| review article | Q7318358 |
| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/0167-5699(93)90186-O |
| P698 | PubMed publication ID | 7903854 |
| P50 | author | Dale I Godfrey | Q56957983 |
| P2093 | author name string | Zlotnik A | |
| P433 | issue | 11 | |
| P304 | page(s) | 547-553 | |
| P577 | publication date | 1993-11-01 | |
| P1433 | published in | Trends in Immunology | Q15265730 |
| P1476 | title | Control points in early T-cell development | |
| P478 | volume | 14 |
| Q41160096 | A T cell clone with three potential TCR alpha chain rearrangements expresses only one receptor combination at the cell surface |
| Q79121883 | A domain of Foxn1 required for crosstalk-dependent thymic epithelial cell differentiation |
| Q37349310 | A dynamic assembly of diverse transcription factors integrates activation and cell-type information for interleukin 2 gene regulation |
| Q77075277 | A linkage between dendritic cell and T-cell development in the mouse thymus: the capacity of sequential T-cell precursors to form dendritic cells in culture |
| Q33309464 | A mechanism misregulating p27 in tumors discovered in a functional genomic screen |
| Q48256073 | A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse. |
| Q33523813 | A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway |
| Q34988374 | A positive look at double-negative thymocytes |
| Q37085216 | A requirement for cyclin-dependent kinase 6 in thymocyte development and tumorigenesis |
| Q46224385 | A role for FADD in T cell activation and development |
| Q26866139 | Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms |
| Q28285957 | Abnormal in vitro thymocyte differentiation in a patient with severe combined immunodeficiency-Nezelof's syndrome |
| Q72238656 | Abnormal patterns of equine leucocyte differentiation antigen expression in severe combined immunodeficiency foals suggests the phenotype of normal equine natural killer cells |
| Q41299074 | Age-associated changes in miRNA expression profiles in thymopoiesis |
| Q40789487 | Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene |
| Q52168533 | Altered aging-related thymic involution in T cell receptor transgenic, MHC-deficient, and CD4-deficient mice. |
| Q59058515 | An HMG-box-containing T-cell factor required for thymocyte differentiation. |
| Q52511681 | An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. |
| Q36403284 | An essential role for c-FLIP in the efficient development of mature T lymphocytes |
| Q41090386 | Analysis of gene function in lymphocytes by RAG-2-deficient blastocyst complementation. |
| Q45370597 | Autoimmune regulator initiates the expression of promiscuous genes in thymic epithelial cells |
| Q37717653 | BAP31 is involved in T cell activation through TCR signal pathways |
| Q28513839 | Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice |
| Q24290782 | Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure |
| Q45113910 | Biology of the interleukin-2 receptor |
| Q41063816 | Block of T lymphocyte differentiation by activation of the cAMP-dependent signal transduction pathway |
| Q34157703 | CD157, the Janus of CD38 but with a unique personality |
| Q41970300 | CD27 cooperates with the pre-T cell receptor in the regulation of murine T cell development |
| Q36437811 | CD3-epsilon overexpressed in prothymocytes acts as an oncogene |
| Q51115466 | CD4 and CD8 expression and T cell antigen receptor gene rearrangement in early intrathymic precursor cells. |
| Q35769448 | CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision |
| Q36401360 | CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity |
| Q64099602 | Canine tissue-associated CD4+CD8α+ double-positive T cells are an activated T cell subpopulation with heterogeneous functional potential |
| Q34082790 | Cell death control in lymphocytes. |
| Q41180587 | Cellular and molecular analysis of lymphoid development using Rag-deficient mice |
| Q40507444 | Cellular and molecular aspects of organotin-induced thymus atrophy |
| Q34054352 | Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice |
| Q33648107 | Cloning and comparative analysis of the human pre-T-cell receptor alpha-chain gene |
| Q77419132 | Co-ordinate expression of the pre-T-cell receptor complex and a novel immature thymocyte-specific antigen, IMT-1, during thymocyte development |
| Q59358928 | Cross-linking CTX, a novel thymocyte-specific molecule, inhibits the growth of lymphoid tumor cells in xenopus |
| Q47740949 | Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment |
| Q51070749 | Cytokine requirement for the development of T-lymphoid lineage potential in clonal lymphohaematopoietic progenitors in vitro. |
| Q45345200 | Deficient T cell fate specification in mice with an induced inactivation of Notch1. |
| Q36367518 | Delayed maturation of CD4- CD8- Fc gamma RII/III+ T and natural killer cell precursors in Fc epsilon RI gamma transgenic mice |
| Q28589945 | Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development |
