CRY2 and FBXL3 Cooperatively Degrade c-MYC.

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CRY2 and FBXL3 Cooperatively Degrade c-MYC. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.MOLCEL.2016.10.012
P932PMC publication ID5123859
P698PubMed publication ID27840026

P50authorA-L HuberQ83924619
P2093author name stringZhizhong Li
Katja A Lamia
Alanna B Chan
Anna Kriebs
Christian M Metallo
Emma Henriksson
Madelena Nguyen
Martina Wallace
Sabine D Jordan
Stephanie J Papp
P2860cites workFbw7 and Usp28 regulate myc protein stability in response to DNA damageQ24293749
Myc-Nick: A Cytoplasmic Cleavage Product of Myc that Promotes α-Tubulin Acetylation and Cell DifferentiationQ24294609
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complexQ24294734
Coupling of human circadian and cell cycles by the timeless proteinQ24299164
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteinsQ24304073
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligaseQ24304122
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasmQ24321406
FBXL21 Regulates Oscillation of the Circadian Clock through Ubiquitination and Stabilization of CryptochromesQ24321496
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7Q24337643
Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligaseQ24337721
The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacementQ24683336
Molecular architecture of the mammalian circadian clockQ27004052
Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligasesQ27644446
Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromesQ27654626
SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocketQ27676853
Crystal structure of mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligaseQ27680111
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivoQ28206180
Coordinated transcription of key pathways in the mouse by the circadian clockQ28217978
Divorcing ARF and p53: an unsettled caseQ28258356
Circadian transcription of the cholesterol 7 alpha hydroxylase gene may involve the liver-enriched bZIP protein DBPQ28264406
c-Myc is a universal amplifier of expressed genes in lymphocytes and embryonic stem cellsQ28275988
The cost of circadian desynchrony: Evidence, insights and open questionsQ28385845
The Circadian Clock in Cancer Development and TherapyQ28390451
Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expressionQ28509189
Delay in feedback repression by cryptochrome 1 is required for circadian clock functionQ28512076
The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian periodQ28594339
Extensive and divergent circadian gene expression in liver and heartQ29615206
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiationQ29616127
Transcriptional architecture and chromatin landscape of the core circadian clock in mammalsQ29616252
Resetting of circadian time in peripheral tissues by glucocorticoid signalingQ29616364
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxiaQ29616650
Inference of cell cycle-dependent proteolysis by laser scanning cytometryQ33424132
Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stressQ33541382
Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in miceQ33601559
Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc.Q33890400
Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis.Q33948902
Control of skin cancer by the circadian rhythmQ34057127
Transcriptional amplification in tumor cells with elevated c-Myc.Q34302542
The circadian factor Period 2 modulates p53 stability and transcriptional activity in unstressed cellsQ34504101
The Molecular Signatures Database (MSigDB) hallmark gene set collectionQ34509167
JETLAG resets the Drosophila circadian clock by promoting light-induced degradation of TIMELESS.Q34541185
Regulation of substrate utilization by the mitochondrial pyruvate carrierQ34710980
Modelling Myc inhibition as a cancer therapyQ34811008
The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradationQ34835596
Association of the circadian factor Period 2 to p53 influences p53's function in DNA-damage signalingQ34960791
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosisQ35081562
Regulation of apoptosis by the circadian clock through NF-kappaB signalingQ35123146
DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilizationQ35156678
Identification of a Novel Cryptochrome Differentiating Domain Required for Feedback Repression in Circadian Clock FunctionQ36122122
Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermisQ36122673
Histone monoubiquitination by Clock-Bmal1 complex marks Per1 and Per2 genes for circadian feedback.Q36144279
CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in DrosophilaQ36421773
Tumor suppression by the mammalian Period genesQ36441046
Circadian clocks, epigenetics, and cancerQ36520424
DNA damage-specific control of cell death by cryptochrome in p53-mutant ras-transformed cellsQ36545099
Aberrant stabilization of c-Myc protein in some lymphoblastic leukemias.Q36569870
Inhibition of Myc family proteins eradicates KRas-driven lung cancer in miceQ36708046
MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells.Q36760018
Tumor suppression and circadian functionQ36895164
Loss of cryptochrome reduces cancer risk in p53 mutant miceQ37081282
SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeedingQ37099495
Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF(Fbxl3)) protein complexQ37289330
Proteolytic Control of the Oncoprotein Transcription Factor MycQ37894329
The circadian clock and cell cycle: interconnected biological circuitsQ38130824
MYC degradationQ38193043
Mutations in the coding region of c-myc occur frequently in acquired immunodeficiency syndrome-associated lymphomas.Q38305728
Carcinogenicity of shift-work, painting, and fire-fightingQ38459347
Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.Q38973733
Circadian Dbp transcription relies on highly dynamic BMAL1-CLOCK interaction with E boxes and requires the proteasomeQ39278235
Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear LocalizationQ40625392
Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice.Q40713268
Circadian Rhythm Disruption Promotes Lung TumorigenesisQ41921459
Ink4‐Arf locus in cancer and agingQ42153635
Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponsesQ48347156
The circadian molecular clock creates epidermal stem cell heterogeneityQ51847597
GSEA-P: a desktop application for Gene Set Enrichment AnalysisQ51909999
Point mutations in the c-Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomasQ55670934
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic miceQ57338722
Comprehensive identification of substrates for F-box proteins by differential proteomics analysisQ83959951
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)774-789
P577publication date2016-10-31
P1433published inMolecular CellQ3319468
P1476titleCRY2 and FBXL3 Cooperatively Degrade c-MYC.
P478volume64

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