| scholarly article | Q13442814 |
| P356 | DOI | 10.1084/JEM.20080829 |
| P8608 | Fatcat ID | release_iegrarwmwrhnvbp4jhxondwm2e |
| P932 | PMC publication ID | 2571927 |
| P698 | PubMed publication ID | 18824585 |
| P5875 | ResearchGate publication ID | 23287303 |
| P50 | author | Freddy Radtke | Q41621239 |
| Rui Benedito | Q42291345 | ||
| António Duarte | Q50596433 | ||
| P2093 | author name string | Ute Koch | |
| Karin Schuster-Gossler | |||
| Michel Pierres | |||
| Nancy R Manley | |||
| Emma Fiorini | |||
| H Robson Macdonald | |||
| Valerie Besseyrias | |||
| P2860 | cites work | Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development | Q22010181 |
| Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation | Q24291744 | ||
| Expression of the mouse Delta1 gene during organogenesis and fetal development | Q28143715 | ||
| Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo | Q28509550 | ||
| Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice | Q28586431 | ||
| Dosage-sensitive requirement for mouse Dll4 in artery development | Q28587979 | ||
| Inducible gene targeting in mice | Q29614544 | ||
| High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP | Q29615159 | ||
| Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus | Q33288108 | ||
| Stepwise specification of lymphocyte developmental lineages. | Q33964101 | ||
| A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer | Q34104543 | ||
| Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development | Q34197865 | ||
| Maintenance of somite borders in mice requires the Delta homologue DII1. | Q34422203 | ||
| Regulation of lymphoid development, differentiation, and function by the Notch pathway. | Q36072476 | ||
| Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation | Q36229695 | ||
| T cell priming by tissue-derived dendritic cells: new insights from recent murine studies | Q36344720 | ||
| Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. | Q36369494 | ||
| Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions | Q36399587 | ||
| Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors | Q37419676 | ||
| Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. | Q37594746 | ||
| Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors. | Q40517723 | ||
| Control points in early T-cell development | Q40619493 | ||
| Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. | Q40683787 | ||
| Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation. | Q45154679 | ||
| Deficient T cell fate specification in mice with an induced inactivation of Notch1. | Q45345200 | ||
| Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling | Q47607371 | ||
| Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells | Q47619638 | ||
| Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles | Q48879922 | ||
| Three-dimensional architecture of the thymus is required to maintain delta-like expression necessary for inducing T cell development. | Q50949410 | ||
| In vivo and in absence of a thymus, the enforced expression of the Notch ligands delta-1 or delta-4 promotes T cell development with specific unique effects. | Q50977568 | ||
| Entry into the thymic microenvironment triggers Notch activation in the earliest migrant T cell progenitors. | Q51031870 | ||
| Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development. | Q51069614 | ||
| Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. | Q52010433 | ||
| Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes. | Q52117223 | ||
| Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. | Q54067406 | ||
| Redefining epithelial progenitor potential in the developing thymus | Q62078508 | ||
| Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision | Q74211426 | ||
| Lack of Delta like 1 and 4 expressions in nude thymus anlages | Q81048463 | ||
| P433 | issue | 11 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | cell fate commitment | Q14860192 |
| P304 | page(s) | 2515-2523 | |
| P577 | publication date | 2008-09-29 | |
| P1433 | published in | Journal of Experimental Medicine | Q3186912 |
| P1476 | title | Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment | |
| P478 | volume | 205 |
| Q58478657 | A Guardian of T Cell Fate |
| Q55114872 | A Review of Notch Processing With New Insights Into Ligand-Independent Notch Signaling in T-Cells. |
| Q50654081 | A cell autonomous role for the Notch ligand Delta-like 3 in αβ T-cell development. |
| Q42078769 | A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors. |
| Q36108839 | A human thymic epithelial cell culture system for the promotion of lymphopoiesis from hematopoietic stem cells. |
| Q45359747 | A key role for IL-7R in the generation of microenvironments required for thymic dendritic cells. |
| Q50044517 | A novel reporter allele for monitoring Dll4 expression within the embryonic and adult mouse. |
| Q37543241 | A roadmap for thymic epithelial cell development. |
| Q34873999 | A simple model system enabling human CD34(+) cells to undertake differentiation towards T cells |