| Q36946535 | Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment. |
| Q51127244 | Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes. |
| Q41239292 | Developmental regulation of V(D)J recombination and lymphocyte differentiation |
| Q42653770 | Developmentally regulated expression of the transmembrane adaptor protein trim in fetal and adult T cells |
| Q73574942 | Different functions of the GTPase Rho in prothymocytes and late pre-T cells |
| Q36363567 | Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation |
| Q41828305 | Disruption of alpha beta but not of gamma delta T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors |
| Q40495515 | Do lymphocytes require calibration? |
| Q36364099 | Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus. |
| Q57275587 | Double-negative thymocyte subsets in CD3′ chain-deficient mice: Absence of HSA+CD44−CD25− cells |
| Q58377243 | Down-Regulation of CD25 Expression on the Surface of Activated Tumor-Infiltrating Lymphocytes in Human Cervical Carcinoma |
| Q28592553 | E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene |
| Q41126128 | Early T-cell development in CD3-deficient mice. |
| Q41429677 | Early alpha beta T cell development in the thymus of normal and genetically altered mice |
| Q51093053 | Early stages in the development of human T, natural killer and thymic dendritic cells. |
| Q41828914 | Early thymocyte development is regulated by modulation of E2A protein activity |
| Q71670844 | Effects of irradiation, glucocorticoid and FK506 on cell-surface antigen expression by rat thymocytes: a three-colour flow cytofluorometric analysis |
| Q41377902 | Encephalitogenic, myelin basic protein-specific T cells from naive rat thymus: preferential use of the T cell receptor gene V beta 8.2 and expression of the CD4-CD8- phenotype |
| Q39958765 | Enforced expression of EBF in hematopoietic stem cells restricts lymphopoiesis to the B cell lineage |
| Q42819942 | Enhancement of activation-induced cell death by fibronectin in murine CD4+ CD8+ thymocytes |
| Q24315853 | Epithelial V-like antigen (EVA), a novel member of the immunoglobulin superfamily, expressed in embryonic epithelia with a potential role as homotypic adhesion molecule in thymus histogenesis |
| Q28141618 | Essential role of LAT in T cell development |
| Q42654229 | Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with beta-selection |
| Q36369290 | Evidence that gammadelta versus alphabeta T cell fate determination is initiated independently of T cell receptor signaling. |
| Q28287124 | Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology |
| Q91935600 | Examining pathogenic concepts of autoimmune hepatitis for cues to future investigations and interventions |
| Q36978827 | Expression of T-cell receptor genes during early T-cell development. |
| Q40853974 | Expression of metabotropic glutamate receptors in murine thymocytes and thymic stromal cells |
| Q40387215 | FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor |
| Q34507508 | Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice |
| Q78213214 | Fetal thymic organ culture in rotating bioreactors |
| Q37999788 | From murine to human nude/SCID: the thymus, T-cell development and the missing link |
| Q35029964 | Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies |
| Q36399540 | Galpha13 mediates a signal that is essential for proliferation and survival of thymocyte progenitors |
| Q41049000 | Gene targeting reveals a hierarchy of transcription factors regulating specification of lymphoid cell fates |
| Q36560011 | Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemia |
| Q73291761 | Gut cryptopatches: direct evidence of extrathymic anatomical sites for intestinal T lymphopoiesis |
| Q28268827 | Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors |
| Q80398194 | Hematological defects in the oc/oc mouse, a model of infantile malignant osteopetrosis |
| Q74086287 | Heterogeneity of the DN4 (CD44-CD25-) subset of CD4-CD8- double negative thymocytes; dependence on CD3 signaling |
| Q36229695 | Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation |
| Q37331641 | Histone deacetylase 1 and 2 are essential for normal T-cell development and genomic stability in mice |
| Q38599476 | Hormonal control of T-cell development in health and disease |
| Q40698897 | Human T-cell lineage development in foetal thymus-engrafted SCID mice |
| Q30853609 | Identification of CD4(-)CD8(-) double-negative natural killer T cell precursors in the thymus |
| Q77769118 | Identification of a fetal hematopoietic precursor with B cell, T cell, and macrophage potential |
| Q36380389 | Identification of a novel developmental stage marking lineage commitment of progenitor thymocytes |
| Q40457915 | Ikaros induces quiescence and T-cell differentiation in a leukemia cell line. |
| Q51970506 | Immature hematopoietic cells display selective requirements for adhesion- and degranulation-promoting adaptor protein in development and homeostatsis. |
