarker-driven cancer therapy: existing tools and remaining gaps
Q37005953Implementation of genetics to personalize medicine
Q38320914Implementation of modern therapy approaches and research for non-small cell lung cancer in Japan
Q36383418Implementing multiplexed genotyping of non-small-cell lung cancers into routine clinical practice
Q34404229Implementing the new IASLC/ATS/ERS classification of lung adenocarcinomas: results from international and Chinese cohorts
Q37118974Implications of EGFR PharmDx kit for cetuximab eligibility
Q26764917Implications of MicroRNAs in the Treatment of Gefitinib-Resistant Non-Small Cell Lung Cancer
Q37678306Implications of key trials in advanced nonsmall cell lung cancer
Q98386333Implications of lipid droplets in lung cancer: Associations with drug resistance
Q83508020Implications of personalized medicine--perspective from a cancer center
Q34838412Importance of molecular features of non-small cell lung cancer for choice of treatment
Q38067427Importance of the cytological samples for the epidermal growth factor receptor gene mutation test for non-small cell lung cancer
Q38389841Improving Clinical Trial Efficiency: Thinking outside the Box.
Q42545098Improving Response Rates to EGFR-Targeted Therapies for Head and Neck Squamous Cell Carcinoma: Candidate Predictive Biomarkers and Combination Treatment with Src Inhibitors
Q42036423Improving clinical trial efficiency by biomarker-guided patient selection
Q51281967In Vitro Enzyme Kinetics Analysis of EGFR.
Q42758535In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma
Q35905204In silico analysis of the effect of mutation on epidermal growth factor receptor in non-small-cell lung carcinoma: from mutational analysis to drug designing
Q47355906In silico evaluation of the resistance of the T790M variant of epidermal growth factor receptor kinase to cancer drug Erlotinib.
Q54578263In silico screening of epidermal growth factor receptor (EGFR) in the tyrosine kinase domain through a medicinal plant compound database.
Q37270405In situ Protein Detection for Companion Diagnostics
Q27014174In vitro and in vivo models for analysis of resistance to anticancer molecular therapies
Q38905987In vitro antiproliferative effect of trastuzumab (Herceptin(®)) combined with cetuximab (Erbitux(®)) in a model of human non-small cell lung cancer expressing EGFR and HER2.
Q37250640In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation
Q27853236In vitro modeling to determine mutation specificity of EGFR tyrosine kinase inhibitors against clinically relevant EGFR mutants in non-small-cell lung cancer
Q39701114In vitro sequence-dependent synergism between paclitaxel and gefitinib in human lung cancer cell lines.
Q38998235In vitro study of normoxic epidermal growth factor receptor-induced hypoxia-inducible factor-1-alpha, vascular endothelial growth factor, and BNIP3 expression in head and neck squamous cell carcinoma cell lines: Implications for anti-epidermal growt
Q40031376In vivo tumor targeting and spectroscopic detection with surface-enhanced Raman nanoparticle tags
Q40290447In-frame deletion in the EGF receptor alters kinase inhibition by gefitinib
Q40462593Inactivation of ErbB3 by siRNA promotes apoptosis and attenuates growth and invasiveness of human lung adenocarcinoma cell line A549.
Q60921926Incense burning smoke sensitizes lung cancer cells to EGFR TKI by inducing AREG expression
Q36406111Incidence and survival of non-small cell lung cancer in Shanghai: a population-based cohort study.
Q35812244Incidence of EGFR exon 19 deletions and L858R in tumor specimens from men and cigarette smokers with lung adenocarcinomas
Q33999412Including total EGFR staining in scoring improves EGFR mutations detection by mutation-specific antibodies and EGFR TKIs response prediction
Q38406514Incorporating Erlotinib or Irinotecan Plus Cisplatin into Chemoradiotherapy for Stage III Non-small Cell Lung Cancer According to EGFR Mutation Status
Q38545768Incorporating traditional and emerging biomarkers in the clinical management of metastatic colorectal cancer.
Q37141676Incorporation of biologic therapies in the management of gastroesophageal cancers
Q36759284Increased detection rates of EGFR and KRAS mutations in NSCLC specimens with low tumour cell content by 454 deep sequencing
Q36082004Increased prevalence of EGFR-mutant lung cancer in women and in East Asian populations: analysis of estrogen-related polymorphisms
Q30279226Increased survival with the combination of stereotactic radiosurgery and gefitinib for non-small cell lung cancer brain metastasis patients: a nationwide study in Taiwan
Q55425422Indirect comparison of efficacy and safety between immune checkpoint inhibitors and antiangiogenic therapy in advanced non-small-cell lung cancer.
Q39367306Individual dose and scheduling determine the efficacy of combining cytotoxic anticancer agents with a kinase inhibitor in non-small-cell lung cancer
Q36318541Individualised cancer therapeutics: dream or reality?
Q36387788Individuality in FGF1 expression significantly influences platinum resistance and progression-free survival in ovarian cancer
Q42535408Individualization of treatment in non-small cell lung cancer
Q86073879Individualized chemotherapy for osteosarcoma and identification of gene mutations in osteosarcoma
Q37579648Individualized therapy in non-small-cell lung cancer: future versus current clinical practice
Q38260343Individualizing kinase-targeted cancer therapy: the paradigm of chronic myeloid leukemia.
Q26801711Induced pluripotent stem cell technology for dissecting the cancer epigenome
Q37552307Inducible Mouse Models for Cancer Drug Target Validation
Q36667008Induction of Apoptosis by PQ1, a Gap Junction Enhancer that Upregulates Connexin 43 and Activates the MAPK Signaling Pathway in Mammary Carcinoma Cells
Q36026392Induction of BIM is essential for apoptosis triggered by EGFR kinase inhibitors in mutant EGFR-dependent lung adenocarcinomas
Q37486272Induction of E-cadherin in lung cancer and interaction with growth suppression by histone deacetylase inhibition
Q34768930Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice
Q24650438Induction of cancer-specific cytotoxicity towards human prostate and skin cells using quercetin and ultrasound
Q90039016Influence of EGFR-activating mutations on sensitivity to tyrosine kinase inhibitors in a KRAS mutant non-small cell lung cancer cell line
Q59794876Influence of afatinib dose on outcomes of advanced EGFR-mutant NSCLC patients with brain metastases
Q35200458Influence of chemotherapy on EGFR mutation status
Q37659062Influence of chemotherapy on EGFR mutation status among patients with non-small-cell lung cancer.
Q51770090Influence of histological type, smoking history and chemotherapy on survival after first-line therapy in patients with advanced non-small cell lung cancer.
Q33586108Infrequent ERBB2 mutations in Chinese patients with non-small cell lung cancer
Q58804391Inherited lung cancer syndromes targeting never smokers
Q46782213Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR.
Q38970301Inhibiting epidermal growth factor receptor at a distance
Q36764876Inhibiting kinases in malignant gliomas
Q58207282Inhibition of EGFR Signaling Protects from Mucormycosis
Q33227206Inhibition of EGFR signaling: all mutations are not created equal
Q33571026Inhibition of Hsp90 down-regulates mutant epidermal growth factor receptor (EGFR) expression and sensitizes EGFR mutant tumors to paclitaxel
Q38866417Inhibition of IGF1R signaling abrogates resistance to afatinib (BIBW2992) in EGFR T790M mutant lung cancer cells
Q35261397Inhibition of Ubiquitin-specific Peptidase 8 Suppresses Growth of Gefitinib-resistant Non-small Cell Lung Cancer Cells by Inducing Apoptosis
Q36150646Inhibition of angiogenesis in cancer patients
Q38852858Inhibition of class IA PI3K enzymes in non-small cell lung cancer cells uncovers functional compensation among isoforms
Q33906140Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases
Q24810622Inhibition of insulin-like growth factor-1 receptor signaling enhances growth-inhibitory and proapoptotic effects of gefitinib (Iressa) in human breast cancer cells
Q24301761Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface
Q35528877Inhibition of the epidermal growth factor receptor by erlotinib prevents immortalization of human cervical cells by Human Papillomavirus type 16
Q40210754Inhibition of the epidermal growth factor receptor in bladder cancer cells treated with the DNA-damaging drug etoposide markedly increases apoptosis.
Q28079309Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application
Q33925323Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach
Q27851654Inhibitor-sensitive FGFR1 amplification in human non-small cell lung cancer
Q37111609Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma
Q46613450Inhibitors of epidermoid growth factor receptor suppress cell growth and enhance chemosensitivity of nasopharyngeal cancer cells in vitro
Q50866526Initiation of a formalized precision medicine program in gynecologic oncology.
Q43807392Insulin-like growth factor-1 receptor inhibition overcomes gefitinib resistance in mucinous lung adenocarcinoma.
Q37418930Insulin-like growth factor-1 receptor-targeted therapy for non-small cell lung cancer: a mini review
Q34330521Insulin-like growth factors and neoplasia.
Q37046462Integrated genomic approaches identify upregulation of SCRN1 as a novel mechanism associated with acquired resistance to erlotinib in PC9 cells harboring oncogenic EGFR mutation
Q37853183Integrating biomarkers in clinical trials
Q28077310Integrating cancer genomic data into electronic health records
Q33517983Integrating complex genomic datasets and tumour cell sensitivity profiles to address a 'simple' question: which patients should get this drug?
Q43040968Integrating molecular diagnostics into anticancer drug discovery.
Q26769744Integrating the molecular background of targeted therapy and immunotherapy in lung cancer: a way to explore the impact of mutational landscape on tumor immunogenicity
Q79227019Integration of EGFR inhibitors with radiochemotherapy
Q38880324Integration of Stereotactic Body Radiation Therapy With Tyrosine Kinase Inhibitors in Stage IV Oncogene-Driven Lung Cancer
Q28271520Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target
Q38057720Integration of phosphoproteomic, chemical, and biological strategies for the functional analysis of targeted protein phosphorylation
Q33673563Integrative analysis of multi-omics data reveals distinct impacts of DDB1-CUL4 associated factors in human lung adenocarcinomas
Q33774682Integrative and comparative genomic analysis of lung squamous cell carcinomas in East Asian patients
Q38322114Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer
Q37216672Integrative genomic approaches to understanding cancer.
Q30860315Integrative modeling of multi-platform genomic data under the framework of mediation analysis
Q37301705Integrative transcriptome analysis identifies deregulated microRNA-transcription factor networks in lung adenocarcinoma.
Q35482150Integrin beta-8 (ITGB8) silencing reverses gefitinib resistance of human hepatic cancer HepG2/G cell line
Q39134067Inter-cellular adhesion disruption and the RAS/RAF and beta-catenin signalling in lung cancer progression
Q46375753Interaction maps for kinase inhibitors
Q33408501Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial.
Q41437605Intercalating and maintenance gefitinib plus chemotherapy versus chemotherapy alone in selected advanced non-small cell lung cancer with unknown EGFR status
Q36474196Interfering with cell-survival signalling as a treatment strategy for prostate cancer.
Q37689066Interleukin-1 blockade overcomes erlotinib resistance in head and neck squamous cell carcinoma
Q38673369Intermittent high-dose treatment with erlotinib enhances therapeutic efficacy in EGFR-mutant lung cancer
Q28303718International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma
Q52446289Interobserver variability in tumor contouring affects the use of radiomics to predict mutational status.
Q36029824Interstitial lung disease in lung cancer: separating disease progression from treatment effects.
Q42278411Interstitial lung disease in patients with non-small-cell lung cancer: causes, mechanisms and management
Q36544282Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation.
Q91941020Intracellular paired agent imaging enables improved evaluation of tyrosine kinase inhibitor target engagement
Q37963231Intratumor heterogeneity and chemotherapy-induced changes in EGFR status in non-small cell lung cancer
Q40005057Intratumor heterogeneity of epidermal growth factor receptor mutations in lung cancer and its correlation to the response to gefitinib
Q35994416Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition
Q33700689Intratumoral distribution of EGFR mutations and copy number in metastatic lung cancer, what impact on the initial molecular diagnosis?
Q24603941Intratumoral epiregulin is a marker of advanced disease in non-small cell lung cancer patients and confers invasive properties on EGFR-mutant cells
Q36559630Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors.
Q26744339Intrinsic resistance to EGFR tyrosine kinase inhibitors in advanced non-small-cell lung cancer with activating EGFR mutations
Q34273541Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells
Q39131097Inverse correlation between Thr-669 and constitutive tyrosine phosphorylation in the asymmetric epidermal growth factor receptor dimer conformation
Q85857386Investigating Molecular Mechanisms of Activation and Mutation of the HER2 Receptor Tyrosine Kinase through Computational Modeling and Simulation
Q37736496Investigational EGFR-targeted therapy in head and neck squamous cell carcinoma
Q46547397Involvement of Rad51 in cytotoxicity induced by epidermal growth factor receptor inhibitor (gefitinib, IressaR) and chemotherapeutic agents in human lung cancer cells.
Q33821320Irreversible inhibitors of the EGF receptor may circumvent acquired resistance to gefitinib
Q42743773Is EGFR expression important in non-small cell lung cancer?
Q41092945Is MPP a good prognostic factor in stage III lung adenocarcinoma with EGFR exon 19 mutation?
Q44607835Is sex associated with the outcome of patients treated with radiation for nonsmall cell lung cancer?
Q26798882Is there a role for epidermal growth factor receptor tyrosine kinase inhibitors in epidermal growth factor receptor wild-type non-small cell lung cancer?
Q53060849Is there any predictor for clinical outcome in EGFR mutant NSCLC patients treated with EGFR TKIs?
Q37537093Is vascular endothelial growth factor modulation a predictor of the therapeutic efficacy of gefitinib for bladder cancer?
Q33403165Isolation of novel EGFR-specific VHH domains
Q33936071It's about time: lessons for solid tumors from chronic myelogenous leukemia therapy
Q35987345JAK2 inhibitor TG101348 overcomes erlotinib-resistance in non-small cell lung carcinoma cells with mutated EGF receptor
Q39328532JAK2-related pathway induces acquired erlotinib resistance in lung cancer cells harboring an epidermal growth factor receptor-activating mutation
Q34879739Jumping on the Train of Personalized Medicine: A Primer for Non- Geneticist Clinicians: Part 3. Clinical Applications in the Personalized Medicine Area
Q57909068KDR expression is associated with the stage and cigarette smoking of the patients with lung cancer
Q53242395KL-6 and CEA levels in epithelial lining fluid microsamples predict response to gefitinib in patients with advanced non-small cell lung cancer.
Q40542208KRAS Mutation Is a Significant Prognostic Factor in Early-stage Lung Adenocarcinoma
Q37815135KRAS and BRAF: drug targets and predictive biomarkers
Q21563446KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib
Q37681051KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling
Q37694808KRAS-mutation status dependent effect of zoledronic acid in human non-small cell cancer preclinical models
Q42950523Keap1 mutations in lung cancer patients
Q55083559Key differences between 13 KRAS mutation detection technologies and their relevance for clinical practice.
Q41768010Key drivers of biomedical innovation in cancer drug discovery
Q82150802Keynote comment: reimbursement for molecularly targeted anticancer agents
Q46555496Killing time for cancer cells
Q37060709Kinase inhibitor-responsive genotypes in EGFR mutated lung adenocarcinomas: moving past common point mutations or indels into uncommon kinase domain duplications and rearrangements
Q34307423Kinase pathway dependence in primary human leukemias determined by rapid inhibitor screening
Q37332008Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib
Q39347810Kinetics of inhibitor cycling underlie therapeutic disparities between EGFR-driven lung and brain cancers
Q64965123Knowledge base toward understanding actionable alterations and realizing precision oncology.
Q38390205Known and putative mechanisms of resistance to EGFR targeted therapies in NSCLC patients with EGFR mutations-a review
Q37728989L1198F Mutation Resensitizes Crizotinib to ALK by Altering the Conformation of Inhibitor and ATP Binding Sites
Q35943143L858R-positive lung adenocarcinoma with KRAS G12V, EGFR T790M and EGFR L858R mutations: A case report
Q64083382LAPTM4B is a novel diagnostic and prognostic marker for lung adenocarcinoma and associated with mutant EGFR
Q43188970LKB1/KRAS mutant lung cancers constitute a genetic subset of NSCLC with increased sensitivity to MAPK and mTOR signalling inhibition
Q64059672LUADpp: an effective prediction model on prognosis of lung adenocarcinomas based on somatic mutational features
Q38206271LUX-Lung 3: redundancy, toxicity or a major step forward? Afatinib as front-line therapy for patients with metastatic EGFR-mutated lung cancer
Q54296884LUX-Lung: determining the best EGFR inhibitor in NSCLC?
Q37696232LYN expression predicts the response to dasatinib in a subpopulation of lung adenocarcinoma patients.
Q58796615Label-free real-time ultrasensitive monitoring of non-small cell lung cancer cell interaction with drugs
Q39400167Lack of AKT activation in lung cancer cells with EGFR mutation is a novel marker of cetuximab sensitivity
Q37755493Lack of Cetuximab induced skin toxicity in a previously irradiated field: case report and review of the literature
Q54562020Lack of EGFR gene mutations in exons 19 and 21 in esophageal (Barrett's) adenocarcinomas.
Q35753530Lack of EGFR mutations benefiting gefitinib treatment in adenocarcinoma of esophagogastric junction
Q35889673Lack of EGFR-activating mutations in European patients with triple-negative breast cancer could emphasise geographic and ethnic variations in breast cancer mutation profiles
Q36616712Lack of clinical efficacy of imatinib in metastatic melanoma
Q36439293Lack of epidermal growth factor receptor gene mutations in exons 19 and 21 in primary lymphoepithelioma-like carcinoma of the lung
Q46965909Lack of prognostic value of EGFR mutations in primary resected non-small cell lung cancer
Q50775865Lack of trastuzumab activity in nonsmall cell lung carcinoma with overexpression of erb-B2: 39810: a phase II trial of Cancer and Leukemia Group B.
Q35831012Landscape of EGFR signaling network in human cancers: biology and therapeutic response in relation to receptor subcellular locations
Q90631641Landscape of Mitochondria Genome and Clinical Outcomes in Stage 1 Lung Adenocarcinoma
Q55485409Landscape of transcriptional deregulation in lung cancer.
Q55070923Lapatinib-associated mucocutaneous toxicities are clinical predictors of improved progression-free survival in patients with human epidermal growth factor receptor (HER2)-positive advanced breast cancer.
Q37059866Large-cell neuroendocrine carcinoma of lung with epidermal growth factor receptor (EGFR) gene mutation and co-expression of adenocarcinoma markers: a case report and review of the literature
Q54486463Large-cell neuroendocrine carcinoma with epidermal growth factor receptor mutation: possible transformation of lung adenocarcinoma.
Q33358603Laser capture microdissection and protein microarray analysis of human non-small cell lung cancer: differential epidermal growth factor receptor (EGPR) phosphorylation events associated with mutated EGFR compared with wild type
Q33788680Leptomeningeal Carcinomatosis in Recurrent Non-Small Cell Lung Cancer: A Case Report and Review of Current Treatment Modalities
Q47133535Leptomeningeal Disease and the Evolving Role of Molecular Targeted Therapy and Immunotherapy
Q36851421Lessons learned from the application of whole-genome analysis to the treatment of patients with advanced cancers
Q37810104Lestaurtinib: a multi-targeted FLT3 inhibitor
Q37708018Leveraging Genomic Factors to Improve Benefit-Risk
Q35965565Leveraging protein quaternary structure to identify oncogenic driver mutations
Q52723140Lgr5+ intestinal stem cells reside in an unlicensed G1 phase.
Q89762208Licochalcone D Induces ROS-Dependent Apoptosis in Gefitinib-Sensitive or Resistant Lung Cancer Cells by Targeting EGFR and MET
Q26797495Ligand-Independent EGFR Signaling
Q36254464Ligand-dependent responses of the ErbB signaling network: experimental and modeling analyses
Q35566222Ligand-independent phosphorylation of Y869 (Y845) links mutant EGFR signaling to stat-mediated gene expression
Q26829104Ligand-triggered resistance to molecular targeted drugs in lung cancer: roles of hepatocyte growth factor and epidermal growth factor receptor ligands
Q49684088Ligation-dependent RT-PCR: a new specific and low-cost technique to detect ALK, ROS, and RET rearrangements in lung adenocarcinoma.
Q33931015Limited importance of the dominant-negative effect of TP53 missense mutations
Q28253671Lineage dependency and lineage-survival oncogenes in human cancer
Q38859701Liquid Biopsies in the Screening of Oncogenic Mutations in NSCLC and its Application in Targeted Therapy
Q92028093Liquid Biopsy for the Detection of Resistance Mechanisms in NSCLC: Comparison of Different Blood Biomarkers
Q39279845Liquid biopsy: unlocking the potentials of cell-free DNA.
Q37716622Liver X receptors agonist GW3965 re-sensitizes gefitinib-resistant human non-small cell lung cancer cell to gefitinib treatment by inhibiting NF-κB in vitro
Q36904551Local therapy with continued EGFR tyrosine kinase inhibitor therapy as a treatment strategy in EGFR-mutant advanced lung cancers that have developed acquired resistance to EGFR tyrosine kinase inhibitors
Q37179405Locally advanced esophageal adenocarcinoma: current standards and molecular predictors of outcome
Q38734500Long and short noncoding RNAs in lung cancer precision medicine: Opportunities and challenges
Q42366666Long non-coding RNAs associated with non-small cell lung cancer
Q38682910Long noncoding RNAs: emerging regulators of tumor angiogenesis
Q102057123Long term follow-up of EGFR mutated NSCLC cases
Q53823427Long-term safety and survival with gefitinib in select patients with advanced non-small cell lung cancer: Results from the US IRESSA Clinical Access Program (ICAP).
Q34130681Long-term survival outcomes by smoking status in surgical and nonsurgical patients with non-small cell lung cancer: comparing never smokers and current smokers.
Q51147438Long-term treatment with EGFR inhibitor erlotinib attenuates renal inflammatory cytokines but not nephropathy in Alport syndrome mouse model.
Q98466270Longitudinal Monitoring of EGFR and PIK3CA Mutations by Saliva-Based EFIRM in Advanced NSCLC Patients With Local Ablative Therapy and Osimertinib Treatment: Two Case Reports
Q36916399Longitudinal monitoring of EGFR mutations in plasma predicts outcomes of NSCLC patients treated with EGFR TKIs: Korean Lung Cancer Consortium (KLCC-12-02)
Q89622158Looking for the high way in EGFR-positive non-small cell lung cancer through the evaluation of survival endpoints
Q49340076Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization.
Q49359622Losmapimod: A Novel Clinical Drug to Overcome Gefitinib-Resistance.
Q33977056Loss of EGFR signaling regulated miR-203 promotes prostate cancer bone metastasis and tyrosine kinase inhibitors resistance
Q36028210Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma
Q28481370Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells
Q36503161Loss of epidermal growth factor receptor expression in oral squamous cell carcinoma is associated with invasiveness and epithelial-mesenchymal transition
Q47653923Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells
Q33779389Loss-of-function CYP2C9 variants: finding the correct clinical role for Type 2 diabetes pharmacogenetic testing
Q39970216Lovastatin enhances gefitinib activity in glioblastoma cells irrespective of EGFRvIII and PTEN status
Q54440196Low prevalence of K-RAS, EGF-R and BRAF mutations in sinonasal adenocarcinomas. Implications for anti-EGFR treatments.
Q92577499Low-abundance mutations in colorectal cancer patients and healthy adults
Q38868797Low-fidelity alternative DNA repair carcinogenesis theory may interpret many cancer features and anticancer strategies
Q39096391Lower gefitinib dose led to earlier resistance acquisition before emergence of T790M mutation in epidermal growth factor receptor-mutated lung cancer model
Q36761452Lung Adenocarcinoma with Anaplastic Lymphoma Kinase (ALK) Rearrangement Presenting as Carcinoma of Unknown Primary Site: Recognition and Treatment Implications
Q39350278Lung Cancer Epidemiology in Korea.
Q38679289Lung Cancer Genomics in the Era of Accelerated Targeted Drug Development.
Q28386607Lung Cancer: Are we up to the Challenge?
Q53776017Lung Cancer: EGFR Inhibitors with Low Nanomolar Activity against a Therapy-Resistant L858R/T790M/C797S Mutant.
Q47127472Lung Cancer: Understanding Its Molecular Pathology and the 2015 WHO Classification
Q35887906Lung adenocarcinoma and human papillomavirus infection
Q53534519Lung adenocarcinoma and its thyroid metastasis characterized on fine-needle aspirates by cytomorphology, immunocytochemistry, and next-generation sequencing.
Q34281228Lung adenocarcinoma from East Asian never-smokers is a disease largely defined by targetable oncogenic mutant kinases
Q33967404Lung adenocarcinoma harboring L858R and T790M mutations in epidermal growth factor receptor, with poor response to gefitinib: A case report
Q35790212Lung adenocarcinoma harboring mutations in the ERBB2 kinase domain
Q36962487Lung adenocarcinoma in the era of targeted therapies: histological classification, sample prioritization, and predictive biomarkers
Q89579716Lung adenocarcinoma patient with an EGFR kinase domain duplication (KDD) and the response to icotinib
Q37438296Lung adenocarcinoma with EGFR amplification has distinct clinicopathologic and molecular features in never-smokers
Q53403793Lung adenocarcinoma: Assessment of epidermal growth factor receptor mutation status based on extended models of diffusion-weighted image.
Q37147755Lung adenocarcinoma: guiding EGFR-targeted therapy and beyond
Q34666826Lung adenocarcinomas induced in mice by mutant EGF receptors found in human lung cancers respond to a tyrosine kinase inhibitor or to down-regulation of the receptors
Q35207787Lung cancer and lung injury: the dual role of ceramide
Q37487153Lung cancer biology: a genetic and genomic perspective.
Q26775396Lung cancer biomarkers, targeted therapies and clinical assays
Q33861083Lung cancer cytology: potential pitfalls and mimics - a review
Q29615414Lung cancer in never smokers--a different disease
Q58804388Lung cancer in never smokers-the East Asian experience
Q34177155Lung cancer in never smokers: molecular profiles and therapeutic implications
Q36026075Lung cancer in never-smokers
Q35861107Lung cancer in the era of precision medicine
Q44477692Lung cancer in women: the differences in epidemiology, biology and treatment outcomes
Q39356534Lung cancer samples preserved in liquid medium: One step beyond cytology
Q34541960Lung cancer therapeutics that target signaling pathways: an update
Q38476124Lung cancer treatment - Biology based decision, from gene to histology
Q37114965Lung cancer with concurrent EGFR mutation and ROS1 rearrangement: a case report and review of the literature
Q35667888Lung cancer, thyroid cancer or both: An unusual case presentation
Q36328370Lung cancer: Biology and treatment options
Q46049056Lung cancer: New biological insights and recent therapeutic advances
Q37622985Lung cancer: a biologically different disease in women?
Q87903213Lung cancer: dropping bars or rising hoops--phase III outcomes of NSCLC
Q34354426Lung cancer: intragenic ERBB2 kinase mutations in tumours
Q39741320Lung cancers unrelated to smoking: characterized by single oncogene addiction?
Q36140332Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.
Q34104798Lung injury and cancer: Mechanistic insights into ceramide and EGFR signaling under cigarette smoke
Q37755025Lung microRNA: from development to disease
Q36501975Lungs don't forget: Comparison of the KRAS and EGFR mutation profile and survival of collegiate smokers and never smokers with advanced lung cancers
Q54337332M2-polarized macrophages contribute to the decreased sensitivity of EGFR-TKIs treatment in patients with advanced lung adenocarcinoma.
Q37268998MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin
Q96431732MDL-800, an allosteric activator of SIRT6, suppresses proliferation and enhances EGFR-TKIs therapy in non-small cell lung cancer
Q38051474MEK and RAF inhibitors for BRAF-mutated cancers
Q37427045MEK inhibitors against MET-amplified non-small cell lung cancer
Q42354586MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated.
Q42019758MEK1/2 inhibition elicits regression of autochthonous lung tumors induced by KRASG12D or BRAFV600E.
Q35872321MEK1/2 inhibitor selumetinib (AZD6244) inhibits growth of ovarian clear cell carcinoma in a PEA-15-dependent manner in a mouse xenograft model
Q36788312MET Exon 14 Skipping in Non-Small Cell Lung Cancer.
Q35606387MET FISH-positive status predicts short progression-free survival and overall survival after gefitinib treatment in lung adenocarcinoma with EGFR mutation
Q28551045MET Gene Amplification and MET Receptor Activation Are Not Sufficient to Predict Efficacy of Combined MET and EGFR Inhibitors in EGFR TKI-Resistant NSCLC Cells
Q38709287MET amplification and epithelial-to-mesenchymal transition exist as parallel resistance mechanisms in erlotinib-resistant, EGFR-mutated, NSCLC HCC827 cells
Q27851406MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
Q24646295MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
Q37520331MET exon 14 skipping defines a unique molecular class of non-small cell lung cancer
Q36140765MET expression and copy number heterogeneity in nonsquamous non-small cell lung cancer (nsNSCLC).