| Q50623106 | A stromal cell free culture system generates mouse pro-T cells that can reconstitute T-cell compartments in vivo. |
| Q40140813 | A type 2 cytokine axis for thymus emigration. |
| Q33728091 | ADAM17 deletion in thymic epithelial cells alters aire expression without affecting T cell developmental progression |
| Q35172457 | AF1q/MLLT11 regulates the emergence of human prothymocytes through cooperative interaction with the Notch signaling pathway |
| Q41660964 | Aberrant Signaling Pathways in T-Cell Acute Lymphoblastic Leukemia |
| Q48183508 | Abscisic acid: an antiangiogenic phytohormone that modulates the phenotypical plasticity of endothelial cells and macrophages |
| Q37280872 | Age-dependent modulation of vascular niches for haematopoietic stem cells |
| Q45373997 | Ameliorating effects of anti-Dll4 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease |
| Q92459022 | An Inconvenient Variable: Sex Hormones and Their Impact on T Cell Responses |
| Q35180702 | An overview of notch signaling in adult tissue renewal and maintenance |
| Q38540667 | Anti-DLL4, a cancer therapeutic with multiple mechanisms of action |
| Q61796555 | Baboon envelope LVs efficiently transduced human adult, fetal, and progenitor T cells and corrected SCID-X1 T-cell deficiency |
| Q36733439 | Blockade of individual Notch ligands and receptors controls graft-versus-host disease |
| Q39277510 | Cell death and thymic tolerance |
| Q27334529 | Characterization of two distinct lymphoproliferative diseases caused by ectopic expression of the Notch ligand DLL4 on T cells |
| Q27025504 | Close link between development and function of gamma-delta T cells |
| Q92469557 | Concise Review: Boosting T-Cell Reconstitution Following Allogeneic Transplantation-Current Concepts and Future Perspectives |
| Q38453659 | Construction of a functional thymic microenvironment from pluripotent stem cells for the induction of central tolerance |
| Q34533929 | Context- and cell-dependent effects of Delta-like 4 targeting in the bone marrow microenvironment |
| Q26752793 | Control of the thymic medulla and its influence on αβT-cell development |
| Q83225644 | Coronary arterial development is regulated by a Dll4-Jag1-EphrinB2 signaling cascade |
| Q45917614 | DL4-mediated Notch signaling is required for the development of fetal αβ and γδ T cells. |
| Q27331693 | DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport |
| Q36073436 | Decision checkpoints in the thymus |
| Q30671103 | Decline of FOXN1 gene expression in human thymus correlates with age: possible epigenetic regulation |
| Q92624025 | Delta-like 1 and Delta-like 4 differently require their extracellular domains for triggering Notch signaling in mice |
| Q33681059 | Delta-like 4 differentially regulates murine CD4 T cell expansion via BMI1 |
| Q50586878 | Delta-like 4-mediated Notch signaling is required for early T-cell development in a three-dimensional thymic structure. |
| Q38810880 | Development and developmental potential of cortical thymic epithelial cells |
| Q39207497 | Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla |
| Q28512115 | Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells |
| Q46340126 | Dll4 and Notch signalling couples sprouting angiogenesis and artery formation |
| Q37933528 | Dll4-Notch signaling as a therapeutic target in tumor angiogenesis |
| Q35946087 | Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice |
| Q36783140 | Dynamics of thymus organogenesis and colonization in early human development |
| Q37400603 | E and ID proteins branch out. |
| Q34356462 | E proteins and the regulation of early lymphocyte development |
| Q37772343 | Eliciting the T cell fate with Notch |
| Q36646371 | Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation |
| Q37091548 | Endothelial Notch activity promotes angiogenesis and osteogenesis in bone |
| Q92767392 | Endothelial proteolytic activity and interaction with non-resorbing osteoclasts mediate bone elongation |
| Q34066833 | Engineering the human thymic microenvironment to support thymopoiesis in vivo |
| Q28510745 | Enhancing T lineage production in aged mice: a novel function of Foxn1 in the bone marrow niche |
| Q33663914 | Evolution of adaptive immune recognition in jawless vertebrates |
| Q92735566 | Ex vivo generated human T-lymphoid progenitors as a tool to accelerate immune reconstitution after partially HLA compatible hematopoietic stem cell transplantation or after gene therapy |
| Q26744673 | FOXN1 in thymus organogenesis and development |
| Q38123164 | FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program |
| Q37730667 | Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands |
| Q54715245 | Flt3 ligand-receptor interaction is important for maintenance of early thymic progenitor numbers in steady-state thymopoiesis. |
| Q36485306 | Foxn1 maintains thymic epithelial cells to support T-cell development via mcm2 in zebrafish. |
