Identification of a Novel Cryptochrome Differentiating Domain Required for Feedback Repression in Circadian Clock Function

scientific article published on June 12, 2012

Identification of a Novel Cryptochrome Differentiating Domain Required for Feedback Repression in Circadian Clock Function is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.368001
P953full work available at URLhttp://www.jbc.org/content/287/31/25917.full.pdf
https://api.elsevier.com/content/article/PII:S0021925820736033?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0021925820736033?httpAccept=text/xml
https://doi.org/10.1074/jbc.m112.368001
https://europepmc.org/articles/PMC3406676
https://europepmc.org/articles/PMC3406676?pdf=render
https://syndication.highwire.org/content/doi/10.1074/jbc.M112.368001
P932PMC publication ID3406676
P698PubMed publication ID22692217

P50authorHiroki R UedaQ56997717
Yongmei WangQ89913341
P2093author name stringHaiyan Xu
Maki Ukai-Tadenuma
Andrew C. Liu
Brittany Burton
Sanjoy K. Khan
P2860cites workRedundant function of REV-ERBalpha and beta and non-essential role for Bmal1 cycling in transcriptional regulation of intracellular circadian rhythmsQ21092485
I-TASSER server for protein 3D structure predictionQ21284202
Biochemical analysis of the canonical model for the mammalian circadian clockQ24304349
The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factorsQ24313506
The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase IepsilonQ24553966
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissuesQ24568134
I-TASSER: a unified platform for automated protein structure and function predictionQ24605680
Vitamin B 2 -based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammalsQ24655563
Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2Q24672297
Analysis and synthesis of high-amplitude Cis-elements in the mammalian circadian clockQ36908152
Mammalian circadian signaling networks and therapeutic targets.Q36944717
Structure and function of animal cryptochromes.Q37140984
Structure of full-length Drosophila cryptochromeQ39864416
A large-scale functional RNAi screen reveals a role for CK2 in the mammalian circadian clock.Q39870718
Melanopsin-dependent photo-perturbation reveals desynchronization underlying the singularity of mammalian circadian clocksQ40064213
Serine phosphorylation of mCRY1 and mCRY2 by mitogen-activated protein kinaseQ40527711
Molecular mechanisms of the biological clock in cultured fibroblastsQ40812685
Ser-557-phosphorylated mCRY2 is degraded upon synergistic phosphorylation by glycogen synthase kinase-3 beta.Q46568210
A new role for cryptochrome in a Drosophila circadian oscillator.Q47070472
Drosophila CRYPTOCHROME is a circadian transcriptional repressorQ47072854
Circadian regulation of cryptochrome genes in the mouseQ47920491
Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponsesQ48347156
Synchronization and maintenance of timekeeping in suprachiasmatic circadian clock cells by neuropeptidergic signalingQ48613532
Feedback repression is required for mammalian circadian clock functionQ24680543
The cryptochromesQ24812351
Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromesQ27654626
Coordination of circadian timing in mammalsQ27860673
Light-independent role of CRY1 and CRY2 in the mammalian circadian clock.Q27863659
Posttranslational Mechanisms Regulate the Mammalian Circadian ClockQ27863710
System-level identification of transcriptional circuits underlying mammalian circadian clocksQ27863806
Role of the CLOCK protein in the mammalian circadian mechanismQ27867710
Time zones: a comparative genetics of circadian clocksQ28215112
Molecular bases for circadian clocksQ28297151
Functional and structural analyses of cryptochrome. Vertebrate CRY regions responsible for interaction with the CLOCK:BMAL1 heterodimer and its nuclear localizationQ28508315
AMPK regulates the circadian clock by cryptochrome phosphorylation and degradationQ28509385
Delay in feedback repression by cryptochrome 1 is required for circadian clock functionQ28512076
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythmsQ28584936
mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loopQ29616207
A transcription factor response element for gene expression during circadian nightQ29617973
A clockwork web: circadian timing in brain and periphery, in health and diseaseQ29618069
Circadian gene expression in individual fibroblasts: cell-autonomous and self-sustained oscillators pass time to daughter cellsQ29619080
A Protocol for Computer-Based Protein Structure and Function PredictionQ30409471
Generation of a novel allelic series of cryptochrome mutants via mutagenesis reveals residues involved in protein-protein interaction and CRY2-specific repressionQ30436629
Structure/function analysis of Xenopus cryptochromes 1 and 2 reveals differential nuclear localization mechanisms and functional domains important for interaction with and repression of CLOCK-BMAL1Q30442560
Intercellular coupling confers robustness against mutations in the SCN circadian clock networkQ30543329
Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expressionQ30545439
SCOWLP classification: structural comparison and analysis of protein binding regions.Q33313642
Harmonics of circadian gene transcription in mammalsQ33426339
HY4 gene of A. thaliana encodes a protein with characteristics of a blue-light photoreceptorQ34344222
Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and timQ34470738
CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivityQ34482717
The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila.Q34482723
Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance.Q34519738
Cryptochromes: enabling plants and animals to determine circadian timeQ35294901
Cryptochrome Structure and Signal TransductionQ35540332
Regulation of the mammalian circadian clock by cryptochromeQ35763166
Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant miceQ35804456
P433issue31
P407language of work or nameEnglishQ1860
P921main subjectcircadian rhythmQ208353
circadian clockQ5121352
physiological feedbackQ70325281
P304page(s)25917-25926
P577publication date2012-06-12
P1433published inJournal of Biological ChemistryQ867727
P1476titleIdentification of a novel cryptochrome differentiating domain required for feedback repression in circadian clock function
Identification of a Novel Cryptochrome Differentiating Domain Required for Feedback Repression in Circadian Clock Function
P478volume287