Q37399525MET gene amplification or EGFR mutation activate MET in lung cancers untreated with EGFR tyrosine kinase inhibitors
Q38390016MET inhibition in lung cancer
Q34033952MET receptor sequence variants R970C and T992I lack transforming capacity
Q64929599MICAL-L2 potentiates Cdc42-dependent EGFR stability and promotes gastric cancer cell migration.
Q35417648ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth.
Q35781614MLH1 V384D polymorphism associates with poor response to EGFR tyrosine kinase inhibitors in patients with EGFR L858R-positive lung adenocarcinoma
Q33570512MMP9 but Not EGFR, MET, ERCC1, P16, and P-53 Is Associated with Response to Concomitant Radiotherapy, Cetuximab, and Weekly Cisplatin in Patients with Locally Advanced Head and Neck Cancer
Q38803437MRP3 as a novel resistance factor for sorafenib in hepatocellular carcinoma.
Q39311676Macroporous hydrogel micropillars for quantifying Met kinase activity in cancer cell lysates
Q39293814Major Tumor Suppressor and Oncogenic Non-Coding RNAs: Clinical Relevance in Lung Cancer.
Q64054076Major vault protein suppresses lung cancer cell proliferation by inhibiting STAT3 signaling pathway
Q46070125Making a difference with teamwork.
Q33846850Making sense of cancer genomic data
Q90947631Making the first move in EGFR-driven or ALK-driven NSCLC: first-generation or next-generation TKI?
Q38089834Malignant glioma drug discovery - targeting protein kinases
Q36499234Malignant gliomas: strategies to increase the effectiveness of targeted molecular treatment
Q35108421Malignant pleural effusion supernatants are substitutes for metastatic pleural tumor tissues in EGFR mutation test in patients with advanced lung adenocarcinoma
Q54166640Management Strategies for Adverse Events Associated With EGFR TKIs in Non-Small Cell Lung Cancer.
Q90300758Management of Brain Metastases in Epidermal Growth Factor Receptor Mutant Non-Small-Cell Lung Cancer
Q38685481Management of EGFR-mutated non-small-cell lung cancer: practical implications from a clinical and pathology perspective
Q38258633Management of NSCLC: focus on crizotinib
Q49887989Management of acquired resistance to EGFR TKI-targeted therapy in advanced non-small cell lung cancer.
Q26865779Management of acquired resistance to epidermal growth factor receptor kinase inhibitors in patients with advanced non-small cell lung cancer
Q38131165Management of non-small-cell lung cancer: recent developments
Q33892597Management of patients with advanced non-small cell lung cancer: role of gefitinib
Q90167972Managing Lung Cancer with Comorbid Interstitial Pneumonia
Q37003374Markers of systemic inflammation predict survival in patients with advanced renal cell cancer.
Q34350615Mass spectrometry-based proteomics: the road to lung cancer biomarker discovery
Q37706977Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2.
Q33398142Matrix metalloproteinase-2 polymorphisms and clinical outcome of Chinese patients with nonsmall cell lung cancer treated with first-line, platinum-based chemotherapy
Q59800637Mechanism of Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors and a Potential Treatment Strategy
Q52568478Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer.
Q36682301Mechanisms and insights into drug resistance in cancer
Q34277873Mechanisms behind the inhibition of lung adenocarcinoma cell by shikonin
Q38459398Mechanisms of Acquired Resistance to ALK Inhibitors and the Rationale for Treating ALK-positive Lung Cancer
Q37217229Mechanisms of Disease: signal transduction in lung carcinogenesis -- a comparison of smokers and never-smokers
Q28069900Mechanisms of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance and Strategies to Overcome Resistance in Lung Adenocarcinoma
Q38669280Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors and Therapeutic Approaches: An Update
Q42043613Mechanisms of Resistance to Epidermal Growth Factor Receptor Inhibitors and Novel Therapeutic Strategies to Overcome Resistance in NSCLC Patients
Q39185608Mechanisms of Resistance to Immune Checkpoint Antibodies.
Q52312436Mechanisms of Resistance to Target Therapies in Non-small Cell Lung Cancer.
Q50146512Mechanisms of acquired resistance to first- and second-generation EGFR tyrosine kinase inhibitors.
Q39308771Mechanisms of acquired resistance to insulin-like growth factor 1 receptor inhibitor in MCF-7 breast cancer cell line.
Q38034816Mechanisms of acquired resistance to targeted cancer therapies.
Q36559283Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy
Q36953160Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway--therapeutic perspectives in cancer
Q36472437Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer
Q39056242Mechanisms of epidermal growth factor receptor signaling as characterized by patterned ligand activation and mutational analysis
Q35043706Mechanisms of resistance to EGFR TKIs and development of a new generation of drugs in non-small-cell lung cancer
Q36887721Mechanisms of resistance to EGFR targeted therapies
Q28077415Mechanisms of resistance to EGFR-targeted drugs: lung cancer
Q39242812Mechanisms of resistance to ErbB-targeted cancer therapeutics
Q37671920Mechanisms of resistance to HER family targeting antibodies
Q28074073Mechanisms of resistance to anti-EGFR therapy in colorectal cancer
Q97538337Mechanisms of resistance to osimertinib
Q36942619Mechanisms of resistance to reversible inhibitors of EGFR tyrosine kinase in non-small cell lung cancer.
Q36573324Mechanisms of resistance to small molecule kinase inhibition in the treatment of solid tumors
Q83390165Mechanisms of tumor resistance to EGFR-targeted therapies
Q90333285Mechanistic insights into differential requirement of receptor dimerization for oncogenic activation of mutant EGFR and its clinical perspective
Q39603355Mechanistic insights into the activation of oncogenic forms of EGF receptor
Q36107597Mediastinal staging of NSCLC with endoscopic and endobronchial ultrasound
Q98467275Medical management of brain metastases
Q42190258Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice
Q36772001Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells
Q34749765Membrane-anchored growth factors, the epidermal growth factor family: beyond receptor ligands
Q36249213Membrane-bound estrogen receptor-α expression and epidermal growth factor receptor mutation are associated with a poor prognosis in lung adenocarcinoma patients
Q36224439Membranous and cytoplasmic expression of epidermal growth factor receptor in metastatic pancreatic ductal adenocarcinoma
Q30415408Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells
Q39911616Met gene copy number predicts the prognosis for completely resected non-small cell lung cancer
Q34449385Meta-analysis of first-line therapies in advanced non-small-cell lung cancer harboring EGFR-activating mutations
Q91646512Metabolic Remodelling: An Accomplice for New Therapeutic Strategies to Fight Lung Cancer
Q36903072Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer
Q35588724Metaplastic breast carcinomas are negative for Her-2 but frequently express EGFR (Her-1): potential relevance to adjuvant treatment with EGFR tyrosine kinase inhibitors?
Q25257542Metaplastic breast carcinomas exhibit EGFR, but not HER2, gene amplification and overexpression: immunohistochemical and chromogenic in situ hybridization analysis
Q36031278Metastatic Squamous Cell Carcinoma Component from an Adenosquamous Carcinoma of the Lung with Identical Epidermal Growth Factor Receptor Mutations
Q37871213Metastatic non-small-cell lung cancer: consensus on pathology and molecular tests, first-line, second-line, and third-line therapy: 1st ESMO Consensus Conference in Lung Cancer; Lugano 2010.
Q93379419Metastatic osteosarcoma challenged by regorafenib
Q92597887Metformin Prolongs Survival in Type 2 Diabetes Lung Cancer Patients With EGFR-TKIs
Q37848661Methodological and practical challenges for personalized cancer therapies
Q36540555Methodological aspects of current problems in target-based anticancer drug development
Q35925441Methylation of death-associated protein kinase is associated with cetuximab and erlotinib resistance
Q42013793Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma
Q38833904MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line
Q37274389MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers
Q37681498MiRNA-125a-5p: a regulator and predictor of gefitinib's effect on nasopharyngeal carcinoma
Q37702742MicroRNA expression profiles and clinicopathological implications in lung adenocarcinoma according to EGFR, KRAS, and ALK status
Q39433270MicroRNA-21 versus microRNA-34: Lung cancer promoting and inhibitory microRNAs analysed in silico and in vitro and their clinical impact
Q38826622MicroRNA-221 targets PTEN to reduce the sensitivity of cervical cancer cells to gefitinib through the PI3K/Akt signaling pathway
Q42315789MicroRNA-30e reduces cell growth and enhances drug sensitivity to gefitinib in lung carcinoma
Q37723702MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab
Q36429673MicroRNAs as a potential magic bullet in cancer.
Q38917573MicroRNAs in non-small cell lung cancer and idiopathic pulmonary fibrosis.
Q37297730MicroRNAs in the pathogenesis of Lung Cancer
Q42354892MicroRNAs: a new tool in the complex biology of KRAS mutated non-small cell lung cancer?
Q38430945Microarray gene expression analysis of chemosensitivity for docetaxel, cisplatin and 5-fluorouracil (TPF) combined chemotherapeutic regimen in hypopharyngeal squamous cell carcinoma
Q34975977Micropapillary lung adenocarcinoma: EGFR, K-ras, and BRAF mutational profile
Q26748947Migraine in the era of precision medicine
Q39214395Milestones in the systemic treatment of lung cancer
Q64936082Miliary lung metastases from non-small cell lung cancer with Exon 20 insertion: A dismal prognostic entity: A case report.
Q48125418Miliary metastases are associated with epidermal growth factor receptor mutations in non-small cell lung cancer: a population-based study.
Q34796086Mind-mapping for lung cancer: towards a personalized therapeutics approach
Q33631471Minireview: Familiar Faces in Unfamiliar Places: The Emerging Role of Nuclear Receptors in Lung Cancer
Q35679203Mir-660 is downregulated in lung cancer patients and its replacement inhibits lung tumorigenesis by targeting MDM2-p53 interaction
Q40467961Missense Mutations in Exons 18-24 of EGFR in Hepatocellular Carcinoma Tissues.
Q37347485Mitochondria: gatekeepers of response to chemotherapy
Q39890068Mitogen-activated protein kinase phosphatase-1 modulated JNK activation is critical for apoptosis induced by inhibitor of epidermal growth factor receptor-tyrosine kinase
Q64298060Mixed response to osimertinib and the beneficial effects of additional local therapy
Q36910615Modeling NSCLC progression: recent advances and opportunities available
Q92531307Modeling Tumor Growth and Treatment Resistance Dynamics Characterizes Different Response to Gefitinib or Chemotherapy in Non-Small Cell Lung Cancer
Q38721547Modeling gene-wise dependencies improves the identification of drug response biomarkers in cancer studies
Q28484612Modeling of tumor progression in NSCLC and intrinsic resistance to TKI in loss of PTEN expression
Q36840172Modeling oncogene addiction using RNA interference.
Q89598805Molecular Analysis of Liquid-Based Cytological Specimen Using Virtually Positive Sputum with Adenocarcinoma Cells
Q37120887Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase
Q28070038Molecular Diagnostics for Precision Medicine in Colorectal Cancer: Current Status and Future Perspective
Q58700723Molecular Diagnostics in Clinical Oncology
Q35849985Molecular Epidemiology of EGFR Mutations in Asian Patients with Advanced Non-Small-Cell Lung Cancer of Adenocarcinoma Histology - Mainland China Subset Analysis of the PIONEER study
Q35216709Molecular Imaging in Optical Coherence Tomography
Q34213559Molecular Mechanisms that Regulate Epidermal Growth Factor Receptor Inactivation
Q26771116Molecular Pathology and Personalized Medicine: The Dawn of a New Era in Companion Diagnostics-Practical Considerations about Companion Diagnostics for Non-Small-Cell-Lung-Cancer
Q42926986Molecular Predictors of Sensitivity to the MET Inhibitor PHA665752 in Lung Carcinoma Cells
Q37347532Molecular Targeted Drugs and Biomarkers in NSCLC, the Evolving Role of Individualized Therapy
Q37589551Molecular Targeted Therapy in Modern Oncology: Imaging Assessment of Treatment Response and Toxicities
Q38869420Molecular Targeting of Growth Factor Receptor Signaling in Radiation Oncology
Q47141828Molecular Targets in Non-Small Cell Lung Cancer
Q38582997Molecular Testing in Multiple Synchronous Lung Adenocarcinomas: Case Report and Literature Review
Q55564375Molecular Therapies in Thyroid Cancer.
Q38258822Molecular alterations in non-small-cell lung cancer: perspective for targeted therapy and specimen management for the bronchoscopist
Q37683112Molecular alterations in uterine serous carcinoma
Q37349875Molecular alterations of EGFR and PIK3CA in uterine serous carcinoma
Q51019080Molecular alterations of EGFR in small intestinal adenocarcinoma.
Q37350516Molecular analysis of metaplastic breast carcinoma: high EGFR copy number via aneusomy
Q46594292Molecular analysis of the EGFR gene in astrocytic gliomas: mRNA expression, quantitative-PCR analysis of non-homogeneous gene amplification and DNA sequence alterations.
Q30811836Molecular analysis of the EGFR-RAS-RAF pathway in pancreatic ductal adenocarcinomas: lack of mutations in the BRAF and EGFR genes
Q38292199Molecular analysis-based treatment strategies for non-small cell lung cancer
Q33843578Molecular and clinical responses in a pilot study of gefitinib with paclitaxel and radiation in locally advanced head-and-neck cancer
Q36993693Molecular basis for multimerization in the activation of the epidermal growth factor receptor
Q36612550Molecular basis for sensitivity and acquired resistance to gefitinib in HER2-overexpressing human gastric cancer cell lines derived from liver metastasis.
Q24606677Molecular biology of lung cancer
Q37653893Molecular biology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.
Q24610335Molecular biology of lung cancer: clinical implications
Q36273001Molecular biology of medulloblastoma: will it ever make a difference to clinical management?
Q33969308Molecular biomarkers in non-small-cell lung cancer: a retrospective analysis of data from the phase 3 FLEX study
Q63366116Molecular characterisation and liquid biomarkers in Carcinoma of Unknown Primary (CUP): taking the ‘U’ out of ‘CUP’
Q34778891Molecular characteristics of non-small cell lung cancer with reduced CHFR expression in The Cancer Genome Atlas (TCGA) project
Q35681816Molecular characteristics predict clinical outcomes: prospective trial correlating response to the EGFR tyrosine kinase inhibitor gefitinib with the presence of sensitizing mutations in the tyrosine binding domain of the EGFR gene
Q33475963Molecular characterization of EGFR, PDGFRA and VEGFR2 in cervical adenosquamous carcinoma.
Q89426902Molecular characterization of pulmonary sarcomatoid carcinoma: analysis of 33 cases
Q37666114Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance
Q36240941Molecular chess? Hallmarks of anti-cancer drug resistance
Q56795277Molecular classification of nonsmall cell lung cancer using a 4-protein quantitative assay
Q58053853Molecular classification of papillary thyroid carcinoma: distinct BRAF, RAS and RET/PTC mutation-specific gene expression profiles discovered by DNA microarray analysis
Q43805944Molecular determinations of EGFR and EML4-ALK on a single slide of NSCLC tissue
Q48458378Molecular diagnostic algorithm for epidermal growth factor receptor mutation detection in Asian lung adenocarcinomas: comprehensive analyses of 445 Taiwanese patients with immunohistochemistry, PCR-direct sequencing and Scorpion/ARMS methods.
Q37037132Molecular diagnostic testing in malignant gliomas: a practical update on predictive markers
Q43226909Molecular diagnostics in lung carcinoma for therapy stratification
Q43690882Molecular diagnostics of lung cancer in the clinic
Q36370600Molecular diagnostics of non-small cell lung cancer using mediastinal lymph nodes sampled by endoscopic ultrasound-guided needle aspiration
Q42822469Molecular dynamics analysis of conserved hydrophobic and hydrophilic bond-interaction networks in ErbB family kinases
Q51099791Molecular dynamics and pharmacophore modelling studies of different subtype (ALK and EGFR (T790M)) inhibitors in NSCLC.
Q41144243Molecular dynamics simulation analysis of the effect of T790M mutation on epidermal growth factor receptor protein architecture in non-small cell lung carcinoma
Q64265169Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare mutations
Q24611043Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: higher susceptibility of women to smoking-related KRAS-mutant cancers
Q42951192Molecular factors related to gefitinib efficacy in advanced non-small cell lung cancer
Q38117105Molecular genetic testing for lung adenocarcinomas: a practical approach to clinically relevant mutations and translocations
Q37206476Molecular genetics of lung cancer in people who have never smoked
Q37732704Molecular imaging and targeted therapies
Q48451660Molecular imaging of EGFR kinase activity in tumors with 124I-labeled small molecular tracer and positron emission tomography.
Q34534164Molecular imaging of active mutant L858R EGF receptor (EGFR) kinase-expressing nonsmall cell lung carcinomas using PET/CT
Q37061902Molecular imaging of nonsmall cell lung carcinomas expressing active mutant EGFR kinase using PET with [(124)i]-morpholino-IPQA
Q28544659Molecular interaction of a kinase inhibitor midostaurin with anticancer drug targets, S100A8 and EGFR: transcriptional profiling and molecular docking study for kidney cancer therapeutics
Q36673960Molecular markers for novel therapeutic strategies in pancreatic endocrine tumors
Q36634023Molecular markers of prognosis and novel therapeutic strategies for urothelial cell carcinomas
Q34560236Molecular mechanism of the schedule-dependent synergistic interaction in EGFR-mutant non-small cell lung cancer cell lines treated with paclitaxel and gefitinib
Q42290027Molecular mechanism underlying the pharmacological interactions of the protein kinase C-β inhibitor enzastaurin and erlotinib in non-small cell lung cancer cells
Q39411432Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers
Q33828409Molecular mechanisms of acquired resistance to tyrosine kinase targeted therapy
Q35104755Molecular mechanisms of cigarette smoke-induced proliferation of lung cells and prevention by vitamin C.
Q38060727Molecular mechanisms of lung-specific toxicity induced by epidermal growth factor receptor tyrosine kinase inhibitors
Q35001415Molecular mechanisms of resistance to the EGFR monoclonal antibody cetuximab
Q39172297Molecular mechanisms of therapy resistance in solid tumors: chasing "moving" targets
Q26769659Molecular mechanisms that underpin EML4-ALK driven cancers and their response to targeted drugs
Q36567573Molecular mechanisms underlying the antitumor activity of 3-aminopropanamide irreversible inhibitors of the epidermal growth factor receptor in non-small cell lung cancer.
Q35256622Molecular methods for somatic mutation testing in lung adenocarcinoma: EGFR and beyond
Q36468815Molecular modeling and description of a newly characterized activating mutation of the EGFR gene in non-small cell lung cancer
Q37602884Molecular modeling of ErbB4/HER4 kinase in the context of the HER4 signaling network helps rationalize the effects of clinically identified HER4 somatic mutations on the cell phenotype
Q37919395Molecular oncology of lung cancer
Q38012566Molecular pathogenesis of malignant mesothelioma
Q38459875Molecular pathology in oncology--the AstraZeneca perspective
Q34194997Molecular pathology of lung cancer: current status and future directions
Q27691299Molecular pathology of lung cancer: key to personalized medicine
Q27690919Molecular pathology of non-small cell lung cancer: a practical guide
Q36868012Molecular phenotype predicts sensitivity of squamous cell carcinoma of the head and neck to epidermal growth factor receptor inhibition
Q37606747Molecular predictive and prognostic markers in non-small-cell lung cancer.
Q36772562Molecular predictors of EGFR-TKI sensitivity in advanced non-small cell lung cancer
Q36788498Molecular predictors of chemotherapy response in non-small-cell lung cancer
Q36498832Molecular predictors of response to tyrosine kinase inhibitors in patients with Non-Small-Cell Lung Cancer
Q33696507Molecular profile of lung cancer in never smokers
Q92536292Molecular profile of non-small cell lung cancer in northeastern Brazil
Q36691733Molecular profiling of lung carcinoma: identifying clinically useful tumor markers for diagnosis and prognosis
Q37417261Molecular profiling of sinonasal undifferentiated carcinoma
Q54461448Molecular profiling of thin-prep FNA samples in assisting clinical management of non-small-cell lung cancer.
Q26830588Molecular recognition of gangliosides and their potential for cancer immunotherapies
Q44070495Molecular spectrum of somatic EGFR and KRAS gene mutations in non small cell lung carcinoma: determination of frequency, distribution pattern and identification of novel variations in Indian patients
Q39214067Molecular subtype and response to dasatinib, an Src/Abl small molecule kinase inhibitor, in hepatocellular carcinoma cell lines in vitro
Q33609045Molecular systems biology of ErbB1 signaling: bridging the gap through multiscale modeling and high-performance computing
Q36944441Molecular targeted therapies for pancreatic cancer
Q46780845Molecular targeted therapy for lung cancer
Q36547758Molecular targeted therapy of lung cancer: EGFR mutations and response to EGFR inhibitors
Q26828860Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors
Q34159011Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular
Q26824599Molecular testing in lung cancer in the era of precision medicine
Q37771888Molecular testing in lung cancer: the time is now.
Q92326347Molecular testing strategies in non-small cell lung cancer: optimizing the diagnostic journey
Q34608584Molecular therapeutic advances in personalized therapy of melanoma and non-small cell lung cancer
Q37458175Molecular therapy in head and neck oncology
Q33699594Molecular tumor board: the University of California-San Diego Moores Cancer Center experience
Q47130146Molecular-Targeted Therapies for Epidermal Growth Factor Receptor and Its Resistance Mechanisms.
Q36929734Molecularly targeted approaches herald a new era of non-small-cell lung cancer treatment
Q36859958Molecularly targeted therapies for advanced or metastatic non-small-cell lung carcinoma
Q33644407Molecularly targeted therapies for malignant glioma: rationale for combinatorial strategies
Q35136424Molecularly targeted therapies in non-small-cell lung cancer annual update 2014
Q36829847Molecularly targeted therapy for malignant glioma
Q36326239Molecularly-targeted therapies for non-small cell lung cancer
Q46793091Molecule-kinase interaction map.
Q35962944Monitoring Conformational Changes in the Receptor Tyrosine Kinase EGFR.
Q80100680Monitoring EGFR-mutant lung cancers by means of the blood
Q35004426Monitoring of epidermal growth factor receptor tyrosine kinase inhibitor-sensitizing and resistance mutations in the plasma DNA of patients with advanced non-small cell lung cancer during treatment with erlotinib
Q36514558Monitoring of high-density lipoprotein cholesterol level is predictive of EGFR mutation and efficacy of EGFR-TKI in patients with advanced lung adenocarcinoma
Q47617131Monoamines in Glioblastoma: complex biology with therapeutic potential.
Q37051227Morphine-induced epidermal growth factor pathway activation in non-small cell lung cancer
Q33594324Morphologic features of adenocarcinoma of the lung predictive of response to the epidermal growth factor receptor kinase inhibitors erlotinib and gefitinib
Q38765690Morphometric and cytomorphologic characterization of EGFR-mutated cancer cells-comparison between cultured lung cancer cell lines and lung adenocarcinoma clinical samples
Q36184798Morphoproteomics: exposing protein circuitries in tumors to identify potential therapeutic targets in cancer patients
Q38431277Mouse hospital and co-clinical trial project--from bench to bedside.
Q36547732Mouse models of human non-small-cell lung cancer: raising the bar.
Q47108604Moving more potent and less toxic options to the frontline in the management of advanced lung cancer
Q24683814Mucinous differentiation correlates with absence of EGFR mutation and presence of KRAS mutation in lung adenocarcinomas with bronchioloalveolar features
Q35541778Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience
Q82976088Multicenter Phase II trial of high-dose imatinib mesylate in metastatic melanoma: significant toxicity with no clinical efficacy
Q84444587Multicenter analysis of lung cancer patients younger than 45 years in Shanghai
Q36494159Multicentre prospective phase II trial of gefitinib for advanced non-small cell lung cancer with epidermal growth factor receptor mutations: results of the West Japan Thoracic Oncology Group trial (WJTOG0403).
Q35799619Multigene amplification and massively parallel sequencing for cancer mutation discovery
Q36936796Multimodality imaging of the HER-kinase axis in cancer
Q34123261Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin
Q35237841Multiplatform comparison of molecular oncology tests performed on cytology specimens and formalin-fixed, paraffin-embedded tissue.
Q89747760Multiple Growth Factor Targeting by Engineered Insulin-like Growth Factor Binding Protein-3 Augments EGF Receptor Tyrosine Kinase Inhibitor Efficacy
Q39246320Multiple analyses of G-protein coupled receptor (GPCR) expression in the development of gefitinib-resistance in transforming non-small-cell lung cancer
Q59807868Multiple configurations of EGFR exon 20 resistance mutations after first- and third-generation EGFR TKI treatment affect treatment options in NSCLC
Q41986671Multiplex Real-Time PCR Assays that Measure the Abundance of Extremely Rare Mutations Associated with Cancer
Q40479483Multiplex Ultrasensitive Genotyping of Patients with Non-Small Cell Lung Cancer for Epidermal Growth Factor Receptor (EGFR) Mutations by Means of Picodroplet Digital PCR.
Q35169273Multiplex mutation screening by mass spectrometry evaluation of 820 cases from a personalized cancer medicine registry
Q37595545Multiplexed fluorescence imaging of tumor biomarkers in gene expression and protein levels for personalized and predictive medicine
Q91741802Multiplexed molecular profiling of lung cancer with malignant pleural effusion using next generation sequencing in Chinese patients
Q36163327Multiplexed quantification of estrogen receptor and HER2/Neu in tissue and cell lysates by peptide immunoaffinity enrichment mass spectrometry
Q37633877Multiplexed transcriptome analysis to detect ALK, ROS1 and RET rearrangements in lung cancer
Q37443767Multiscale cancer modeling
Q51128947Mutant allele frequency predicts the efficacy of EGFR-TKIs in lung adenocarcinoma harboring the L858R mutation.
Q59812799Mutation Detection and Its Association With Clinicopathological Characters of Lung Cancer Patients
Q89206835Mutation Yield of a 34-Gene Solid Tumor Panel in Community-Based Tumor Samples
Q52642806Mutation abundance affects the therapeutic efficacy of EGFR-TKI in patients with advanced lung adenocarcinoma: A retrospective analysis.
Q38804094Mutation analysis of EGFR and its correlation with the HPV in Indian cervical cancer patients.
Q31162700Mutation analysis of genes in the EGFR pathway in Head and Neck cancer patients: implications for anti-EGFR treatment response
Q51437092Mutation analysis of the EGFR gene and its downstream signaling pathway in thymic carcinoma patients from a Chinese Han population.
Q55004879Mutation analysis of the EGFR pathway genes, EGFR, RAS, PIK3CA, BRAF, and AKT1, in salivary gland adenoid cystic carcinoma.
Q40149065Mutation and polymorphism in the EGFR-TK domain associated with lung cancer.
Q60445017Mutation de l’EGFR, de l’étude du gène à la pratique clinique : exemplarité ou exception ?
Q33412122Mutation detection by real-time PCR: a simple, robust and highly selective method
Q33856261Mutation detection of epidermal growth factor receptor and KRAS genes using the smart amplification process version 2 from formalin-fixed, paraffin-embedded lung cancer tissue
Q50613227Mutation of ERBB2 provides a novel alternative mechanism for the ubiquitous activation of RAS-MAPK in ovarian serous low malignant potential tumors.
Q39813481Mutation of epidermal growth factor receptor is associated with MIG6 expression
Q36383360Mutation of the PIK3CA oncogene in human cancers
Q40237141Mutation profile of EGFR gene detected by denaturing high-performance liquid chromatography in Japanese lung cancer patients
Q43223369Mutation profile of JAK2 transcripts in patients with chronic myeloproliferative neoplasias
Q34457501Mutation profiling of tumor DNA from plasma and tumor tissue of colorectal cancer patients with a novel, high-sensitivity multiplexed mutation detection platform
Q28484396Mutation scanning using MUT-MAP, a high-throughput, microfluidic chip-based, multi-analyte panel
Q54373177Mutation status of somatic EGFR and KRAS genes in Chinese patients with prostate cancer (PCa).
Q37512938Mutation-associated fusion cancer genes in solid tumors.
Q97885892Mutational Portrait of Lung Adenocarcinoma in Brazilian Patients: Past, Present, and Future of Molecular Profiling in the Clinic
Q55281004Mutational Screening in Tyrosine-Kinase Domain of erbB1 And erbB2 Genes.
Q36824808Mutational activation of ErbB family receptor tyrosine kinases: insights into mechanisms of signal transduction and tumorigenesis
Q46881384Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism
Q37558631Mutational analyses of multiple oncogenic pathways in intraductal papillary mucinous neoplasms of the pancreas.
Q54671910Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas.
