| scholarly article | Q13442814 |
| P50 | author | Jeffrey W. Harper | Q57326226 |
| P2093 | author name string | Mathew E Sowa | |
| Bing Hao | |||
| Nikola P Pavletich | |||
| Stephanie Oehlmann | |||
| P433 | issue | 1 | |
| P921 | main subject | phosphorylation | Q242736 |
| phosphothreonine residue binding | Q21107330 | ||
| F-box and WD repeat domain containing 7 | Q21113973 | ||
| P304 | page(s) | 131-143 | |
| P577 | publication date | 2007-04-01 | |
| P1433 | published in | Molecular Cell | Q3319468 |
| P1476 | title | Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases | |
| P478 | volume | 26 |
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| Q27664416 | A Dual E3 Mechanism for Rub1 Ligation to Cdc53 |
| Q52763617 | A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles. |
| Q30844250 | A design principle underlying the paradoxical roles of E3 ubiquitin ligases |
| Q47716658 | A growth hormone receptor SNP promotes lung cancer by impairment of SOCS2-mediated degradation |
| Q27934969 | A longevity protein, Lag2, interacts with SCF complex and regulates SCF function |
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| Q41103145 | ASPM regulates symmetric stem cell division by tuning Cyclin E ubiquitination |
| Q33673861 | Activation domain-dependent degradation of somatic Wee1 kinase |
| Q24336527 | Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase |
| Q28817978 | An allosteric conduit facilitates dynamic multisite substrate recognition by the SCF(Cdc4) ubiquitin ligase |
| Q27662837 | An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase |
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| Q38044435 | Analysis of LRRK2 accessory repeat domains: prediction of repeat length, number and sites of Parkinson's disease mutations |
| Q51652979 | Backbone and side chain assignments of human cell cycle regulatory protein S-phase kinase-associated protein 1. |
| Q27680055 | Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling |
| Q27027816 | Building and remodelling Cullin-RING E3 ubiquitin ligases |
| Q50959185 | CK1δ/GSK3β/FBXW7α axis promotes degradation of the ZNF322A oncoprotein to suppress lung cancer progression. |
| Q38015388 | CRL Ubiquitin Ligases and DNA Damage Response |
| Q27681419 | CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing |
| Q34544579 | CRY2 and FBXL3 Cooperatively Degrade c-MYC. |
| Q36850952 | Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins |
| Q24633046 | Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase |
| Q27933468 | Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase |
| Q36148380 | Cell cycle-dependent ubiquitylation and destruction of NDE1 by CDK5-FBW7 regulates ciliary length |
| Q33310273 | Cell cycle-specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA. |
| Q35691235 | Circadian Clock Gene CRY2 Degradation Is Involved in Chemoresistance of Colorectal Cancer. |
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| Q36720967 | Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo. |
| Q33564629 | Cyclin E-dependent protein kinase activity regulates niche retention of Drosophila ovarian follicle stem cells |
| Q36293026 | DEC1 regulates breast cancer cell proliferation by stabilizing cyclin E protein and delays the progression of cell cycle S phase |
| Q43655626 | DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation |
| Q38065487 | Deciphering the retinoblastoma protein phosphorylation code |
| Q96813220 | Derangements in HUWE1/c-MYC pathway confer sensitivity to the BET bromodomain inhibitor GS-626510 in uterine cervical carcinoma |
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| Q35013503 | Developmental downregulation of Xenopus cyclin E is phosphorylation and nuclear import dependent and is mediated by ubiquitination |
| Q36674327 | Differences in degradation lead to asynchronous expression of cyclin E1 and cyclin E2 in cancer cells |
| Q35879408 | Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2. |
| Q38514605 | Discovery of candidate KEN-box motifs using cell cycle keyword enrichment combined with native disorder prediction and motif conservation |
| Q24642979 | Diversity of degradation signals in the ubiquitin-proteasome system |
| Q42121008 | Double-negative feedback between S-phase cyclin-CDK and CKI generates abruptness in the G1/S switch |
| Q38750226 | Drugging the undruggable: targeting challenging E3 ligases for personalized medicine |
| Q35938545 | Dynamic Protein Interaction Networks and New Structural Paradigms in Signaling |
| Q34879997 | Dynamic equilibrium engagement of a polyvalent ligand with a single-site receptor |
| Q27655601 | E2 interaction and dimerization in the crystal structure of TRAF6 |
| Q39131523 | E3 ubiquitin ligase Fbw7 negatively regulates granulocytic differentiation by targeting G-CSFR for degradation |
| Q93140545 | E3 ligase Fbw7 participates in oxidative stress‑induced myocardial cell injury via interacting with Mcl‑1 |
