| scholarly article | Q13442814 |
| P50 | author | Christel Brou | Q73280313 |
| Julien Moretti | Q37383082 | ||
| P2093 | author name string | Christel Brou | |
| P2860 | cites work | AIP4/Itch regulates Notch receptor degradation in the absence of ligand | Q21144278 |
| USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma | Q24305427 | ||
| Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains | Q24306305 | ||
| The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice | Q24308721 | ||
| The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation | Q24310748 | ||
| Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover | Q24315524 | ||
| SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation | Q24548288 | ||
| The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase. | Q42090202 | ||
| Mapping the Deltex-binding surface on the notch ankyrin domain using analytical ultracentrifugation | Q42211947 | ||
| Delta-like 4 is indispensable in thymic environment specific for T cell development | Q42277361 | ||
| Numb regulates Notch1, but not Notch3, during myogenesis. | Q42813982 | ||
| Notch signalling acts in postmitotic avian myogenic cells to control MyoD activation | Q44023836 | ||
| Drosophila Epsin mediates a select endocytic pathway that DSL ligands must enter to activate Notch. | Q45094726 | ||
| Regulation of Notch signalling by non-visual beta-arrestin | Q45345847 | ||
| Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway | Q45729099 | ||
| The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking | Q46075460 | ||
| An activated form of Notch influences the choice between CD4 and CD8 T cell lineages | Q46109980 | ||
| Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene | Q46284220 | ||
| Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth | Q47070549 | ||
| Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation | Q47070716 | ||
| The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking | Q47070768 | ||
| Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway. | Q47071878 | ||
| Drosophila HOPS and AP-3 complex genes are required for a Deltex-regulated activation of notch in the endosomal trafficking pathway | Q47071885 | ||
| Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila | Q47072009 | ||
| Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins | Q47072858 | ||
| Genetic identification of intracellular trafficking regulators involved in Notch-dependent binary cell fate acquisition following asymmetric cell division. | Q50794013 | ||
| The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. | Q51131644 | ||
| Drosophila deltex mediates suppressor of Hairless-independent and late-endosomal activation of Notch signaling. | Q52086514 | ||
| Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells. | Q52086944 | ||
| Requirement for dynamin during Notch signaling in Drosophila neurogenesis. | Q52191286 | ||
| neuralized Encodes a peripheral membrane protein involved in delta signaling and endocytosis. | Q52592923 | ||
| USP22 antagonizes p53 transcriptional activation by deubiquitinating Sirt1 to suppress cell apoptosis and is required for mouse embryonic development. | Q53171868 | ||
| Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis | Q61873100 | ||
| Itch genetically interacts with Notch1 in a mouse autoimmune disease model | Q79344563 | ||
| HECT and RING finger families of E3 ubiquitin ligases at a glance | Q24599672 | ||
| The Notch1 receptor is cleaved constitutively by a furin-like convertase | Q24671866 | ||
| Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila | Q24798051 | ||
| Ubiquitylation of an ERAD substrate occurs on multiple types of amino acids | Q26781978 | ||
| Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase | Q27640370 | ||
| Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases | Q27644446 | ||
| Breaking the chains: structure and function of the deubiquitinases | Q28131738 | ||
| The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases | Q28139237 | ||
| A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE | Q28139998 | ||
| Archipelago regulates Cyclin E levels in Drosophila and is mutated in human cancer cell lines | Q28188140 | ||
| The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity | Q28188156 | ||
| Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor | Q28203706 | ||
| The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog | Q28207494 | ||
| Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia | Q28294011 | ||
| Mechanism and function of deubiquitinating enzymes | Q28295758 | ||
| Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1 | Q28505074 | ||
| Mind bomb 1 is essential for generating functional Notch ligands to activate Notch | Q28511742 | ||
| sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins | Q28512956 | ||
| Delta-like 1-Lysine613 regulates notch signaling | Q28513181 | ||
| Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin | Q28582960 | ||
| The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands | Q28584296 | ||
| Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice | Q28586431 | ||
| Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis | Q28588058 | ||
| Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1 | Q28589104 | ||
| The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity | Q28591150 | ||
| Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta | Q28646245 | ||
| Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta | Q28646258 | ||
| Notch signalling: a simple pathway becomes complex | Q29555851 | ||
| Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1 | Q29614651 | ||
| Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia | Q29614659 | ||
| Notch1 functions as a tumor suppressor in mouse skin | Q29614987 | ||
| FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation | Q29616127 | ||
| Enhancement of proteasome activity by a small-molecule inhibitor of USP14 | Q29616735 | ||
| The ESCRT pathway | Q29620052 | ||
| NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. | Q30668571 | ||
| An obligatory role of mind bomb-1 in notch signaling of mammalian development | Q33307527 | ||
| Intracellular trafficking of Notch receptors and ligands | Q37290434 | ||
| gamma-Secretase in biology and medicine | Q37375252 | ||
| Numb regulates post-endocytic trafficking and degradation of Notch1. | Q37446670 | ||
| Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. | Q37594746 | ||
| Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster | Q37607991 | ||
| Canonical and non-canonical Notch ligands | Q37785194 | ||
| Notch Targets and Their Regulation | Q37785199 | ||
| Mechanism and significance of cis-inhibition in Notch signalling. | Q37826900 | ||
| Neuralized-like 1 (Neurl1) targeted to the plasma membrane by N-myristoylation regulates the Notch ligand Jagged1. | Q38295374 | ||