Q33283995Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4
Q35948040Mutational analysis of the insulin-like growth factor 1 receptor tyrosine kinase domain in non-small cell lung cancer patients
Q34650735Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1
Q41545847Mutational frequency of KRAS, NRAS, IDH2, PIK3CA, and EGFR in North Indian gallbladder cancer patients.
Q21261249Mutational profiling of kinases in glioblastoma
Q41535851Mutational profiling of second primary lung cancers in patients who have received radiation for the treatment of Hodgkin's disease
Q33534522Mutations in epidermal growth factor receptor and K-ras in Chinese patients with colorectal cancer
Q34747189Mutations in epidermal growth factor receptor gene in esophageal squamous cell carcinoma patients in kashmir- a high incidence area of India.
Q27851720Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer
Q24669579Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
Q35558988Mutations in the epidermal growth factor receptor (EGFR) gene in triple negative breast cancer: possible implications for targeted therapy
Q37110011Mutations in the epidermal growth factor receptor gene and effects of EGFR-tyrosine kinase inhibitors on lung cancers.
Q36615150Mutations in the epidermal growth factor receptor gene are linked to smoking-independent, lung adenocarcinoma
Q37823422Mutations in the epidermal growth factor receptor gene in non-small cell lung cancer: Impact on treatment beyond gefitinib and erlotinib
Q80241919Mutations in the epidermal growth factor receptor tyrosine kinase may predict response to gefitinib in non-small-cell lung cancer
Q37349031Mutations in the polybasic juxtamembrane sequence of both plasma membrane- and endoplasmic reticulum-localized epidermal growth factor receptors confer ligand-independent cell transformation
Q46973585Mutations in the tyrosine kinase domain of the EGFR gene are rare in synovial sarcoma
Q51051494Mutations of the EGFR and K-ras genes in resected stage I lung adenocarcinoma and their clinical significance.
Q52892289Mutations of the EGFR, K-ras, EML4-ALK, and BRAF genes in resected pathological stage I lung adenocarcinoma.
Q36121584Mutations of the epidermal growth factor receptor gene in NSCLC patients
Q35551048Mutations within the tyrosine kinase domain of EGFR gene specifically occur in lung adenocarcinoma patients with a low exposure of tobacco smoking
Q35380919N-cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells
Q34631703N-cadherin expression is associated with acquisition of EMT phenotype and with enhanced invasion in erlotinib-resistant lung cancer cell lines
Q38631853NF-κB drives acquired resistance to a novel mutant-selective EGFR inhibitor
Q64055892NGFI-A Binding Protein 2 Promotes EGF-Dependent HNSCC Cell Invasion
Q92255821NSCLC Mutated Isoforms of CCDC6 Affect the Intracellular Distribution of the Wild Type Protein Promoting Cisplatinum Resistance and PARP Inhibitors Sensitivity in Lung Cancer Cells
Q38793074NSCLC harboring EGFR exon-20 insertions after the regulatory C-helix of kinase domain responds poorly to known EGFR inhibitors
Q35063769NVP-BEZ235 overcomes gefitinib-acquired resistance by down-regulating PI3K/AKT/mTOR phosphorylation
Q27011692Nanomedicine therapeutic approaches to overcome cancer drug resistance
Q57377197Nanoparticles combined with growth factors: recent progress and applications
Q37822705Nanoparticles for the development of improved (bio)sensing systems
Q28072745Narrowing the focus: a toolkit to systematically connect oncogenic signaling pathways with cancer phenotypes
Q24305218Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors
Q34551144Nedd4-1 is an exceptional prognostic biomarker for gastric cardia adenocarcinoma and functionally associated with metastasis
Q42292974Neoadjuvant Oncogene-Targeted Therapy in Early Stage Non-Small-Cell Lung Cancer as a Strategy to Improve Clinical Outcome and Identify Early Mechanisms of Resistance
Q38694837Neoadjuvant chemotherapy by bronchial arterial infusion in patients with unresectable stage III squamous cell lung cancer
Q38185175Neoadjuvant therapy for localized prostate cancer: Examining mechanism of action and efficacy within the tumor
Q47915799Neoantigens in the immuno-oncology space
Q37603346Neratinib: an oral, irreversible dual EGFR/HER2 inhibitor for breast and non-small cell lung cancer
Q33813119Network biomarkers, interaction networks and dynamical network biomarkers in respiratory diseases
Q28677268Network-based drug discovery by integrating systems biology and computational technologies
Q37579308Neuromedin B receptors regulate EGF receptor tyrosine phosphorylation in lung cancer cells.
Q55709770Neuropeptide G Protein-Coupled Receptors as Oncotargets.
Q34483541Neurotensin (NTS) and its receptor (NTSR1) causes EGFR, HER2 and HER3 over-expression and their autocrine/paracrine activation in lung tumors, confirming responsiveness to erlotinib
Q45268799Never-smoking nonsmall cell lung cancer as a separate entity: clinicopathologic features and survival
Q92377401New Era for Next-Generation Sequencing in Japan
Q39453653New Insight into microRNA Functions in Cancer: Oncogene-microRNA-Tumor Suppressor Gene Network.
Q35088122New Response Evaluation Criteria in Solid Tumors (RECIST) guidelines for advanced non-small cell lung cancer: comparison with original RECIST and impact on assessment of tumor response to targeted therapy
Q38947183New and emerging targeted treatments in advanced non-small-cell lung cancer.
Q38163931New approach to cancer therapy based on a molecularly defined cancer classification.
Q52646651New drug candidates for treatment of atypical meningiomas: An integrated approach using gene expression signatures for drug repurposing.
Q36616537New drugs for the treatment of metastatic or refractory soft tissue sarcomas in children
Q58769699New drugs in thoracic oncology: needs and knowledge - an online ERS Lung Cancer Assembly survey
Q47159366New insights in non-small-cell lung cancer: circulating tumor cells and cell-free DNA.
Q24680988New molecularly targeted therapies for lung cancer
Q39139889New options in the management of intractable ALK(+) metastatic non-small-cell lung cancer
Q34998576New prognostic factors and scoring system for patients with skeletal metastasis
Q26775385New strategies in immunotherapy for non-small cell lung cancer
Q37724947New strategies in personalized medicine for solid tumors: molecular markers and clinical trial designs
Q37080517New strategies in squamous cell carcinoma of the lung: identification of tumor drivers to personalize therapy
Q37853198New targeted therapies for gastric cancer
Q42024692New targets and challenges in the molecular therapeutics of cancer
Q37936432New targets and targeted drugs for the treatment of cancer: an outlook to pediatric oncology
Q24806486New targets for therapy in breast cancer: small molecule tyrosine kinase inhibitors
Q38114835New targets in non-small cell lung cancer
Q38949133New therapeutic perspectives in CCDC6 deficient lung cancer cells
Q26746230New treatment options for ALK+ advanced non-small-cell lung cancer: critical appraisal of ceritinib
Q28067439Next generation sequencing techniques in liquid biopsy: focus on non-small cell lung cancer patients
Q39114552Next-Generation EGFR Tyrosine Kinase Inhibitors for Treating EGFR-Mutant Lung Cancer beyond First Line
Q28079320Next-generation EGFR/HER tyrosine kinase inhibitors for the treatment of patients with non-small-cell lung cancer harboring EGFR mutations: a review of the evidence
Q35726787Next-generation sequencing for molecular diagnosis of lung adenocarcinoma specimens obtained by fine needle aspiration cytology
Q35078128Next-generation sequencing of lung cancer EGFR exons 18-21 allows effective molecular diagnosis of small routine samples (cytology and biopsy).
Q34657670Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants.
Q60957062Nile Tilapia Derived TP4 Shows Broad Cytotoxicity Toward to Non-Small-Cell Lung Cancer Cells
Q33779303Nimotuzumab plus chemotherapy versus chemotherapy alone in advanced non-small-cell lung cancer: a multicenter, randomized, open-label Phase II study
Q39139857Nimotuzumab, a novel monoclonal antibody to the epidermal growth factor receptor, in the treatment of non-small cell lung cancer
Q37558534Nimotuzumab: a novel anti-EGFR monoclonal antibody that retains anti-EGFR activity while minimizing skin toxicity
Q34385995Nomogram Predicting Clinical Outcomes in Non-small Cell Lung Cancer Patients Treated with Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors
Q90747070Non-Small Cell Lung Cancer in Countries of Central and Southeastern Europe: Diagnostic Procedures and Treatment Reimbursement Surveyed by the Central European Cooperative Oncology Group
Q64244179Non-Smoking-Associated Lung Cancer: A distinct Entity in Terms of Tumor Biology, Patient Characteristics and Impact of Hereditary Cancer Predisposition
Q28730066Non-antioxidant properties of α-tocopherol reduce the anticancer activity of several protein kinase inhibitors in vitro
Q52716935Non-canonical functions of the RB protein in cancer.
Q39163315Non-classic EGFR mutations in a cohort of Dutch EGFR-mutated NSCLC patients and outcomes following EGFR-TKI treatment.
Q100694461Non-invasive detection of EGFR mutations by cell-free loop-mediated isothermal amplification (CF-LAMP)
Q36924440Non-small Cell Lung Cancer with Concomitant EGFR, KRAS, and ALK Mutation: Clinicopathologic Features of 12 Cases
Q47146342Non-small cell lung cancer (NSCLC), EGFR downstream pathway activation and TKI targeted therapies sensitivity: Effect of the plasma membrane-associated NEU3.
Q37874487Non-small cell lung cancer in never smokers as a representative 'non-smoking-associated lung cancer': epidemiology and clinical features
Q37859221Non-small cell lung cancer in never-smokers: a new disease entity?
Q47139758Non-small cell lung cancer treatment (r)evolution: ten years of advances and more to come.
Q34558586Non-small cell lung cancer with EML4-ALK translocation in Chinese male never-smokers is characterized with early-onset
Q26740333Non-small cell lung cancer: current treatment and future advances
Q28278682Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship
Q37645231Non-small cell lung cancer: the era of targeted therapy
Q37692660Non-small-cell lung cancer harbouring mutations in the EGFR kinase domain
Q36850900Non-small-cell lung cancer: molecular targeted therapy and personalized medicine - drug resistance, mechanisms, and strategies
Q38233321Non-small-cell lung cancers: a heterogeneous set of diseases
Q36622817Noncovalent wild-type-sparing inhibitors of EGFR T790M
Q37321820Noncytotoxic suramin as a chemosensitizer in patients with advanced non-small-cell lung cancer: a phase II study.
Q33735738Noninvasive saliva-based EGFR gene mutation detection in patients with lung cancer.
Q33909660Noninvasive urinary metabolomic profiling identifies diagnostic and prognostic markers in lung cancer.
Q38865192Norcantharidin combined with EGFR-TKIs overcomes HGF-induced resistance to EGFR-TKIs in EGFR mutant lung cancer cells via inhibition of Met/PI3k/Akt pathway
Q26744284Not all epidermal growth factor receptor mutations in lung cancer are created equal: Perspectives for individualized treatment strategy
Q58790384Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC
Q38999795Novel [99mTcN]2+ labeled EGFR inhibitors as potential radiotracers for single photon emission computed tomography (SPECT) tumor imaging.
Q34389263Novel agents in development for advanced non-small cell lung cancer
Q46255077Novel and existing mutations in the tyrosine kinase domain of the epidermal growth factor receptor are predictors of optimal resectability in malignant peritoneal mesothelioma
Q37923386Novel approaches to treating leptomeningeal metastases
Q37772496Novel biomarkers of metastatic cancer
Q38152899Novel cancer therapies: treatments driven by tumour biology
Q39238873Novel dithiocarbamic acid esters derived from 6-aminomethyl-4-anilinoquinazolines and 6-aminomethyl-4-anilino-3-cyanoquinolines as potent EGFR inhibitors
Q34158952Novel epidermal growth factor receptor mutation-specific antibodies for non-small cell lung cancer: immunohistochemistry as a possible screening method for epidermal growth factor receptor mutations
Q36612451Novel heteroduplex method using small cytology specimens with a remarkably high success rate for analysing EGFR gene mutations with a significant correlation to gefitinib efficacy in non-small-cell lung cancer
Q28386773Novel insights into the molecular origins and treatment of lung cancer
Q36045973Novel kinase inhibitors in renal cell carcinoma: progressive development of static agents
Q82562299Novel kinase inhibitors in renal cell carcinoma: progressive development of static agents
Q37702126Novel multi-targeted ErbB family inhibitor afatinib blocks EGF-induced signaling and induces apoptosis in neuroblastoma
Q37038500Novel targets in non-small cell lung cancer: ROS1 and RET fusions
Q36187046Novel therapeutics in adult malignant brain gliomas
Q51707848Novel use for an EGFR mutation-specific antibody in discriminating lung adenocarcinoma from reactive pneumocyte hyperplasia.
Q36864786Nuclear excision repair-based personalized therapy for non-small cell lung cancer: from hypothesis to reality
Q36798851Nuclear mode of the EGFR signaling network: biology, prognostic value, and therapeutic implications
Q38810432Nuclear trafficking of EGFR by Vps34 represses Arf expression to promote lung tumor cell survival
Q35063410Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells
Q42431173Numerical indices based on circulating tumor DNA for the evaluation of therapeutic response and disease progression in lung cancer patients
Q46073617O-Mel-Inib: a Cancéro-pôle Nord-Ouest multicenter phase II trial of high-dose imatinib mesylate in metastatic uveal melanoma.
Q36530038Observation of hepatotoxicity during long-term gefitinib administration in patients with non-small-cell lung cancer
Q41976220Occupy EGFR.
Q50316870Octogenarians with EGFR-mutated non-small cell lung cancer treated by tyrosine-kinase inhibitor: a multicentric real-world study assessing tolerance and efficacy (OCTOMUT study).
Q36108082Oligo-recurrence predicts favorable prognosis of brain-only oligometastases in patients with non-small cell lung cancer treated with stereotactic radiosurgery or stereotactic radiotherapy: a multi-institutional study of 61 subjects
Q90349512Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors
Q91761286Oligosaccharyltransferase: A Gatekeeper of Health and Tumor Progression
Q37188017Omics and therapy - a basis for precision medicine
Q91238291Onco-omics Approaches and Applications in Clinical Trials for Cancer Patients
Q44945808Oncocytic, focally anaplastic, thyroid cancer responding to erlotinib
Q38355156Oncogene addiction: pathways of therapeutic response, resistance, and road maps toward a cure
Q35729391Oncogene mutation profiling of pediatric solid tumors reveals significant subsets of embryonal rhabdomyosarcoma and neuroblastoma with mutated genes in growth signaling pathways
Q33510334Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells
Q36016428Oncogene status predicts patterns of metastatic spread in treatment-naive nonsmall cell lung cancer
Q35623817Oncogenes come of age.
Q41009749Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.
Q36337966Oncogenic PI3K deregulates transcription and translation
Q27852800Oncogenic RIT1 mutations in lung adenocarcinoma
Q33902463Oncogenic activity of epidermal growth factor receptor kinase mutant alleles is enhanced by the T790M drug resistance mutation
Q45916835Oncogenic driver mutations in patients with non-small-cell lung cancer at various clinical stages.
Q47147399Oncogenic driver mutations, treatment, and EGFR-TKI resistance in a Caucasian population with non-small cell lung cancer: survival in clinical practice
Q38213830Oncogenic drivers, targeted therapies, and acquired resistance in non-small-cell lung cancer
Q33943421Oncogenic mutant forms of EGFR: lessons in signal transduction and targets for cancer therapy
Q34073766Oncogenic mutations are associated with histological subtypes but do not have an independent prognostic value in lung adenocarcinoma
Q24321210Oncogenic mutations counteract intrinsic disorder in the EGFR kinase and promote receptor dimerization
Q24810573Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants
Q37295261Oncologist's/haematologist's view on the roles of pathologists for molecular targeted cancer therapy
Q37782592Oncomutations as biomarkers of cancer risk.
Q37069689Opportunities and challenges in the era of molecularly targeted agents and radiation therapy
Q38520010Opportunities and challenges in using studies without a control group in comparative effectiveness reviews
Q36883671Optimal duration of chemotherapy in advanced non-small cell lung cancer
Q37822780Optimal management of patients with non-small cell lung cancer and epidermal growth factor receptor mutations
Q26859993Optimal therapeutic strategy for non-small cell lung cancer with mutated epidermal growth factor receptor
Q36406541Optimization of dosing for EGFR-mutant non-small cell lung cancer with evolutionary cancer modeling
Q37756959Optimization of genetics to create therapies for metastatic (stage IV) non-small-cell lung cancer
Q38405477Optimization of patient selection for EGFR-TKIs in advanced non-small cell lung cancer by combined analysis of KRAS, PIK3CA, MET, and non-sensitizing EGFR mutations
Q36354945Optimized expression-based microdissection of formalin-fixed lung cancer tissue.
Q36430307Optimizing chemotherapy and targeted agent combinations in NSCLC.
Q53088478Optimizing endobronchial ultrasound for molecular analysis. How many passes are needed?
Q36441490Optimizing response to gefitinib in the treatment of non-small-cell lung cancer
Q35112467Optimizing the sequence of anti-EGFR-targeted therapy in EGFR-mutant lung cancer
Q39128273Optimizing treatment for patients with anaplastic lymphoma kinase-positive lung cancer
Q37996453Oral tyrosine kinase inhibitors in the first-line treatment of advanced non-small cell lung cancer
Q28652806Organizing knowledge to enable personalization of medicine in cancer
Q28083032Organoid development in cancer genome discovery
Q47131461Organotypic three-dimensional cancer cell cultures mirror drug responses in vivo: lessons learned from the inhibition of EGFR signaling.
Q54213250Osimertinib Western and Asian clinical pharmacokinetics in patients and healthy volunteers: implications for formulation, dose, and dosing frequency in pivotal clinical studies.
Q38790929Osimertinib for EGFR T790M mutation-positive non-small cell lung cancer
Q39002726Osimertinib for the treatment of non-small cell lung cancer
Q33757134Osimertinib in patients with advanced epidermal growth factor receptor T790M mutation-positive non-small cell lung cancer: rationale, evidence and place in therapy
Q38598893Osimertinib in the treatment of non-small-cell lung cancer: design, development and place in therapy
Q38991958Osimertinib in the treatment of patients with epidermal growth factor receptor T790M mutation-positive metastatic non-small cell lung cancer: clinical trial evidence and experience
Q54959395Osimertinib in untreated epidermal growth factor receptor (EGFR)-mutated advanced non-small cell lung cancer.
Q35368205Our changing view of the genomic landscape of cancer
Q35584972Outcomes after combined modality therapy for EGFR-mutant and wild-type locally advanced NSCLC.
Q51317673Outcomes of Malaysian patients with advanced lung adenocarcinoma and unknown epidermal growth factor receptor mutation status treated with gefitinib.
Q50122983Outcomes of an Australian testing programme for epidermal growth factor receptor mutations in non-small cell lung cancer.
Q45936261Outpacing cancer.
Q38040628Ovarian cancer: advances in first-line treatment strategies with a particular focus on anti-angiogenic agents.
Q81578551Ovarian granulosa cell tumors frequently express EGFR (Her-1), Her-3, and Her-4: An immunohistochemical study
Q36750945Overall survival benefits of first-line EGFR tyrosine kinase inhibitors in EGFR-mutated non-small-cell lung cancers: a systematic review and meta-analysis.
Q37057914Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors
Q58599659Overcoming EGFR-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors
Q42716087Overcoming erlotinib resistance with tailored treatment regimen in patient-derived xenografts from naïve Asian NSCLC patients
Q40996325Overcoming resistance of targeted EGFR monotherapy by inhibition of STAT3 escape pathway in soft tissue sarcoma
Q26745427Overcoming resistance to first/second generation epidermal growth factor receptor tyrosine kinase inhibitors and ALK inhibitors in oncogene-addicted advanced non-small cell lung cancer
Q36812355Overcoming resistance to molecularly targeted anticancer therapies: Rational drug combinations based on EGFR and MAPK inhibition for solid tumours and haematologic malignancies
Q26795556Overcoming resistance to targeted therapies in NSCLC: current approaches and clinical application
Q37357692Overcoming resistance to tyrosine kinase inhibitors: lessons learned from cancer cells treated with EGFR antagonists
Q48301559Overexpression of ATP-Binding Cassette Subfamily G Member 2 Confers Resistance to Phosphatidylinositol 3-Kinase Inhibitor PF-4989216 in Cancer Cells.
Q24678516Overexpression of PIAS3 suppresses cell growth and restores the drug sensitivity of human lung cancer cells in association with PI3-K/Akt inactivation
Q36615322Overexpression of aurora B kinase (AURKB) in primary non-small cell lung carcinoma is frequent, generally driven from one allele, and correlates with the level of genetic instability
Q37619679Overexpression of mutant EGFR protein indicates a better survival benefit from EGFR-TKI therapy in non-small cell lung cancer
Q37157333Overview of chemoradiation clinical trials for locally advanced non-small cell lung cancer in Japan
Q37579644Overview of molecular testing in non-small-cell lung cancer: mutational analysis, gene copy number, protein expression and other biomarkers of EGFR for the prediction of response to tyrosine kinase inhibitors.
Q35763328Overview of the development of personalized genomic medicine and surgery
Q36690248Overview of the pharmacoeconomics of pharmacogenetics
Q86506613PCR-sequencing is a complementary method to amplification refractory mutation system for EGFR gene mutation analysis in FFPE samples
Q37013280PD-1/PD-L1 expression in non-small-cell lung cancer and its correlation with EGFR/KRAS mutations
Q47124504PD-L1 promoter methylation mediates the resistance response to anti-PD-1 therapy in NSCLC patients with EGFR-TKI resistance
Q42942636PDGFRA, PDGFRB, EGFR, and downstream signaling activation in malignant peripheral nerve sheath tumor
Q50326521PET Imaging-Based Phenotyping as a Predictive Biomarker of Response to Tyrosine Kinase Inhibitor Therapy in Non-small Cell Lung Cancer: Are We There Yet?
Q35653992PET imaging of patients with non-small cell lung cancer employing an EGF receptor targeting drug as tracer.
Q37039348PI3K signaling in glioma--animal models and therapeutic challenges
Q35808438PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations
Q34028766PIK3CA and KRAS mutations predict for response to everolimus therapy: now that’s RAD001
Q36545534PIK3CA mutation detection in metastatic biliary cancer using cell-free DNA
Q54360869PIK3CA mutation is an early event in the development of endometriosis-associated ovarian clear cell adenocarcinoma.
Q38584695PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab
Q34616536PIK3CA mutations and EGFR overexpression predict for lithium sensitivity in human breast epithelial cells
Q33987852PIK3CA mutations frequently coexist with RAS and BRAF mutations in patients with advanced cancers
Q39826662PKC-delta binds to E-cadherin and mediates EGF-induced cell scattering
Q38087648PROFILing non-small-cell lung cancer patients for treatment with crizotinib according to anaplastic lymphoma kinase abnormalities: translating science into medicine.
Q38732488PROTOCADHERIN 7 Acts through SET and PP2A to Potentiate MAPK Signaling by EGFR and KRAS during Lung Tumorigenesis
Q38629644PTEN and PI3K/AKT in non-small-cell lung cancer.
Q44846498PTEN and PIK3CA expression is associated with prolonged survival after gefitinib treatment in EGFR-mutated lung cancer patients.
Q39398876PTMScan direct: identification and quantification of peptides from critical signaling proteins by immunoaffinity enrichment coupled with LC-MS/MS.
Q36788450Paclitaxel poliglumex (PPX, CT-2103): macromolecular medicine for advanced non-small-cell lung cancer
Q36487089Paclitaxel-carboplatin combination chemotherapy in advanced breast cancer: accumulating evidence for synergy, efficacy, and safety
Q36900261Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer
Q37398845Parameters for individualizing systemic therapy in non-small cell lung cancer
Q35584647Part 4: pharmacogenetic variability in anticancer pharmacodynamic drug effects
Q88790399Past, present and future of gene expression-tailored therapy for lung cancer
Q37389526Pathogenesis of lung cancer signalling pathways: roadmap for therapies
Q36233709Pathogenesis of lung cancer: 100 year report
Q34781357Pathways driving the endocytosis of mutant and wild-type EGFR in cancer
Q44507827Patient harboring a novel PIK3CA point mutation after acquired resistance to crizotinib in an adenocarcinoma with ROS1 rearrangement: A case report and literature review
Q47895107Patient selection criteria and the FLEX Study
Q40340984Patient selection in non-small cell lung cancer: Histologic versus molecular subtypes?
Q28080046Patient-derived tumour xenografts for breast cancer drug discovery
Q39377749Patients with peritoneal mesothelioma lack epidermal growth factor receptor tyrosine kinase mutations that would make them sensitive to tyrosine kinase inhibitors
Q64267035Pattern of recurrence after CyberKnife stereotactic body radiotherapy for peripheral early non-small cell lung cancer
Q93136766Patterns of brain metastasis in anaplastic lymphoma kinase - rearranged and epidermal growth factor receptor-mutated lung cancer patients in magnetic resonance imaging
Q36334789Patterns of epidermal growth factor receptor mutation in non-small-cell lung cancers in the Gulf region
Q41559395Patterns of spread and prognostic implications of lung cancer metastasis in an era of driver mutations.
Q48322740Paul Ehrlich's magic bullet concept: 100 years of progress
Q36273006Pediatric high-grade glioma: molecular genetic clues for innovative therapeutic approaches
Q80671770Pediatric oncology
Q36187075Pemetrexed Singlet Versus Nonpemetrexed-Based Platinum Doublet as Second-Line Chemotherapy after First-Line Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitor Failure in Non-small Cell Lung Cancer Patients with EGFR Mutations
Q47952924Pemetrexed monotherapy for chemo-naïve elderly (aged ≥80) patients with non-squamous non-small cell lung cancer: results from combined analysis of two single arm phase II studies (HANSHIN002 and 003).
Q55070748Pemetrexed-based chemotherapy in advanced lung adenocarcinoma patients with different EGFR genotypes.
Q36187118Peptide Nucleic Acid Clamping Versus Direct Sequencing for the Detection of EGFR Gene Mutation in Patients with Non-small Cell Lung Cancer
Q40013710Peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based detection test for gefitinib-refractory T790M epidermal growth factor receptor mutation.
Q38176989Peptide nucleic acids: a review on recent patents and technology transfer
Q33520512Peptidic tumor targeting agents: the road from phage display peptide selections to clinical applications
Q53338991Percutaneous computed tomography-guided lung biopsy and pleural dissemination: an assessment by intraoperative pleural lavage cytology.
Q46862765Percutaneous image-guided biopsy of prostate cancer metastases yields samples suitable for genomics and personalised oncology
Q34235130Performance of standard procedures in detection of EGFR mutations in daily practice in advanced NSCLC patients selected according to the ESMO guideline: a large Caucasian cohort study
Q36462861Perimembrane Aurora-A expression is a significant prognostic factor in correlation with proliferative activity in non-small-cell lung cancer (NSCLC).
Q40479158Peroxisome proliferator-activated receptor-gamma (PPAR(gamma)) inhibits tumorigenesis by reversing the undifferentiated phenotype of metastatic non-small-cell lung cancer cells (NSCLC).
Q64354468Personalised Medicine: The Odyssey from Hope to Practice
Q36089579Personalized Combined Modality Therapy for Locally Advanced Non-small Cell Lung Cancer
Q39453553Personalized and precision medicine: integrating genomics into treatment decisions in gastrointestinal malignancies
Q37965048Personalized cancer medicine and the future of pathology.
Q38976521Personalized learning: From neurogenetics of behaviors to designing optimal language training
Q37651778Personalized management of chronic obstructive pulmonary disease via transcriptomic profiling of the airway and lung.
Q36441548Personalized medicine and treatment approaches in non-small-cell lung carcinoma
Q37932029Personalized medicine for lung cancer: new challenges for pathology
Q35757107Personalized medicine for pathological circadian dysfunctions
Q36817080Personalized medicine for targeted and platinum-based chemotherapy of lung and bladder cancer
Q35680026Personalized medicine in a phase I clinical trials program: the MD Anderson Cancer Center initiative
Q37921595Personalized medicine in lung cancer: what we need to know.
Q57177486Personalized medicine in non-small cell lung cancer: a review from a pharmacogenomics perspective
Q51828510Personalized medicine in oncology: the future is now.
Q74441598Personalized medicine: Special treatment
Q42697296Personalized medicine: hype or reality
Q38232150Personalized oncology: genomic screening in phase 1.
Q37214412Personalized prediction of EGFR mutation-induced drug resistance in lung cancer.
Q27027259Personalized respiratory medicine: exploring the horizon, addressing the issues. Summary of a BRN-AJRCCM workshop held in Barcelona on June 12, 2014
Q36321826Personalized targeted therapy for lung cancer
Q58792324Personalized therapy for lung cancer: Striking a moving target
Q37996505Personalized therapy for non-small cell lung cancer: which drug for which patient?
