Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway

scientific journal article

Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M608194200
P698PubMed publication ID17062563

P2093author name stringYing Chen
Min Li
John Marshall
Jeffrey D. Singer
Gregory D. Salinas
Justina D. Gonzales
Leigh A. Needleman
Leslie A. C. Blair
P2860cites workCullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cellsQ22010574
Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathwayQ24296695
Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathwayQ24306215
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligaseQ24558689
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2Q24563807
Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIPQ24608270
Novel kelch-like protein, KLEIP, is involved in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cellsQ24632871
Regulation of nicotinic receptor expression by the ubiquitin-proteasome systemQ37592899
A C-terminal determinant of GluR6 kainate receptor trafficking.Q40596914
Activity-dependent endocytic sorting of kainate receptors to recycling or degradation pathwaysQ40619917
BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3.Q40633677
Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptorsQ41918860
Structural requirements for palmitoylation of surfactant protein C precursorQ42908052
Primary sequence requirements for S-acylation of beta(2)-adrenergic receptor peptidesQ43647807
Ubiquitin and AP180 regulate the abundance of GLR-1 glutamate receptors at postsynaptic elements in C. elegansQ44068092
Targeted Protein Degradation and Synapse Remodeling by an Inducible Protein KinaseQ44630506
Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptideQ44880702
X-chromosome-counting mechanisms that determine nematode sex.Q46067137
Identification of an endoplasmic reticulum-retention motif in an intracellular loop of the kainate receptor subunit KA2.Q48484059
Neuroprotection of Tat-GluR6-9c against neuronal death induced by kainate in rat hippocampus via nuclear and non-nuclear pathwaysQ48577934
The synaptic activation of kainate receptorsQ48659127
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.Q53616483
Experimental observations on the development of polarity by hippocampal neurons in cultureQ24679532
Differential regulation of EGF receptor internalization and degradation by multiubiquitination within the kinase domainQ28119149
Function and regulation of cullin-RING ubiquitin ligasesQ28131707
Accessory protein facilitated CFTR-CFTR interaction, a molecular mechanism to potentiate the chloride channel activityQ28142263
Kainate receptor activation induces mixed lineage kinase-mediated cellular signaling cascades via post-synaptic density protein 95Q28142396
Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestinQ28190513
Cell Surface Expression of GluR5 Kainate Receptors Is Regulated by an Endoplasmic Reticulum Retention SignalQ28207435
Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97Q28208675
Palmitoylation of the GluR6 kainate receptorQ28277285
SAP90 binds and clusters kainate receptors causing incomplete desensitizationQ28288167
The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradationQ28302850
Distinct roles for the kainate receptor subunits GluR5 and GluR6 in kainate-induced hippocampal gamma oscillationsQ28505000
Kainate receptors are involved in short- and long-term plasticity at mossy fiber synapses in the hippocampusQ28505878
Activity-dependent dynamics and sequestration of proteasomes in dendritic spinesQ28507040
Activity-dependent NMDA receptor degradation mediated by retrotranslocation and ubiquitinationQ28510206
Actinfilin, a brain-specific actin-binding protein in postsynaptic densityQ28565888
Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neuronsQ28570199
Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapsesQ28571057
Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient miceQ28586796
The kainate receptor subunit GluR6 mediates metabotropic regulation of the slow and medium AHP currents in mouse hippocampal neuronesQ28589502
Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genesQ28593237
A mosaic of functional kainate receptors in hippocampal interneuronsQ28594162
Subunit composition and alternative splicing regulate membrane delivery of kainate receptorsQ28594583
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligaseQ29616502
Activity level controls postsynaptic composition and signaling via the ubiquitin-proteasome systemQ29617400
Process elongation of oligodendrocytes is promoted by the Kelch-related actin-binding protein MayvenQ30160315
ER protein quality control and proteasome-mediated protein degradationQ33794243
KEL-8 is a substrate receptor for CUL3-dependent ubiquitin ligase that regulates synaptic glutamate receptor turnoverQ34407303
Ubiquitin and the synapse.Q34988295
Protein degradation: CUL-3 and BTB--partners in proteolysisQ35636019
Cullin-based ubiquitin ligases: Cul3-BTB complexes join the family.Q35740993
The BACK domain in BTB-kelch proteins.Q35950674
Kainate receptor physiologyQ36345319
Kainate receptors.Q36539074
P433issue52
P407language of work or nameEnglishQ1860
P921main subjectubiquitin-proteasome systemQ47175589
protein catabolic process at synapseQ56058200
protein catabolic process at postsynapseQ56058202
regulation protein catabolic process at postsynapseQ56058205
P304page(s)40164–40173
P577publication date2006-12-29
P1433published inJournal of Biological ChemistryQ867727
P1476titleActinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway
P478volume281

