Role of BCRP 421C>A polymorphism on rosuvastatin pharmacokinetics in healthy Chinese males

article

Role of BCRP 421C>A polymorphism on rosuvastatin pharmacokinetics in healthy Chinese males is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CCA.2006.05.010
P698PubMed publication ID16784736

P50authorZhao-Qian LiuQ69033386
P2093author name stringQing Li
Wei Zhang
An Wang
Hong-Hao Zhou
Lan Fan
Yi-Jing He
Zhi-Rong Tan
Ya-Li Liu
Bang-Ning Yu
Fen-Jiang
Yuan-Fei Huang
P433issue1-2
P921main subjectpharmacokineticsQ323936
P304page(s)99-103
P577publication date2006-11-01
P1433published inClinica Chimica ActaQ5133740
P1476titleRole of BCRP 421C>A polymorphism on rosuvastatin pharmacokinetics in healthy Chinese males
P478volume373

Reverse relations

cites work (P2860)
Q929601753D structure of the transporter ABCG2-What's new?
Q35617587A 30-years review on pharmacokinetics of antibiotics: is the right time for pharmacogenetics?
Q37050337A perspective on efflux transport proteins in the liver
Q38107993ABC transporters in multidrug resistance and pharmacokinetics, and strategies for drug development.
Q43174441ABCG2 polymorphism is associated with the low-density lipoprotein cholesterol response to rosuvastatin
Q45993642ABCG2 polymorphism markedly affects the pharmacokinetics of atorvastatin and rosuvastatin.
Q46294694ABT-335, the choline salt of fenofibric acid, does not have a clinically significant pharmacokinetic interaction with rosuvastatin in humans
Q60916021ATP-Binding Cassette Transporters in the Clinical Implementation of Pharmacogenetics
Q36597410ATP-binding cassette, subfamily G (ABCG family).
Q39486373Acyclovir is a substrate for the human breast cancer resistance protein (BCRP/ABCG2): implications for renal tubular transport and acyclovir-induced nephrotoxicity
Q36593505BCRP/ABCG2 in the placenta: expression, function and regulation
Q33704930Breast cancer resistance protein (ABCG2) and drug disposition: intestinal expression, polymorphisms and sulfasalazine as an in vivo probe
Q90613746Cellular Processing of the ABCG2 Transporter-Potential Effects on Gout and Drug Metabolism
Q38160088Clinical impact of genetic variants of drug transporters in different ethnic groups within and across regions
Q43109279Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population
Q36796490Current Perspectives on rosuvastatin
Q34702620Decreased hepatic breast cancer resistance protein expression and function in multidrug resistance-associated protein 2-deficient (TR⁻) rats
Q92435676Development of precision medicine approaches based on inter-individual variability of BCRP/ABCG2
Q43258273Different effects of the ABCG2 c.421C>A SNP on the pharmacokinetics of fluvastatin, pravastatin and simvastatin
Q90814739Dose-Dependent Inhibition of OATP1B by Rifampicin in Healthy Volunteers: Comprehensive Evaluation of Candidate Biomarkers and OATP1B Probe Drugs
Q37793056Drug transport by breast cancer resistance protein.
Q38177333Drug-drug interaction with statins.
Q39985485Dyslipidemia in Special Ethnic Populations
Q35573543Dyslipidemia in special ethnic populations
Q54006194Effect of CYP2C19 polymorphism on the pharmacokinetics of rosuvastatin in healthy Taiwanese subjects.
Q89690229Effect of P-glycoprotein (P-gp) Inducers on Exposure of P-gp Substrates: Review of Clinical Drug-Drug Interaction Studies
Q33686542Effect of epigallocatechin-3-gallate, major ingredient of green tea, on the pharmacokinetics of rosuvastatin in healthy volunteers
Q51266635Effect of polymorphisms in CYP3A4, PPARA, NR1I2, NFKB1, ABCG2 and SLCO1B1 on the pharmacokinetics of lovastatin in healthy Chinese volunteers.
Q37371551Effect of pregnancy on nitrofurantoin disposition in mice
Q40018547Effect of silymarin supplement on the pharmacokinetics of rosuvastatin
Q38071700Effect of the ATP-binding cassette transporter ABCG2 on pharmacokinetics: experimental findings and clinical implications
Q46062183Effects of polymorphisms in ABCG2, SLCO1B1, SLC10A1 and CYP2C9/19 on plasma concentrations of rosuvastatin and lipid response in Chinese patients
Q37724381Efflux and uptake transporters as determinants of statin response.
Q35183649Eltrombopag increases plasma rosuvastatin exposure in healthy volunteers