Q35911350Personalized therapy in endometrial cancer: challenges and opportunities
Q38266308Personalized treatment of EGFR mutant and ALK-positive patients in NSCLC.
Q28075800Personalized treatment of advanced non-small-cell lung cancer in routine clinical practice
Q36015295Personalized tumor response assessment in the era of molecular medicine: cancer-specific and therapy-specific response criteria to complement pitfalls of RECIST
Q27851614Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer
Q37080513Personalizing lung cancer prevention through a reverse migration strategy
Q36811453Personalizing therapy in advanced non-small cell lung cancer
Q35679361Personalizing therapy with targeted agents in non-small cell lung cancer
Q47240432Perspective: The clinical trial barriers
Q43061648Perspectives in adjuvant chemotherapy in NSCLC.
Q36163982Perspectives on novel therapies for bronchial carcinoma
Q39940683Perspectives on the development of imatinib and the future of cancer research
Q28537769Perturbation biology: inferring signaling networks in cellular systems
Q24339394Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
Q34042708Pgrmc1 (progesterone receptor membrane component 1) associates with epidermal growth factor receptor and regulates erlotinib sensitivity
Q28382921PharmGKB summary: very important pharmacogene information for the epidermal growth factor receptor
Q28278381Pharmacodynamic biomarkers for molecular cancer therapeutics
Q37194753Pharmacoeconomic evaluations of pharmacogenetic and genomic screening programmes: a systematic review on content and adherence to guidelines
Q35889619Pharmacogenetics - five decades of therapeutic lessons from genetic diversity
Q35889605Pharmacogenetics and drug development: the path to safer and more effective drugs
Q40218486Pharmacogenetics and stomach cancer: an update.
Q36478845Pharmacogenetics approach to therapeutics
Q35038056Pharmacogenetics in drug development
Q37275470Pharmacogenetics in drug discovery and development: a translational perspective
Q36256445Pharmacogenetics in gastrointestinal tumors
Q36493347Pharmacogenetics in the management of breast cancer -- prospects for individualised treatment.
Q35840645Pharmacogenetics in type 2 diabetes: potential implications for clinical practice
Q38010747Pharmacogenetics of EGFR in lung cancer: perspectives and clinical applications
Q23919667Pharmacogenetics, pharmacogenomics, and individualized medicine
Q36294685Pharmacogenetics/genomics and personalized medicine
Q37430384Pharmacogenetics: implementing personalized medicine
Q38262008Pharmacogenomic biomarkers for personalized cancer treatment.
Q28392982Pharmacogenomic discovery using cell-based models
Q35873676Pharmacogenomics and stomach cancer.
Q38596926Pharmacogenomics in the treatment of lung cancer: an update
Q27025558Pharmacogenomics of chemotherapeutic susceptibility and toxicity
Q36966043Pharmacogenomics of lung cancer: with a view to address EGFR-targeted therapies
Q56446183Pharmacogenomics steps toward personalized medicine
Q35876017Pharmacogenomics: bench to bedside
Q36658763Pharmacogenomics: challenges and opportunities
Q36465177Pharmacogenomics: from bedside to clinical practice
Q37353853Pharmacokinetic considerations for new targeted therapies.
Q46375104Pharmacokinetics of gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, in rat and dog.
Q37492540Pharmacologic and chemical adjuvants in tumor virotherapy
Q39396274Pharmacologic synergy between dual phosphoinositide-3-kinase and mammalian target of rapamycin inhibition and 5-fluorouracil in PIK3CA mutant gastric cancer cells.
Q37822760Pharmacometabonomics as an effector for personalized medicine.
Q38248997Pharmacotherapy targeting the EGFR oncogene in NSCLC.
Q33161299Phase 1 dose-escalation trial evaluating the combination of the selective MET (mesenchymal-epithelial transition factor) inhibitor tivantinib (ARQ 197) plus erlotinib
Q53545682Phase 1 trial of everolimus and gefitinib in patients with advanced nonsmall-cell lung cancer.
Q49962860Phase 1b Trial of Ficlatuzumab, a Humanized Hepatocyte Growth Factor Inhibitory Monoclonal Antibody, in Combination With Gefitinib in Asian Patients With NSCLC.
Q45904308Phase 2 trial of afatinib, an ErbB family blocker, in solid tumors genetically screened for target activation.
Q37069238Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma.
Q50933613Phase I study of 5-aza-2'-deoxycytidine in combination with valproic acid in non-small-cell lung cancer.
Q91796969Phase I study of TAS-121, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, in patients with non-small-cell lung cancer harboring EGFR mutations
Q36317627Phase I study of icotinib, an EGFR tyrosine kinase inhibitor combined with IMRT in nasopharyngeal carcinoma
Q35527148Phase I study of irinotecan and gefitinib in patients with gefitinib treatment failure for non-small cell lung cancer
Q43092698Phase I trial of liposomal doxorubicin and ZD1839 in patients with refractory gynecological malignancies or metastatic breast cancer
Q34549722Phase I trial of oxaliplatin, infusional 5-fluorouracil, and leucovorin (FOLFOX4) with erlotinib and bevacizumab in colorectal cancer
Q36938818Phase I/II Study of HSP90 Inhibitor AUY922 and Erlotinib for EGFR-Mutant Lung Cancer With Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors.
Q34578584Phase I/II study of the Src inhibitor dasatinib in combination with erlotinib in advanced non-small-cell lung cancer
Q64107367Phase II Trial of Cabozantinib Plus Erlotinib in Patients With Advanced Epidermal Growth Factor Receptor ()-Mutant Non-small Cell Lung Cancer With Progressive Disease on Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Therapy: A California
Q37705422Phase II clinical trials in oncology: are we hitting the target?
Q42162257Phase II randomized study of daily gefitinib treatment alone or with vinorelbine every 2 weeks in patients with adenocarcinoma of the lung who failed at least 2 regimens of chemotherapy
Q33390208Phase II study of S-1, a novel oral fluoropyrimidine, and biweekly administration of docetaxel for previously treated advanced non-small-cell lung cancer
Q36614114Phase II study of erlotinib (OSI-774) in patients with metastatic colorectal cancer
Q52941341Phase II study of erlotinib in elderly patients with non-small cell lung cancer harboring epidermal growth factor receptor mutations.
Q44656784Phase II study of nimotuzumab, a humanized monoclonal anti-epidermal growth factor receptor (EGFR) antibody, in patients with locally advanced or metastatic pancreatic cancer
Q34427320Phase II study of pemetrexed and carboplatin plus bevacizumab, followed by maintenance pemetrexed and bevacizumab in Japanese patients with non-squamous non-small cell lung cancer
Q37693919Phase II trial of dose-dense chemotherapy followed by dose-intense erlotinib for patients with newly diagnosed metastatic non-small cell lung cancer
Q54403335Phase II trial of erlotinib in patients with advanced non‑small‑cell lung cancer harboring epidermal growth factor receptor mutations: additive analysis of pharmacokinetics.
Q36625206Phase II trial of erlotinib plus concurrent whole-brain radiation therapy for patients with brain metastases from non-small-cell lung cancer
Q33608491Phase II trial of gefitinib and everolimus in advanced non-small cell lung cancer
Q51493357Phase II trial of gefitinib in pretreated Chinese women with advanced non-small-cell lung cancer.
Q46791717Phase II trial of imatinib mesylate in patients with recurrent platinum- and taxane-resistant epithelial ovarian and primary peritoneal cancers.
Q35208151Phase II trial of modified FOLFOX6 and erlotinib in patients with metastatic or advanced adenocarcinoma of the oesophagus and gastro-oesophageal junction
Q42663635Phase III, randomized, open-label, first-line study in Asia of gefitinib versus carboplatin/paclitaxel in clinically selected patients with advanced non-small-cell lung cancer: evaluation of patients recruited from mainland China.
Q37414810Phase-1 trial of gefitinib and temozolomide in patients with malignant glioma: a North American brain tumor consortium study
Q47723850Phase1 study of cisplatin plus pemetrexed with erlotinib and bevacizumab for chemotherapy-naïve advanced non-squamous non-small cell lung cancer with EGFR mutations
Q94545721Phenotypic screening using large-scale genomic libraries to identify drug targets for the treatment of cancer
Q35256618Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway in non-small cell lung cancer
Q36642695Phosphatidylinositol-3-kinase α catalytic subunit gene somatic mutations in bronchopulmonary neuroendocrine tumours
Q36346828Phosphoinositide 3-kinase: from viral oncoprotein to drug target
Q38757884Phosphoproteomics Reveals MAPK Inhibitors Enhance MET- and EGFR-Driven AKT Signaling in KRAS-Mutant Lung Cancer.
Q36219744Phosphoproteomics for oncology discovery and treatment
Q34539788Phosphoproteomics in cancer
Q27851872Phosphorylated EGFR expression may predict outcome of EGFR-TKIs therapy for the advanced NSCLC patients with wild-type EGFR
Q36717778Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer
Q35082185Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells in human renal cell carcinoma is a primary target for therapy by tyrosine kinase inhibitors
Q24644787Phosphorylated epidermal growth factor receptor on tumor-associated endothelial cells is a primary target for therapy with tyrosine kinase inhibitors
Q39561256Phosphorylated insulin-like growth factor 1 receptor is implicated in resistance to the cytostatic effect of gefitinib in colorectal cancer cells
Q34598322Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.
Q54503313Phosphorylation of epidermal growth factor receptor and chromosome 7 polysomy in gastric adenocarcinoma.
Q38943113Phosphotyrosine profiling identifies ephrin receptor A2 as a potential therapeutic target in esophageal squamous-cell carcinoma.
Q36524232Photodynamic therapy activated signaling from epidermal growth factor receptor and STAT3: Targeting survival pathways to increase PDT efficacy in ovarian and lung cancer
Q36962642Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling
Q34039413Physicochemical properties of epidermal growth factor receptor inhibitors and development of a nanoliposomal formulation of gefitinib
Q47387077Physiologically Based Pharmacokinetic Modeling to Evaluate the Systemic Exposure of Gefitinib in CYP2D6 Ultrarapid Metabolizers and Extensive Metabolizers
Q36558400Picoliter-Droplet Digital Polymerase Chain Reaction-Based Analysis of Cell-Free Plasma DNA to Assess EGFR Mutations in Lung Adenocarcinoma That Confer Resistance to Tyrosine-Kinase Inhibitors
Q39089524Piecing it together: Unraveling the elusive structure-function relationship in single-pass membrane receptors
Q35187806Pilot study of gefitinib and fulvestrant in the treatment of post-menopausal women with advanced non-small cell lung cancer
Q42835389Pitfalls in immunohistochemical assessment of EGFR expression in soft tissue sarcomas
Q35996716Pituitary adenylate cyclase-activating polypeptide causes tyrosine phosphorylation of the epidermal growth factor receptor in lung cancer cells
Q54961209Pituitary-Directed Therapies for Cushing's Disease.
Q45998326Placental overgrowth and fertility defects in mice with a hypermorphic allele of epidermal growth factor receptor.
Q51239492Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?
Q36020891Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity
Q36632245Point mutations of protein kinases and individualised cancer therapy
Q51415798Polymer nanofiber-based microchips for EGFR mutation analysis of circulating tumor cells in lung adenocarcinoma.
Q36385082Polymorphisms in intron 1 of the EGFR gene in non-small cell lung cancer patients
Q28757672Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers
Q35800638Polynuclear platinum anticancer drugs are more potent than cisplatin and induce cell cycle arrest in glioma.
Q37623532Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations
Q51029938Pooled Analysis of the Prognostic and Predictive Effects of TP53 Comutation Status Combined With KRAS or EGFR Mutation in Early-Stage Resected Non-Small-Cell Lung Cancer in Four Trials of Adjuvant Chemotherapy.
Q34311186Pooled analysis of clinical outcome for EGFR TKI-treated patients with EGFR mutation-positive NSCLC
Q36905639Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers
Q89493481Poor Prognosis With Coexistence Of EGFR T790M Mutation And Common EGFR-Activating Mutation In Non- Small Cell Lung Cancer
Q37528486Poor response to erlotinib in patients with tumors containing baseline EGFR T790M mutations found by routine clinical molecular testing.
Q42340129Poor response to platinum-based chemotherapy is associated with KRAS mutation and concomitant low expression of BRAC1 and TYMS in NSCLC.
Q43515674Population pharmacokinetics/pharmacodynamics of erlotinib and pharmacogenomic analysis of plasma and cerebrospinal fluid drug concentrations in Japanese patients with non-small cell lung cancer
Q28394485Population-based trends in lung cancer incidence in women
Q26778987Positional proteomics in the era of the human proteome project on the doorstep of precision medicine
Q36420719Positron emission tomography measurement of tumor metabolism and growth: its expanding role in oncology
Q27026940Positron emission tomography to assess hypoxia and perfusion in lung cancer
Q36439506Positron emission tomography-computed tomography on predicting the efficacy of targeted therapy for lung adenocarcinoma
Q99565904Postoperative management for non-small cell lung cancer harboring EGFR mutations
Q95723908Postoperative survival According to the Glasgow Prognostic Score in Patients with Resected Lung Adenocarcinoma
Q36537788Posttranslational protein modifications: current implications for cancer detection, prevention, and therapeutics
Q35941562Potent antitumor effects of bevacizumab in a microenvironment-dependent human lymphoma mouse model.
Q26775315Potential targets for ovarian clear cell carcinoma: a review of updates and future perspectives
Q33520624Power to detect selective allelic amplification in genome-wide scans of tumor data
Q38555223Practical Value of Molecular Pathology in Stage I-III Lung Cancer: Implications for the Clinical Surgeon
Q47597667Practical recommendations for pharmacogenomics-based prescription: 2010 ESF-UB Conference on Pharmacogenetics and Pharmacogenomics
Q89429141Pragmatic approaches to address expansion cohort design
Q35702897Precise Classification of Cervical Carcinomas Combined with Somatic Mutation Profiling Contributes to Predicting Disease Outcome.
Q89975407Precision Medicine Tumor Boards: Clinical Applicability of Personalized Treatment Concepts in Ovarian Cancer
Q33714064Precision Medicine: The New Frontier in Idiopathic Pulmonary Fibrosis
Q38838757Precision Oncology Medicine: The Clinical Relevance of Patient-Specific Biomarkers Used to Optimize Cancer Treatment
Q50195535Precision Oncology: The Road Ahead.
Q38810911Precision medicine in pediatric oncology: Lessons learned and next steps
Q47566249Precision medicine: does ethnicity information complement genotype-based prescribing decisions?
Q52857191Preclinical Study of a Combination of Erlotinib and Bevacizumab in Early Stages of Unselected Non-Small Cell Lung Cancer Patient-Derived Xenografts.
Q40373819Preclinical evaluation of ZD1839 alone or in combination with oxaliplatin in a panel of human tumor cell lines -- implications for clinical use.
Q27322080Preclinical mouse cancer models: a maze of opportunities and challenges
Q40365247Preclinical study of a "tailor-made" combination of NK4-expressing gene therapy and gefitinib (ZD1839, Iressa) for disseminated peritoneal scirrhous gastric cancer
Q36547786Predicting clinical benefit in non-small-cell lung cancer patients treated with epidermal growth factor tyrosine kinase inhibitors
Q37209222Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions
Q34572279Predicting interactome network perturbations in human cancer: application to gene fusions in acute lymphoblastic leukemia
Q36788485Predicting response to epidermal growth factor receptor-targeted therapy in colorectal cancer.
Q36042375Predicting survival of patients with resectable non-small cell lung cancer: Beyond TNM
Q33247966Predicting survival within the lung cancer histopathological hierarchy using a multi-scale genomic model of development
Q35151544Prediction and prioritization of rare oncogenic mutations in the cancer Kinome using novel features and multiple classifiers
Q40053178Prediction of EGFR and KRAS mutation in non-small cell lung cancer using quantitative 18F FDG-PET/CT metrics
Q40327150Prediction of anticancer drug potency from expression of genes involved in growth factor signaling
Q43162278Prediction of epidermal growth factor receptor mutations in the plasma/pleural effusion to efficacy of gefitinib treatment in advanced non-small cell lung cancer
Q45248889Prediction of response to tyrosine kinase epithelial cell growth factor receptor inhibitors: a major breakthrough in the treatment of non-small-cell lung cancer
Q45116933Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839).
Q51743342Prediction of sensitivity to gefitinib/erlotinib for EGFR mutations in NSCLC based on structural interaction fingerprints and multilinear principal component analysis.
Q57896476Predictive Tumor Biomarkers for EGFR Inhibitors
Q34620545Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: a systemic review of current development, evidence, and recommendation
Q35076206Predictive and prognostic markers for epidermal growth factor receptor inhibitor therapy in non-small cell lung cancer
Q33311133Predictive and prognostic markers in neuro-oncology
Q38137764Predictive biomarkers for cancer therapy with PARP inhibitors.
Q26824536Predictive biomarkers in precision medicine and drug development against lung cancer
Q46066416Predictive biomarkers in the development of oncology drugs: a therapeutic industry perspective.
Q52991200Predictive efficacy of (11)C-PD153035 PET imaging for EGFR-tyrosine kinase inhibitor sensitivity in non-small cell lung cancer patients.
Q35077521Predictive efficacy of low burden EGFR mutation detected by next-generation sequencing on response to EGFR tyrosine kinase inhibitors in non-small-cell lung carcinoma
Q36610291Predictive factors associated with prolonged survival in patients with advanced non-small-cell lung cancer (NSCLC) treated with gefitinib
Q35773852Predictive factors for epidermal growth factor receptor inhibitors--the bull's-eye hits the arrow
Q34427439Predictive factors in patients with EGFR mutation-negative non-small cell lung cancer treated with erlotinib
Q39028004Predictive factors of early distant brain failure after gamma knife radiosurgery alone in patients with brain metastases of non-small-cell lung cancer
Q37579647Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer
Q54510031Predictive value of loci in VEGF pathway genes in bevacizumab treatment.
Q47143835Predictors of EGFR mutation and factors associated with clinical tumor stage at diagnosis: Experience of the INSIGHT study in Poland.
Q36808416Predictors of survival in never-smokers with non-small cell lung cancer: a large-scale, two-phase genetic study
Q81601035Predominance of high-grade pathway in breast cancer development of Middle East women
Q35145369Preexisting oncogenic events impact trastuzumab sensitivity in ERBB2-amplified gastroesophageal adenocarcinoma
Q94371037Preface
Q36088722Preliminary Evidence on the Diagnostic and Molecular Role of Circulating Soluble EGFR in Non-Small Cell Lung Cancer
Q30890447Preparation of EGFR monoclonal antibody conjugated nanoparticles and targeting to hepatocellular carcinoma
Q41869566Presence of EGFR mutation in pathologically non-malignant specimens from computed tomography-guided lung needle biopsies
Q51168062Presence of pleural effusion is associated with a poor prognosis in patients with epidermal growth factor receptor-mutated lung cancer receiving tyrosine kinase inhibitors as first-line treatment.
Q35877737Present status and problems on molecular targeted therapy of cancer
Q35478632Pretreatment levels of the serum biomarkers CEA, CYFRA 21-1, SCC and the soluble EGFR and its ligands EGF, TGF-alpha, HB-EGF in the prediction of outcome in erlotinib treated non-small-cell lung cancer patients
Q35671830Prevalence and Clinicopathological Characteristics of HER2 and BRAF Mutation in Chinese Patients with Lung Adenocarcinoma
Q45370579Prevalence and detection of low-allele-fraction variants in clinical cancer samples.
Q36330709Prevalence and outcome of epidermal growth factor receptor mutations in non-squamous non-small cell lung cancer patients
Q38661269Prevalence of EGFR Mutations in Lung Cancer in Uruguayan Population
Q39073840Prevalence of EGFR Tyrosine Kinase Domain Mutations in Head and Neck Squamous Cell Carcinoma: Cohort Study and Systematic Review
Q41461334Prevalence of EGFR and ALK Mutations in Lung Adenocarcinomas in the Levant Area - a Prospective Analysis
Q36085837Prevalence of KRAS, BRAF, PI3K and EGFR mutations among Asian patients with metastatic colorectal cancer
Q60949785Prevalence of ROS1 fusion in Chinese patients with non-small cell lung cancer
Q92107648Prevalence of the epidermal growth factor receptor mutations in lung adenocarcinoma patients from the Middle East region
Q54384637Prevalence, clinicopathologic characteristics, and molecular associations of EGFR exon 20 insertion mutations in East Asian patients with lung adenocarcinoma.
Q36654338Prevention of breast cancer: current state of the science and future opportunities
Q38745430Primary Double-Strike Therapy for Cancers to Overcome EGFR Kinase Inhibitor Resistance: Proposal from the Bench
Q38008698Primary and acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer: an update
Q37799825Primary and secondary therapeutic strategies for EGF receptor pathway inhibition in non-small-cell lung cancer
Q27009148Primary chemotherapy and radiation as a treatment strategy for HPV-positive oropharyngeal cancer
Q39649266Primary pulmonary lymphoepithelioma-like carcinoma: fifty-two patients with long-term follow-up
Q36180606Priorities and standards in pharmacogenetic research
Q43259078Prioritizing molecular markers to test for in the initial workup of advanced non-small cell lung cancer: wants versus needs
Q38262620Prioritizing targets for precision cancer medicine
Q38694064Pro-tumoural CXCL10/CXCR3-A autocrine loop in invasive mucinous lung adenocarcinoma.
Q38470647ProKinO: a unified resource for mining the cancer kinome
Q92282893Profile of Daniel A. Haber
Q39106800Profile of the Roche cobas® EGFR mutation test v2 for non-small cell lung cancer.
Q51139197Profile of the therascreen® EGFR RGQ PCR kit as a companion diagnostic for gefitinib in non-small cell lung cancer.
Q21562343Profiling critical cancer gene mutations in clinical tumor samples
Q92767063Profiling of protein-protein interactions via single-molecule techniques predicts the dependence of cancers on growth-factor receptors
Q37652622Prognosis of recurrent non-small cell lung cancer following complete resection
Q91906497Prognostic analysis of patients with mutant and wild-type EGFR gene lung adenocarcinoma
Q38089884Prognostic and predictive factors in resected non-small-cell lung cancer
Q34443983Prognostic and predictive role of the VeriStrat plasma test in patients with advanced non-small-cell lung cancer treated with erlotinib or placebo in the NCIC Clinical Trials Group BR.21 trial
Q38019976Prognostic and predictive value of K-RAS mutations in non-small cell lung cancer
Q38493294Prognostic and predictive value of MET deregulation in non-small cell lung cancer
Q30498101Prognostic and predictive value of epidermal growth factor receptor tyrosine kinase domain mutation status and gene copy number for adjuvant chemotherapy in non-small cell lung cancer
Q54632156Prognostic and predictive values of pERK1/2 and pAkt-1 expression in non-small cell lung cancer patients treated with adjuvant chemotherapy.
Q33620091Prognostic effect of activated EGFR expression in human colon carcinomas: comparison with EGFR status
Q34616626Prognostic effect of epidermal growth factor receptor gene mutations and the aberrant phosphorylation of Akt and ERK in ovarian cancer
Q48551119Prognostic factors for brain metastases from non-small cell lung cancer with EGFR mutation: influence of stable extracranial disease and erlotinib therapy.
Q44462744Prognostic factors for gefitinib-treated postoperative recurrence in non-small cell lung cancer
Q55035103Prognostic factors of afatinib as a first-line therapy for advanced EGFR mutation-positive lung adenocarcinoma: a real-world, large cohort study.
Q37702165Prognostic factors of successful on-purpose tumor biopsies in metastatic cancer patients included in the SHIVA prospective clinical trial
Q34544677Prognostic impact of [18F]fluorothymidine and [18F]fluoro-D-glucose baseline uptakes in patients with lung cancer treated first-line with erlotinib.
Q38399545Prognostic impact of a new score using neutrophil-to-lymphocyte ratios in the serum and malignant pleural effusion in lung cancer patients
Q36399028Prognostic impact of initial maximum standardized uptake value of (18)F-FDG PET/CT on treatment response in patients with metastatic lung adenocarcinoma treated with erlotinib
Q34860000Prognostic impact of serum CYFRA 21-1 in patients with advanced lung adenocarcinoma: a retrospective study
Q46620066Prognostic implication of EGFR gene mutations and histological classification in patients with resected stage I lung adenocarcinoma
Q46416422Prognostic nomogram for sunitinib in patients with metastatic renal cell carcinoma
Q35681087Prognostic role of p53 and Ki-67 immunohistochemical expression in patients with surgically resected lung adenocarcinoma: a retrospective study
Q34775815Prognostic significance of PIK3CA and SOX2 in Asian patients with lung squamous cell carcinoma
Q34181641Prognostic significance of adenocarcinoma in situ, minimally invasive adenocarcinoma, and nonmucinous lepidic predominant invasive adenocarcinoma of the lung in patients with stage I disease
Q45751366Prognostic significance of expression of cyclooxygenase-2, vascular endothelial growth factor, and epidermal growth factor receptor in nasopharyngeal carcinoma.
Q54485965Prognostic significance of the IASLC/ATS/ERS classification in Chinese patients-A single institution retrospective study of 292 lung adenocarcinoma.
Q90087574Prognostic value of EGFR 19-del and 21-L858R mutations in patients with non-small cell lung cancer
Q34937417Prognostic value of EGFR mutation and ERCC1 in patients with non-small cell lung cancer undergoing platinum-based chemotherapy
Q51678342Prognostic value of EGFR mutations in surgically resected pathological stage I lung adenocarcinoma.
Q41296140Prognostic value of LIPC in non-small cell lung carcinoma
Q47547523Prognostic value of epidermal growth factor receptor mutations and histologic subtypes with lung adenocarcinoma.
Q46757816Prognostic value of epidermal growth factor receptor mutations in resected lung adenocarcinomas
Q27692669Prognostic value of epidermal growth factor receptor mutations in resected non-small cell lung cancer: a systematic review with meta-analysis
Q37902246Prognostic, therapeutic and diagnostic potential of microRNAs in non-small cell lung cancer
Q49163406Programmed death-ligand 1 expression according to epidermal growth factor receptor mutation status in pretreated non-small cell lung cancer.
Q35632548Progression-free Survival Decreases with Each Subsequent Therapy in Patients Presenting for Phase I Clinical Trials
Q44171169Progressive patterns of gifitinib treating advanced non-small cell lung cancer after obtained resistance
Q41956993Proliferation of Ewing sarcoma cell lines is suppressed by the receptor tyrosine kinase inhibitors gefitinib and vandetanib
Q36838905Prolonged survival with erlotinib followed by afatinib in a caucasian smoker with metastatic, poorly differentiated large cell carcinoma of the lung: a case report
Q36235591Promises and pitfalls in the prediction of antiepidermal growth factor receptor activity
Q33283634Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers
Q28294647Prompt control of bronchorrhea in patients with bronchioloalveolar carcinoma treated with gefitinib (Iressa)
Q36095223Proposal for a novel methodology to screen and score cost versus survival for anticancer drugs in metastatic disease: could cost weigh in evaluation?
Q37483993Prospect of JAK2 inhibitor therapy in myeloproliferative neoplasms
Q35975657Prospective Evaluation of First-Line Erlotinib in Advanced Non-Small Cell Lung Cancer (NSCLC) Carrying an Activating EGFR Mutation: A Multicenter Academic Phase II Study in Caucasian Patients (FIELT).
Q53573913Prospective validation for prediction of gefitinib sensitivity by epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer.
Q41970534Prospective, high-throughput molecular profiling of human gliomas
Q37775627Prospects for molecular staging of non-small-cell lung cancer from genomic alterations
Q34554617Prospects on strategies for therapeutically targeting oncogenic regulatory factors by small-molecule agents
Q54518974Protein expression, gene amplification, and mutational analysis of EGFR in triple-negative breast cancer.
Q35208584Protein kinase C-beta gene variants, pathway activation, and enzastaurin activity in lung cancer
Q38205518Protein kinase inhibitors to treat non-small-cell lung cancer
Q37417742Protein kinase inhibitors: contributions from structure to clinical compounds
Q51540449Protein overexpression and gene amplification of epidermal growth factor receptor in nonsmall cell lung carcinomas. An immunohistochemical and fluorescence in situ hybridization study.
Q24337213Protein phosphorylation profiling using an in situ proximity ligation assay: phosphorylation of AURKA-elicited EGFR-Thr654 and EGFR-Ser1046 in lung cancer cells
Q36969009Proteins, drug targets and the mechanisms they control: the simple truth about complex networks
Q38461516Proteome research in urothelial carcinoma.
Q35814785Proteomic analysis of HEK293 cells expressing non small cell lung carcinoma associated epidermal growth factor receptor variants reveals induction of heat shock response
Q36168391Proteomic analysis of cellular signaling
Q37709355Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor
Q39282659Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
Q39868726Proteomic signatures of epidermal growth factor receptor and survival signal pathways correspond to gefitinib sensitivity in head and neck cancer.
