The N-terminal LIM domain negatively regulates the kinase activity of LIM-kinase 1.

scientific article published on October 1999

The N-terminal LIM domain negatively regulates the kinase activity of LIM-kinase 1. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/0264-6021:3430099
10.1042/BJ3430099
P932PMC publication ID1220529
P698PubMed publication ID10493917
P5875ResearchGate publication ID12806154

P50authorKazumasa OhashiQ73011337
P2093author name stringYang N
Nagata K
Mizuno K
P2860cites workLIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognitionQ24309104
Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifsQ24314259
Molecular characterization of abLIM, a novel actin-binding and double zinc finger proteinQ24321409
The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factorsQ24329116
Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal developmentQ24604432
Actinin-associated LIM protein: identification of a domain interaction between PDZ and spectrin-like repeat motifsQ24678805
Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase bindingQ24681861
Protein-protein interaction of zinc finger LIM domains with protein kinase CQ28116160
PDZ domains: targeting signalling molecules to sub-membranous sitesQ28242408
LIM domains: multiple roles as adapters and functional modifiers in protein interactionsQ28271283
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganizationQ28275839
Actin-based cell motility and cell locomotionQ28276582
Transmembrane neuregulins interact with LIM kinase 1, a cytoplasmic protein kinase implicated in development of visuospatial cognitionQ28278050
Self-association of LIM-kinase 1 mediated by the interaction between an N-terminal LIM domain and a C-terminal kinase domainQ28300342
Interactions between LIM domains and the LIM domain-binding protein Ldb1Q28511893
LIMK-1 and LIMK-2, two members of a LIM motif-containing protein kinase familyQ28564883
Comparison of tissue distribution of two novel serine/threonine kinase genes containing the LIM motif (LIMK-1 and LIMK-2) in the developing ratQ28583486
Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteinsQ28593772
Kiz-1, a protein with LIM zinc finger and kinase domains, is expressed mainly in neuronsQ28611476
Rho GTPases and signaling networksQ28646215
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinaseQ29614246
Active and inactive protein kinases: structural basis for regulationQ29616320
Activation of the Src-family tyrosine kinase Hck by SH3 domain displacementQ30014848
The LIM domain is a modular protein-binding interfaceQ34325141
Identification of a human cDNA encoding a novel protein kinase with two repeats of the LIM/double zinc finger motifQ34341179
The ADF/cofilin proteins: stimulus-responsive modulators of actin dynamicsQ34452627
CRP1, a LIM domain protein implicated in muscle differentiation, interacts with alpha-actininQ36273968
Molecular cloning of a chicken lung cDNA encoding a novel protein kinase with N-terminal two LIM/double zinc finger motifsQ36715543
The LIM domain: a new structural motif found in zinc-finger-like proteins.Q36728285
Role of the LIM class homeodomain protein Xlim-1 in neural and muscle induction by the Spemann organizer in XenopusQ38301250
Substrate and pseudosubstrate interactions with protein kinases: determinants of specificityQ40592829
The cysteine-rich LIM domains inhibit DNA binding by the associated homeodomain in Isl-1.Q40874279
Accelerating on a treadmill: ADF/cofilin promotes rapid actin filament turnover in the dynamic cytoskeleton.Q41408428
Structure and function of LIM domainsQ41662734
Nuclear export of LIM-kinase 1, mediated by two leucine-rich nuclear-export signals within the PDZ domainQ42158928
Cytoplasmic localization of LIM-kinase 1 is directed by a short sequence within the PDZ domainQ47952388
Reactivation of phosphorylated actin depolymerizing factor and identification of the regulatory siteQ71892123
P407language of work or nameEnglishQ1860
P304page(s)99-105
P577publication date1999-10-01
P1433published inBiochemical JournalQ864221
P1476titleThe N-terminal LIM domain negatively regulates the kinase activity of LIM-kinase 1
P478volume343 Pt 1

Reverse relations

cites work (P2860)
Q37700520Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis
Q28216136Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1
Q40569892CD29 integrin- and LIMK1/cofilin-mediated actin reorganization regulates the migration of haematopoietic progenitor cells underneath bone marrow stromal cells.
Q44930829Caspase-mediated cleavage and activation of LIM-kinase 1 and its role in apoptotic membrane blebbing.
Q90356562Cofilin and profilin: partners in cancer aggressiveness
Q24600408Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton
Q46516339Inhibition of nuclear import of LIMK2 in endothelial cells by protein kinase C-dependent phosphorylation at Ser-283.
Q38818738LIM kinases: cofilin and beyond.
Q28287736LIM kinases: function, regulation and association with human disease
Q24532377LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505
Q46985030Lim kinase regulates the development of olfactory and neuromuscular synapses
Q24541390MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration
Q35970347Mutations in an Atypical TIR-NB-LRR-LIM Resistance Protein Confer Autoimmunity
Q36326463Phosphorylation of ADF/cofilin abolishes EGF-induced actin nucleation at the leading edge and subsequent lamellipod extension
Q22011174Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop
Q39673753Stromal cell-derived factor 1alpha activates LIM kinase 1 and induces cofilin phosphorylation for T-cell chemotaxis
Q28291172The LIM domain: from the cytoskeleton to the nucleus

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