| Q38735111 | EYA1's Conformation Specificity in Dephosphorylating Phosphothreonine in Myc and Its Activity on Myc Stabilization in Breast Cancer |
| Q42722274 | Effects of bisphenol A exposure on the proliferation and senescence of normal human mammary epithelial cells. |
| Q33665274 | Ehrlichia chaffeensis Tandem Repeat Effector Targets Differentially Influence Infection |
| Q41492918 | Emerging Roles for Noncanonical NF-κB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology |
| Q38596749 | Emerging roles for the FBXW7 ubiquitin ligase in leukemia and beyond |
| Q37292420 | Engineering New Protein–Protein Interactions on the β‐Propeller Fold by Yeast Cell Surface Display |
| Q36226432 | Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2 |
| Q37220619 | Expression, purification and crystallization of the FP domain of the human F-box protein Fbxo7 |
| Q34359847 | Expression, regulation and activity of a B2-type cyclin in mitotic and endoreduplicating maize endosperm. |
| Q36119930 | F-box protein specificity for g1 cyclins is dictated by subcellular localization |
| Q64240685 | F-box/WD-40 repeat-containing protein 7: A potential target in the progression and treatment of gastrointestinal malignancy |
| Q90480385 | FBW7 in hematological tumors |
| Q50050008 | FBW7 is associated with prognosis, inhibits malignancies and enhances temozolomide sensitivity in glioblastoma cells. |
| Q36229551 | FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors |
| Q41667106 | FBW7 regulates DNA interstrand cross-link repair by modulating FAAP20 degradation |
| Q29616127 | FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation |
| Q27010419 | FBW7-mediated ubiquitination and degradation of KLF5 |
| Q28116320 | FBXO32, encoding a member of the SCF complex, is mutated in dilated cardiomyopathy |
| Q33889158 | FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma. |
| Q35463880 | FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification |
| Q33845217 | FBXW7 mutations in melanoma and a new therapeutic paradigm |
| Q48094154 | FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system |
| Q92023426 | FBXW7-mediated stability regulation of signal transducer and activator of transcription 2 in melanoma formation |
| Q37388879 | Fbw7 dimerization determines the specificity and robustness of substrate degradation. |
| Q37576259 | Fbw7 regulates apoptosis in activated B-cell like diffuse large B-cell lymphoma by targeting Stat3 for ubiquitylation and degradation |
| Q36506569 | Fbw7α and Fbw7γ Collaborate To Shuttle Cyclin E1 into the Nucleolus for Multiubiquitylation |
| Q24651352 | Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation |
| Q35919057 | Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma |
| Q42099090 | Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein |
| Q35562631 | Flexible Cullins in Cullin-RING E3 Ligases Allosterically Regulate Ubiquitination |
| Q27316805 | Functional diversity and structural disorder in the human ubiquitination pathway |
| Q37267971 | Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression |
| Q35741620 | Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1. |
| Q37648157 | Hepatic cytochrome P450 ubiquitination: conformational phosphodegrons for E2/E3 recognition? |
| Q37725290 | Hst3 is turned over by a replication stress-responsive SCF(Cdc4) phospho-degron |
| Q35905381 | Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors. |
| Q30635246 | IMAAAGINE: a webserver for searching hypothetical 3D amino acid side chain arrangements in the Protein Data Bank |
| Q24624622 | Identification, analysis, and prediction of protein ubiquitination sites |
| Q34391209 | Identifying the Hotspots on the Top Faces of WD40-Repeat Proteins from Their Primary Sequences by β-Bulges and DHSW Tetrads |
| Q34613635 | Inactivation of FBXW7/hCDC4-β expression by promoter hypermethylation is associated with favorable prognosis in primary breast cancer |
| Q35956904 | Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface. |
| Q58236900 | Inhibitors for E3 ubiquitin ligases |
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| Q36637663 | Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma |
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| Q37983242 | Many jobs for one good cop – The COP9 signalosome guards development and defense |
| Q33300676 | Mass spectrometry-based functional proteomics: from molecular machines to protein networks |
| Q28473912 | Mathematical modelling of DNA replication reveals a trade-off between coherence of origin activation and robustness against rereplication |
| Q35237385 | Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase |
| Q37307464 | Mechanisms and function of substrate recruitment by F-box proteins. |
| Q34341554 | Mechanisms of generating polyubiquitin chains of different topology |
| Q64233666 | Merkel cell polyomavirus Tumor antigens expressed in Merkel cell carcinoma function independently of the ubiquitin ligases Fbw7 and β-TrCP |