Q30402667Proteomics and biomarkers in clinical trials for drug development
Q33233797Proteomics: clinical applications for head and neck squamous cell carcinoma
Q64269953Provisional Guideline Recommendation for EGFR Gene Mutation Testing in Liquid Samples of Lung Cancer Patients: A Proposal by the Korean Cardiopulmonary Pathology Study Group
Q92951808Proximity proteomics identifies cancer cell membrane cis-molecular complex as a potential cancer target
Q90383683Pulmonary Administration: Strengthening the Value of Therapeutic Proximity
Q53190932Pulmonary adenocarcinoma with epidermal growth factor receptor-mutations in asbestos exposed non-smokers: A case series.
Q28395348Pulmonary adenocarcinoma: a renewed entity in 2011
Q34404209Pulmonary adenocarcinoma: implications of the recent advances in molecular biology, treatment and the IASLC/ATS/ERS classification
Q34284660Pyrosequencing data analysis software: a useful tool for EGFR, KRAS, and BRAF mutation analysis
Q38658503Quality Assessment of Reporting Performance for EGFR Molecular Diagnosis in Non-Small Cell Lung Cancer
Q36051542Quality of life with gefitinib in patients with EGFR-mutated non-small cell lung cancer: quality of life analysis of North East Japan Study Group 002 Trial
Q28541305Quantification and kinetic analysis of Grb2-EGFR interaction on micro-patterned surfaces for the characterization of EGFR-modulating substances
Q54979720Quantification and localization of oncogenic receptor tyrosine kinase variant transcripts using molecular inversion probes.
Q37480093Quantification of EGFR mutations in primary and metastatic tumors in non-small cell lung cancer
Q37190448Quantification of mutant alleles in circulating tumor DNA can predict survival in lung cancer.
Q34158755Quantifying the sensitivities of EGF receptor (EGFR) tyrosine kinase inhibitors in drug resistant non-small cell lung cancer (NSCLC) cells using hydrogel-based peptide array
Q37210782Quantitative Secretomic Analysis Identifies Extracellular Protein Factors That Modulate the Metastatic Phenotype of Non-Small Cell Lung Cancer
Q60307896Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states
Q90292140Quantitative features of dual-energy spectral computed tomography for solid lung adenocarcinoma with EGFR and KRAS mutations, and ALK rearrangement: a preliminary study
Q37330722Quantitative modeling perspectives on the ErbB system of cell regulatory processes
Q37340472Quantitative prediction of fold resistance for inhibitors of EGFR.
Q37649220Quantitative proteomic profiling identifies protein correlates to EGFR kinase inhibition
Q98386425Quantitative volumetric assessment of the solid portion percentage on CT images to predict ROS1/ALK rearrangements in lung adenocarcinomas
Q35138060Quantum coupled mutation finder: predicting functionally or structurally important sites in proteins using quantum Jensen-Shannon divergence and CUDA programming.
Q42633890Quantum dots immunofluorescence histochemical detection of EGFR gene mutations in the non-small cell lung cancers using mutation-specific antibodies
Q34143354Quinacrine overcomes resistance to erlotinib by inhibiting FACT, NF-κB, and cell-cycle progression in non-small cell lung cancer
Q90447993R-spondin family members as novel biomarkers and prognostic factors in lung cancer
Q37399367RAD18 polymorphisms are associated with platinum-based chemotherapy toxicity in Chinese patients with non-small cell lung cancer
Q34138262RADical response puts an exceptional responder in CHKmate: a synthetic lethal curative response to DNA-damaging chemotherapy?
Q37065818RECIST 1.1 in NSCLC patients with EGFR mutations treated with EGFR tyrosine kinase inhibitors: comparison with RECIST 1.0.
Q36530631RET expression and detection of KIF5B/RET gene rearrangements in Japanese lung cancer
Q37650677RET-rearranged non-small-cell lung carcinoma: a clinicopathological and molecular analysis
Q46700376RETRACTED: Ca(2+)/calmodulin-dependent protein kinase IIγ, a critical mediator of the NF-κB network, is a novel therapeutic target in non-small cell lung cancer
Q35461504RETRACTED: Silencing EGFR/HER3 signaling with a novel anti-EGFR domain II/IV antibody
Q40484644RNA interference against a glioma-derived allele of EGFR induces blockade at G2M.
Q33569727RNA interference and nonviral targeted gene therapy of experimental brain cancer
Q35934254RNAi and HTS: exploring cancer by systematic loss-of-function
Q37187716RNAi screen for rapid therapeutic target identification in leukemia patients
Q33306326RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia
Q41985336RNAi-induced synthetic lethality in cancer therapy
Q36946705ROS1 copy number alterations are frequent in non-small cell lung cancer
Q43101538ROS1 mutation and treatment with crizotinib in a 30-year old Caucasian woman with stage IV non-small cell lung cancer/adenocarcinoma and complete remission
Q27851700ROS1 rearrangements define a unique molecular class of lung cancers
Q39325857RUNX3 downregulation in human lung adenocarcinoma is independent of p53, EGFR or KRAS status.
Q38178095Race and ethnicity in cancer therapy: what have we learned?
Q40340394Race, gender and mutations in the prediction of anti-EGFR activity
Q36440803Racial differences in oncogene mutations detected in early-stage low-grade endometrial cancers
Q52985571Radiogenomic correlation in lung adenocarcinoma with epidermal growth factor receptor mutations: Imaging features and histological subtypes.
Q40409078Radiogenomic evaluation of lung cancer - Are there imaging characteristics associated with lung adenocarcinomas harboring BRAF mutations?
Q60922021Radiogenomics as association between non-invasive imaging features and molecular genomics of lung cancer
Q36634305Radiographic assessment and therapeutic decisions at RECIST progression in EGFR-mutant NSCLC treated with EGFR tyrosine kinase inhibitors
Q33673131Radiological and Clinical Features associated with Epidermal Growth Factor Receptor Mutation Status of Exon 19 and 21 in Lung Adenocarcinoma
Q35814752Radiotherapy for asymptomatic brain metastasis in epidermal growth factor receptor mutant non-small cell lung cancer without prior tyrosine kinase inhibitors treatment: a retrospective clinical study
Q38564088Radiotherapy of non-small-cell lung cancer in the era of EGFR gene mutations and EGF receptor tyrosine kinase inhibitors
Q35810510Randomized Adjuvant Chemotherapy of EGFR-Mutated Non-Small Cell Lung Cancer Patients with or without Icotinib Consolidation Therapy
Q50300068Randomized Phase II Study of Afatinib Plus Simvastatin Versus Afatinib Alone in Previously Treated Patients with Advanced Nonadenocarcinomatous Non-small Cell Lung Cancer.
Q36951721Randomized international phase III trial of ERCC1 and RRM1 expression-based chemotherapy versus gemcitabine/carboplatin in advanced non-small-cell lung cancer
Q49928885Randomized phase 2 trial of pemetrexed, pemetrexed/bevacizumab, and pemetrexed/carboplatin/bevacizumab in patients with stage IIIB/IV non-small cell lung cancer and an Eastern Cooperative Oncology Group performance status of 2.
Q37290704Randomized phase II clinical trial of chemo-immunotherapy in advanced nonsmall cell lung cancer
Q37658881Randomized phase II study of erlotinib in combination with placebo or R1507, a monoclonal antibody to insulin-like growth factor-1 receptor, for advanced-stage non-small-cell lung cancer
Q35817772Randomized phase II study of paclitaxel/carboplatin intercalated with gefitinib compared to paclitaxel/carboplatin alone for chemotherapy-naïve non-small cell lung cancer in a clinically selected population excluding patients with non-smoking adenoc
Q37104233Randomized phase II study of pulse erlotinib before or after carboplatin and paclitaxel in current or former smokers with advanced non-small-cell lung cancer.
Q37594039Randomized phase II study of sequential carboplatin plus paclitaxel and gefitinib in chemotherapy-naïve patients with advanced or metastatic non-small-cell lung cancer: Long-term follow-up results
Q33407127Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034.
Q38410994Rapid and efficient detection of EGFR mutations in problematic cytologic specimens by high-resolution melting analysis
Q41956182Rapid and simple detection of hot spot point mutations of epidermal growth factor receptor, BRAF, and NRAS in cancers using the loop-hybrid mobility shift assay
Q33872030Rapid detection of epidermal growth factor receptor mutations with multiplex PCR and primer extension in lung cancer
Q39661497Rapid detection of the epidermal growth factor receptor mutation in non-small-cell lung cancer for analysis of acquired resistance using molecular beacons
Q40026743Rapid identification of somatic mutations in colorectal and breast cancer tissues using mismatch repair detection (MRD).
Q37185267Rapid induction of lung adenocarcinoma by fibroblast growth factor 9 signaling through FGF receptor 3.
Q89116419Rapid magnetic isolation of extracellular vesicles via lipid-based nanoprobes
Q35789960Rapid polymerase chain reaction-based detection of epidermal growth factor receptor gene mutations in lung adenocarcinomas
Q42204869Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine
Q37404105Rare EGFR exon 18 and exon 20 mutations in non-small-cell lung cancer on 10 117 patients: a multicentre observational study by the French ERMETIC-IFCT network
Q90484072Rare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch
Q47864863Rare and complex mutations of epidermal growth factor receptor, and efficacy of tyrosine kinase inhibitor in patients with non-small cell lung cancer
Q38730141Rare cancers: a sea of opportunity
Q90343085Rare epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer
Q38104414Rare mutations in non-small-cell lung cancer
Q42506718Rare oncogenic mutations of predictive markers for targeted therapy in triple-negative breast cancer
Q46466221Rare subtypes of adenocarcinoma of the lung
Q37672002Rate of EGFR mutation testing for patients with nonsquamous non-small-cell lung cancer with implementation of reflex testing by pathologists
Q34773458Rational, biologically based treatment of EGFR-mutant non-small-cell lung cancer
Q36046225Rationale and clinical experience with epidermal growth factor receptor inhibitors in gynecologic malignancies
Q92282031Rationale for Using Irreversible Epidermal Growth Factor Receptor Inhibitors in Combination with Phosphatidylinositol 3-Kinase Inhibitors for Advanced Head and Neck Squamous Cell Carcinoma
Q46486238Rationale for combination use of targeted agents in ovarian cancer: do we have one?
Q38514601Rationale for targeting the ErbB family of receptors in patients with advanced squamous cell carcinoma of the lung.
Q36085487Re-biopsy by endobronchial ultrasound procedures for mutation analysis of non-small cell lung cancer after EGFR tyrosine kinase inhibitor treatment
Q42945763Readministration of gefitinib in a responder after treatment discontinuation due to gefinitib-related interstitial lung disease: a case report
Q36372611Real-World Data on Prognostic Factors for Overall Survival in EGFR Mutation-Positive Advanced Non-Small Cell Lung Cancer Patients Treated with First-Line Gefitinib
Q36050294Real-World Patterns of EGFR Testing and Treatment with Erlotinib for Non-Small Cell Lung Cancer in the United States
Q92326226Real-time PCR and targeted next-generation sequencing in the detection of low level EGFR mutations: Instructive case analyses
Q47102256Real-world experience of afatinib as a first-line therapy for advanced EGFR mutation-positive lung adenocarcinoma.
Q36729611Rearranged EML4-ALK fusion transcripts sequester in circulating blood platelets and enable blood-based crizotinib response monitoring in non-small-cell lung cancer
Q37458182Reasons for response differences seen in the V15-32, INTEREST and IPASS trials
Q42004900Rebiopsy of Histological Samples in Pretreated Non-small Cell Lung Cancer: Comparison Among Rebiopsy Procedures
Q34762839Rebiopsy of lung cancer patients with acquired resistance to EGFR inhibitors and enhanced detection of the T790M mutation using a locked nucleic acid-based assay
Q43611330Rebiopsy of non-small cell lung cancer patients with acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitor: Comparison between T790M mutation-positive and mutation-negative populations.
Q38672650Recent Advances in Conjugated Polymer Materials for Disease Diagnosis
Q39079553Recent Development of the Second and Third Generation Irreversible Epidermal Growth Factor Receptor Inhibitors
Q34678073Recent advances in personalized lung cancer medicine
Q40143039Recent advances in targeted advanced lung cancer therapy in the elderly
Q36709566Recent advances in targeted therapy for non-small cell lung cancer.
Q36318531Recent advances in targeted therapy of human myelogenous leukaemia
Q36491838Recent advances in targeting regulators of apoptosis in cancer cells for therapeutic gain
Q28070120Recent advances in the biology of human circulating tumour cells and metastasis
Q88487552Recent advances in the management of lung cancer
Q47105316Recent advances in the management of non-small cell lung cancer
Q21092930Recent advances of novel targeted therapy in non-small cell lung cancer
Q36874335Recent development in pharmacogenomics: from candidate genes to genome-wide association studies.
Q36636637Recent developments in the chemotherapeutic options for nonsmall cell lung cancer
Q51106997Recent mass spectrometry-based proteomics for biomarker discovery in lung cancer, COPD, and asthma.
Q36492444Recent trends in the treatment of advanced lung cancer
Q38023942Recent understanding of the molecular mechanisms for the efficacy and resistance of EGF receptor-specific tyrosine kinase inhibitors in non-small cell lung cancer.
Q91310921Receptor Tyrosine Kinase Fusions as an Actionable Resistance Mechanism to EGFR TKIs in EGFR-Mutant Non-Small-Cell Lung Cancer
Q58607138Receptor Tyrosine Kinase-Targeted Cancer Therapy
Q37368256Receptor signaling as a regulatory mechanism of DNA repair
Q37831148Receptor tyrosine kinases as therapeutic targets in rhabdomyosarcoma
Q27851674Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers
Q28082793Receptor tyrosine kinases: Characterisation, mechanism of action and therapeutic interests for bone cancers
Q36738608Receptor tyrosine kinases: mechanisms of activation and signaling
Q46047035Receptor-based predictors of response in breast cancer
Q35102025Receptor-tyrosine-kinase-targeted therapies for head and neck cancer
Q37194503Recurrent gene fusions in prostate cancer
Q37118936Recurrent head and neck cancer: current treatment and future prospects.
Q37262314Reduced Erlotinib sensitivity of epidermal growth factor receptor-mutant non-small cell lung cancer following cisplatin exposure: a cell culture model of second-line erlotinib treatment
Q57806346Reducing DNA damage by formaldehyde in liquid-based cytology preservation solutions to enable the molecular testing of lung cancer specimens
Q51587643Reducing experimental variability in variance-based sensitivity analysis of biochemical reaction systems.
Q40426911Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefitinib (IRESSA).
Q35957585Reevaluation and reclassification of resected lung carcinomas originally diagnosed as squamous cell carcinoma using immunohistochemical analysis
Q38473472Refining the treatment of NSCLC according to histological and molecular subtypes
Q37645169Refining the treatment of advanced nonsmall cell lung cancer.
Q28603408Registered report: A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations
Q37226800Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.
Q37096248Regulation of H-Ras-driven MAPK signaling, transformation and tumorigenesis, but not PI3K signaling and tumor progression, by plasma membrane microdomains
Q36738312Regulation of MAPKs by growth factors and receptor tyrosine kinases
Q35206258Regulation of cell transformation by Rb-controlled redox homeostasis
Q38074713Regulatory perspective on remaining challenges for utilization of pharmacogenomics-guided drug developments
Q28391395Reinventing diagnostics for personalized therapy in oncology
Q83964708Relapsing high grade mucoepidermoid carcinoma. Long-lasting complete response following reirradiation and EGFR blockade
Q33634703Relationship between EGFR expression, copy number and mutation in lung adenocarcinomas
Q37183593Relationship between epidermal growth factor receptor gene mutation and copy number in Chinese patients with non-small cell lung cancer
Q50989318Relationship between icotinib hydrochloride exposure and clinical outcome in Chinese patients with advanced non-small cell lung cancer.
Q37058782Relationship between serum carcinoembryonic antigen level and epidermal growth factor receptor mutations with the influence on the prognosis of non-small-cell lung cancer patients
Q36341825Relevance of epidermal growth factor receptor genomic gain in predicting clinical response to kinase inhibitors in non-small-cell lung cancer
Q35791117Relevant molecular markers and targets
Q54561641Reliability of the peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based test for epidermal growth factor receptor mutations integrated into the clinical practice for non-small cell lung cancers.
Q54120286Reliability of using circulating tumor cells for detecting epidermal growth factor receptor mutation status in advanced non-small-cell lung cancer patients: a meta-analysis and systematic review.
Q41767944Remarkable Effect of Gefitinib Retreatment in a Lung Cancer Patient With Lepidic Predominat Adenocarcinoma who had Experienced Favorable Results From Initial Treatment With Gefitinib: A Case Report
Q36307379Remarkably high frequency of EGFR expression in breast carcinomas with squamous differentiation
Q35166782Renal cell carcinoma and the use of sorafenib
Q38581146Renal toxicity of anticancer agents targeting HER2 and EGFR.
Q36741917Repeated favorable responses to epidermal growth factor receptor-tyrosine kinase inhibitors in a case of advanced lung adenocarcinoma
Q24658420Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses
Q35063579Reproducible copy number variation patterns among single circulating tumor cells of lung cancer patients
Q34185518Reproductive factors, hormone use, and risk for lung cancer in postmenopausal women, the Nurses' Health Study
Q58792355Requirement for MUC5AC in KRAS-dependent lung carcinogenesis
Q36330264Research progress on criteria for discontinuation of EGFR inhibitor therapy
Q36113804Research resource: Diagnostic and therapeutic potential of nuclear receptor expression in lung cancer
Q27853298Resensitization to Crizotinib by the Lorlatinib ALK Resistance Mutation L1198F.
Q53718494Resistance is futile: overcoming resistance to targeted therapies in lung adenocarcinoma.
Q37487158Resistance mechanisms of tumour cells to EGFR inhibitors
Q47715159Resistance mediated by alternative receptor tyrosine kinases in FGFR1-amplified lung cancer
Q42557873Resistance to EGFR-TKI can be mediated through multiple signaling pathways converging upon cap-dependent translation in EGFR-wild type NSCLC.
Q51004850Resistance to RET-Inhibition in RET-Rearranged NSCLC Is Mediated By Reactivation of RAS/MAPK Signaling.
Q34392733Resistance to ROS1 inhibition mediated by EGFR pathway activation in non-small cell lung cancer
Q38930367Resistance to Therapy
Q38626744Resistance to cancer treatment: the role of somatic genetic events and the challenges for targeted therapies
Q55191884Resistance to epidermal growth factor receptor tyrosine kinase inhibitors, T790M, and clinical trials.
Q79443198Resistance to gefitinib
Q37715457Resistance to irreversible EGF receptor tyrosine kinase inhibitors through a multistep mechanism involving the IGF1R pathway
Q26739760Resistance to receptor tyrosine kinase inhibitors in solid tumors: can we improve the cancer fighting strategy by blocking autophagy?
Q41634338Resistances to targeted therapies and strategy for following therapeutic lines in metastatic NSCLC
Q38012422Respiratory cytology in the era of molecular diagnostics: a review
Q38931077Response to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma with the Rare Epidermal Growth Factor Receptor Mutation S768I: a Retrospective Analysis and Literature Review
Q46941491Response to dual blockade of epidermal growth factor receptor (EGFR) and cycloxygenase-2 in nonsmall cell lung cancer may be dependent on the EGFR mutational status of the tumor
Q33576476Response to erlotinib in recurrent glioblastoma multiforme showing coexpression of EGFRvIII and PTEN.
Q36225230Responses of cancer cells with wild-type or tyrosine kinase domain-mutated epidermal growth factor receptor (EGFR) to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible factor-1alpha
Q28306934Restoration of Wnt-7a expression reverses non-small cell lung cancer cellular transformation through frizzled-9-mediated growth inhibition and promotion of cell differentiation
Q29618727Restoration of p53 function leads to tumour regression in vivo
Q44843905Restriction endonuclease-mediated real-time digestion-PCR for somatic mutation detection
Q58417919Results of the UK NEQAS for Molecular Genetics reference sample analysis
Q33881153Retinoic Acid affects Lung Adenocarcinoma growth by inducing differentiation via GATA6 activation and EGFR and Wnt inhibition
Q84723308Retrospective subset analyses in early breast cancer revisited
Q24611142Retroviral oncogenes: a historical primer
Q54794454Reversed mutation rates of KRAS and EGFR genes in adenocarcinoma of the lung in Taiwan and their implications.
Q36041152Review article: the potential of combinational regimen with non-steroidal anti-inflammatory drugs in the chemoprevention of colorectal cancer
Q34180683Review of EGFR TKIs in Metastatic NSCLC, Including Ongoing Trials
Q37290444Review of erlotinib in the treatment of advanced non-small cell lung cancer.
Q27015079Review of the current targeted therapies for non-small-cell lung cancer
Q34449725Review of the regulations for clinical research in herbal medicines in USA.
Q36461805Review of the treatment of non-small cell lung cancer with gefitinib
Q37093554Revisiting clinical trials using EGFR inhibitor-based regimens in patients with advanced non-small cell lung cancer: a retrospective analysis of an MD Anderson Cancer Center phase I population
Q35668629Rewiring of human lung cell lineage and mitotic networks in lung adenocarcinomas.
Q36015618Rhizoma Paridis Saponins Induces Cell Cycle Arrest and Apoptosis in Non-Small Cell Lung Carcinoma A549 Cells
Q36413425Rhodomycin A, a novel Src-targeted compound, can suppress lung cancer cell progression via modulating Src-related pathways
Q57918768Risk factors differ for non-small-cell lung cancers with and without EGFR mutation: assessment of smoking and sex by a case-control study in Japanese
Q37697247Risk factors of brain metastasis during the course of EGFR-TKIs therapy for patients with EGFR-mutated advanced lung adenocarcinoma
Q35584486Role of 18F-fluorodeoxyglucose positron emission tomography in predicting epidermal growth factor receptor mutations in non-small cell lung cancer
Q38818845Role of Cytochrome P450 3A4 and 1A2 Phenotyping in Patients with Advanced Non-small-Cell Lung Cancer Receiving Erlotinib Treatment.
Q38486882Role of EGFR mutations in lung cancers: prognosis and tumor chemosensitivity.
Q54980093Role of Epidermal Growth Factor Receptor (EGFR) Inhibitors and Radiation in the Management of Brain Metastases from EGFR Mutant Lung Cancers.
Q37153625Role of ErbB4 in breast cancer
Q38087392Role of FGF receptors as an emerging therapeutic target in lung squamous cell carcinoma.
Q26781683Role of HER2 in NSCLC
Q53711253Role of HGF-MET Signaling in Primary and Acquired Resistance to Targeted Therapies in Cancer.
Q35067488Role of IGF-binding protein 3 in the resistance of EGFR mutant lung cancer cells to EGFR-tyrosine kinase inhibitors
Q54340378Role of [¹⁸F]FDG PET in prediction of KRAS and EGFR mutation status in patients with advanced non-small-cell lung cancer.
Q36622102Role of deltaNp63(pos)CD44v(pos) cells in the development of N-nitroso-tris-chloroethylurea-induced peripheral-type mouse lung squamous cell carcinomas.
Q37320346Role of epidermal growth factor receptor in breast cancer
Q36155957Role of epidermal growth factor receptor mutations in predicting sensitivity or resistance to targeted agents in non-small-cell lung cancer
Q36475391Role of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of esophageal carcinoma and the suggested mechanisms of action
Q34417886Role of erlotinib in first-line and maintenance treatment of advanced non-small-cell lung cancer
Q35919264Role of erlotinib in the management of pancreatic cancer.
Q37591935Role of erlotinib in the targeted treatment of non-small-cell lung cancer in Chinese patients
Q26866485Role of erlotinib in the treatment of non-small cell lung cancer: clinical outcomes in wild-type epidermal growth factor receptor patients
Q26750428Role of gefitinib in the targeted treatment of non-small-cell lung cancer in Chinese patients
Q37956397Role of genotyping in non-small cell lung cancer treatment: current status
Q92134595Role of liquid biopsy in oncogene-addicted non-small cell lung cancer
Q27027957Role of mesenchymal-epithelial transition amplification in resistance to anti-epidermal growth factor receptor agents
Q36950439Role of miRNA in carcinogenesis and biomarker selection: a methodological view
Q33576845Role of network branching in eliciting differential short-term signaling responses in the hypersensitive epidermal growth factor receptor mutants implicated in lung cancer
Q36616926Role of novel targeted therapies in the clinic
Q50050619Role of particle beam therapy in a trimodality approach to locally advanced non-small cell lung cancer.
Q37288681Role of race in oncogenic driver prevalence and outcomes in lung adenocarcinoma: Results from the Lung Cancer Mutation Consortium
Q28242840Role of receptor tyrosine kinases in gastric cancer: new targets for a selective therapy
Q34705858Roles for growth factors in cancer progression
Q35111284Roles of EGFR and KRAS Mutations in the Treatment Of Patients With Non-Small-Cell Lung Cancer
Q36477469Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes.
Q37627937Roles of pathologists in molecular targeted cancer therapy
Q41605055Routine clinical use of circulating tumor cells for diagnosis of mutations and chromosomal rearrangements in non-small cell lung cancer-ready for prime-time?
Q33599057Routine genetic testing of lung cancer specimens derived from surgery, bronchoscopy and fluid aspiration by next generation sequencing
Q40096915Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT).
Q36695771S100A2 is strongly expressed in airway basal cells, preneoplastic bronchial lesions and primary non-small cell lung carcinomas
Q100512512S6K1 blockade overcomes acquired resistance to EGFR-TKIs in non-small cell lung cancer
Q84706708SEOM clinical guidelines for using molecular markers in clinical practice
Q38833666SFK/FAK Signaling Attenuates Osimertinib Efficacy in Both Drug-Sensitive and Drug-Resistant Models of EGFR-Mutant Lung Cancer
Q37246242SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers
Q28818608SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers
Q41876194SMC1A knockdown induces growth suppression of human lung adenocarcinoma cells through G1/S cell cycle phase arrest and apoptosis pathways in vitro
Q34989327SNP (-617C>A) in ARE-like loci of the NRF2 gene: a new biomarker for prognosis of lung adenocarcinoma in Japanese non-smoking women
Q41642309SPARC is a possible predictive marker for albumin-bound paclitaxel in non-small-cell lung cancer
Q37662776SR48692 inhibits non-small cell lung cancer proliferation in an EGF receptor-dependent manner
Q35570442SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines
Q30821792STAC: A method for testing the significance of DNA copy number aberrations across multiple array-CGH experiments
Q47412228Safety and discomfort during bronchoscopy performed under sedation with fentanyl and midazolam: a prospective study
Q44555068Safety and effectiveness of stereotactic body radiotherapy for a clinically diagnosed primary stage I lung cancer without pathological confirmation
Q46764329Safety and efficacy of sequential chemotherapy with carboplatin plus gemcitabine followed by weekly paclitaxel in advanced non-small cell lung cancer
Q43965995Safety and pharmacokinetics of high-dose gefitinib in patients with solid tumors: results of a phase I study.
Q38841473Safety of gefitinib in non-small cell lung cancer treatment
Q38786021Safety profiles of first-line therapies for metastatic non-squamous non-small-cell lung cancer
Q37364638Salivary gland-type lung carcinomas: an EGFR immunohistochemical, molecular genetic, and mutational analysis study.
Q58704176Score for lung adenocarcinoma in China with EGFR mutation of exon 19: Combination of clinical and radiological characteristics analysis
Q34497010Screening for EGFR Mutations in Patients with Head and Neck Cancer Treated with Gefitinib on a Compassionate-Use Program: A Hellenic Cooperative Oncology Group Study
Q34032012Screening for EGFR and KRAS mutations in endobronchial ultrasound derived transbronchial needle aspirates in non-small cell lung cancer using COLD-PCR.
Q40251351Screens using RNAi and cDNA expression as surrogates for genetics in mammalian tissue culture cells
Q30488528SePreSA: a server for the prediction of populations susceptible to serious adverse drug reactions implementing the methodology of a chemical-protein interactome
Q37177594Searching for a magic bullet in NSCLC: the role of epidermal growth factor receptor mutations and tyrosine kinase inhibitors
Q93185180Second-generation EGFR and ErbB tyrosine kinase inhibitors as first-line treatments for non-small cell lung cancer
Q36904574Second-generation epidermal growth factor receptor tyrosine kinase inhibitors in lung cancers
Q36268315Second-generation kinase inhibitors
Q38155201Second-line systemic therapy for metastatic urothelial carcinoma of the bladder
Q47861831Second-line therapy of squamous non-small cell lung cancer: an evolving landscape
Q80100973Second-line treatment of non-small cell lung cancer: big targets, small progress; small targets, big progress?
Q37945643Second-line treatment of non-small-cell lung cancer: chemotherapy or tyrosine kinase inhibitors?
