SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function

scientific article

SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function is …
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scholarly articleQ13442814

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P356DOI10.7554/ELIFE.24325
P932PMC publication ID5419743
P698PubMed publication ID28475037

P50authorKate E ColemanQ88004189
Tony T HuangQ88004193
Beatrix UeberheideQ56435647
Mathew J K JonesQ82034734
P2093author name stringMiklós Békés
Jessica R Chapman
Sarah B Crist
P2860cites workStructural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1Q24293794
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1Q24301361
ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domainQ24303631
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.Q24304921
Regulation of nucleolar signalling to p53 through NEDDylation of L11Q24310534
Identification of c-MYC as a target of the APC pathwayQ24310637
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complexQ24312855
Ribosomal proteins are targets for the NEDD8 pathwayQ24313502
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugationQ24314520
Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 proteinQ24314987
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modificationQ24316067
SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylationQ24317319
Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1.Q24529121
RNA-guided human genome engineering via Cas9Q24598394
Systematic and quantitative assessment of the ubiquitin-modified proteomeQ24634631
Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosisQ39782770
Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymesQ41141041
Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible systemQ41483751
Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2.Q41792392
Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progressionQ42376622
Depletion of Uhrf1 inhibits chromosomal DNA replication in Xenopus egg extractsQ42585685
Human ARF binds E2F1 and inhibits its transcriptional activity.Q43583428
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesisQ45345755
DEN1 deneddylates non-cullin proteins in vivo.Q45345762
Nuclear localization signal sequence is required for VACM-1/CUL5-dependent regulation of cellular growthQ47597881
DENEDDYLASE1 deconjugates NEDD8 from non-cullin protein substrates in Arabidopsis thalianaQ58001200
Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin EQ58236966
Wnt/β-catenin signaling and diseaseQ26823272
Basis for a ubiquitin-like protein thioester switch toggling E1–E2 affinityQ27641129
Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligasesQ27644446
Dcn1 functions as a scaffold-type E3 ligase for cullin neddylationQ27649565
Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situQ27659474
N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein ComplexQ27674398
Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation EnzymesQ27675332
Crystal structure of the human COP9 signalosomeQ27694578
Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosomeQ27704406
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resourcesQ27860739
The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.Q27863647
Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPsQ27865192
Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.Q27931858
Ubiquitylation, neddylation and the DNA damage responseQ28087342
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene listsQ28131785
Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damageQ28182301
The SCF(Skp2) ubiquitin ligase complex interacts with the human replication licensing factor Cdt1 and regulates Cdt1 degradationQ28184480
Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosomeQ28187304
Expression of VACM-1 protein in cultured rat adrenal endothelial cells is linked to the cell cycleQ28202165
Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phaseQ28202311
NEDP1, a highly conserved cysteine protease that deNEDDylates CullinsQ28202321
Identification and characterization of DEN1, a deneddylase of the ULP familyQ28205400
DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1Q28205415
Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligaseQ28215069
SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphataseQ28234989
Deregulated expression of E2F-1 induces cyclin A- and E-associated kinase activities independently from cell cycle positionQ28240239
The retinoblastoma gene and its product are targeted by ICBP90: a key mechanism in the G1/S transition during the cell cycleQ28260808
Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activityQ28270986
A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC)Q28296386
A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2Q28297403
Dual mode of degradation of Cdc25 A phosphataseQ28386155
Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin EQ28504517
Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK phosphorylation and maspin degradation and converts cells to the angiogenic phenotypeQ28578323
Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinasesQ28610271
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantificationQ29547200
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancerQ29616732
CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradationQ30430339
Cleavage of the C-terminus of NEDD8 by UCH-L3.Q31990233
Phosphorylation of VACM-1/Cul5 by protein kinase A regulates its neddylation and antiproliferative effectQ33717656
The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.Q33889383
Downregulation of miR-7 upregulates Cullin 5 (CUL5) to facilitate G1/S transition in human hepatocellular carcinoma cellsQ34039349
Protein neddylation: beyond cullin-RING ligasesQ34042816
Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profilingQ34159143
The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and TherapyQ34202686
CRL4Cdt2-Mediated Destruction of the Histone Methyltransferase Set8 Prevents Premature Chromatin Compaction in S PhaseQ34215301
The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteasesQ34695640
Identification of SCF ubiquitin ligase substrates by global protein stability profilingQ34874145
Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer propertiesQ34989248
FOXP1 potentiates Wnt/β-catenin signaling in diffuse large B cell lymphoma.Q35167200
Suppression of glioblastoma by targeting the overactivated protein neddylation pathwayQ36082492
Large-scale identification of ubiquitination sites by mass spectrometryQ36496727
Deubiquitinases as a signaling target of oxidative stressQ36501472
RNF111-dependent neddylation activates DNA damage-induced ubiquitinationQ36677932
Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteinsQ36850952
Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugationQ37101488
A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins.Q37178794
Targeted inhibition of the COP9 signalosome for treatment of cancerQ37364323
Uncovering the role of APC-Cdh1 in generating the dynamics of S-phase onsetQ37582528
UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinomaQ37632823
Overactivated neddylation pathway as a therapeutic target in lung cancer.Q38992669
DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cellsQ39065396
Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores.Q39131699
DNA damage regulates UHRF1 stability via the SCF(β-TrCP) E3 ligaseQ39214600
NEDDylation controls the target specificity of E2F1 and apoptosis induction.Q39273538
NEDDylation regulates E2F-1-dependent transcriptionQ39307613
Global identification of modular cullin-RING ligase substratesQ39462405
Increased Cul1 expression promotes melanoma cell proliferation through regulating p27 expressionQ39650489
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectprotein neddylationQ21115705
P577publication date2017-05-05
P1433published ineLifeQ2000008
P1476titleSENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function
P478volume6

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cites work (P2860)
Q91838646Genome-wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma
Q89519289Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics
Q91774381Inhibition of neddylation induces mitotic defects and alters MKLP1 accumulation at the midbody during cytokinesis
Q58768271Maneuvers on PCNA Rings during DNA Replication and Repair
Q47918567NEDDylation antagonizes ubiquitination of proliferating cell nuclear antigen and regulates the recruitment of polymerase η in response to oxidative DNA damage
Q48538797Protein neddylation and its alterations in human cancers for targeted therapy
Q50355495Regulation of Cellular Antiviral Signaling by Modifications of Ubiquitin and Ubiquitin-like Molecules
Q90438658The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity
Q49887000The COP9 signalosome inhibits Cullin-RING E3 ubiquitin ligases independently of its deneddylase activity
Q92705381Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations
Q89187341UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F
Q63976958Unanchored tri-NEDD8 inhibits PARP-1 to protect from oxidative stress-induced cell death

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