Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity

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Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity is …
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scholarly articleQ13442814

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P356DOI10.1038/SREP18494
P2888exact matchhttps://scigraph.springernature.com/pub.10.1038/srep18494
P932PMC publication ID4683444
P698PubMed publication ID26678097
P5875ResearchGate publication ID287583666

P50authorJoaquín DopazoQ31034660
Enrique VidalQ41536859
Alicia AmadozQ41723837
P2093author name stringPatricia Sebastian-Leon
Francisco Salavert
P2860cites workEnhanced apoptosis and tumor growth suppression elicited by combination of MEK (selumetinib) and mTOR kinase inhibitors (AZD8055).Q53390153
Bioconductor: open software development for computational biology and bioinformaticsQ21194861
Pharmacogenetics, pharmacogenomics, and individualized medicineQ23919667
The Reactome pathway knowledgebaseQ24567743
Data, information, knowledge and principle: back to metabolism in KEGGQ24568332
RNA-Seq: a revolutionary tool for transcriptomicsQ24596169
Systems pharmacology: network analysis to identify multiscale mechanisms of drug actionQ26824166
Identification of aberrant pathways and network activities from high-throughput dataQ26829854
The ErbB/HER family of protein-tyrosine kinases and cancerQ28302611
Repeatability of published microarray gene expression analysesQ28307780
Utilization of genomic signatures to identify phenotype-specific drugsQ28476014
The Connectivity Map: a new tool for biomedical researchQ28530408
Potentiating the efficacy of molecular targeted therapy for hepatocellular carcinoma by inhibiting the insulin-like growth factor pathwayQ28534009
A network flow-based method to predict anticancer drug sensitivityQ28547323
affy--analysis of Affymetrix GeneChip data at the probe levelQ29547353
Network medicine: a network-based approach to human diseaseQ29547462
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and diseaseQ29547614
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivityQ29547693
Systematic identification of genomic markers of drug sensitivity in cancer cellsQ29547695
Ten years of pathway analysis: current approaches and outstanding challengesQ29615564
Interactome networks and human diseaseQ29615773
An integrative genomics approach to infer causal associations between gene expression and diseaseQ29616385
A strategy for predicting the chemosensitivity of human cancers and its application to drug discoveryQ30443764
The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive modelsQ30512428
Babelomics 5.0: functional interpretation for new generations of genomic data.Q30937737
Identification of drug-specific pathways based on gene expression data: application to drug induced lung injuryQ30941816
The evolution of molecular biology into systems biology.Q51602866
Hyperactivation of MEK-ERK1/2 signaling and resistance to apoptosis induced by the oncogenic B-RAF inhibitor, PLX4720, in mutant N-RAS melanoma cells.Q53302291
CEBS--Chemical Effects in Biological Systems: a public data repository integrating study design and toxicity data with microarray and proteomics data.Q31134298
Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanismQ33264052
Identification of key processes underlying cancer phenotypes using biologic pathway analysisQ33283999
A chemical and phosphoproteomic characterization of dasatinib action in lung cancerQ33742159
Chemosensitivity prediction by transcriptional profilingQ33943845
Pathway-based evaluation in early onset colorectal cancer suggests focal adhesion and immunosuppression along with epithelial-mesenchymal transitionQ34229772
Understanding disease mechanisms with models of signaling pathway activities.Q34422921
An investigation of biomarkers derived from legacy microarray data for their utility in the RNA-seq eraQ34460312
Predicting in vitro drug sensitivity using Random ForestsQ34480086
Thousands of samples are needed to generate a robust gene list for predicting outcome in cancerQ34596148
Bidirectional crosstalk between leptin and insulin-like growth factor-I signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptorQ35234141
Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growthQ35928707
A systems biology approach for pathway level analysisQ36004656
Prediction of human population responses to toxic compounds by a collaborative competitionQ36056166
An argument for mechanism-based statistical inference in cancer.Q36182146
Wnt-pathway activation in two molecular classes of hepatocellular carcinoma and experimental modulation by sorafenib.Q36247123
Toxicogenomics in drug discovery and development: mechanistic analysis of compound/class-dependent effects using the DrugMatrix databaseQ36629988
Pathway activation strength is a novel independent prognostic biomarker for cetuximab sensitivity in colorectal cancer patientsQ36671291
Rationale and clinical results of multi-target treatments in oncology.Q36829711
Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibitionQ36905632
Inferring the functional effect of gene expression changes in signaling pathways.Q36954066
Comparison and validation of genomic predictors for anticancer drug sensitivityQ37039879
The insulin-like growth factor pathway in lung cancerQ37231655
A novel signaling pathway impact analysis.Q37319638
Molecular networks as sensors and drivers of common human diseasesQ37594580
Identification of predictive markers of response to the MEK1/2 inhibitor selumetinib (AZD6244) in K-ras-mutated colorectal cancer.Q37596249
Epidermal growth factor receptor (EGFR) and squamous cell carcinoma of the skin: molecular bases for EGFR-targeted therapyQ37870482
A targeted therapy for protein and lipid kinases in chronic lymphocytic leukemiaQ38029359