Q53854603Selected highlights from the 5th International Conference on Ovarian Cancer. Houston, TX, USA, 1-4 December 2004.
Q90468769Selecting short length nucleic acids localized in exosomes improves plasma EGFR mutation detection in NSCLC patients
Q44915706Selecting the right patient for tumor therapy
Q37730020Selection criteria for c-Met-targeted therapies: emerging evidence for biomarkers
Q41678123Selection of Non-small Cell Lung Cancer Patients for Intercalated Chemotherapy and Tyrosine Kinase Inhibitors
Q34384968Selection of extreme phenotypes: the role of clinical observation in translational research.
Q58151801Selective Energy Transfer Between Quantum Dots and Gold Nanoparticles for Detection of Multiple Mutations in Epidermal Growth Factor Receptor
Q34354339Selective antitumor activity of ibrutinib in EGFR-mutant non-small cell lung cancer cells
Q47226790Selective heat generation in cancer cells using a combination of 808 nm laser irradiation and the folate-conjugated Fe2O3@Au nanocomplex.
Q36616873Selective inhibition of TNF-alpha-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinib
Q40862682Selectivity profile of afatinib for EGFR-mutated non-small-cell lung cancer.
Q61456218Semaphorin 7A promotes EGFR-TKI resistance in EGFR mutant lung adenocarcinoma cells
Q51293195Semiautomated laser capture microdissection of lung adenocarcinoma cytology samples.
Q36746316Sensitive cytometry based system for enumeration, capture and analysis of gene mutations of circulating tumor cells
Q79787202Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing
Q35189160Sensitivity analysis of biological Boolean networks using information fusion based on nonadditive set functions
Q37468539Sensitivity and resistance to EGF-R inhibitors: approaches to enhance the efficacy of EGF-R antibodies
Q36611196Sensitivity of epidermal growth factor receptor and ErbB2 exon 20 insertion mutants to Hsp90 inhibition
Q33510934Sequence and structure signatures of cancer mutation hotspots in protein kinases
Q34201724Sequence-dependent effect of docetaxel with gefitinib on the proliferation and apoptosis of lung adenocarcinoma cell H1975
Q91704405Sequential analysis of transcript expression patterns improves survival prediction in multiple cancers
Q37378176Sequential molecular changes during multistage pathogenesis of small peripheral adenocarcinomas of the lung
Q33995172Sequential treatment of icotinib after first-line pemetrexed in advanced lung adenocarcinoma with unknown EGFR gene status
Q34614608Serum APE1 autoantibodies: a novel potential tumor marker and predictor of chemotherapeutic efficacy in non-small cell lung cancer
Q36695530Serum EGF-receptor and HER-2 extracellular domains and prognosis of non-small-cell lung cancer
Q90409971Serum Platelet-Derived Growth Factor Is Significantly Lower in Patients with Lung Cancer and Continued to Decrease After Platinum-Based Chemotherapy
Q55011252Serum VEGF levels in the early diagnosis and severity assessment of non-small cell lung cancer.
Q46946875Serum carcinoembryonic antigen level is associated with epidermal growth factor receptor mutations in recurrent lung adenocarcinomas
Q54680146Serum levels of surfactant protein D predict the anti-tumor activity of gefitinib in patients with advanced non-small cell lung cancer.
Q54977786Serum peptide expression and treatment responses in patients with advanced non-small-cell lung cancer.
Q35034044Serum proteomic study on EGFR-TKIs target treatment for patients with NSCLC.
Q36839768Setting the benchmark for tailoring treatment with EGFR tyrosine kinase inhibitors
Q40201980Setup and characterization of a human head and neck squamous cell carcinoma xenograft model in nude rats
Q37401172Sex-specific aspects of tumor therapy
Q39194466Shedding of c-Met ectodomain correlates with c-Met expression in non-small cell lung cancer
Q41701853Shikonin enhances Adriamycin antitumor effects by inhibiting efflux pumps in A549 cells
Q58759414Short-Term Responders of Non-Small Cell Lung Cancer Patients to EGFR Tyrosine Kinase Inhibitors Display High Prevalence of TP53 Mutations and Primary Resistance Mechanisms
Q37411082Should primary tumor be resected for non-small cell lung cancer with malignant pleural disease unexpectedly found during operation?-a systemic review and meta-analysis
Q37847104Signal transduction inhibitors and antiangiogenic therapies for malignant glioma
Q27027778Signaling cross-talk in the resistance to HER family receptor targeted therapy
Q35987785Signaling multiplex of the epidermal growth factor receptor
Q36392991Signaling networks assembled by oncogenic EGFR and c-Met
Q34072567Signaling of ERBB receptor tyrosine kinases promotes neuroblastoma growth in vitro and in vivo
Q38805800Signatures of drug sensitivity in nonsmall cell lung cancer
Q64250706Significance of EGFR and PTEN Expression and PLR and NLR for Predicting the Prognosis of Epithelioid Malignant Peritoneal Mesothelioma
Q34886787Significance of targeted therapy and genetic alterations in EGFR, ALK, or KRAS on survival in patients with non-small cell lung cancer treated with radiotherapy for brain metastases
Q34427354Significance of the progesterone receptor and epidermal growth factor receptor, but not the estrogen receptor, in chemically induced lung carcinogenesis in female A/J mice
Q37034341Significant increase in hEGF uptake is correlated with formation of EGFR dimers induced by the EGFR tyrosine kinase inhibitor gefitinib
Q89497005Silence of S1 RNA binding domain 1 represses cell growth and promotes apoptosis in human non-small cell lung cancer cells
Q28547292Silencing of Receptor Tyrosine Kinase ROR1 Inhibits Tumor-Cell Proliferation via PI3K/AKT/mTOR Signaling Pathway in Lung Adenocarcinoma
Q36216766Simultaneous detection of expression and gene mutations of HER2/neu in Chinese patients with gastric cancer
Q43860596Simultaneous diagnostic platform of genotyping EGFR, KRAS, and ALK in 510 Korean patients with non-small-cell lung cancer highlights significantly higher ALK rearrangement rate in advanced stage
Q36782324Simultaneous gene silencing of KRAS and anti-apoptotic genes as a multitarget therapy
Q34589774Simultaneous inhibition of EGFR, VEGFR, and platelet-derived growth factor receptor signaling combined with gemcitabine produces therapy of human pancreatic carcinoma and prolongs survival in an orthotopic nude mouse model.
Q40472879Simultaneous inhibition of epidermal growth factor receptor (EGFR) signaling and enhanced activation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-mediated apoptosis induction by an scFv:sTRAIL fusion protein with speci
Q52583236Single Locked Nucleic Acid-Enhanced Nanopore Genetic Discrimination of Pathogenic Serotypes and Cancer Driver Mutations.
Q34523257Single-Tube Mutation Scanning of The Epidermal Growth Factor Receptor Gene Using Multiplex LATE-PCR and Lights-On/Lights-Off Probes
Q83015772Single-arm phase II study of multiagent concurrent chemoradiotherapy and gefitinib in locoregionally advanced squamous cell carcinoma of the head and neck
Q91721637Single-molecule functional anatomy of endogenous HER2-HER3 heterodimers
Q28069454Skin problems and EGFR-tyrosine kinase inhibitor
Q39637704Slug confers resistance to the epidermal growth factor receptor tyrosine kinase inhibitor
Q48070194Small Molecule T315 Promotes Casitas B-Lineage Lymphoma-Dependent Degradation of Epidermal Growth Factor Receptor via Y1045 Autophosphorylation
Q27027835Small molecule compounds targeting the p53 pathway: are we finally making progress?
Q38219688Small-molecule EGFR tyrosine kinase inhibitors for the treatment of cancer
Q37238413Smoking status and self-reported race affect the frequency of clinically relevant oncogenic alterations in non-small-cell lung cancers at a United States-based academic medical practice.
Q46971338Solid predominant histology predicts EGFR tyrosine kinase inhibitor response in patients with EGFR mutation-positive lung adenocarcinoma
Q35602124Soluble epidermal growth factor receptor (sEGFR) and carcinoembryonic antigen (CEA) concentration in patients with non-small cell lung cancer: correlation with survival after erlotinib and gefitinib treatment
Q37502708Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC.
Q36200850Somatic Mutation Spectrum of Non-Small-Cell Lung Cancer in African Americans: A Pooled Analysis.
Q37294797Somatic microindels in human cancer: the insertions are highly error-prone and derive from nearby but not adjacent sense and antisense templates
Q99607554Somatic mutation detection efficiency in EGFR: a comparison between high resolution melting analysis and Sanger sequencing
Q36014517Somatic mutation in synchronous primary adenocarcinomas of the left lung: a case report
Q46880458Somatic mutation of PHF6 gene in T-cell acute lymphoblatic leukemia, acute myelogenous leukemia and hepatocellular carcinoma
Q24648102Somatic mutations affect key pathways in lung adenocarcinoma
Q42706743Somatic mutations and immunotherapy outcome with CTLA-4 blockade in melanoma
Q52590998Somatic mutations of ErbB4: selective loss-of-function phenotype affecting signal transduction pathways in cancer.
Q38512879Somatic mutations of the ERBB4 kinase domain in human cancers
Q24648133Somatic mutations of the epidermal growth factor receptor and non-small-cell lung cancer
Q37235024Somatic pharmacogenomics in cancer
Q35749438Somatic sequence alterations in twenty-one genes selected by expression profile analysis of breast carcinomas
Q36028660Some lessons learned from imatinib mesylate clinical development in gastrointestinal stromal tumors
Q33582914Sorafenib blocks tumour growth, angiogenesis and metastatic potential in preclinical models of osteosarcoma through a mechanism potentially involving the inhibition of ERK1/2, MCL-1 and ezrin pathways
Q38020917Sorafenib in non-small cell lung cancer
Q36708741Sorafenib: where do we go from here?
Q39202557Sorting nexin 2-mediated membrane trafficking of c-Met contributes to sensitivity of molecular-targeted drugs
Q33405933Southwestern oncology group phase II trial (S0526) of pemetrexed in bronchioloalveolar carcinoma subtypes of advanced adenocarcinoma
Q39714753Spatial and temporal genetic heterogeneity of epidermal growth factor receptor gene status in a patient with non-small cell lung cancer: a case report
Q37995451Specific biomarkers of receptors, pathways of inhibition and targeted therapies: pre-clinical developments.
Q40127625Specific isolation of disseminated cancer cells: a new method permitting sensitive detection of target molecules of diagnostic and therapeutic value
Q40669345Specific killing of Rb mutant cancer cells by inactivating TSC2.
Q89750470Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis
Q35036895Spectrum of EGFR gene copy number changes and KRAS gene mutation status in Korean triple negative breast cancer patients
Q36815913Spectrum of EGFR gene mutations and ALK rearrangements in lung cancer patients in Turkey
Q47930093Spectrum of EGFR gene mutations in Vietnamese patients with non-small cell lung cancer
Q33563803Spectrum of LKB1, EGFR, and KRAS mutations in chinese lung adenocarcinomas
Q30837003SpliceNet: recovering splicing isoform-specific differential gene networks from RNA-Seq data of normal and diseased samples
Q37137372Sputum-based molecular biomarkers for the early detection of lung cancer: limitations and promise
Q30278774Src inhibitors act through different mechanisms in Non-Small Cell Lung Cancer models depending on EGFR and RAS mutational status
Q39033091Src mediates ERK reactivation in gefitinib resistance in non-small cell lung cancer
Q35207876Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells
Q47390697Standard-dose osimertinib for refractory leptomeningeal metastases in T790M-positive EGFR-mutant non-small cell lung cancer
Q35167923Standardization of epidermal growth factor receptor (EGFR) measurement by quantitative immunofluorescence and impact on antibody-based mutation detection in non-small cell lung cancer
Q52673091Standardizing biomarker testing for Canadian patients with advanced lung cancer.
Q36271949State of the art in therapy for non-small cell lung cancer
Q34681069State of the art: Response assessment in lung cancer in the era of genomic medicine
Q34089332State-of-the-art MS technology applications in lung disease.
Q36269651Statin improves survival in patients with EGFR-TKI lung cancer: A nationwide population-based study
Q36117881Strategic plans to promote head and neck cancer translational research within the radiation therapy oncology group: a report from the translational research program
Q84623471Strategies for overcoming EGFR resistance in the treatment of advanced-stage NSCLC
Q37856721Strategies to improve radiotherapy with targeted drugs
Q38838227Strategies to overcome acquired resistances conferred by mutations in the kinase domain of EGFR.
Q35968384Strategies to overcome resistance to targeted protein kinase inhibitors
Q35017477Stratification of non-small cell lung cancer patients for therapy with epidermal growth factor receptor inhibitors: the EGFR fluorescence in situ hybridization assay
Q54957856Stressing the need to overcome EGFR tyrosine kinase inhibitor resistance.
Q42119491Structural Differences between Wild-Type and Double Mutant EGFR Modulated by Third-Generation Kinase Inhibitors
Q33810641Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer
Q27677383Structural basis for the altered drug sensitivities of non-small cell lung cancer-associated mutants of human epidermal growth factor receptor
Q41593246Structural basis of mutant-selectivity and drug-resistance related to CO-1686.
Q90179057Structural characterization of EGFR exon 19 deletion mutation using molecular dynamics simulation
Q52345422Structural insights into drug development strategy targeting EGFR T790M/C797S.
Q35652106Structural investigations of T854A mutation in EGFR and identification of novel inhibitors using structure activity relationships
Q42768815Structural signature of the G719S-T790M double mutation in the EGFR kinase domain and its response to inhibitors.
Q36181814Structural systems biology and multiscale signaling models
Q92658888Structural variation and its potential impact on genome instability: Novel discoveries in the EGFR landscape by long-read sequencing
Q27680966Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer
Q92934599Structure and Dynamics of the EGF Receptor as Revealed by Experiments and Simulations and Its Relevance to Non-Small Cell Lung Cancer
Q37122918Structure and clinical relevance of the epidermal growth factor receptor in human cancer
Q33680363Structure and function of epigen, the last EGFR ligand
Q33812445Structure-Guided Design of C4-alkyl-1,4-dihydro-2H-pyrimido[4,5-d][1,3]oxazin-2-ones as Potent and Mutant-Selective Epidermal Growth Factor Receptor (EGFR) L858R/T790M Inhibitors.
Q49344251Structure-based pharmacophore design and virtual screening for novel potential inhibitors of epidermal growth factor receptor as an approach to breast cancer chemotherapy.
Q38987589Structure-functional prediction and analysis of cancer mutation effects in protein kinases.
Q27643967Structure-guided development of affinity probes for tyrosine kinases using chemical genetics
Q27644014Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity
Q40694780Study of Gefitinib and Pemetrexed as First-Line Treatment in Patients with Advanced Non-Small Cell Lung Cancer Harboring EGFR Mutation
Q37389611Study of efficacy and safety of pulsatile administration of high-dose gefitinib or erlotinib for advanced non-small cell lung cancer patients with secondary drug resistance: A single center, single arm, phase II clinical trial
Q35700405Study on expression of lncRNA RGMB-AS1 and repulsive guidance molecule b in non-small cell lung cancer
Q35929525Studying a complex tumor: potential and pitfalls
Q35596310Studying clonal dynamics in response to cancer therapy using high-complexity barcoding.
Q37127423Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
Q89995873Subtyping and EGFR mutation testing from blocks of cytological materials, based on liquid-based cytology for lung cancer at bronchoscopic examinations
Q44574005Subtyping of pulmonary adenocarcinoma in cytologic specimens: the next challenge
Q36324363Successes and failures of the teachable moment: smoking cessation in cancer patients
Q38721743Sufficiency of Single-Arm Studies to Support Registration of Targeted Agents in Molecularly Selected Patients with Cancer: Lessons from the Clinical Development of Crizotinib
Q44126874Sunitinib in pretreated advanced non-small-cell lung carcinoma: a primary result from Asian population
Q38721555Superior Efficacy and Selectivity of Novel Small-Molecule Kinase Inhibitors of T790M-Mutant EGFR in Preclinical Models of Lung Cancer
Q61798869Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity
Q28477887Suppression of expression of heat shock protein 70 by gefitinib and its contribution to pulmonary fibrosis
Q37179584Surgical treatment for primary pulmonary lymphoepithelioma-like carcinoma
Q36439350Surgical treatment for pulmonary pleomorphic carcinoma: A retrospective study of 60 patients
Q47417911Surrogate end points for survival in the target treatment of advanced non-small-cell lung cancer with gefitinib or erlotinib
Q40315977Survival Gains from First-Line Systemic Therapy in Metastatic Non-Small Cell Lung Cancer in the U.S., 1990-2015: Progress and Opportunities
Q54977347Survival analysis and pathological features of advanced non-small cell lung cancer with miliary pulmonary metastases in patients harboring epidermal growth factor receptor mutations.
Q30574736Survival and death signals can predict tumor response to therapy after oncogene inactivation
Q36311791Survival impact of epidermal growth factor receptor overexpression in patients with non-small cell lung cancer: a meta-analysis
Q51785555Survival outcome and predictors of gefitinib antitumor activity in East Asian chemonaive patients with advanced nonsmall cell lung cancer.
Q37761935Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics
Q49873962Survival-associated factors of first-line EGFR-tyrosine kinase inhibitor responders and non-responders in lung adenocarcinoma patients with common EGFR mutations.
Q54375452Survivin mRNA expression in blood as a predictor of the response to EGFR-tyrosine kinase inhibitors and prognosis in patients with non-small cell lung cancer.
Q45041454Switching on kinases: oncogenic activation of BRAF and the PDGFR family
Q41969702Synergism of EGFR and c-Met pathways, cross-talk and inhibition, in non-small cell lung cancer
Q33837881Synergistic down-regulation of receptor tyrosine kinases by combinations of mAbs: implications for cancer immunotherapy
Q49387613Synergistic effect of targeting dishevelled-3 and the epidermal growth factor receptor-tyrosine kinase inhibitor on mesothelioma cells in vitro.
Q39388106Synergistic effects of erlotinib and everolimus on bronchial carcinoids and large-cell neuroendocrine carcinomas with activated EGFR/AKT/mTOR pathway
Q40409431Synergistic growth inhibition by Iressa and Rapamycin is modulated by VHL mutations in renal cell carcinoma
Q39429719Synergistic inhibitory effects by the combination of gefitinib and genistein on NSCLC with acquired drug-resistance in vitro and in vivo
Q39499521Synergistic interaction between sunitinib and docetaxel is sequence dependent in human non-small lung cancer with EGFR TKIs-resistant mutation
Q39280914Synonymous EGFR variant p.Q787Q is neither prognostic nor predictive in patients with lung adenocarcinoma
Q44851135Synthesis and anticancer activity of new quinazoline derivatives
Q33847057Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents
Q28820988Synthesis and biological evaluation of matrine derivatives containing benzo-α-pyrone structure as potent anti-lung cancer agents
Q39413333Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer
Q38801969Systematic Computational Identification of Variants That Activate Exonic and Intronic Cryptic Splice Sites
Q36539506Systematic Prioritization of Druggable Mutations in ∼5000 Genomes Across 16 Cancer Types Using a Structural Genomics-based Approach
Q35854835Systematic analysis of genetic alterations in tumors using Cancer Genome WorkBench (CGWB).
Q89900731Systematic comparison of somatic variant calling performance among different sequencing depth and mutation frequency
Q33826328Systematic comparison of two whole-genome amplification methods for targeted next-generation sequencing using frozen and FFPE normal and cancer tissues
Q29547695Systematic identification of genomic markers of drug sensitivity in cancer cells
Q37331472Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer
Q58774943Systemic Drug-induced Chronic Paronychia and Periungual Pyogenic Granuloma
Q34865629Systemic Nocardiosis Mimicking Disease Flare-up after Discontinuation of Gefitinib in a Patient with EGFR-Mutant Lung Cancer
Q54978262Systemic Therapy of Lung Cancer CNS Metastases Using Molecularly Targeted Agents and Immune Checkpoint Inhibitors.
Q38285931Systemic therapy of brain metastases.
Q47585577Systems Biology: a new hope for drug discovery?
Q90324481Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition
Q38066235Systems biology technologies enable personalized traditional Chinese medicine: a systematic review
Q54627325Systems biology-embedded target validation: improving efficacy in drug discovery.
Q58765906T790M Correlates with Longer Progression-free Survival in Non-small Cell Lung Carcinomas Harboring Mutations
Q40012030TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer
Q34345632TAGCNA: a method to identify significant consensus events of copy number alterations in cancer
Q35525917TAK-701, a humanized monoclonal antibody to hepatocyte growth factor, reverses gefitinib resistance induced by tumor-derived HGF in non-small cell lung cancer with an EGFR mutation
Q42286893TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling
Q28393844TERT Polymorphism rs2736100-C Is Associated with EGFR Mutation-Positive Non-Small Cell Lung Cancer
Q34100276TGF-beta IL-6 axis mediates selective and adaptive mechanisms of resistance to molecular targeted therapy in lung cancer
Q45286133TGFalpha expression impairs Trastuzumab-induced HER2 downregulation
Q36285249TIP30 loss enhances cytoplasmic and nuclear EGFR signaling and promotes lung adenocarcinogenesis in mice
Q41959361TKIs in NSCLC: the down of a new era?
Q38853578TLG-S criteria are superior to both EORTC and PERCIST for predicting outcomes in patients with metastatic lung adenocarcinoma treated with erlotinib
Q52317261TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer.
Q42259718TRAIL apoptotic pathway-targeted therapies for NSCLC.
Q39373269TRPC1 protein channel is major regulator of epidermal growth factor receptor signaling
Q34137429TWIST1 a new determinant of epithelial to mesenchymal transition in EGFR mutated lung adenocarcinoma
Q36836799TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia
Q36956724Tackling EGFR signaling with TACE antagonists: a rational target for metalloprotease inhibitors in cancer
Q36430761Tailor-made chemotherapy for non-small cell lung cancer patients
Q35927501Taking aim at Mer and Axl receptor tyrosine kinases as novel therapeutic targets in solid tumors
Q37851009Taming the dragon: genomic biomarkers to individualize the treatment of cancer.
Q38669277Target Therapy in Lung Cancer
Q34898454Target therapies in lung cancer
Q42582783Target therapy in NSCLC patients: Relevant clinical agents and tumour molecular characterisation
Q42328292Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer
Q90672582Targeted Molecular Treatments in Non-Small Cell Lung Cancer: A Clinical Guide for Oncologists
Q38930362Targeted Therapies for Lung Cancer
Q34030379Targeted Therapies in Lung Cancer
Q28083446Targeted Therapies in Non-Small Cell Lung Cancer-Beyond EGFR and ALK
Q39192200Targeted Treatment of Brain Metastases
Q38100162Targeted agents in non-small cell lung cancer therapy: What is there on the horizon?
Q36616922Targeted antitumour therapy--future perspectives
Q36920799Targeted cancer therapies based on antibodies directed against epidermal growth factor receptor: status and perspectives
Q36786085Targeted cancer therapy: promise and reality
Q34356166Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer
Q38956321Targeted inhibition in tumors with ALK dependency
Q34683348Targeted inhibition of kinases in cancer therapy
Q44992034Targeted lung cancer therapies
Q26862516Targeted molecular therapies against epidermal growth factor receptor: past experiences and challenges
Q37807159Targeted molecular therapy in melanoma
Q36113026Targeted molecular therapy of malignant gliomas
Q82494790Targeted molecular therapy of malignant gliomas
Q37392703Targeted sequencing identifies genetic alterations that confer primary resistance to EGFR tyrosine kinase inhibitor (Korean Lung Cancer Consortium).
Q36128449Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA
Q26738986Targeted therapies and immunotherapy in non-small-cell lung cancer
Q35589492Targeted therapies for advanced Ewing sarcoma family of tumors
Q35919642Targeted therapies for cancer 2004.
Q36046241Targeted therapies for gynecologic malignancies
Q54411624Targeted therapies for locally advanced or metastatic squamous cell carcinoma of the lung.
Q36054970Targeted therapies for lung cancer: clinical experience and novel agents
Q42431459Targeted therapies for lung cancer: how did the game begin?
Q36150842Targeted therapies for prostate cancer
Q49961144Targeted therapies for targeted populations: Anti-EGFR treatment for EGFR amplified gastroesophageal adenocarcinoma.
Q38625550Targeted therapies for treatment of non-small cell lung cancer--Recent advances and future perspectives
Q36934791Targeted therapies in bladder cancer--an update
Q36051459Targeted therapies in breast cancer.
Q27022852Targeted therapies in development for non-small cell lung cancer
Q33606699Targeted therapies in epithelial ovarian cancer
Q34878868Targeted therapies in epithelial ovarian cancer: Molecular mechanisms of action
Q36990546Targeted therapies in non-small cell lung cancer
Q42845478Targeted therapies: Tyrosine-kinase inhibitors--new standard for NSCLC therapy
Q37956110Targeted therapies: how personal should we go?
Q33807742Targeted therapy for cancer: the gastrointestinal stromal tumor model
Q38390200Targeted therapy for non-small cell lung cancer: current standards and the promise of the future
Q37096910Targeted therapy for squamous cell lung cancer
Q37204270Targeted therapy in cancer
Q35207561Targeted therapy in hepatocellular carcinoma
Q37246286Targeted therapy in lung cancer: IPASS and beyond, keeping abreast of the explosion of targeted therapies for lung cancer
Q38042324Targeted therapy in rare cancers--adopting the orphans
Q37290520Targeted therapy of advanced non-small cell lung cancer: the role of bevacizumab
Q49956245Targeted therapy of brain metastases: latest evidence and clinical implications.
Q37897792Targeted therapy of non-small-cell lung carcinoma.
Q36026004Targeted therapy: a new approach for the treatment of locally advanced oropharyngeal cancer.
Q37781113Targeted therapy: an evolving world of lung cancer.
Q35671213Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer
Q36933081Targeting ALK in neuroblastoma--preclinical and clinical advancements
Q38673845Targeting ALK-rearranged non-small-cell lung cancer: an update
Q90133295Targeting Autophagy for Overcoming Resistance to Anti-EGFR Treatments
Q27658951Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors
Q33889144Targeting CCR2 with its antagonist suppresses viability, motility and invasion by downregulating MMP-9 expression in non-small cell lung cancer cells
Q40095585Targeting EGFR in bladder cancer
Q37258827Targeting EGFR in lung cancer: Lessons learned and future perspectives
Q37405633Targeting EGFR resistance networks in head and neck cancer.
Q27027433Targeting EGFR signalling in chronic lung disease: therapeutic challenges and opportunities
Q33750719Targeting EGFR/HER2 pathways enhances the antiproliferative effect of gemcitabine in biliary tract and gallbladder carcinomas
Q27002155Targeting EML4-ALK driven non-small cell lung cancer (NSCLC)
Q92035698Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer
Q34174883Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
Q53688274Targeting General Transcriptional Machinery as a Therapeutic Strategy for Adult T-Cell Leukemia.
Q36898642Targeting HER proteins in cancer therapy and the role of the non-target HER3.
Q36429516Targeting HER1/EGFR in cancer therapy: experience with erlotinib
Q35890128Targeting HER3 by interfering with its Sec61-mediated cotranslational insertion into the endoplasmic reticulum
Q37603214Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells
Q42606238Targeting IGF-1R: throwing out the baby with the bathwater?
Q36398758Targeting KRAS-mutant non-small cell lung cancer: challenges and opportunities.
Q37539304Targeting MET as a strategy to overcome crosstalk-related resistance to EGFR inhibitors
Q42369856Targeting Novel but Less Common Driver Mutations and Chromosomal Translocations in Advanced Non-Small Cell Lung Cancer
Q29617685Targeting PI3K signalling in cancer: opportunities, challenges and limitations
Q33554884Targeting PTPs with small molecule inhibitors in cancer treatment
Q37293656Targeting SHP2 for EGFR inhibitor resistant non-small cell lung carcinoma
Q38608540Targeting Signaling Transduction Pathways in Bladder Cancer
Q35575242Targeting TACE-dependent EGFR ligand shedding in breast cancer
Q36580144Targeting Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer by Inducing Epidermal Growth Factor Receptor Degradation via Methionine 790 Oxidation
Q92693295Targeting an EGFR Water Network with 4-Anilinoquin(az)oline Inhibitors for Chordoma
Q37435616Targeting aromatase and estrogen signaling in human non-small cell lung cancer
Q38767073Targeting asparagine and autophagy for pulmonary adenocarcinoma therapy
Q37800284Targeting cytoskeleton reorganisation as antimetastatic treatment.
Q36983136Targeting epidermal growth factor receptor and SRC pathways in head and neck cancer
Q36656097Targeting epidermal growth factor receptor for head and neck squamous cell carcinoma: still lost in translation?