| Q52126537 | Immature thymocytes that fail to express TCRbeta and/or TCRgamma delta proteins die by apoptotic cell death in the CD44(-)CD25(-) (DN4) subset. |
| Q44064541 | Immunomodulating effects after perinatal exposure to methylmercury in mice |
| Q36381045 | Impairment of T and B cell development by treatment with a type I interferon |
| Q37130575 | In vitro differentiation of adult bone marrow progenitors into antigen-specific CD4 helper T cells using engineered stromal cells expressing a notch ligand and a major histocompatibility complex class II protein |
| Q52107361 | In vivo ligation of CD3 on neonatal scid thymocytes blocks gamma-irradiation-induced TCRbeta rearrangements and thymic lymphomagenesis. |
| Q52117223 | Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes. |
| Q36363541 | Increased B lymphopoiesis in genetically sex steroid-deficient hypogonadal (hpg) mice |
| Q39188242 | Influence of CD4+CD25+ T cells on Plasmodium berghei NK65 infection in BALB/c mice |
| Q73722333 | Influence of atrial natriuretic peptide on thymocyte development in fetal thymic organ culture |
| Q71047930 | Inhibition of I-Ad-, but not Db-restricted peptide-induced thymic apoptosis by glucocorticoid receptor antagonist RU486 in T cell receptor transgenic mice |
| Q72797947 | Inhibition of proliferation and differentiation during early T cell development by anti-transferrin receptor antibody |
| Q71681938 | Interactions between stem cell factor and c-Kit are required for intestinal immune system homeostasis |
| Q73399348 | Interferons alpha/beta inhibit IL-7-induced proliferation of CD4- CD8- CD3- CD44+ CD25+ thymocytes, but do not inhibit that of CD4- CD8- CD3- CD44- CD25- thymocytes |
| Q33917389 | Intrathymic T cell development and selection proceeds normally in the absence of glucocorticoid receptor signaling |
| Q51125242 | Intrathymic T cell receptor (TcR) targeting in mice lacking CD4 or major histocompatibility complex (MHC) class II: rescue of CD4 T cell lineage without co-engagement of TcR/CD4 by MHC class II. |
| Q38353243 | Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus |
| Q42028277 | Isolation of the most immature population of murine fetal thymocytes that includes progenitors capable of generating T, B, and myeloid cells |
| Q35096697 | JNK and p38 MAP kinases in CD4+ and CD8+ T cells |
| Q36525985 | Kinetics of T cell receptor beta, gamma, and delta rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44(+)CD25(+) Pro-T thymocytes |
| Q36369398 | Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development |
| Q51093055 | Lineage commitment and differentiation of T and natural killer lymphocytes in the fetal mouse. |
| Q42048706 | Long-term cytokine production from engineered primary human stromal cells influences human hematopoiesis in an in vivo xenograft model |
| Q36486682 | Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase |
| Q38578067 | MicroRNAs (MiRs) Precisely Regulate Immune System Development and Function in Immunosenescence Process |
| Q46768493 | Models of haematopoiesis: seeing the wood for the trees |
| Q54697860 | Multiple T-cell clones specific for the same foreign pMHC ligand can be generated from a single, ancestral TCR-VDJbeta precursor. |
| Q33546854 | Multiple gamma c-dependent cytokines regulate T-cell development |
| Q34722561 | Multiple sclerosis complexity in selected populations: the challenge of Sardinia, insular Italy. |
| Q40957792 | Murine natural killer cell differentiation: past, present, and future |
| Q36371320 | Mutation in fas ligand impairs maturation of thymocytes bearing moderate affinity T cell receptors |
| Q37861191 | NOTCH and phosphatidylinositide 3-kinase/phosphatase and tensin homolog deleted on chromosome ten/AKT/mammalian target of rapamycin (mTOR) signaling in T-cell development and T-cell acute lymphoblastic leukemia |
| Q71779941 | Non-Hodgkin's lymphoma |
| Q37419676 | Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors |
| Q41701543 | Nur77 transcription activity correlates with its apoptotic function in vivo |
| Q36375444 | Pre-T cell receptor (TCR) and TCR-controlled checkpoints in T cell differentiation are set by Ikaros |
| Q41177069 | Pre-thymic transcription of TCR genes by adult murine bone marrow cells |
| Q33930862 | Presenilin-dependent gamma-secretase activity modulates thymocyte development |
| Q43513983 | Progression of T cell lineage restriction in the earliest subpopulation of murine adult thymus visualized by the expression of lck proximal promoter activity |
| Q42948016 | Proliferation kinetics associated with T cell receptor-beta chain selection of fetal murine thymocytes |
| Q36366739 | Protection from anti-TCR/CD3-induced apoptosis in immature thymocytes by a signal through thymic shared antigen-1/stem cell antigen-2 |
| Q24677017 | Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction |
| Q34482799 | RAG reexpression and DNA recombination at T cell receptor loci in peripheral CD4+ T cells |