| Q24621432 | MicroRNA-223 regulates cyclin E activity by modulating expression of F-box and WD-40 domain protein 7 |
| Q54618110 | Minimum protein oscillator based on multisite phosphorylation/dephosphorylation |
| Q38869143 | Mitotic phosphorylation of Bloom helicase at Thr182 is required for its proteasomal degradation and maintenance of chromosomal stability. |
| Q38898687 | Modular engineering of cellular signaling proteins and networks |
| Q41037621 | Molecular Characterization of Somatic Alterations in Dukes' B and C Colorectal Cancers by Targeted Sequencing |
| Q40337840 | Molecular basis for lysine specificity in the yeast ubiquitin-conjugating enzyme Cdc34. |
| Q33665546 | Molecular dynamics reveal the essential role of linker motions in the function of cullin-RING E3 ligases |
| Q54233905 | Molecular dynamics simulations elucidate the mode of protein recognition by Skp1 and the F-box domain in the SCF complex |
| Q38200391 | Monitoring Keap1-Nrf2 interactions in single live cells |
| Q26775592 | Motif co-regulation and co-operativity are common mechanisms in transcriptional, post-transcriptional and post-translational regulation |
| Q44129459 | Multisite light-induced phosphorylation of the transcription factor PIF3 is necessary for both its rapid degradation and concomitant negative feedback modulation of photoreceptor phyB levels in Arabidopsis |
| Q91595380 | Multisite phosphorylation code of CDK |
| Q41847977 | Multisite phosphorylation networks as signal processors for Cdk1. |
| Q34078905 | Multisite phosphorylation of human liver cytochrome P450 3A4 enhances Its gp78- and CHIP-mediated ubiquitination: a pivotal role of its Ser-478 residue in the gp78-catalyzed reaction |
| Q33585907 | Multisite phosphorylation of the Saccharomyces cerevisiae filamentous growth regulator Tec1 is required for its recognition by the E3 ubiquitin ligase adaptor Cdc4 and its subsequent destruction in vivo |
| Q33778197 | Multisite phosphorylation provides an effective and flexible mechanism for switch-like protein degradation |
| Q41959691 | Multistep phosphorylation systems: tunable components of biological signaling circuits |
| Q89686909 | NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly |
| Q34742737 | Nucleolar targeting of the fbw7 ubiquitin ligase by a pseudosubstrate and glycogen synthase kinase 3. |
| Q41066859 | Oligomerization of SCFTIR1 Is Essential for Aux/IAA Degradation and Auxin Signaling in Arabidopsis |
| Q42750072 | Oncoprotein ubiquitylation: dimers, degrons, and degradation |
| Q33782728 | PP2A-B55β antagonizes cyclin E1 proteolysis and promotes its dysregulation in cancer. |
| Q55395928 | PPI network analyses of human WD40 protein family systematically reveal their tendency to assemble complexes and facilitate the complex predictions. |
| Q24308897 | Parkin-dependent degradation of the F-box protein Fbw7β promotes neuronal survival in response to oxidative stress by stabilizing Mcl-1 |
| Q36063743 | Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets. |
| Q36472440 | Phosphorylation of CHIP at Ser20 by Cdk5 promotes tAIF-mediated neuronal death |
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| Q26865081 | Protein monoubiquitination and polyubiquitination generate structural diversity to control distinct biological processes |
| Q34722684 | Protein ubiquitination in lymphoid malignancies |
| Q35160414 | Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway. |
| Q39372566 | RACK1 to the future--a historical perspective |
| Q39486111 | Rack1 protects N-terminal phosphorylated c-Jun from Fbw7-mediated degradation |
| Q24322903 | Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates |
| Q47738218 | Rational redesign of a cation···π···π stacking at cardiovascular Fbw7-Skp1 complex interface and its application for deriving self-inhibitory peptides to disrupt the complex interaction |
| Q64982277 | Recognition of the Diglycine C-End Degron by CRL2KLHDC2 Ubiquitin Ligase. |
| Q39152605 | Regulation of APC(Cdh1) E3 ligase activity by the Fbw7/cyclin E signaling axis contributes to the tumor suppressor function of Fbw7. |
| Q39980994 | Regulation of BRAF protein stability by a negative feedback loop involving the MEK-ERK pathway but not the FBXW7 tumour suppressor. |
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| Q38262962 | Regulation of SOX10 stability via ubiquitination-mediated degradation by Fbxw7α modulates melanoma cell migration |
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| Q38065012 | SCF-mediated degradation of p100 (NF-κB2): mechanisms and relevance in multiple myeloma |
| Q27938903 | SCFCdc4 enables mating type switching in yeast by cyclin-dependent kinase-mediated elimination of the Ash1 transcriptional repressor. |
| Q28588762 | SCFFbxw5 mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression |
| Q38102567 | SCFs in the new millennium |
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| Q42009353 | SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function |
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