Q37768460Targeting epidermal growth factor receptor in the treatment of non-small-cell lung cancer
Q36613969Targeting epidermal growth factor receptor signaling in the treatment of head and neck cancer
Q37789955Targeting erbB receptors
Q64118764Targeting exon 20 insertion mutations in non-small cell lung cancer
Q53078264Targeting focal adhesion kinase overcomes erlotinib resistance in smoke induced lung cancer by altering phosphorylation of epidermal growth factor receptor.
Q89533973Targeting gallbladder cancer: a pathway based perspective
Q37068767Targeting genomic alterations in squamous cell lung cancer
Q90481579Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors
Q37849013Targeting mutant fibroblast growth factor receptors in cancer
Q34627751Targeting of Both the c-Met and EGFR Pathways Results in Additive Inhibition of Lung Tumorigenesis in Transgenic Mice
Q39007950Targeting of EGF-displayed protein nanoparticles with anticancer drugs.
Q38388217Targeting of MEK in lung cancer therapeutics
Q35751013Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia
Q37847584Targeting p27Kip1 protein: its relevance in the therapy of human cancer.
Q35987779Targeting protein kinases in cancer therapy: a success?
Q37600910Targeting the EGF receptor ectodomain in the context of cancer
Q39047294Targeting the EGFR T790M mutation in non-small-cell lung cancer
Q34246558Targeting the EGFR signaling pathway in cancer therapy
Q91329983Targeting the IL-1β/EHD1/TUBB3 axis overcomes resistance to EGFR-TKI in NSCLC
Q37792116Targeting the MET oncogene in cancer and metastases.
Q37265126Targeting the PI3-kinase/Akt/mTOR signaling pathway
Q29618155Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
Q33584823Targeting the cyclin E-Cdk-2 complex represses lung cancer growth by triggering anaphase catastrophe
Q37485865Targeting the epidermal growth factor receptor in epithelial ovarian cancer: current knowledge and future challenges.
Q37076172Targeting the epidermal growth factor receptor in high-grade astrocytomas
Q36858198Targeting the epidermal growth factor receptor in non-small-cell lung cancer: who, which, when, and how?
Q37990044Targeting the epidermal growth factor receptor in solid tumor malignancies.
Q36564975Targeting the epidermal growth factor receptor in the treatment of colorectal cancer: state of the art.
Q90138425Targeting the evolution of drug resistance in lung cancer
Q37863629Targeting the growth factors and angiogenesis pathways: small molecules in solid tumors
Q37862077Targeting the human EGFR family in esophagogastric cancer
Q41830456Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features.
Q41825773Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation.
Q36472432Technology insight: pharmacoproteomics for cancer--promises of patient-tailored medicine using protein microarrays
Q35876022Technology platforms for pharmacogenomic diagnostic assays
Q35007976Telomere length and recurrence risk after curative resection in patients with early-stage non-small-cell lung cancer: a prospective cohort study
Q36077604Temporal resolution of autophosphorylation for normal and oncogenic forms of EGFR and differential effects of gefitinib.
Q36246336Ten years of marketing approvals of anticancer drugs in Europe: regulatory policy and guidance documents need to find a balance between different pressures
Q64916419Test Feasibility of Next-Generation Sequencing Assays in Clinical Mutation Detection of Small Biopsy and Fine Needle Aspiration Specimens.
Q36280333Tetrathiomolybdate mediates cisplatin-induced p38 signaling and EGFR degradation and enhances response to cisplatin therapy in gynecologic cancers
Q36587373The 5 stages of biotechnology management
Q42143312The Antitumor Effect of C-terminus of Hsp70-Interacting Protein via Degradation of c-Met in Small Cell Lung Cancer
Q47655278The Association of Acquired T790M Mutation with Clinical Characteristics after Resistance to First-Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Lung Adenocarcinoma
Q36197375The Association of EGFR Mutations with Stage at Diagnosis in Lung Adenocarcinomas
Q35208501The BATTLE to personalize lung cancer prevention through reverse migration
Q34275011The BATTLE trial: personalizing therapy for lung cancer
Q27010154The BCL2 Family: Key Mediators of the Apoptotic Response to Targeted Anticancer Therapeutics
Q35800375The CTC-chip: an exciting new tool to detect circulating tumor cells in lung cancer patients
Q34763495The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy
Q36939336The Clinical Significance of the Insulin-Like Growth Factor-1 Receptor Polymorphism in Non-Small-Cell Lung Cancer with Epidermal Growth Factor Receptor Mutation
Q49544424The Dawning of Translational Breast Cancer: From Bench to Bedside.
Q64055489The Diagnostic Value of Quantitative CT Analysis of Ground-Glass Volume Percentage in Differentiating Epidermal Growth Factor Receptor Mutation and Subtypes in Lung Adenocarcinoma
Q37026204The Difference of Clinical Characteristics Between Patients With Exon 19 Deletion and Those With L858R Mutation in Nonsmall Cell Lung Cancer
Q49887941The E3 ubiquitin ligase NEDD4 mediates cell migration signaling of EGFR in lung cancer cells.
Q36154748The E3 ubiquitin ligase RNF135 regulates the tumorigenesis activity of tongue cancer SCC25 cells
Q92640668The EGFR Exon 19 Mutant L747-A750>P Exhibits Distinct Sensitivity to Tyrosine Kinase Inhibitors in Lung Adenocarcinoma
Q58605631The EGFR T790M mutation is acquired through AICDA-mediated deamination of 5-methylcytosine following TKI treatment in lung cancer
Q38201344The EGFR family: not so prototypical receptor tyrosine kinases
Q40158764The EGFR inhibitor gefitinib suppresses ligand-stimulated endocytosis of EGFR via the early/late endocytic pathway in non-small cell lung cancer cell lines
Q37365512The EGFR tyrosine kinase inhibitors as second-line therapy for EGFR wild-type non-small-cell lung cancer: a real-world study in People's Republic of China
Q38598710The EGFR-HER2 module: a stem cell approach to understanding a prime target and driver of solid tumors
Q37888326The EMT regulator slug and lung carcinogenesis
Q54498075The ERBB network: at last, cancer therapy meets systems biology.
Q37135372The ERBB3 receptor in cancer and cancer gene therapy
Q40701318The Efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors for Molecularly Selected Patients with Non-Small Cell Lung Cancer: A Meta-Analysis of 30 Randomized Controlled Trials
Q36095650The Emergent Landscape of Detecting EGFR Mutations Using Circulating Tumor DNA in Lung Cancer.
Q37257613The ErbB kinase domain: structural perspectives into kinase activation and inhibition
Q52673453The Evolving Landscape of Brain Metastasis.
Q35835931The Evolving Role of Maintenance Therapy Using Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR TKIs) in the Management of Advanced Non-Small-Cell Lung Cancer
Q39829525The Frequency of EGFR Mutation in Lung Adenocarcinoma and the Efficacy of Tyrosine Kinase Inhibitor Therapy in a Hungarian Cohort of Patients
Q35608617The Frequency of Epidermal Growth Factor Receptor Mutation of Nonsmall Cell Lung Cancer according to the Underlying Pulmonary Diseases
Q34558080The HER family and cancer: emerging molecular mechanisms and therapeutic targets
Q35702309The Impact of Coexisting Asthma, Chronic Obstructive Pulmonary Disease and Tuberculosis on Survival in Patients with Lung Squamous Cell Carcinoma
Q28067196The Impact of Genomic Profiling for Novel Cancer Therapy--Recent Progress in Non-Small Cell Lung Cancer
Q36280050The Impact of Sequence of Chemotherapy and EGFR-TKI Treatment on Different EGFR Mutation Lung Adenocarcinoma
Q46861636The Impact of Smoking and TP53 mutations in lung adenocarcinoma patients with targetable mutations - the Lung Cancer Mutation Consortium (LCMC2).
Q39015512The Importance of Biopsy in the Era of Molecular Medicine
Q35778529The Jeremiah Metzger Lecture: intelligent design of cancer therapy: trials and tribulations.
Q39752575The LUX-Lung clinical trial program of afatinib for non-small-cell lung cancer
Q34459097The MAPK pathway across different malignancies: a new perspective
Q34173500The Met oncogene and basal-like breast cancer: another culprit to watch out for?
Q38679301The Microenvironment of Lung Cancer and Therapeutic Implications
Q35078950The Molecular Crosstalk between the MET Receptor Tyrosine Kinase and the DNA Damage Response-Biological and Clinical Aspects
Q41043732The Myb-p300 Interaction Is a Novel Molecular Pharmacologic Target
Q97569221The National Lung Matrix Trial of personalized therapy in lung cancer
Q36316643The National Lung Matrix Trial: translating the biology of stratification in advanced non-small-cell lung cancer
Q54388246The PCR-invader method (structure-specific 5' nuclease-based method), a sensitive method for detecting EGFR gene mutations in lung cancer specimens; comparison with direct sequencing.
Q33699378The PIK3CA gene as a mutated target for cancer therapy
Q37838120The Pharmacogenetic Rescue of Side-Lined Anticancer Drugs to the Front-Line: Gefitinib as a Case Example
Q58781611The Prognostic Role of Circulating Tumor Cells (CTCs) in Lung Cancer
Q30009944The Rak/Frk tyrosine kinase associates with and internalizes the epidermal growth factor receptor
Q36535465The Role of Adaptive Immunity in the Efficacy of Targeted Cancer Therapies
Q39316449The Role of ErbB Receptors in Infection
Q37335920The Role of PIK3CA Mutations among Lung Adenocarcinoma Patients with Primary and Acquired Resistance to EGFR Tyrosine Kinase Inhibition
Q92830541The Role of Precision Medicine in the Diagnosis and Treatment of Patients with Rare Cancers
Q38199934The Role of STAT3 in Non-Small Cell Lung Cancer
Q37189951The Role of the NF-kappaB Transcriptome and Proteome as Biomarkers in Human Head and Neck Squamous Cell Carcinomas
Q24649549The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP
Q49963088The T790M resistance mutation in EGFR is only found in cfDNA from erlotinib-treated NSCLC patients that harbored an activating EGFR mutation before treatment.
Q38994746The TGFβ-miR200-MIG6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors
Q37689252The Translational Research Working Group developmental pathway for anticancer agents (drugs or biologics).
Q38768030The Use of EGFR Tyrosine Kinase Inhibitors in EGFR Wild-Type Non-Small-Cell Lung Cancer
Q30978835The Use of Non-Variant Sites to Improve the Clinical Assessment of Whole-Genome Sequence Data
Q64062553The Value of Liquid Biopsies for Guiding Therapy Decisions in Non-small Cell Lung Cancer
Q42378470The activation of SRC family kinases and focal adhesion kinase with the loss of the amplified, mutated EGFR gene contributes to the resistance to afatinib, erlotinib and osimertinib in human lung cancer cells
Q40439596The antiepidermal growth factor receptor monoclonal antibody cetuximab/C225 reduces hypoxia-inducible factor-1 alpha, leading to transcriptional inhibition of vascular endothelial growth factor expression
Q38418344The apoptotic effect of simvastatin via the upregulation of BIM in nonsmall cell lung cancer cells
Q37397842The aqueous extract of Brucea javanica suppresses cell growth and alleviates tumorigenesis of human lung cancer cells by targeting mutated epidermal growth factor receptor
Q37709481The association between clinical prognostic factors and epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) efficacy in advanced non-small-cell lung cancer patients: a retrospective assessment of 94 cases with EGFR mutations
Q36533669The bioinformatics analysis of miRNAs signatures differentially expressed in HER2(+) versus HER2(-) breast cancers
Q49826396The biology and management of non-small cell lung cancer.
Q36780601The bronchioloalveolar carcinoma and peripheral adenocarcinoma spectrum of diseases.
Q34342864The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2.
Q34276557The cellular origin for malignant glioma and prospects for clinical advancements
Q37871875The challenges of integrating molecular imaging into the optimization of cancer therapy.
Q39134733The changing landscape of clinical trial and approval processes in China.
Q39037647The changing landscape of gynaecological cancer diagnosis: implications for histopathological practice in the 21st century
Q92644598The combination of bevacizumab/Avastin and erlotinib/Tarceva is relevant for the treatment of metastatic renal cell carcinoma: the role of a synonymous mutation of the EGFR receptor
Q28268061The concept of synthetic lethality in the context of anticancer therapy
Q37077933The content of mutant EGFR DNA correlates with response to EGFR-TKIs in lung adenocarcinoma patients with common EGFR mutations
Q34622547The contribution of cetuximab in the treatment of recurrent and/or metastatic head and neck cancer
Q50050305The detection of EGFR mutation status in plasma is reproducible and can dynamically predict the efficacy of EGFR-TKI.
Q38907580The development of biomarkers to reduce attrition rate in drug discovery focused on oncology and central nervous system
Q38233179The diagnosis and treatment of brain metastases in EGFR mutant lung cancer.
Q90843191The diagnosis of non-small cell lung cancer in the molecular era
Q26781159The distinctive nature of adenocarcinoma of the lung
Q90728910The ectopic expression of meiCT genes promotes meiomitosis and may facilitate carcinogenesis
Q39425405The effects of artesunate on the expression of EGFR and ABCG2 in A549 human lung cancer cells and a xenograft model.
Q86183346The effects of ketoconazole and rifampin on the single-dose pharmacokinetics of crizotinib in healthy subjects
Q35164824The efficacy and safety of EGFR inhibitor monotherapy in non-small cell lung cancer: a systematic review
Q39314771The efficacy and safety of nivolumab in previously treated advanced non-small-cell lung cancer: a meta-analysis of prospective clinical trials
Q53165144The efficacy of first-line chemotherapy is associated with KRAS mutation status in patients with advanced non-small cell lung cancer: a meta-analysis.
Q99365521The efficacy of first-line tyrosine kinase inhibitors combined with co-medications in Asian patients with EGFR mutation non-small cell lung cancer
Q37996424The emerging role of ALK inhibitors in the treatment of advanced non-small cell lung cancer
Q64078507The emerging role of cell-free DNA as a molecular marker for cancer management
Q90481899The emerging role of circulating tumor cells in cancer management
Q35076292The emerging role of epidermal growth factor receptor (EGFR) inhibitors in first-line treatment for patients with advanced non-small cell lung cancer positive for EGFR mutations
Q34343043The emerging role of nimotuzumab in the treatment of non-small cell lung cancer
Q42643276The emerging roles of NGS-based liquid biopsy in non-small cell lung cancer
Q92221532The emerging treatment landscape of targeted therapy in non-small-cell lung cancer
Q38697702The enhanced tumor inhibitory effects of gefitinib and L-ascorbic acid combination therapy in non-small cell lung cancer cells
Q40323538The epidermal growth factor receptor (EGFR)-S442F mutant displays increased affinity for neuregulin-2beta and agonist-independent coupling with downstream signalling events
Q35196749The epidermal growth factor receptor (EGRF) in lung cancer
Q35876412The epidermal growth factor receptor as a target for gastrointestinal cancer therapy
Q34692233The epidermal growth factor receptor family: biology driving targeted therapeutics
Q36268324The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it?
Q55147369The era of precision oncogenomics.
Q44486103The estimation of tumor cell percentage for molecular testing by pathologists is not accurate
Q37953478The evolution of phase I trials in cancer medicine: a critical review of the last decade
Q34852043The evolving genomic classification of lung cancer
Q37046861The expression of plakoglobin is a potential prognostic biomarker for patients with surgically resected lung adenocarcinoma
Q37389768The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFR-specific tyrosine kinase inhibitors in non-small cell lung cancer
Q30539397The frequency of EGFR and KRAS mutations in non-small cell lung cancer (NSCLC): routine screening data for central Europe from a cohort study
Q36606755The future in diagnosis and staging of lung cancer. Molecular techniques
Q38151562The genetic complexity of common cancers and the promise of personalized medicine: is there any hope?
Q33389608The genetic polymorphisms of HER-2 and the risk of lung cancer in a Korean population
Q36605965The genetics of health
Q41891513The genomics of lung adenocarcinoma: opportunities for targeted therapies
Q35124798The global landscape of intron retentions in lung adenocarcinoma
Q39648363The hominoid-specific oncogene TBC1D3 activates Ras and modulates epidermal growth factor receptor signaling and trafficking
Q34057608The human epidermal growth factor receptor (EGFR) gene in European patients with advanced colorectal cancer harbors infrequent mutations in its tyrosine kinase domain
Q29619884The impact of O2 availability on human cancer
Q90532509The impact of PRDX4 and the EGFR mutation status on cellular proliferation in lung adenocarcinoma
Q36872857The impact of cigarette smoking on the frequency of and qualitative differences in KRAS mutations in Korean patients with lung adenocarcinoma
Q26741041The impact of epidermal growth factor receptor mutations on patterns of disease recurrence after chemoradiotherapy for locally advanced non-small cell lung cancer: a literature review and pooled analysis
Q64098196The impact of epidermal growth factor receptor mutations on the prognosis of resected non-small cell lung cancer: a meta-analysis of literatures
Q36303828The impact of epidermal-growth-factor-receptor mutations in response to lung-cancer therapy
Q37304354The impact of genomic changes on treatment of lung cancer
Q38822314The impact of immunohistochemistry on the classification of lung tumors.
Q36927984The impact of initial gefitinib or erlotinib versus chemotherapy on central nervous system progression in advanced non-small cell lung cancer with EGFR mutations
Q37536556The impact of intermittent versus continuous exposure to EGFR tyrosine kinase inhibitor on selection of EGFR T790M-mutant drug-resistant clones in a lung cancer cell line carrying activating EGFR mutation
Q54271001The impact of rare EGFR mutations on the treatment response of patients with non-small cell lung cancer.
Q80833899The impact of systems approaches on biological problems in drug discovery
Q38587521The importance of molecular markers for diagnosis and selection of targeted treatments in patients with cancer
Q36040638The importance of multidisciplinary team management of patients with non-small-cell lung cancer
Q39148511The induction of MIG6 under hypoxic conditions is critical for dormancy in primary cultured lung cancer cells with activating EGFR mutations
Q84230583The influence of intracellular epidermal growth factor receptor (EGFR) signal activation on the outcome of EGFR tyrosine kinase inhibitor treatment for pulmonary adenocarcinoma
Q52651786The interplay of reactive oxygen species and the epidermal growth factor receptor in tumor progression and drug resistance.
Q51689988The inverted pyramid of biomarker-driven trials.
Q26823305The latest therapeutic strategies after resistance to first generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) in patients with non-small cell lung cancer (NSCLC)
Q35568803The long non-coding RNA, GAS5, enhances gefitinib-induced cell death in innate EGFR tyrosine kinase inhibitor-resistant lung adenocarcinoma cells with wide-type EGFR via downregulation of the IGF-1R expression
Q40169126The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272.
Q37976416The management of EGFR inhibitor adverse events: a case series and treatment paradigm
Q36348036The mannose-binding lectin: a prototypic pattern recognition molecule
Q38726762The marine-derived pachycladin diterpenoids as novel inhibitors of wild-type and mutant EGFR.
Q37022191The mechanism of acquired resistance to irreversible EGFR tyrosine kinase inhibitor-afatinib in lung adenocarcinoma patients
Q39899686The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors
Q53512510The molecular approach to diagnosis in lung cancer.
Q37703901The molecular genetic basis of ovarian cancer and its roadmap towards a better treatment
Q42583219The need for an individual approach to lung cancer treatment
Q38292875The next generation of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of lung cancer
Q26998894The next steps in next-gen sequencing of cancer genomes
Q37672566The next-generation sequencing revolution and its impact on genomics
Q42360041The non-small cell lung cancer EGFR extracellular domain mutation, M277E, is oncogenic and drug-sensitive
Q50237958The novel phosphoinositide 3-kinase-mammalian target of rapamycin inhibitor, BEZ235, circumvents erlotinib resistance of epidermal growth factor receptor mutant lung cancer cells triggered by hepatocyte growth factor.
Q89497176The optional approach of oncogene-addicted non-small cell lung cancer with brain metastases in the new generation targeted therapies era
Q35870933The pan-HDAC inhibitor panobinostat acts as a sensitizer for erlotinib activity in EGFR-mutated and -wildtype non-small cell lung cancer cells
Q36545226The pan-HER family tyrosine kinase inhibitor afatinib overcomes HER3 ligand heregulin-mediated resistance to EGFR inhibitors in non-small cell lung cancer
Q45288154The pathologist and EGFR in 2004: I like you, nor do it
Q54306159The peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp-based test for epidermal growth factor receptor mutations in bronchoscopic cytological specimens of non-small cell lung cancer.
Q33693948The percentage of Epidermal Growth Factor Receptor (EGFR)-mutated neoplastic cells correlates to response to tyrosine kinase inhibitors in lung adenocarcinoma.
Q36752662The pharmacogenetics research network: from SNP discovery to clinical drug response.
Q54560801The phosphatase inhibitor menadione (vitamin K3) protects cells from EGFR inhibition by erlotinib and cetuximab.
Q45671065The polymorphism of EGFR 142285G > A exerts no risk effect on breast cancer
Q34480697The polynuclear platinum BBR3610 induces G2/M arrest and autophagy early and apoptosis late in glioma cells
Q57283047The positive inotropic agent DPI-201106 selectively reverses ABCB1-mediated multidrug resistance in cancer cell lines
Q28072144The possibility of clinical sequencing in the management of cancer
Q38632346The potential diagnostic power of circulating tumor cell analysis for non-small-cell lung cancer
Q37194315The potential role of pharmacogenomic and genomic in the adjuvant treatment of early stage non small cell lung cancer
Q89927858The prognostic factors of recurrence and survival in female patients with lung adenocarcinoma and breast cancer
Q92869196The prognostic implications of EGFR mutation and ALK rearrangement for the long-term outcomes of patients with resected lung adenocarcinomas
Q41612540The prognostic role of pretreatment epidermal growth factor receptor T790M mutation in advanced non-small cell lung cancer patients treated with EGFR tyrosine kinase inhibitors
Q28282889The promise and perils of 'targeted therapy' of advanced ovarian cancer
Q38981780The prospect of patritumab for treating non-small cell lung cancer
Q39272353The protein tyrosine phosphatase receptor type J is regulated by the pVHL-HIF axis in clear cell renal cell carcinoma
Q33725976The quest to overcome resistance to EGFR-targeted therapies in cancer
Q35151853The relationship between TTF-1 expression and EGFR mutations in lung adenocarcinomas
Q54675285The relationship between drug exposure and clinical outcomes of non-small cell lung cancer patients treated with gefitinib.
Q92798542The relationship between preliminary efficacy and prognosis after first-line EGFR tyrosine kinase inhibitor (EGFR-TKI) treatment of advanced non-small cell lung cancer
Q55439654The relationship between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase, excision repair cross-complementation group 1 and class III β-tubulin, and the therapeutic effect of S-1 or carbopla
Q34918878The relative expression of Mig6 and EGFR is associated with resistance to EGFR kinase inhibitors
Q38089953The relevance of molecular diagnostics in the practice of surgical pathology.
Q38976895The reverse effect of X-ray irradiation on acquired gefitinib resistance in non-small cell lung cancer cell line NCI-H1975 in vitro
Q50345037The rise of genomic profiling in ovarian cancer.
Q39028181The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer
Q34349389The role of HER3, the unpretentious member of the HER family, in cancer biology and cancer therapeutics
Q37868445The role of LKB1 in lung cancer
Q36704645The role of STATs in lung carcinogenesis: an emerging target for novel therapeutics
Q36561648The role of companion diagnostics in the development and use of mutation-targeted cancer therapies
Q42095201The role of cooperativity with Src in oncogenic transformation mediated by non-small cell lung cancer-associated EGF receptor mutants
Q33274011The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target
Q35667688The role of epidermal growth factor receptor tyrosine kinase inhibitors in the treatment of advanced stage non-small cell lung cancer
Q35043066The role of epigenetics in personalized medicine: challenges and opportunities
Q26749110The role of epithelial to mesenchymal transition in resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer
Q28397662The role of estrogen, progesterone and aromatase in human non-small-cell lung cancer
Q35602147The role of funding and policies on innovation in cancer drug development
Q51757887The role of gefitinib treatment for Korean never-smokers with advanced or metastatic adenocarcinoma of the lung: a prospective study.
Q37715991The role of irreversible EGFR inhibitors in the treatment of non-small cell lung cancer: overcoming resistance to reversible EGFR inhibitors
Q27021738The role of irreversible HER family inhibition in the treatment of patients with non-small cell lung cancer
Q33779663The role of metabolic tumor volume (MTV) measured by [18F] FDG PET/CT in predicting EGFR gene mutation status in non-small cell lung cancer
Q26825678The role of obesity in gastrointestinal cancer: evidence and opinion
Q36463971The role of pharmacoethnicity in the development of cytotoxic and molecular targeted drugs in oncology
Q37430412The role of pharmacogenetics and pharmacogenomics in improving translational medicine.
Q36536674The role of pharmacogenetics in cancer therapeutics
Q39996855The role of repair protein Rad51 in synergistic cytotoxicity and mutagenicity induced by epidermal growth factor receptor inhibitor (Gefitinib, IressaR) and benzo[a]pyrene in human lung cancer.
Q28068169The role of surgical intervention in lung cancer with carcinomatous pleuritis
Q38085500The role of tumour-stromal interactions in modifying drug response: challenges and opportunities
Q58741629The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications
Q37085219The safety and efficacy of osimertinib for the treatment of EGFR T790M mutation positive non-small-cell lung cancer
Q39337947The safety and efficacy of ramucirumab in combination with docetaxel in the treatment of lung cancer
Q50782338The second annual symposium on the future of lung cancer: a translational focus. 11-12 November 2005, Washington D.C., USA.
Q82498098The second wave in kinase cancer drugs
Q38704952The selective c-Met inhibitor tepotinib can overcome epidermal growth factor receptor inhibitor resistance mediated by aberrant c-Met activation in NSCLC models
Q36839141The small GTPase ADP-Ribosylation Factor 1 mediates the sensitivity of triple negative breast cancer cells to EGFR tyrosine kinase inhibitors
Q26746895The steady progress of targeted therapies, promising advances for lung cancer
Q44968164The story of gefitinib, an EGFR kinase that works in lung cancer
Q35256540The suitability of small biopsy and cytology specimens for EGFR and other mutation testing in non-small cell lung cancer
Q89456689The synergistic inhibitory effect of combining therapies targeting EGFR and mitochondria in sarcomas
Q47214772The synergistic role of ATP-dependent drug efflux pump and focal adhesion signaling pathways in vinorelbine resistance in lung cancer.
Q96231168The top 100 cited articles in lung cancer - a bibliometric analysis
Q36446457The transcriptional consequences of somatic amplifications, deletions, and rearrangements in a human lung squamous cell carcinoma
Q36354852The transcriptional landscape and mutational profile of lung adenocarcinoma.
Q33772611The translation of cancer genomics: time for a revolution in clinical cancer care
Q43128868The treatment of metastatic non-small cell lung cancer in a new era of personalized medicine
Q28534476The tumor suppressor gene TUSC2 (FUS1) sensitizes NSCLC to the AKT inhibitor MK2206 in LKB1-dependent manner
Q36928853The use of EGFR exon 19 and 21 unlabeled DNA probes to screen for activating mutations in non-small cell lung cancer
Q37177597The use of first-generation tyrosine kinase inhibitors in patients with NSCLC and somatic EGFR mutations
Q87345449The use of mutation-specific antibodies in predicting the effect of EGFR-TKIs in patients with non-small-cell lung cancer
Q35829847The use of single-agent dasatinib in molecularly unselected non-small-cell lung cancer patients
Q33689655The utility of napsin-A in the identification of primary and metastatic lung adenocarcinoma among cytologically poorly differentiated carcinomas
Q83153095The wind of change in the therapy of lung cancer
Q37755154Theme: oncology--molecular mechanisms determining the efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates
Q48100116Theoretical method for evaluation of therapeutic effects and adverse effects of epidermal growth factor receptor tyrosine kinase inhibitors in clinical treatment.
Q26824717Theragnostic imaging using radiolabeled antibodies and tyrosine kinase inhibitors
Q37632230Therapeutic approach to treating patients with BRAF-mutant lung cancer: latest evidence and clinical implications
Q28187576Therapeutic approaches in arterial thrombosis
Q36429446Therapeutic potential of EGFR-related protein, a universal EGFR family antagonist
Q38172182Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks
Q27011293Therapeutic strategy for postoperative recurrence in patients with non-small cell lung cancer
Q35986801Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations
Q36158717Therapeutic targeting of receptor tyrosine kinases in lung cancer
Q35976350Therapeutic targets for antimetastatic therapy
Q36562233Therapeutic targets in melanoma: map kinase pathway
Q35918439Therapy for recurrent malignant glioma in adults
Q40462770Therapy's Shadow: A Short History of the Study of Resistance to Cancer Chemotherapy.
