Inhibition of nuclear import of LIMK2 in endothelial cells by protein kinase C-dependent phosphorylation at Ser-283.

scientific article published on 27 May 2005

Inhibition of nuclear import of LIMK2 in endothelial cells by protein kinase C-dependent phosphorylation at Ser-283. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M504448200
P698PubMed publication ID15923181

P2093author name stringDharmendra Pandey
Pankaj Goyal
Wolfgang Siess
Antje Behring
P2860cites workNuclear localization of protein kinase U-alpha is regulated by 14-3-3Q22003811
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factorQ22009126
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamicsQ22010790
Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loopQ22011174
Transport between the cell nucleus and the cytoplasmQ22065411
Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinaseQ24290361
Subcellular localization and protein interaction of the human LIMK2 gene expressing alternative transcripts with tissue-specific regulationQ24336202
LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505Q24532377
Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilinQ28202536
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganizationQ28275839
Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1Q28277890
Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zetaQ28280588
Self-association of LIM-kinase 1 mediated by the interaction between an N-terminal LIM domain and a C-terminal kinase domainQ28300342
Requirement for protein kinase C theta for cell cycle progression and formation of actin stress fibers and filopodia in vascular endothelial cellsQ28569696
Impaired spermatogenic ability of testicular germ cells in mice deficient in the LIM-kinase 2 geneQ28584910
Stimulation and inhibition of angiogenesis by placental proliferin and proliferin-related proteinQ28592911
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinaseQ29614246
Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteriaQ29616614
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNAQ29620175
Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifsQ31100056
Structural features of LIM kinase that control effects on the actin cytoskeletonQ33858179
Regulation of protein kinase C and role in cancer biology.Q40504332
Mitosis-specific activation of LIM motif-containing protein kinase and roles of cofilin phosphorylation and dephosphorylation in mitosisQ40741193
Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymesQ41173469
Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible systemQ41483751
The N-terminal LIM domain negatively regulates the kinase activity of LIM-kinase 1.Q41915767
Nuclear import of Cdk/cyclin complexes: identification of distinct mechanisms for import of Cdk2/cyclin E and Cdc2/cyclin B1.Q42014638
Nuclear export of LIM-kinase 1, mediated by two leucine-rich nuclear-export signals within the PDZ domainQ42158928
Involvement of RhoA/Rho kinase signaling in VEGF-induced endothelial cell migration and angiogenesis in vitroQ42437147
Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genesQ42800956
Mitosis-dependent phosphorylation and activation of LIM-kinase 1.Q43866878
Phosphorylation at the nuclear localization signal of Ca2+/calmodulin-dependent protein kinase II blocks its nuclear targetingQ46289164
Gö 6983 exerts cardioprotective effects in myocardial ischemia/reperfusionQ47797886
Cytoplasmic localization of LIM-kinase 1 is directed by a short sequence within the PDZ domainQ47952388
Identification of testis-specific (Limk2t) and brain-specific (Limk2c) isoforms of mouse LIM-kinase 2 gene transcriptsQ48018998
Nuclear translocation of LIM kinase mediates Rho-Rho kinase regulation of cyclin D1 expressionQ56765312
P433issue30
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
phosphorylationQ242736
P304page(s)27569-27577
P577publication date2005-05-27
P1433published inJournal of Biological ChemistryQ867727
P1476titleInhibition of nuclear import of LIMK2 in endothelial cells by protein kinase C-dependent phosphorylation at Ser-283.
P478volume280

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Q28287736LIM kinases: function, regulation and association with human disease
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