| The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta | Q38328025 | ||
| Expression of members of the novel membrane linked metalloproteinase family ADAM in cells derived from a range of haematological malignancies. | Q38344895 | ||
| Role of recycling, Mindbomb1 association, and exclusion from lipid rafts of δ-like 4 for effective Notch signaling to drive T cell development | Q39242809 | ||
| MDM2 protein-mediated ubiquitination of numb protein: identification of a second physiological substrate of MDM2 that employs a dual-site docking mechanism | Q39396134 | ||
| Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface | Q40305242 | ||
| Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor | Q40538132 | ||
| c-Cbl binding and ubiquitin-dependent lysosomal degradation of membrane-associated Notch1. | Q40759027 | ||
| Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling. | Q40764200 | ||
| The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling | Q41602986 | ||
| Cargo ubiquitination is essential for multivesicular body intralumenal vesicle formation | Q41966581 | ||
| A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive notch interaction network. | Q33584616 | ||
| Notch ligand activity is modulated by glycosphingolipid membrane composition in Drosophila melanogaster | Q33689588 | ||
| Regulation of EGFR and Notch signaling by distinct isoforms of D-cbl during Drosophila development | Q33838124 | ||
| The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor | Q33840072 | ||
| Ligand endocytosis drives receptor dissociation and activation in the Notch pathway | Q33892395 | ||
| Neuralized promotes basal to apical transcytosis of delta in epithelial cells | Q33907082 | ||
| Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. | Q34116313 | ||
| The role of notch in promoting glial and neural stem cell fates | Q34132317 | ||
| Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain | Q34189079 | ||
| dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions | Q34244105 | ||
| Optical tweezers studies on Notch: single-molecule interaction strength is independent of ligand endocytosis | Q34289897 | ||
| A human genome-wide screen for regulators of clathrin-coated vesicle formation reveals an unexpected role for the V-ATPase | Q34319285 | ||
| The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation. | Q34331846 | ||
| Maintenance of somite borders in mice requires the Delta homologue DII1. | Q34422203 | ||
| Structure and Notch receptor binding of the tandem WWE domain of Deltex | Q34465487 | ||
| Trp53 regulates Notch 4 signaling through Mdm2. | Q34667624 | ||
| A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. | Q34978382 | ||
| Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. | Q35000965 | ||
| T cells develop normally in the absence of both Deltex1 and Deltex2 | Q35131705 | ||
| Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized. | Q35621018 | ||
| Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal | Q35621031 | ||
| Drosophila Epsin's role in Notch ligand cells requires three Epsin protein functions: the lipid binding function of the ENTH domain, a single Ubiquitin interaction motif, and a subset of the C-terminal protein binding modules | Q35784508 | ||
| DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur | Q36117781 | ||
| Divergent functions and distinct localization of the Notch ligands DLL1 and DLL3 in vivo | Q36119745 | ||
| Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting | Q36226090 | ||
| A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance | Q36338365 | ||
| A targeted in vivo RNAi screen reveals deubiquitinases as new regulators of Notch signaling. | Q36451302 | ||
| Endosomal entry regulates Notch receptor activation in Drosophila melanogaster | Q36492053 | ||
| The E3 ligase Mind bomb-1 (Mib1) modulates Delta-Notch signaling to control neurogenesis and gliogenesis in the developing spinal cord. | Q36562045 | ||
| Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. | Q36946535 | ||
| The multifaceted role of Notch in cardiac development and disease | Q37028771 | ||
| Functions of O-fucosyltransferase in Notch trafficking and signaling: towards the end of a controversy? | Q37099193 | ||
| Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants | Q37248192 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | protein ubiquitination | Q3547638 |
| P304 | page(s) | 6359-6381 | |
| P577 | publication date | 2013-03-19 | |
| P1433 | published in | International Journal of Molecular Sciences | Q3153277 |
| P1476 | title | Ubiquitinations in the notch signaling pathway | |
| P478 | volume | 14 |
| Q64241193 | Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells |
| Q57109688 | Crosstalk between Notch, HIF-1α and GPER in Breast Cancer EMT |
| Q37325408 | Deficits in adult neurogenesis, contextual fear conditioning, and spatial learning in a Gfap mutant mouse model of Alexander disease |
| Q90134949 | Deubiquitylation and stabilization of Notch1 intracellular domain by ubiquitin-specific protease 8 enhance tumorigenesis in breast cancer |
| Q43094561 | Editorial of the special issue: signaling molecules and signal transduction in cells |
| Q93161617 | Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer |
| Q37277780 | High expression of Notch ligand Jagged2 is associated with the metastasis and recurrence in urothelial carcinoma of bladder |
| Q35745353 | Human Cytomegalovirus Infection Dysregulates the Localization and Stability of NICD1 and Jag1 in Neural Progenitor Cells. |
| Q47337253 | Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells |
| Q36957912 | Identification of a Paralog-Specific Notch1 Intracellular Domain Degron |
| Q90028615 | NUMB enhances Notch signaling by repressing ubiquitination of NOTCH intracellular domain |
| Q48032747 | Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin Ligases |
| Q38261302 | Notch signaling in mammalian hair cell regeneration |
| Q37551137 | Original Research: Featured Article: Imatinib mesylate (Gleevec) inhibits Notch and c-Myc signaling: Five-day treatment permanently rescues mammary development |
| Q44774332 | Pofut1 point-mutations that disrupt O-fucosyltransferase activity destabilize the protein and abolish Notch1 signaling during mouse somitogenesis. |
| Q89771851 | Regulation of Notch Signaling in Drosophila melanogaster: The Role of the Heterogeneous Nuclear Ribonucleoprotein Hrp48 and Deltex |
| Q26748681 | Targeting Notch degradation system provides promise for breast cancer therapeutics |
| Q91908379 | Therapeutic Targeting of Notch Signaling Pathway in Hematological Malignancies |
| Q33364683 | Turn It Down a Notch |
| Q39033646 | Ubiquitination and the Regulation of Membrane Proteins |
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