Q33740707Third-Generation Tyrosine Kinase Inhibitors Targeting Epidermal Growth Factor Receptor Mutations in Non-Small Cell Lung Cancer
Q92134589Third-generation epidermal growth factor receptor tyrosine kinase inhibitors for the treatment of non-small cell lung cancer
Q33302913Thirty years into the genomics era: tumor viruses led the way.
Q50133191Thoracic Complications of Precision Cancer Therapies: A Practical Guide for Radiologists in the New Era of Cancer Care.
Q54570755Three cheers for targeted therapy in non-small cell lung cancer... When we hit the target!
Q39090203Three-color crystal digital PCR.
Q39813810Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death
Q39290667Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance
Q36050719Throwing new light on lung cancer pathogenesis: updates on three recent topics
Q51750277Thymosin alpha1 as a chemopreventive agent in lung and breast cancer.
Q35076227Thyroid cancer: emerging role for targeted therapies
Q36065174Thyroid transcription factor-1 expression is significantly associated with mutations in exon 21 of the epidermal growth factor receptor gene in Chinese patients with lung adenocarcinoma.
Q43056665Time for molecularly targeted maintenance therapy for non-small-cell lung cancer?
Q58128825Time to give a rest to cetuximab in the treatment of advanced non-small cell lung carcinoma?
Q53313789Timeline: Chemotherapy and the war on cancer.
Q36141341Tissue biomarkers for prostate cancer radiation therapy
Q34323926Tissue phosphoproteomics with PolyMAC identifies potential therapeutic targets in a transgenic mouse model of HER2 positive breast cancer.
Q37586979Tissue specificity in the nuclear envelope supports its functional complexity.
Q34006509Tissue-specific gene expression templates for accurate molecular characterization of the normal physiological states of multiple human tissues with implication in development and cancer studies
Q37109569Tobacco Smoking and Lung Cancer: Perception-changing facts
Q39784247Tolfenamic acid decreases c-Met expression through Sp proteins degradation and inhibits lung cancer cells growth and tumor formation in orthotopic mice
Q37701499Total DNA input is a crucial determinant of the sensitivity of plasma cell-free DNA EGFR mutation detection using droplet digital PCR.
Q40393934Total and mutated EGFR quantification in cell-free DNA from non-small cell lung cancer patients detects tumor heterogeneity and presents prognostic value
Q36472802Toward personalized cancer nanomedicine - past, present, and future
Q37972865Towards clinical applications of selected reaction monitoring for plasma protein biomarker studies
Q35897673Towards pathway-centric cancer therapies via pharmacogenomic profiling analysis of ERK signalling pathway
Q34978252Towards personalized therapy for patients with glioblastoma
Q42178081Toxicity profile of epidermal growth factor receptor tyrosine kinase inhibitors in patients with epidermal growth factor receptor gene mutation-positive lung cancer
Q35889315Tracking Down Response and Resistance to TRK Inhibitors
Q37688667Trajectory of chemotherapy for patients with EGFR wild-type advanced pulmonary adenocarcinoma: a single-institution retrospective study
Q30436756Transcription-dependent epidermal growth factor receptor activation by hepatocyte growth factor
Q33306709Transcriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations
Q24653386Transcriptome sequencing to detect gene fusions in cancer
Q58116294Transcriptomic and functional network features of lung squamous cell carcinoma through integrative analysis of GEO and TCGA data
Q51733149Transformation to small-cell lung cancer following treatment with icotinib in a patient with lung adenocarcinoma.
Q93188555Transglutaminase 2 induces intrinsic EGFR-TKI resistance in NSCLC harboring EGFR sensitive mutations
Q22241760Translatability scoring in drug development: eight case studies
Q35694365Translating cancer 'omics' to improved outcomes
Q36411676Translating genomic biomarkers into clinically useful diagnostics
Q36354845Translating genomic information into clinical medicine: lung cancer as a paradigm
Q37127235Translating insights from the cancer genome into clinical practice
Q38114641Translating next generation sequencing to practice: opportunities and necessary steps
Q43010001Translating research into cancer molecular diagnostics and patents
Q34344855Translation of pharmacogenomics and pharmacogenetics: a regulatory perspective
Q24806201Translation research: from accurate diagnosis to appropriate treatment
Q42922307Translational Bioinformatics Approaches to Drug Development
Q38257126Translational research in oncology--10 years of progress and future prospects
Q46544726Translational research: the full cycle
Q35977396Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor.
Q37392560Transtinib, a potent tyrosine kinase inhibitor inhibits L858R/T790M mutant NSCLC cell lines and xenografts
Q43195737Treating acquired resistance to EGFR-tyrosine kinase inhibitors:still a work in progress.
Q34494115Treatment approaches for EGFR-inhibitor-resistant patients with non-small-cell lung cancer
Q37698613Treatment choice in epidermal growth factor receptor mutation-positive non-small cell lung carcinoma: latest evidence and clinical implications.
Q38739807Treatment modalities for advanced ALK-rearranged non-small-cell lung cancer
Q50104127Treatment of EGFR T790M-Positive Non-Small Cell Lung Cancer.
Q40244548Treatment of HNSCC cell lines with the EGFR-specific inhibitor cetuximab (Erbitux) results in paradox phosphorylation of tyrosine 1173 in the receptor
Q35623614Treatment of Non-Small-Cell Lung Cancer with Erlotinib following Gefitinib-Induced Hepatotoxicity: Review of 8 Clinical Cases
Q37011144Treatment of Non-small Cell Lung Carcinoma after Failure of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
Q35667817Treatment of advanced non small cell lung cancer
Q59872738Treatment of brain metastasis from lung cancer
Q36185627Treatment of hematologic malignancies and solid tumors by inhibiting IGF receptor signaling
Q87296355Treatment of non-small cell lung cancer, advanced disease, with erlotinib in 2(nd) and 3(rd) lines. Two cases report
Q37354440Treatment of pancreatic cancer with epidermal growth factor receptor-targeted therapy
Q37218978Treatment of recurrent metastatic head and neck cancer: focus on cetuximab
Q53547530Treatment of squamous cell vulvar cancer with the anti-EGFR tyrosine kinase inhibitor Tarceva.
Q36412597Treatment of stage IV non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines
Q35583860Treatment of unresectable and metastatic cutaneous squamous cell carcinoma
Q92895800Treatment outcome and clinical characteristics of HER2 mutated advanced non-small cell lung cancer patients in China
Q40071770Treatment schedule is of importance when gefitinib is combined with irradiation of glioma and endothelial cells in vitro
Q95282127Trial Design and Endpoints in hepatocellular carcinoma: AASLD Consensus Conference
Q36038408Trial Watch: Monoclonal antibodies in cancer therapy
Q56932681Trial watch: Monoclonal antibodies in cancer therapy
Q35970324Trial-Based Cost-Utility Analysis of Icotinib versus Gefitinib as Second-Line Therapy for Advanced Non-Small Cell Lung Cancer in China
Q24564024Trials to Overcome Drug Resistance to EGFR and ALK Targeted Therapies - Past, Present, and Future
Q37204363Trichomegaly and scalp hair changes following treatment with erlotinib in pulmonary adenocarcinoma patients: A case report and literature review
Q34041747Triple inhibition of EGFR, Met, and VEGF suppresses regrowth of HGF-triggered, erlotinib-resistant lung cancer harboring an EGFR mutation
Q37594358Triple negative breast carcinoma EGFR amplification is not associated with EGFR, Kras or ALK mutations
Q36747692Triple-negative breast cancer: therapeutic options
Q36048159Tumor Hypoxia Response After Targeted Therapy in EGFR-Mutant Non-Small Cell Lung Cancer: Proof of Concept for FMISO-PET.
Q36439444Tumor MET expression profile predicts the outcome of non-small cell lung cancer patients receiving epidermal growth factor receptor tyrosine kinase inhibitors.
Q37548937Tumor dormancy and metastasis.
Q36616513Tumor dormancy and the role of metastasis suppressor genes in regulating ectopic growth
Q36196817Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma.
Q35584773Tumor epidermal growth factor receptor genotype and depression in stage IV non-small cell lung cancer
Q97538366Tumor evolution in epidermal growth factor receptor mutated non-small cell lung cancer
Q38192631Tumor heterogeneity in the clinic: is it a real problem?
Q38390044Tumor heterogeneity: evolution through space and time in EGFR mutant non small cell lung cancer patients
Q91774076Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration of inflammatory immune cells in EGFR mutant lung tumors
Q45204330Tumor response to gefitinib (IRESSA) in pulmonary adenocarcinoma: toward a molecular basis for therapeutic targetting
Q37021940Tumor volume decrease at 8 weeks is associated with longer survival in EGFR-mutant advanced non-small-cell lung cancer patients treated with EGFR TKI.
Q39839864Tumorigenicity of cortical astrocyte cell line induced by the protease ADAM17.
Q89579304Tumour content ratio matters for detecting epidermal growth factor receptor mutation by cobas test in small biopsies; a retrospective study
Q58599910Tumour-targeting bacteria engineered to fight cancer
Q89651597Turning liabilities into opportunities: Off-target based drug repurposing in cancer
Q35896601Two sides of the same coin: EGFR exon 19 deletions and insertions in lung cancer
Q36022297Tyr1068-phosphorylated epidermal growth factor receptor (EGFR) predicts cancer stem cell targeting by erlotinib in preclinical models of wild-type EGFR lung cancer
Q26741318Tyrosine Kinase Receptor Landscape in Lung Cancer: Therapeutical Implications
Q46590868Tyrosine kinase activating mutations in human malignancies: implications for diagnostic pathology
Q37712380Tyrosine kinase domain mutations of EGFR gene in head and neck squamous cell carcinoma.
Q37894095Tyrosine kinase inhibitors for non-small-cell lung cancer: finding patients who will be responsive
Q35908430Tyrosine kinase inhibitors in lung cancer
Q36977823Tyrosine kinase inhibitors in pediatric malignancies
Q34983846Tyrosine kinase inhibitors: Multi-targeted or single-targeted?
Q37408903Tyrosine phosphorylation: thirty years and counting
Q92840636UBE2T silencing inhibited non-small cell lung cancer cell proliferation and invasion by suppressing the wnt/β-catenin signaling pathway
Q58577633USP17 is required for trafficking and oncogenic signaling of mutant EGFR in NSCLC cells
Q39962704Ultra-micro samples can be used for mRNA quantification of lung cancer biomarkers.
Q36185551Ultrasensitive measurement of hotspot mutations in tumor DNA in blood using error-suppressed multiplexed deep sequencing.
Q48128121Uncommon frame-shift exon 19 EGFR mutations are sensitive to EGFR tyrosine kinase inhibitors in non-small cell lung carcinoma.
Q39002233Understanding Mechanisms of Resistance in the Epithelial Growth Factor Receptor in Non-Small Cell Lung Cancer and the Role of Biopsy at Progression
Q46915997Understanding and targeting resistance mechanisms in NSCLC.
Q34088424Understanding resistance to EGFR inhibitors-impact on future treatment strategies
Q27691330Understanding the Impact of ErbB Activating Events and Signal Transduction on Antigen Processing and Presentation: MHC Expression as a Model
Q28546245Understanding the Interplay between Expression, Mutation and Activity of ALK Receptor in Rhabdomyosarcoma Cells for Clinical Application of Small-Molecule Inhibitors
Q52648399Underutilization and disparities in access to EGFR testing among Medicare patients with lung cancer from 2010 - 2013.
Q46787342Unexpected rapid progression of metastatic adenoid cystic carcinoma during treatment with imatinib mesylate.
Q37039734Unifying electrostatic mechanism for phosphates and sulfates in cell signaling
Q33833942Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population
Q81831688Unique issues in the development of "targeted" antineoplastic pharmaceutical agents
Q40344816Unique prevalence of oncogenic genetic alterations in young patients with lung adenocarcinoma
Q36173303Unlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer
Q60044591Up-Regulated FGFR1 Expression as a Mediator of Intrinsic TKI Resistance in EGFR-Mutated NSCLC
Q37443898Update in antiepidermal growth factor receptor therapy in the management of metastatic colorectal cancer.
Q36429911Update in lung cancer 2005.
Q36796569Update in lung cancer 2006
Q35667802Update on anti-angiogenic therapy in non-small cell lung cancer: Are we making progress?
Q61810147Update on emerging biomarkers in lung cancer
Q50802132Update on epidermal growth factor receptor inhibitor development in lung cancer.
Q38237463Update on systemic therapy of advanced non-small-cell lung cancer
Q37721218Update on the Treatment of Metastatic Squamous Non-Small Cell Lung Cancer in New Era of Personalized Medicine
Q44701539Updated overall survival results from a randomized phase III trial comparing gefitinib with carboplatin-paclitaxel for chemo-naïve non-small cell lung cancer with sensitive EGFR gene mutations (NEJ002).
Q89485969Upfront radiosurgery plus targeted agents followed by active brain control using radiosurgery delays neurological death in non-small cell lung cancer with brain metastasis
Q91845232Urinary Epidermal Growth Factor as a Marker of Disease Progression in Children With Nephrotic Syndrome
Q48604114Urinary circulating DNA detection for dynamic tracking of EGFR mutations for NSCLC patients treated with EGFR-TKIs.
Q47564108Urine test for EGFR analysis in patients with non-small cell lung cancer
Q37779308Use of K-Ras as a predictive biomarker for selecting anti-EGF receptor/pathway treatment
Q33859472Use of Nanotechnology to Develop Multi-Drug Inhibitors For Cancer Therapy
Q89560168Use of a plasma test for verifying epidermal growth factor receptor gene (EGFR) mutations in fluid samples from non-small cell lung cancer patients
Q37630180Use of a tyrosine kinase inhibitor as neoadjuvant therapy for non-small cell lung cancer: A case report.
Q37269473Use of dedicated gene panel sequencing using next generation sequencing to improve the personalized care of lung cancer
Q57556407Use of genome-wide high-throughput technologies in biomarker development
Q36369836Use of genomic signatures in therapeutics development in oncology and other diseases
Q30585673Use of multiple imputation to correct for bias in lung cancer incidence trends by histologic subtype
Q34003351Use of the epidermal growth factor receptor inhibitors gefitinib and erlotinib in the treatment of non-small cell lung cancer: a systematic review.
Q27022535Use of the epidermal growth factor receptor inhibitors gefitinib, erlotinib, afatinib, dacomitinib, and icotinib in the treatment of non-small-cell lung cancer: a systematic review
Q52723939Usefulness of Bronchoscopic Rebiopsy of Non-Small Cell Lung Cancer with Acquired Resistance to Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor.
Q54586663Usefulness of EGFR mutation screening in pleural fluid to predict the clinical outcome of gefitinib treated patients with lung cancer.
Q24813486Ushering in the new toxicology: toxicogenomics and the public interest
Q55182205Using Regularization to Infer Cell Line Specificity in Logical Network Models of Signaling Pathways.
Q28476059Using expression and genotype to predict drug response in yeast
Q35829133Using germ-line genetic variation to investigate and treat cancer
Q31038214Using high-throughput sequencing transcriptome data for INDEL detection: challenges for cancer drug discovery.
Q34474427Using iTRAQ combined with tandem affinity purification to enhance low-abundance proteins associated with somatically mutated EGFR core complexes in lung cancer.
Q34175045Using multiplexed assays of oncogenic drivers in lung cancers to select targeted drugs
Q35602598Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib
Q37354097Using the theory of coevolution to predict protein-protein interactions in non-small cell lung cancer.
Q38679628Utility of Genomic Assessment of Blood-Derived Circulating Tumor DNA (ctDNA) in Patients with Advanced Lung Adenocarcinoma
Q54390545Utilization of cell-transferred cytologic smears in detection of EGFR and KRAS mutation on adenocarcinoma of lung.
Q37238134Utilization of epidermal growth factor receptor (EGFR) testing in the United States: a case study of T3 translational research
Q37301478VEGF-D expression correlates with colorectal cancer aggressiveness and is downregulated by cetuximab
Q37393004VHL gene mutations in renal cell carcinoma: role as a biomarker of disease outcome and drug efficacy
Q52803546Validation and comparison of two NGS assays for the detection of EGFR T790M resistance mutation in liquid biopsies of NSCLC patients.
Q89985173Validation and implementation of a modular targeted capture assay for the detection of clinically significant molecular oncology alterations
Q41906700Validation and implementation of targeted capture and sequencing for the detection of actionable mutation, copy number variation, and gene rearrangement in clinical cancer specimens
Q92989775Validation of Immunohistochemistry for the Detection of BRAF V600E-Mutated Lung Adenocarcinomas
Q54118788Validation of [18F]FLT as a perfusion-independent imaging biomarker of tumour response in EGFR-mutated NSCLC patients undergoing treatment with an EGFR tyrosine kinase inhibitor.
Q41331019Validation of a locked nucleic acid based wild-type blocking PCR for the detection of EGFR exon 18/19 mutations
Q34231456Validation of a multiparameter flow cytometry method for the determination of phosphorylated extracellular-signal-regulated kinase and DNA in circulating tumor cells
Q35663913Validation of an Ion Torrent Sequencing Platform for the Detection of Gene Mutations in Biopsy Specimens from Patients with Non-Small-Cell Lung Cancer
Q80731960Validation of chromogenic in situ hybridization for detection of EGFR copy number amplification in nonsmall cell lung carcinoma
Q48502619Validation of liquid biopsy: plasma cell-free DNA testing in clinical management of advanced non-small cell lung cancer.
Q34903217Validation of next generation sequencing technologies in comparison to current diagnostic gold standards for BRAF, EGFR and KRAS mutational analysis
Q87928043Value of ¹⁸F-FDG uptake on PET/CT and CEA level to predict epidermal growth factor receptor mutations in pulmonary adenocarcinoma
Q37177871Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma
Q38016190Vandetanib for the treatment of lung cancer
Q39203869Vandetanib in patients with previously treated RET-rearranged advanced non-small-cell lung cancer (LURET): an open-label, multicentre phase 2 trial
Q39218984Vandetanib is effective in EGFR-mutant lung cancer cells with PTEN deficiency
Q42598308VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research
Q38731617Variability in Platelet-Derived Growth Factor Receptor Alpha Antibody Specificity May Impact Clinical Utility of Immunohistochemistry Assays
Q36615850Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors.
Q35456811Variation in pre-PCR processing of FFPE samples leads to discrepancies in BRAF and EGFR mutation detection: a diagnostic RING trial.
Q36691776Vascular endothelial growth factor pharmacogenetics: a new perspective for anti-angiogenic therapy
Q35122066Very low prevalence of epidermal growth factor receptor (EGFR) protein expression and gene amplification in Saudi breast cancer patients.
Q35387710Virotherapy induces massive infiltration of neutrophils in a subset of tumors defined by a strong endogenous interferon response activity
Q57521562Visceral obesity, metabolic syndrome, insulin resistance and cancer
Q36553854Volumetric Tumor Response and Progression in EGFR-mutant NSCLC Patients Treated with Erlotinib or Gefitinib
Q37280018Volumetric tumor growth in advanced non-small cell lung cancer patients with EGFR mutations during EGFR-tyrosine kinase inhibitor therapy: developing criteria to continue therapy beyond RECIST progression
Q37001330Von Hippel-Lindau tumor suppressor gene loss in renal cell carcinoma promotes oncogenic epidermal growth factor receptor signaling via Akt-1 and MEK-1
Q36427381Whacking a mole-cule: clinical activity and mechanisms of resistance to third generation EGFR inhibitors in EGFR mutated lung cancers with EGFR-T790M.
Q35927471What are the reasons for negative phase III trials of molecular-target-based drugs?
Q34213994What are we learning from the cancer genome?
Q38312059What is the best strategy for targeting EGF receptors in non-small-cell lung cancer?
Q46787079What is the best way to manage patients treated with gefitinib for non-small-cell lung cancer?
Q48639219What is the future for cancer clinical trials?
Q48241759What is the potential of nanolock- and nanocross-nanopore technology in cancer diagnosis?
Q81352782What oncologists need and require from nuclear medicine
Q24812087When clinical trials are compromised: a perspective from a patient advocate
Q36496065Where next for gefitinib in patients with lung cancer?
Q36610132Which biomarker predicts benefit from EGFR-TKI treatment for patients with lung cancer?
Q44340382Which drugs for which patients?
Q38222703Which tyrosine kinase inhibitor should be recommended as initial treatment for non-small cell lung cancer patients with EGFR mutations?
Q43071284Who will take up the gauntlet? Challenges and opportunities for systems biology and drug discovery
Q28269291Whole-genome analysis informs breast cancer response to aromatase inhibition
Q48431386Why Cancer matters.
Q33304557Why do cancer cells become "addicted" to oncogenic epidermal growth factor receptor?
Q35929119Will tomorrow's medicines work for everyone?
Q37952291Winning the arms race by improving drug discovery against mutating targets
Q34876177Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium.
Q38113540Worldwide trend of increasing primary adenocarcinoma of the lung
Q36568760Worldwide trends in lung cancer pathology
Q47097774Worse disease-free, tumor-specific, and overall survival in surgically-resected lung adenocarcinoma patients with ALK rearrangement
Q88682201Xenograft tumors derived from malignant pleural effusion of the patients with non-small-cell lung cancer as models to explore drug resistance
Q41281151YM155 as an inhibitor of cancer stemness simultaneously inhibits autophosphorylation of epidermal growth factor receptor and G9a-mediated stemness in lung cancer cells
Q37829768Year in review 2010: interstitial lung diseases, acute lung injury, sleep, physiology, imaging, bronchoscopic intervention and lung cancer
Q37624912Yin-Cold or Yang-Heat Syndrome Type of Traditional Chinese Medicine Was Associated with the Epidermal Growth Factor Receptor Gene Status in Non-Small Cell Lung Cancer Patients: Confirmation of a TCM Concept
Q42690204Young cancer researchers rewarded
Q36146882ZD6474--clinical experience to date
Q80403956["Targeted Therapies" in NSCLC - present and future]
Q54329437[A comparison of direct sequencing and ARMS assay performance in EGFR mutation analysis of non-small cell lung cancer patients].
Q55436763[A study on the long-term non-small cell lung cancer survivors in the Expand Access Program of gefitinib in China].
Q55020044[Afatinib as first-line therapy in mutation-positive EGFR. Results by type of mutation].
Q64884192[Anatomy, biology and concepts, pertaining to lung cancer stage classification].
Q79317745[Anti-EGFR therapy: towards a "à la carte" targeting of hepatocellular carcinoma]
Q55464970[Classification and regression tree analysis of clinical patterns that predict survival in 127 Chinese patients with advanced non-small cell lung cancer treated by gefitinib who failed to previous chemotherapy].
Q55464335[Classification and regression tree analysis of clinical patterns to predict the survival of patients with advanced non-small cell lung cancer treated with erlotinib].
Q53340641[Clinical Experience of Gefitinib in the Treatment of 32 Lung Adenocarcinoma Patients with Brain Metastases].
Q53520768[Clinical Research of EGFR and KRAS Mutation in Fine Needle Aspiration Cytology Specimens of Non-small Cell Lung Carcinoma].
Q54389938[Clinical significance of ROS1 rearrangements in non-small cell lung cancer].
Q54611055[Comparison of EGFR mutation status in paired pre- and post-chemotherapy serum for advanced pulmonary adenocarcinoma].
Q55437669[Development of Precision Medicine in the Surgical Treatment of Lung Cancer].
Q54584671[Discordance of epidermal growth factor receptor mutations between primary and corresponding metastatic tumors in non-small cell lung cancer].
Q53654923[EGF receptor blockade with monoclonal antibodis and so-called "small molecules"].
Q49958940[EGFR and KRAS Gene Mutations in 754 Patients with Resectable Stage I-IIIa Non-small Cell Lung Cancer and Its Clinical Significance].
Q54482790[EGFR gene mutation statuses in advanced non-small cell lung cancer patients and their influence on effect of gefitinib].
Q54282828[Effectiveness of EGFR-TKIs versus chemotherapy as first-line treatment for advanced non-small cell lung cancer: a meta-analysis].
Q54169610[Effects of Erlotinib on 34 Patients with Advanced Squamous Cell Lung Cancer].
Q55465317[Effects of monoclonal antibody cetuximab on proliferation of non-small cell lung cancer cell lines].
Q79761419[Gefitinib treatment for carcinomatous meningitis in non-small cell lung cancer]
Q84170796[Histology-based algorithm in the molecular diagnosis of mutations of the Epidernal Growth Factor Receptor (EGFR) in non-small cell lung cancer]
Q55432482[Local treatment combined with EGFR-TKIs for advanced non-small cell lung cancer with solitary progression during EGFR-TKI treatment].
Q64941333[Lung cancer in women: a different entity?].
Q80294340[Molecular diagnosis and response prediction to anti-tyrosine kinase receptors in oncology]
Q63979899[Molecular diagnostics of lung cancer for treatment stratification]
Q80606168[Molecular high throughput research in prostate carcinoma]
Q54262588[Molecular targeted therapies and cytotoxics: Friends or foes?].
Q82663591[Multi-targeting drugs and multi-drug targeting in metastatic renal cell carcinoma. Concept of co-inhibition of the epidermal growth]
Q80212282[New biological treatments for lung cancer]
Q81596236[New therapeutic approaches in glioblastomas]
Q87254396[Personalized targeted therapy for lung cancer]
Q54164031[Relationship between EGFR Promoter Region Methylation and Secondary Resistance Which may be Induced by Gefitinib].
Q51057061[Research Advancement on EGFR Mutation Detection of Cell-free DNA and Tumor Cell in Peripheral Blood of Patients with Non-small Cell Lung Cancer].
Q54602050[Retreatment with epidermal growth factor receptor inhibitor after initial failure in advanced non-small cell lung cancer].
Q54177645[Serum CYFRA21-1 is Correlated with the Efficacy of Epidermal Growth Factor Receptor-tyrosine Kinase Inhibitor in Non-small Cell Lung Cancer Patients Harboring EGFR Mutations].
Q89862647[Studies and Progress of EGFR exon 20 Insertion Mutation in Non-small Cell Lung Cancer]
Q81891643[Targeted biotherapies in digestive oncology: a new era in therapeutic management?]
Q54176392[Targeted therapy and precision medicine : More than just words in the treatment of lung cancer].
Q55427171[The detection methods of EGFR mutations in non-small cell lung cancer].
Q80737378[Therapeutic management of extensive bronchiolo-alveolar adenocarcinoma: chemotherapy or inhibitors of epidermal growth factor receptor tyrosine kinase?]
Q80149575[Therapy of malignant melanoma. First-, second- and pathogenesis-oriented third-line therapies]
Q55020040[Toxicity associated with EGRF inhibition: review and key aspects in the management of afatinib].
Q54484638[Translational research and diagnostics in lung cancer].
Q54337306[Treatment progress for EGFR wild-type advanced non-small cell lung cancer].
Q83901136[Tyrosine kinase inhibitors in oncology]
Q35088202[¹⁸F]FDG positron emission tomography within two weeks of starting erlotinib therapy can predict response in non-small cell lung cancer patients
Q53340770c-Jun N-terminal kinase is activated in non-small-cell lung cancer and promotes neoplastic transformation in human bronchial epithelial cells.
Q35997750c-kit expression in adenocarcinomas of the lung.
Q38304521hEGR1 is induced by EGF, inhibited by gefitinib in bladder cell lines and related to EGF receptor levels in bladder tumours
Q34729796mTOR inhibitors control the growth of EGFR mutant lung cancer even after acquiring resistance by HGF.
Q39165050mTOR inhibitors radiosensitize PTEN-deficient non-small-cell lung cancer cells harboring an EGFR activating mutation by inducing autophagy
Q33774131miR-19a contributes to gefitinib resistance and epithelial mesenchymal transition in non-small cell lung cancer cells by targeting c-Met
Q38366840miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells
Q34136203miRNA expression profiling of lung adenocarcinomas: correlation with mutational status
Q33412928nab-paclitaxel for the management of patients with advanced non-small-cell lung cancer
Q39373570p14(ARF) inhibits the growth of lung adenocarcinoma cells harbouring an EGFR L858R mutation by activating a STAT3-dependent pro-apoptotic signalling pathway
Q47136556p40 & thyroid transcription factor-1 immunohistochemistry: A useful panel to characterize non-small cell lung carcinoma-not otherwise specified (NSCLC-NOS) category
Q40124869s-RT-MELT for rapid mutation scanning using enzymatic selection and real time DNA-melting: new potential for multiplex genetic analysis
Q40074891siRNA mediated the type 1 insulin-like growth factor receptor and epidermal growth factor receptor silencing induces chemosensitization of liver cancer cells.
Q46707269siRNA targeting against EGFR, a promising candidate for a novel therapeutic application to lung adenocarcinoma
Q51512508therascreen® EGFR RGQ PCR Kit: A Companion Diagnostic for Afatinib and Gefitinib in Non-Small Cell Lung Cancer.
Q64884710xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression.
Q38922926γ Secretase inhibitor BMS-708163 reverses resistance to EGFR inhibitor via the PI3K/Akt pathway in lung cancer

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