Q33433942Ethnic sensitivity assessment of the antibody-drug conjugate trastuzumab emtansine (T-DM1) in patients with HER2-positive locally advanced or metastatic breast cancer
Q38084901Ethnic variability in the plasma exposures of OATP1B1 substrates such as HMG-CoA reductase inhibitors: a kinetic consideration of its mechanism
Q44737065Evaluation of Proposed In Vivo Probe Substrates and Inhibitors for Phenotyping Transporter Activity in Humans
Q38155218Evaluation of the pharmacokinetics and drug interactions of the two recently developed statins, rosuvastatin and pitavastatin
Q48811919Evaluation of the usefulness of breast cancer resistance protein (BCRP) knockout mice and BCRP inhibitor-treated monkeys to estimate the clinical impact of BCRP modulation on the pharmacokinetics of BCRP substrates.
Q37790379Fetoprotective activity of breast cancer resistance protein (BCRP, ABCG2): expression and function throughout pregnancy
Q57110508Gene-by-Environment Interaction of Bcrp-/- and MCD Diet-Induced Nonalcoholic Steatohepatitis Alters SN-38 Disposition
Q48893219Generation and Characterization of a Breast Cancer Resistance Protein Humanized Mouse Model.
Q37481450Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs
Q34292537Genetic variation in drug transporters in ethnic populations
Q37331801Hepatic basolateral efflux contributes significantly to rosuvastatin disposition I: characterization of basolateral versus biliary clearance using a novel protocol in sandwich-cultured hepatocytes
Q37331821Hepatic basolateral efflux contributes significantly to rosuvastatin disposition II: characterization of hepatic elimination by basolateral, biliary, and metabolic clearance pathways in rat isolated perfused liver.
Q38560889Hepatic drug transporters: the journey so far.
Q53611791Impact of ABCG2 and SLCO1B1 polymorphisms on pharmacokinetics of rosuvastatin, atorvastatin and simvastatin acid in Caucasian and Asian subjects: a class effect?
Q85432136Impact of Menopause on Pharmacokinetics of Rosuvastatin Compared with Premenopausal Women
Q38888369Impact of Transporter Polymorphisms on Drug Development: Is It Clinically Significant?
Q38888365Importance of Hepatic Transporters in Clinical Disposition of Drugs and Their Metabolites
Q42933358Influence of CYP3A5 and drug transporter polymorphisms on imatinib trough concentration and clinical response among patients with chronic phase chronic myeloid leukemia
Q92132562Influence of OATP1B1 and BCRP polymorphisms on the pharmacokinetics and pharmacodynamics of rosuvastatin in elderly and young Korean subjects
Q36687277Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans
Q39034284Interindividual and interethnic variability in drug disposition: polymorphisms in organic anion transporting polypeptide 1B1 (OATP1B1; SLCO1B1).
Q38379295Intestinal and hepatic drug transporters: pharmacokinetic, pathophysiological, and pharmacogenetic roles
Q37339515Investigation of the Bioequivalence of Rosuvastatin 20 mg Tablets after a Single Oral Administration in Mediterranean Arabs Using a Validated LC-MS/MS Method
Q28570070Knocking down breast cancer resistance protein (Bcrp) by adenoviral vector-mediated RNA interference (RNAi) in sandwich-cultured rat hepatocytes: a novel tool to assess the contribution of Bcrp to drug biliary excretion
Q38129422Lipid-lowing pharmacogenomics in Chinese patients
Q34897883Membrane topology of the human breast cancer resistance protein (BCRP/ABCG2) determined by epitope insertion and immunofluorescence
Q29616802Membrane transporters in drug development
Q89372273No effects of pantoprazole on the pharmacokinetics of rosuvastatin in healthy subjects
Q57500318Organic anion transporting polypeptide-1B1 haplotypes in Chinese patients
Q28068014Pediatric Statin Administration: Navigating a Frontier with Limited Data
Q37182212PhRMA white paper on ADME pharmacogenomics.
Q46826559Pharmacogenetic characterization of sulfasalazine disposition based on NAT2 and ABCG2 (BCRP) gene polymorphisms in humans
Q37074291Pharmacogenetics of response to statins
Q23919667Pharmacogenetics, pharmacogenomics, and individualized medicine