Reverse relations

cites work (P2860)
Q36524975A mechanism for robust circadian timekeeping via stoichiometric balance
Q53078281An evolutionary hotspot defines functional differences between CRYPTOCHROMES.
Q39021800Animal Cryptochromes: Divergent Roles in Light Perception, Circadian Timekeeping and Beyond
Q34544579CRY2 and FBXL3 Cooperatively Degrade c-MYC.
Q28541855Cell type-specific functions of period genes revealed by novel adipocyte and hepatocyte circadian clock models
Q46677190Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.
Q24321406Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm
Q42123920Cry1−/− Circadian Rhythmicity Depends on SCN Intercellular Coupling
Q52731213Cry2 Is Critical for Circadian Regulation of Myogenic Differentiation by Bclaf1-Mediated mRNA Stabilization of Cyclin D1 and Tmem176b
Q34475929Cryptochrome 1 regulates the circadian clock through dynamic interactions with the BMAL1 C terminus
Q53434049Cryptochrome Regulates Circadian Locomotor Rhythms in the Small Brown Planthopper Laodelphax striatellus (Fallén).
Q35156678DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization
Q28593978Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation.
Q89891216Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing
Q28249506Emerging models for the molecular basis of mammalian circadian timing
Q41908841Formation of a repressive complex in the mammalian circadian clock is mediated by the secondary pocket of CRY1.
Q36904260Genetic redundancy strengthens the circadian clock leading to a narrow entrainment range
Q27004052Molecular architecture of the mammalian circadian clock
Q91452385Molecular mechanisms and physiological importance of circadian rhythms
Q34554954Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder
Q58606720Periodicity, repression, and the molecular architecture of the mammalian circadian clock
Q41161152Phosphorylation Regulating the Ratio of Intracellular CRY1 Protein Determines the Circadian Period
Q28590815Phosphorylation of the cryptochrome 1 C-terminal tail regulates circadian period length
Q36684822Rhythmic expression of cryptochrome induces the circadian clock of arrhythmic suprachiasmatic nuclei through arginine vasopressin signaling
Q97643945SIRT7 couples light-driven body temperature cues to hepatic circadian phase coherence and gluconeogenesis
Q64079348The Circadian Clock Protein CRY1 Is a Negative Regulator of HIF-1α
Q26821907The Maintenance of Mitochondrial DNA Integrity--Critical Analysis and Update
Q37377856Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling
Q52873148Vertebrate-like CRYPTOCHROME 2 from monarch regulates circadian transcription via independent repression of CLOCK and BMAL1 activity

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