Reverse relations

cites work (P2860)
Q46027095A mutation in the Proteosomal Regulatory Particle AAA-ATPase-3 in Arabidopsis impairs the light-specific hypocotyl elongation response elicited by a glutamate receptor agonist, BMAA.
Q33579886A transmembrane accessory subunit that modulates kainate-type glutamate receptors
Q37895567BTB-Kelch proteins and ubiquitination of kainate receptors
Q30486714Bidirectional regulation of kainate receptor surface expression in hippocampal neurons.
Q28506695Constitutive turnover of cyclin E by Cul3 maintains quiescence
Q100311434Control of craniofacial and brain development by Cullin3-RING ubiquitin ligases: Lessons from human disease genetics
Q35591685Copy number variants and infantile spasms: evidence for abnormalities in ventral forebrain development and pathways of synaptic function
Q28710353Dancing partners at the synapse: auxiliary subunits that shape kainate receptor function
Q35074545Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
Q50999853Ectodermal-Neural Cortex 1 Isoforms Have Contrasting Effects on MC3T3-E1 Osteoblast Mineralization and Gene Expression.
Q24323175Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level
Q21090923Enhanced hippocampal long-term potentiation and fear memory in Btbd9 mutant mice
Q47262073Exciting Times: New Advances Towards Understanding the Regulation and Roles of Kainate Receptors.
Q47413250Functional analysis of Cullin 3 E3 ligases in tumorigenesis.
Q54960355Gene expression profile analysis in epilepsy by using the partial least squares method.
Q28290774Glutamate receptor ion channels: structure, regulation, and function
Q37238425Identification of C-terminal domain residues involved in protein kinase A-mediated potentiation of kainate receptor subtype 6.
Q31032654Identification of network-based biomarkers of cardioembolic stroke using a systems biology approach with time series data.
Q34289505Intellectual disability and autism spectrum disorders: causal genes and molecular mechanisms
Q24606030Kainate receptors coming of age: milestones of two decades of research
Q33938103Novel Cul3 binding proteins function to remodel E3 ligase complexes
Q27657284Novel  -Propeller of the BTB-Kelch Protein Krp1 Provides a Binding Site for Lasp-1 That Is Necessary for Pseudopodial Extension
Q47911299PKC SUMOylation inhibits the binding of 14-3-3τ to GluK2.
Q33717656Phosphorylation of VACM-1/Cul5 by protein kinase A regulates its neddylation and antiproliferative effect
Q34706306Post-translational modification biology of glutamate receptors and drug addiction
Q34401021Profilin II regulates the exocytosis of kainate glutamate receptors
Q34196045Progressive myoclonic epilepsy-associated gene KCTD7 is a regulator of potassium conductance in neurons.
Q24321736Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase
Q97692983Remodeling without destruction: non-proteolytic ubiquitin chains in neural function and brain disorders
Q36481737Selective proteasomal degradation of the B'β subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15
Q27657740Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases
Q39951973The BTB/kelch protein, KRIP6, modulates the interaction of PICK1 with GluR6 kainate receptors
Q24317195The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells
Q37304018The role of the ubiquitin proteasome system in synapse remodeling and neurodegenerative diseases
Q37188181The ubiquitin conjugating enzyme, UbcM2, engages in novel interactions with components of cullin-3 based E3 ligases
Q35228692Trafficking of kainate receptors.
Q37925180Ubiquitin-dependent endocytosis, trafficking and turnover of neuronal membrane proteins
Q26777280Ubiquitin-dependent trafficking and turnover of ionotropic glutamate receptors
Q35186220Ubiquitination in postsynaptic function and plasticity
Q36616412Ubiquitination of neurotransmitter receptors and postsynaptic scaffolding proteins
Q40122897Vaccinia virus gene F3L encodes an intracellular protein that affects the innate immune response.
Q59038881Wrestling with SUMO
Q43980915Xenopus BTBD6 and its Drosophila homologue lute are required for neuronal development

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