Q37235629Pharmacogenomic importance of ABCG2.
Q38112823Pharmacogenomics of lipid-lowering therapies
Q88061446Pharmacokinetic study of rosuvastatin in males and females
Q42562160Pharmacokinetics of rosuvastatin in 30 healthy Zimbabwean individuals of African ancestry
Q58073610Physiologically based pharmacokinetic models for the optimization of antiretroviral therapy: recent progress and future perspective
Q38243832Polymorphisms of the drug transporters ABCB1, ABCG2, ABCC2 and ABCC3 and their impact on drug bioavailability and clinical relevance
Q39773424Quantitative Analyses of Hepatic OATP-Mediated Interactions Between Statins and Inhibitors Using PBPK Modeling With a Parameter Optimization Method
Q30244632Racial Differences in the Cholesterol-Lowering Effect of Statin
Q39140289Renal Drug Transporters and Drug Interactions
Q34774854Repositioning of Tyrosine Kinase Inhibitors as Antagonists of ATP-Binding Cassette Transporters in Anticancer Drug Resistance
Q46109720Reverse Translational Research of ABCG2 (BCRP) in Human Disease and Drug Response
Q34871636Role of the breast cancer resistance protein (BCRP/ABCG2) in drug transport--an update
Q46204648Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions.
Q41512597Rosuvastatin pharmacokinetics and pharmacogenetics in Caucasian and Asian subjects residing in the United States
Q34579035SLCO1B1 (OATP1B1, an uptake transporter) and ABCG2 (BCRP, an efflux transporter) variant alleles and pharmacokinetics of pitavastatin in healthy volunteers
Q41737190Safety and pharmacokinetics of the CIME combination of drugs and their metabolites after a single oral dosing in healthy volunteers.
Q89642081Simvastatin intolerance genetic determinants: some features in ethnic Uzbek patients with coronary artery disease
Q53417201Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1 and ABCG2), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP.
Q38207943Structure and function of BCRP, a broad specificity transporter of xenobiotics and endobiotics
Q40359311Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P-Glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP).
Q34035243Sulindac and its metabolites inhibit multiple transport proteins in rat and human hepatocytes.
Q36803379The ABCG2 C421A polymorphism does not affect oral nitrofurantoin pharmacokinetics in healthy Chinese male subjects.
Q37810986The ABCG2 transporter and its relations with the pharmacokinetics, drug interaction and lipid-lowering effects of statins
Q53736039The Effect of Genetic Polymorphisms in SLCO2B1 on the Lipid-Lowering Efficacy of Rosuvastatin in Healthy Adults with Elevated Low-Density Lipoprotein.
Q42151027The effect of ABCG2 V12M, Q141K and Q126X, known functional variants in vitro, on the disposition of lamivudine
Q43003337The effect of acute administration of rifampicin and imatinib on the enterohepatic transport of rosuvastatin in vivo
Q81241502The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion-transporting polypeptide 1B1
Q38303543The identification of two germ-line mutations in the human breast cancer resistance protein gene that result in the expression of a low/non-functional protein
Q50868889The influence of CYP3A5*3 and BCRPC421A genetic polymorphisms on the pharmacokinetics of felodipine in healthy Chinese volunteers.
Q34613443The influence of SLCO1B1 (OATP1B1) gene polymorphisms on response to statin therapy.
Q34079760The influence of herbal medicine ursolic acid on the uptake of rosuvastatin mediated by OATP1B1*1a and *5.
Q37537018The role of transporters in the pharmacokinetics of orally administered drugs
Q37862942Therapeutic drug monitoring of imatinib for chronic myeloid leukemia patients in the chronic phase
Q35927508Three-dimensional structure of the human breast cancer resistance protein (BCRP/ABCG2) in an inward-facing conformation
Q46766214Understanding the Potential Interethnic Difference in Rosuvastatin Pharmacokinetics
Q88118125Using Physiologically Based Pharmacokinetic (PBPK) Modeling to Evaluate the Impact of Pharmaceutical Excipients on Oral Drug Absorption: Sensitivity Analyses
Q33714593Xenobiotic, bile acid, and cholesterol transporters: function and regulation.

Search more.