A regulatory science perspective on warfarin therapy: a pharmacogenetic opportunity

scientific article published on February 2009

A regulatory science perspective on warfarin therapy: a pharmacogenetic opportunity is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1177/0091270008328098
P8608Fatcat IDrelease_ntpmk2g77nandmqzlr4bl5u23e
P698PubMed publication ID19179293

P2093author name stringShiew-Mei Huang
Urs A Meyer
Atiqur Rahman
Lawrence J Lesko
Myong-Jin Kim
P2860cites workAdvanced age, anticoagulation intensity, and risk for intracranial hemorrhage among patients taking warfarin for atrial fibrillationQ28210235
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CYP2C9 gene variants, drug dose, and bleeding risk in warfarin-treated patients: a HuGEnet systematic review and meta-analysisQ34394876
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Bleeding complications with warfarin use: a prevalent adverse effect resulting in regulatory actionQ34647850
Complications of oral anticoagulant therapy: bleeding and nonbleeding, rates and risk factorsQ35806446
Genetic-based dosing in orthopedic patients beginning warfarin therapy.Q35989429
Drug-metabolizing enzymes: evidence for clinical utility of pharmacogenomic testsQ36336291
Pharmacogenetics of target genes across the warfarin pharmacological pathwayQ36656419
Dosing algorithms to predict warfarin maintenance dose in Caucasians and African AmericansQ36882317
Pharmacogenetics of warfarin: regulatory, scientific, and clinical issuesQ36956360
A rapid-ACCE review of CYP2C9 and VKORC1 alleles testing to inform warfarin dosing in adults at elevated risk for thrombotic events to avoid serious bleedingQ37087333
Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarinQ37196787
The critical path of warfarin dosing: finding an optimal dosing strategy using pharmacogeneticsQ37247571
CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: a prospective randomized controlled study.Q40174813
Prevalence and quality of warfarin use for patients with atrial fibrillation in the long-term care settingQ43793456
Major bleeding caused by warfarin in a genetically susceptible patientQ43856655
Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapyQ43942672
Improving the quality of anticoagulation of patients with atrial fibrillation in managed care organizations: results of the managing anticoagulation services trialQ44054411
Association of pharmacokinetic (CYP2C9) and pharmacodynamic (factors II, VII, IX, and X; proteins S and C; and gamma-glutamyl carboxylase) gene variants with warfarin sensitivityQ44680862
Contribution of age, body size, and CYP2C9 genotype to anticoagulant response to warfarinQ44787224
A polymorphism in the VKORC1 gene is associated with an interindividual variability in the dose-anticoagulant effect of warfarin.Q45052744
Warfarin and pharmacogenomic testing: the case for restraintQ46421340
Influence of CYP2C9 polymorphisms, demographic factors and concomitant drug therapy on warfarin metabolism and maintenance doseQ46433362
The impact of CYP2C9 and VKORC1 genetic polymorphism and patient characteristics upon warfarin dose requirements: proposal for a new dosing regimenQ46537717
Prospective study of warfarin dosage requirements based on CYP2C9 and VKORC1 genotypesQ46816940
The risk of hemorrhage among patients with warfarin-associated coagulopathyQ46951753
A warfarin-dosing model in Asians that uses single-nucleotide polymorphisms in vitamin K epoxide reductase complex and cytochrome P450 2C9.Q51932266
Genotypes of vitamin K epoxide reductase, gamma-glutamyl carboxylase, and cytochrome P450 2C9 as determinants of daily warfarin dose in Japanese patients.Q53248119
Influence of coagulation factor, vitamin K epoxide reductase complex subunit 1, and cytochrome P450 2C9 gene polymorphisms on warfarin dose requirements.Q53257773
P433issue2
P921main subject(RS)-warfarinQ407431
P304page(s)138-146
P577publication date2009-02-01
P1433published inThe Journal of Clinical PharmacologyQ7743562
P1476titleA regulatory science perspective on warfarin therapy: a pharmacogenetic opportunity
P478volume49

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cites work (P2860)
Q43089518A pharmacometric model describing the relationship between warfarin dose and INR response with respect to variations in CYP2C9, VKORC1, and age.
Q33846255Applied pharmacogenomics in cardiovascular medicine
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Q47584698Clinical Pharmacokinetic and Pharmacodynamic Profile of Riociguat
Q35032378Clinically relevant genetic variations in drug metabolizing enzymes
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Q84265482Extreme sensitivity to acenocoumarol therapy in patient with both VKORC.-1639 A/A and CYP2C9*1/*3 genotypes
Q49142379Genetics and the clinical response to warfarin and edoxaban: findings from the randomised, double-blind ENGAGE AF-TIMI 48 trial.
Q36015458Meta-analysis of Randomized Controlled Trials of Genotype-Guided vs Standard Dosing of Warfarin
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Q38100809Personalized diagnostics and biosensors: a review of the biology and technology needed for personalized medicine
Q37142852Personalized vascular medicine: individualizing drug therapy
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Q84523980Pharmacogenetic tests could be helpful in predicting of VKA maintenance dose in elderly patients at treatment initiation
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Q94410300Privacy in Pharmacogenetics: An End-to-End Case Study of Personalized Warfarin Dosing
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Q31131437Warfarin anticoagulant therapy: a Southern Italy pharmacogenetics-based dosing model
Q55652414Warfarin therapy that results in an International Normalization Ratio above the therapeutic range is associated with accelerated progression of chronic kidney disease.
Q39862947Worldwide allele frequency distribution of four polymorphisms associated with warfarin dose requirements.

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