Genomics and transcriptomics in drug discoveryQ38115030
Emerging signaling pathways in hepatocellular carcinoma.Q38155507
Identifying novel targets of oncogenic EGF receptor signaling in lung cancer through global phosphoproteomics.Q38420747
Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma.Q38466630
Understanding cellular function and disease with comparative pathway analysisQ38646518
Systems biology and the future of medicineQ38647215
Inhibition of Hedgehog signaling sensitizes NSCLC cells to standard therapies through modulation of EMT-regulating miRNAsQ39066320
Lapatinib alters the malignant phenotype of osteosarcoma cells via downregulation of the activity of the HER2-PI3K/AKT-FASN axis in vitroQ39068761
Autophagy stimulates apoptosis in HER2-overexpressing breast cancers treated by lapatinibQ39136014
CXC chemokine receptor 4 is essential for maintenance of renal cell carcinoma-initiating cells and predicts metastasis.Q39158412
Tumor suppressor BLU promotes paclitaxel antitumor activity by inducing apoptosis through the down-regulation of Bcl-2 expression in tumorigenesisQ39158623
Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylasesQ39180227
Sorafenib induces endometrial carcinoma apoptosis by inhibiting Elk-1-dependent Mcl-1 transcription and inducing Akt/GSK3β-dependent protein degradationQ39184863
Tracking molecular relapse of chronic myeloid leukemia by measuring Hedgehog signaling statusQ39319816
Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cellsQ39386176
Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinomaQ39486469
PI-103 and sorafenib inhibit hepatocellular carcinoma cell proliferation by blocking Ras/Raf/MAPK and PI3K/AKT/mTOR pathwaysQ39615186
A sub-pathway-based approach for identifying drug response principal networkQ39615546
Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinibQ39700483
In vitro sequence-dependent synergism between paclitaxel and gefitinib in human lung cancer cell lines.Q39701114
Microtubule-mediated NF-kappaB activation in the TNF-alpha signaling pathwayQ39803323
The Hedgehog signaling pathway plays an essential role in maintaining the CD44+CD24-/low subpopulation and the side population of breast cancer cellsQ39837550
Synergistic growth inhibition of squamous cell carcinoma of the head and neck by erlotinib and epigallocatechin-3-gallate: the role of p53-dependent inhibition of nuclear factor-kappaB.Q39846889
Paclitaxel (Taxol) upregulates expression of functional interleukin-6 in human ovarian cancer cells through multiple signaling pathwaysQ40302272
EGF activates intracellular and intercellular calcium signaling by distinct pathways in tumor cells.Q40478413
Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cellsQ40736468
Along signal paths: an empirical gene set approach exploiting pathway topology.Q41431283
Signaling pathways activation profiles make better markers of cancer than expression of individual genes.Q41874902
Basal and treatment-induced activation of AKT mediates resistance to cell death by AZD6244 (ARRY-142886) in Braf-mutant human cutaneous melanoma cellsQ42478581
Outcome signature genes in breast cancer: is there a unique set?Q42633433
Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitroQ42709816
Prediction model of potential hepatocarcinogenicity of rat hepatocarcinogens using a large-scale toxicogenomics databaseQ42729239
Analysis of gene sets based on the underlying regulatory networkQ42790547
AZD6244 (ARRY-142886) enhances the antitumor activity of rapamycin in mouse models of human hepatocellular carcinoma.Q43184161
Systems diagnostics: anticipating the next generation of diagnostic tests based on mechanistic insight into diseaseQ43607881
PPAR signaling pathway may be an important predictor of breast cancer response to neoadjuvant chemotherapyQ44727677
Antiangiogenic activity of paclitaxel is associated with its cytostatic effect, mediated by the initiation but not completion of a mitochondrial apoptotic signaling pathwayQ45108177
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesaffyQ113334509
P407language of work or nameEnglishQ1860
P921main subjectbiomarkerQ864574
P304page(s)18494
P577publication date2015-12-18
P1433published inScientific ReportsQ2261792
P1476titleUsing activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity
P478volume5

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cites work (P2860)
Q57837744A comparison of mechanistic signaling pathway activity analysis methods
Q41723803Actionable pathways: interactive discovery of therapeutic targets using signaling pathway models
Q39945009Chronic subordination stress selectively downregulates the insulin signaling pathway in liver and skeletal muscle but not in adipose tissue of male mice
Q57837743Differential metabolic activity and discovery of therapeutic targets using summarized metabolic pathway models
Q64039986Differential metabolic activity and discovery of therapeutic targets using summarized metabolic pathway models
Q64099093FoPA: identifying perturbed signaling pathways in clinical conditions using formal methods
Q112294186Genome-scale mechanistic modeling of signaling pathways made easy: A bioconductor/cytoscape/web server framework for the analysis of omic data
Q42117770High throughput estimation of functional cell activities reveals disease mechanisms and predicts relevant clinical outcomes.
Q55017642PanDrugs: a novel method to prioritize anticancer drug treatments according to individual genomic data.
Q59336758The poly-omics of ageing through individual-based metabolic modelling
Q91933694Using mechanistic models for the clinical interpretation of complex genomic variation
Q36051062Web-based network analysis and visualization using CellMaps

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