Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling

scientific article published on 05 December 2016

Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1073/PNAS.1612520114
P932PMC publication ID5187670
P698PubMed publication ID27930311

P2093author name stringAimin Liu
Hongchen Cai
P2860cites workBrachydactylyQ21202913
Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limbQ22253250
Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligaseQ24336527
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formationQ24600279
Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin LigasesQ27657740
Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathwaysQ28142399
Hair cycle regulation of Hedgehog signal receptionQ28185267
Genetic manipulation of hedgehog signaling in the endochondral skeleton reveals a direct role in the regulation of chondrocyte proliferationQ28211798
Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in miceQ28506102
Gli1can rescue the in vivo function ofGli2Q28506239
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradationQ28507411
Ihh signaling is directly required for the osteoblast lineage in the endochondral skeletonQ28508641
PTHrP regulates growth plate chondrocyte differentiation and proliferation in a Gli3 dependent manner utilizing hedgehog ligand dependent and independent mechanismsQ28585066
Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conservedQ28585804
Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophyQ28592610
Efficient in vivo manipulation of mouse genomic sequences at the zygote stageQ29547306
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressorsQ33874551
Osteoporosis: now and the futureQ36564425
Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate UbiquitinationQ36782739
Stabilization of speckle-type POZ protein (Spop) by Daz interacting protein 1 (Dzip1) is essential for Gli turnover and the proper output of Hedgehog signalingQ37289340
Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligaseQ37482039
The skeleton: a multi-functional complex organ: the growth plate chondrocyte and endochondral ossification.Q37885084
Building strong bones: molecular regulation of the osteoblast lineageQ37970567
Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradationQ39739721
A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasomeQ40174315
Suppressor of fused (Sufu) mediates the effect of parathyroid hormone-like hormone (Pthlh) on chondrocyte differentiation in the growth plateQ42413475
The Gli2 transcriptional activator is a crucial effector for Ihh signaling in osteoblast development and cartilage vascularizationQ42658620
Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptusQ47071381
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.Q47071852
The Xt J allele generates a Gli 3 fusion transcriptQ47781329
Immunohistochemistry and RNA in situ hybridization in mouse brain developmentQ49015883
Impaired endochondral bone development and osteopenia in Gli2-deficient miceQ51022793
Expression of Cre recombinase in the developing mouse limb bud driven by aPrxl enhancerQ64965676
Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular developmentQ81159312
P433issue51
P407language of work or nameEnglishQ1860
P304page(s)14751-14756
P577publication date2016-12-05
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleSpop promotes skeletal development and homeostasis by positively regulating Ihh signaling
P478volume113

Reverse relations

cites work (P2860)
Q64972623A catalog of single nucleotide changes distinguishing modern humans from archaic hominins.
Q89782116Association of SPOP Expression with the Immune Response to Salmonella Infection in Chickens
Q47284253Cullin 3-Based Ubiquitin Ligases as Master Regulators of Mammalian Cell Differentiation.
Q50173178Effect of superparamagnetic iron oxide on differentiation of rat bone marrow stem cells into chondrocytes in vitro
Q47413250Functional analysis of Cullin 3 E3 ligases in tumorigenesis.
Q64245029Gli Proteins: Regulation in Development and Cancer
Q92605335Gli promotes tumor progression through regulating epithelial-mesenchymal transition in non-small-cell lung cancer
Q99549299Hedgehog Signaling in Skeletal Development: Roles of Indian Hedgehog and the Mode of Its Action
Q93137434Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy
Q92701745Regulation of Hedgehog signaling Offers A Novel Perspective for Bone Homeostasis Disorder Treatment
Q91713061SPOP and cancer: a systematic review
Q99241388SPOP attenuates migration and invasion of choriocarcinoma cells by promoting DHX9 degradation
Q93165664SPOP inhibits mice pancreatic stellate cell activation by promoting FADD degradation in cerulein-induced chronic pancreatitis
Q92481994SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer
Q51056272Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord.
Q90662887Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals
Q92579042The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation
Q50041211The inhibitory roles of Ihh downregulation on chondrocyte growth and differentiation
Q53078772Uterine function in the mouse requires speckle-type poz protein.

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