Phosphorylation of VACM-1/Cul5 by protein kinase A regulates its neddylation and antiproliferative effect

scientific article

Phosphorylation of VACM-1/Cul5 by protein kinase A regulates its neddylation and antiproliferative effect is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M109.085225
P932PMC publication ID2836093
P698PubMed publication ID19917606

P50authorMaria A Burnatowska-HledinQ96246337
P2093author name stringAlyssa E Johnson
Isabelle P Le
Gabriel A Marquez
Michael P Hledin
Elizabeth Oosterhouse
Shirley E Bradley
P2860cites workIdentification and analysis of expression of human VACM-1, a cullin gene family member located on chromosome 11q22-23Q24320339
Characterization of NEDD8, a developmentally down-regulated ubiquitin-like proteinQ24322977
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene familyQ24336422
Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor functionQ24682460
Cdc53p acts in concert with Cdc4p and Cdc34p to control the G1-to-S-phase transition and identifies a conserved family of proteinsQ27933764
Function and regulation of cullin-RING ubiquitin ligasesQ28131707
Identification of NEDD8-conjugation site in human cullin-2Q28139623
Covalent modification of all members of human cullin family proteins by NEDD8Q28140243
VACM-1, a cullin gene family member, regulates cellular signalingQ28140946
VACM-1, a cul-5 gene, inhibits cellular growth by a mechanism that involves MAPK and p53 signaling pathwaysQ28201553
Expression of VACM-1 protein in cultured rat adrenal endothelial cells is linked to the cell cycleQ28202165
The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insultsQ28210433
ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damageQ28260019
T47D breast cancer cell growth is inhibited by expression of VACM-1, a cul-5 geneQ28265603
Expression cloning of an AVP-activated, calcium-mobilizing receptor from rabbit kidney medullaQ28293389
VACM-1 receptor is specifically expressed in rabbit vascular endothelium and renal collecting tubuleQ28296762
Analysis of Nedd8-associated polypeptides: a model for deciphering the pathway for ubiquitin-like modificationsQ28299357
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligaseQ28506124
Requirement for protein kinase C theta for cell cycle progression and formation of actin stress fibers and filopodia in vascular endothelial cellsQ28569696
Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotypeQ28578323
Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathwayQ28579883
The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in miceQ28592951
Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complexQ29041391
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancerQ29616732
Nedd8 on cullin: building an expressway to protein destruction.Q33976667
Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational changeQ34478754
Issues and progress with protein kinase inhibitors for cancer treatmentQ35096214
Targeting E3 ubiquitin ligases for cancer therapy.Q35612694
The ubiquitin-proteasome system in cardiovascular diseases-a hypothesis extendedQ35633109
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activityQ35748395
E3 ubiquitin ligases as regulators of membrane protein trafficking and degradationQ36121124
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugationQ37101488
Characterization of cullin-based E3 ubiquitin ligases in intact mammalian cells--evidence for cullin dimerizationQ40178983
Estrogen-dependent growth and estrogen receptor (ER)-alpha concentration in T47D breast cancer cells are inhibited by VACM-1, a cul 5 geneQ40190998
The COP9 signalosome regulates Skp2 levels and proliferation of human cells.Q40237851
Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes.Q40339876
Phosphorylation status of Fas-associated death domain-containing protein (FADD) is associated with prostate cancer progressionQ40419581
Regulated protein degradation controls PKA function and cell-type differentiation in DictyosteliumQ40424067
Cell cycle effects by C-FADD depend on its C-terminal phosphorylation site.Q40637893
Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signalQ42807908
Cytoskeletal regulation by the Nedd8 ubiquitin-like protein modification pathwayQ43888176
Inhibition of nuclear import of LIMK2 in endothelial cells by protein kinase C-dependent phosphorylation at Ser-283.Q46516339
Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase ItchQ46802020
Protein kinase A-regulated nucleocytoplasmic shuttling of Id1 during angiogenesis.Q50690396
Adenovirus E4orf6 assembles with Cullin5-ElonginB-ElonginC E3 ubiquitin ligase through an HIV/SIV Vif-like BC-box to regulate p53Q64377210
Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesisQ78257398
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
protein neddylationQ21115705
P304page(s)4883-4895
P577publication date2009-11-16
P1433published inJournal of Biological ChemistryQ867727
P1476titlePhosphorylation of VACM-1/Cul5 by protein kinase A regulates its neddylation and antiproliferative effect
P478volume285

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cites work (P2860)
Q54215914CUL5 is required for thalidomide-dependent inhibition of cellular proliferation.
Q36641178Cullin-5, a ubiquitin ligase scaffold protein, is significantly underexpressed in endometrial adenocarcinomas and is a target of miR-182.
Q35192868Kaposi's sarcoma-associated herpesvirus-encoded latency-associated nuclear antigen reduces interleukin-8 expression in endothelial cells and impairs neutrophil chemotaxis by degrading nuclear p65.
Q39531701Mutational analysis of VACM-1/cul5 exons in cancer cell lines
Q47597881Nuclear localization signal sequence is required for VACM-1/CUL5-dependent regulation of cellular growth
Q39643768Resveratrol enhances anti-proliferative effect of VACM-1/cul5 in T47D cancer cells
Q42009353SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function
Q41147812Suppressive role of neddylation in dendritic cells during Mycobacterium tuberculosis infection.
Q90482001The functions and properties of cullin-5, a potential therapeutic target for cancers
Q26749274The role of cullin 5-containing ubiquitin ligases
Q34031947VACM-1/cul5 expression in vascular tissue in vivo is induced by water deprivation and its expression in vitro regulates aquaporin-1 concentrations

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