Potentiating the efficacy of molecular targeted therapy for hepatocellular carcinoma by inhibiting the insulin-like growth factor pathway

scientific article (publication date: 2013)

Potentiating the efficacy of molecular targeted therapy for hepatocellular carcinoma by inhibiting the insulin-like growth factor pathway is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...866589O
P356DOI10.1371/JOURNAL.PONE.0066589
P3181OpenCitations bibliographic resource ID2605875
P932PMC publication ID3688529
P698PubMed publication ID23818948
P5875ResearchGate publication ID244482602

P50authorLiang-In LinQ56418529
Da-Liang OuQ59680214
Ann-Lii ChengQ38639483
P2093author name stringJun-Yang Liou
Chiun Hsu
Ya-Chi Chang
Bin-Shyun Lee
P2860cites workInsulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).Q53985281
Dissimilar immunohistochemical expression of ERK and AKT between paired biopsy and hepatectomy tissues of hepatocellular carcinoma.Q54471459
Evidence of autocrine regulation in human hepatoma cell linesQ69828722
DNA damage response and growth factor signaling pathways in gliomagenesis and therapeutic resistanceQ26825975
Sorafenib in advanced hepatocellular carcinomaQ27861075
Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulatorsQ28267500
Tumor suppressor CHK2: regulator of DNA damage response and mediator of chromosomal stabilityQ28298710
Insulin-like growth factor-I receptor signalling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cellsQ28299546
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trialQ29547903
The effects of insulin-like growth factors on tumorigenesis and neoplastic growthQ33945357
IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage.Q34102411
Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liverQ35810600
An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosisQ35863982
Dual targeting of the Akt/mTOR signaling pathway inhibits castration-resistant prostate cancer in a genetically engineered mouse model.Q36204972
Identification of angiogenic properties of insulin-like growth factor II in in vitro angiogenesis modelsQ36621109
???Q28256350
CHK2 kinase: cancer susceptibility and cancer therapy - two sides of the same coin?Q37001375
Molecular targeted therapies in hepatocellular carcinomaQ37003665
Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinomaQ37284612
Molecular targeted therapy for advanced hepatocellular carcinoma: current status and future perspectivesQ37766798
Targeting the insulin-like growth factor axis for the development of novel therapeutics in oncologyQ37973047
Combination of PI3K/mTOR inhibitors: antitumor activity and molecular correlatesQ39538508
Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinomaQ39585554
Efficacy of and resistance to anti-IGF-1R therapies in Ewing's sarcoma is dependent on insulin receptor signalingQ39600616
A kinase-independent role for unoccupied insulin and IGF-1 receptors in the control of apoptosis.Q39622751
A dominant negative type I insulin-like growth factor receptor inhibits metastasis of human cancer cells.Q40616617
Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes; implications for a gain-of-function during the formation of hepatocellular carcinomaQ40860429
Characterization of the insulin-like growth factor axis in a human hepatoma cell line (PLC).Q40981388
Increased expression of the insulin-like growth factor I (IGF-I) receptor gene in hepatocellular carcinoma cell lines: implications of IGF-I receptor gene activation by hepatitis B virus X gene product.Q42519906
In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinaseQ42799629
Insulin-like growth factor I (IGF-I) and the IGF-I receptor prevent etoposide-induced apoptosis.Q42830680
Induction of Bim expression contributes to the antitumor synergy between sorafenib and mitogen-activated protein kinase/extracellular signal-regulated kinase kinase inhibitor CI-1040 in hepatocellular carcinomaQ43279511
An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferationQ44564128
A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenograftsQ45073541
The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4.Q45755634
A novel orthotopic tumor model to study growth factors and oncogenes in hepatocarcinogenesis.Q46361400
Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cellsQ46431072
Stability of phosphoprotein as a biological marker of tumor signalingQ46549087
Autocrine insulin-like growth factor-II stimulation of tumor cell migration is a progression step in human hepatocarcinogenesisQ46553511
Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumorsQ47860361
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjecthepatocellular carcinomaQ1148337
preproinsulinQ7240673
P304page(s)e66589
P577publication date2013-01-01
P1433published inPLOS OneQ564954
P1476titlePotentiating the efficacy of molecular targeted therapy for hepatocellular carcinoma by inhibiting the insulin-like growth factor pathway
P478volume8

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cites work (P2860)
Q36232448Exosomes derived from miR-122-modified adipose tissue-derived MSCs increase chemosensitivity of hepatocellular carcinoma
Q53066756Interplay of genetic and epigenetic alterations in hepatocellular carcinoma.
Q38862452MK-2206 induces apoptosis of AML cells and enhances the cytotoxicity of cytarabine.
Q34292802Picropodophyllin and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells
Q38936589Promising new strategies for hepatocellular carcinoma
Q52345488Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight.
Q37413127Synergistic activity of vorinostat combined with gefitinib but not with sorafenib in mutant KRAS human non-small cell lung cancers and hepatocarcinoma.
Q36382520Using activation status of signaling pathways as mechanism-based biomarkers to predict drug sensitivity

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