How polymorphisms of the cytochrome P450 genes affect ibuprofen and diclofenac metabolism and toxicity

scientific article published on March 2016

How polymorphisms of the cytochrome P450 genes affect ibuprofen and diclofenac metabolism and toxicity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1515/AIHT-2016-67-2754
P698PubMed publication ID27092633

P50authorAleksandar J DimovskiQ91153321
P2093author name stringValon Krasniqi
Nada Božina
Iva Klarica Domjanović
Ivan Bilić
P2860cites workPharmacogenetics, pharmacogenomics, and individualized medicineQ23919667
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Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes.Q51769708
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Diclofenac and Its Acyl Glucuronide: Determination of In Vivo Exposure in Human Subjects and Characterization as Human Drug Transporter Substrates In Vitro.Q53232379
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The effect of the cytochrome P450 CYP2C8 polymorphism on the disposition of (R)-ibuprofen enantiomer in healthy subjects.Q35827277
Cytochrome P450 2C8: substrates, inhibitors, pharmacogenetics, and clinical relevanceQ36131028
The apical conjugate efflux pump ABCC2 (MRP2).Q36539096
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Global variation in CYP2C8-CYP2C9 functional haplotypesQ37434738
Genetic polymorphism of metabolic enzymes P450 (CYP) as a susceptibility factor for drug response, toxicity, and cancer riskQ37542607
Personalized therapy in pain management: where do we stand?Q37760955
Genetic polymorphism and toxicology--with emphasis on cytochrome p450.Q37819666
Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transportQ39578741
Regioselective and stereoselective metabolism of ibuprofen by human cytochrome P450 2C.Q41100709
Disposition and covalent binding of ibuprofen and its acyl glucuronide in the elderlyQ42279636
Effects of CYP2C9*3 and CYP2C9*13 on Diclofenac Metabolism and Inhibition-based Drug-Drug Interactions.Q42918844
Functional characterization of five CYP2C8 variants and prediction of CYP2C8 genotype-dependent effects on in vitro and in vivo drug-drug interactionsQ43066596
Hepatic clearance of reactive glucuronide metabolites of diclofenac in the mouse is dependent on multiple ATP-binding cassette efflux transportersQ43189634
Characterization of rat and human UDP-glucuronosyltransferases responsible for the in vitro glucuronidation of diclofenacQ43569654
The role of CYP2C9 genotype in the metabolism of diclofenac in vivo and in vitroQ43877657
Enantiospecific effects of cytochrome P450 2C9 amino acid variants on ibuprofen pharmacokinetics and on the inhibition of cyclooxygenases 1 and 2.Q44085582
Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicityQ44880285
Interindividual variability in ibuprofen pharmacokinetics is related to interaction of cytochrome P450 2C8 and 2C9 amino acid polymorphismsQ45004302
Pharmacokinetic studies of enantiomers of ibuprofen and its chiral metabolites in humans with different variants of genes coding CYP2C8 and CYP2C9 isoenzymes.Q45990596
Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitroQ46372792
Influence of CYP2C8 and CYP2C9 polymorphisms on pharmacokinetic and pharmacodynamic parameters of racemic and enantiomeric forms of ibuprofen in healthy volunteersQ46434971
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 4.0 InternationalQ24082749
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectDiclofenacQ244408
P304page(s)1-8
P577publication date2016-03-01
P1433published inArchives of Industrial Hygiene and ToxikologyQ15724434
P1476titleHow polymorphisms of the cytochrome P450 genes affect ibuprofen and diclofenac metabolism and toxicity
P478volume67

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