| Q28589335 | Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence |
| Q34248553 | From the cradle to the grave: activities of GATA‐3 throughout T‐cell development and differentiation |
| Q38803570 | Future perspectives: therapeutic targeting of notch signalling may become a strategy in patients receiving stem cell transplantation for hematologic malignancies |
| Q93346022 | Generation of Tumor Antigen-Specific Cytotoxic T Lymphocytes from Pluripotent Stem Cells |
| Q49041421 | Generation of adult human T-cell progenitors for immunotherapeutic applications |
| Q39187317 | Generation of diversity in thymic epithelial cells. |
| Q41606459 | Genetic and non-genetic determinants of thymic epithelial cell number and function |
| Q26822390 | HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticity |
| Q36177924 | HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes. |
| Q64076263 | High mitogenic stimulation arrests angiogenesis |
| Q36178314 | High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells. |
| Q42115699 | Human T-lymphoid progenitors generated in a feeder-cell-free Delta-like-4 culture system promote T-cell reconstitution in NOD/SCID/γc(-/-) mice |
| Q55055910 | Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis. |
| Q42807292 | Identification of Domains for Efficient Notch Signaling Activity in Immobilized Notch Ligand Proteins |
| Q36762777 | Identification of a Bipotent Epithelial Progenitor Population in the Adult Thymus. |
| Q34541233 | Immature single-positive CD8+ thymocytes represent the transition from Notch-dependent to Notch-independent T-cell development. |
| Q26801403 | In Vitro T-Cell Generation From Adult, Embryonic, and Induced Pluripotent Stem Cells: Many Roads to One Destination |
| Q46127530 | Inhibition of proteolysis of Delta-like-1 does not promote or reduce T-cell developmental potential |
| Q37519602 | Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors |
| Q38786279 | Interaction of Ras with p110γ is required for thymic β-selection in the mouse |
| Q46593686 | Interleukin-7 supports survival of T-cell receptor-β-expressing CD4(-) CD8(-) double-negative thymocytes |
| Q37132158 | Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. |
| Q83226295 | Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation |
| Q36905544 | Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions |
| Q36595299 | LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance. |
| Q33865120 | Lineage divergence at the first TCR-dependent checkpoint: preferential γδ and impaired αβ T cell development in nonobese diabetic mice |
| Q34141670 | Low-dosage inhibition of Dll4 signaling promotes wound healing by inducing functional neo-angiogenesis |
| Q24302346 | MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development |
| Q38810904 | Microenvironmental cues for T-cell acute lymphoblastic leukemia development |
| Q34355912 | Molecular and cellular basis of T cell lineage commitment |
| Q36206799 | Myeloid DLL4 Does Not Contribute to the Pathogenesis of Non-Alcoholic Steatohepatitis in Ldlr-/- Mice |
| Q37753095 | NOTCH1 PEST domain mutants bind DLL4 |
| Q50298621 | NOTCH1 binds DLL4 |
| Q34244256 | Notch dimerization is required for leukemogenesis and T-cell development |
| Q37325713 | Notch signaling in hematopoietic cell transplantation and T cell alloimmunity. |
| Q37594765 | Notch signaling in the hematopoietic system |
| Q34898535 | Notch signaling in the malignant bone marrow microenvironment: implications for a niche-based model of oncogenesis |
| Q26765033 | Notch signaling: its roles and therapeutic potential in hematological malignancies |
| Q35894203 | Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells |
| Q28587298 | Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling |
| Q28477072 | Notch3 is dispensable for thymocyte β-selection and Notch1-induced T cell leukemogenesis |
| Q51866669 | Ongoing Dll4-Notch signaling is required for T-cell homeostasis in the adult thymus. |
| Q89946679 | PAX1 is essential for development and function of the human thymus |
| Q28488493 | Pharmacological inhibition of glycogen synthase kinase 3 regulates T cell development in vitro |
| Q42061814 | Placing ion channels into a signaling network of T cells: from maturing thymocytes to healthy T lymphocytes or leukemic T lymphoblasts. |
| Q47162542 | Polarized actin and VE-cadherin dynamics regulate junctional remodelling and cell migration during sprouting angiogenesis |
| Q48252098 | Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration. |
| Q38732523 | Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1. |
| Q36269844 | RB inactivation in keratin 18 positive thymic epithelial cells promotes non-cell autonomous T cell hyperproliferation in genetically engineered mice |
| Q39552928 | RasGRP1 and RasGRP3 Are Required for Efficient Generation of Early Thymic Progenitors |
| Q104459140 | Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds |
| Q34414351 | Regeneration of the aged thymus by a single transcription factor. |
| Q35807736 | Regenerative capacity of adult cortical thymic epithelial cells |
| Q38105858 | Regulation of innate and adaptive immunity by Notch |
| Q41030514 | Regulation of monocyte cell fate by blood vessels mediated by Notch signalling. |
| Q26995184 | Regulatory gene network circuits underlying T cell development from multipotent progenitors |
| Q35205379 | Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway |
| Q35256189 | Resuscitating cancer immunosurveillance: selective stimulation of DLL1-Notch signaling in T cells rescues T-cell function and inhibits tumor growth |
| Q48247297 | Retinoic Acid Receptor γ Regulates B and T Lymphopoiesis via Nestin-Expressing Cells in the Bone Marrow and Thymic Microenvironments. |
| Q36761513 | Role of LRF/Pokemon in lineage fate decisions |
| Q51097602 | Roles of RUNX Complexes in Immune Cell Development. |
| Q39752995 | Sequential Notch activation regulates ventricular chamber development |
| Q34533121 | Sex steroid blockade enhances thymopoiesis by modulating Notch signaling |
| Q30557264 | Sox17 is indispensable for acquisition and maintenance of arterial identity |
| Q47294669 | Spatially restricted JAG1-Notch signaling in human thymus provides suitable DC developmental niches. |
| Q36750033 | Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength. |
| Q35568443 | Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow. |
| Q34375200 | Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses |
| Q35898874 | Stat3 Signaling Promotes Survival And Maintenance Of Medullary Thymic Epithelial Cells. |
| Q38239869 | Staying innate: transcription factor maintenance of innate lymphoid cell identity. |
| Q37786778 | Stromal cell-derived factor 1α and CXCR4: newly defined requirements for efficient thymic β-selection |
| Q34773394 | T-cell differentiation of multipotent hematopoietic cell line EML in the OP9-DL1 coculture system |
| Q38042619 | TNF receptor family signaling in the development and functions of medullary thymic epithelial cells |
| Q38739472 | TNF-alpha and Notch signaling regulates the expression of HOXB4 and GATA3 during early T lymphopoiesis |
| Q39858021 | Targeting DLL4 in tumors shows preclinical activity but potentially significant toxicity |
| Q38945239 | The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia |
| Q64102143 | The RANKL-RANK Axis: A Bone to Thymus Round Trip |
| Q92447480 | The Role of Notch Signaling in Macrophages during Inflammation and Infection: Implication in Rheumatoid Arthritis? |
| Q93012764 | The bone marrow microenvironment at single-cell resolution |
| Q41609272 | The development of T cells from stem cells in mice and humans |
| Q37802422 | The intrathymic crossroads of T and NK cell differentiation |
| Q38763612 | The osteoimmunology of alveolar bone loss |
| Q51855659 | The preTCR-dependent DN3 to DP transition requires Notch signaling, is improved by CXCL12 signaling and is inhibited by IL-7 signaling. |
| Q34422017 | The role of dendritic cells in tissue-specific autoimmunity. |
| Q37934968 | Therapeutic potential of Notch inhibition in T-cell acute lymphoblastic leukemia: rationale, caveats and promises |
| Q38367121 | Therapeutic promise and challenges of targeting DLL4/NOTCH1. |
| Q50026703 | Thymic B cell development is controlled by the B potential of progenitors via both hematopoietic-intrinsic and thymic microenvironment-intrinsic regulatory mechanisms |
| Q99711515 | Thymic Engraftment by in vitro-Derived Progenitor T Cells in Young and Aged Mice |
| Q27004003 | Thymic epithelial cell development and differentiation: cellular and molecular regulation |
| Q37593760 | Thymic epithelial cell development and its dysfunction in human diseases. |
| Q91718584 | Thymic epithelial cell heterogeneity: TEC by TEC |
| Q33729251 | Thymic homing of activated CD4+ T cells induces degeneration of the thymic epithelium through excessive RANK signaling |
| Q38716135 | Thymic stromal cell subsets for T cell development |
| Q93043055 | Thymus Regeneration and Future Challenges |
| Q38139859 | Thymus involution and regeneration: two sides of the same coin? |
| Q24629126 | Transcription factor RORα is critical for nuocyte development |
| Q38363596 | Transcription factors and target genes of pre-TCR signaling. |
| Q37802415 | T‐cell lineage determination |
| Q38091944 | Ubiquitinations in the notch signaling pathway. |
| Q37408715 | Untangling the T branch of the hematopoiesis tree |
| Q35783525 | Young, proliferative thymic epithelial cells engraft and function in aging thymuses |
| Q92906458 | Zebrafish and Medaka: Two Teleost Models of T-Cell and Thymic Development |
| Q37724122 | c-Myc-Induced Survivin Is Essential for Promoting the Notch-Dependent T Cell Differentiation from Hematopoietic Stem Cells. |
| Q64051780 | iSuRe-Cre is a genetic tool to reliably induce and report Cre-dependent genetic modifications |
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