| Q24598872 | RANK is essential for osteoclast and lymph node development |
| Q33112255 | Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609. |
| Q28513432 | Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1 |
| Q28207414 | Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL |
| Q42943666 | Regulation of pre-T cell receptor (pT alpha-TCR beta) gene expression during human thymic development. |
| Q34831713 | Regulation of surface expression of the human pre-T cell receptor complex. |
| Q41049031 | Regulation of thymocyte development from immature progenitors. |
| Q51094782 | Requirement for the thymus in alphabeta T lymphocyte lineage commitment. |
| Q73615230 | SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression |
| Q43760317 | Scheduled kinetics of cell proliferation and phenotypic changes during immature thymocyte generation |
| Q36906677 | Sonic hedgehog signalling in T-cell development and activation |
| Q36757921 | Specific requirement for CD3epsilon in T cell development. |
| Q24791532 | Stage-specific changes in fetal thymocyte proliferation during the CD4-8- to CD4+8+ transition in wild type, Rag1-/-, and Hoxa3,Pax1 mutant mice |
| Q36363831 | Sublethal gamma-radiation induces differentiation of CD4-/CD8- into CD4+/CD8+ thymocytes without T cell receptor beta rearrangement in recombinase activation gene 2-/- mice |
| Q24643012 | Synergistic action of stem-cell factor and interleukin-7 in a human immature T-cell line |
| Q36400581 | T cell development in mice lacking all T cell receptor zeta family members (Zeta, eta, and FcepsilonRIgamma). |
| Q73101469 | T cell receptor alpha gene rearrangement and transcription in adult thymic gamma delta cells |
| Q51118999 | T cell receptor delta gene rearrangement and T early alpha (TEA) expression in immature alpha beta lineage thymocytes: implications for alpha beta/gamma delta lineage commitment. |
| Q36370531 | T cell receptor gene rearrangement lineage analysis reveals clues for the origin of highly restricted antigen-specific repertoires |
| Q71069042 | T cell receptor-gamma, delta-expressing fetal mouse thymocytes are generated without T cell receptor V beta selection |
| Q35940897 | T cell-specific FADD-deficient mice: FADD is required for early T cell development |
| Q35131705 | T cells develop normally in the absence of both Deltex1 and Deltex2 |
| Q33755135 | TCF transcription factors: molecular switches in carcinogenesis |
| Q41514626 | TCR zeta chain in T cell development and selection |
| Q36363213 | Temporal and lineage-specific control of T cell receptor alpha/delta gene rearrangement by T cell receptor alpha and delta enhancers |
| Q33937432 | Ten-color flow cytometry reveals distinct patterns of expression of CD124 and CD126 by developing thymocytes |
| Q36228644 | The E delta enhancer controls the generation of CD4- CD8- alphabetaTCR-expressing T cells that can give rise to different lineages of alphabeta T cells |
| Q28512367 | The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells |
| Q42113516 | The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis |
| Q47112797 | The Hedgehog Signaling Pathway Emerges as a Pathogenic Target |
| Q40444843 | The bHLH gene Hes1 is essential for expansion of early T cell precursors |
| Q72715937 | The balance between deletion and activation of CD4+8+ thymocytes is controlled by T cell receptor-antigen interactions and is affected by cyclosporin A |
| Q26824492 | The chemokine superfamily revisited |
| Q36380706 | The common cytokine receptor gamma chain controls survival of gamma/delta T cells |
| Q35129719 | The control of apoptosis in lymphocyte selection |
| Q36364447 | The development of T and non-T cell lineages from CD34+ human thymic precursors can be traced by the differential expression of CD44. |
| Q51097761 | The developmental fate of T cells is critically influenced by TCRgammadelta expression. |
| Q28508171 | The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression |
| Q36364680 | The effect of in vivo IL-7 deprivation on T cell maturation |
| Q34572188 | The function of E- and Id proteins in lymphocyte development |
| Q92214785 | The histone methyltransferase Setd2 is indispensable for V(D)J recombination |
| Q52181534 | The linkage between T-cell and dendritic cell development in the mouse thymus. |
| Q36403817 | The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling |
| Q46268969 | The regulation and function of the Id proteins in lymphocyte development |
| Q52054979 | The role of Notch and IL-7 signaling in early thymocyte proliferation and differentiation. |
| Q36295655 | The role of apoptosis in the development and function of T lymphocytes |
| Q47821082 | The role of interleukin-7 in early T-cell development. |
| Q34242695 | The role of orphan nuclear receptor in thymocyte differentiation and lymphoid organ development |
| Q36229615 | The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells. |
| Q51093048 | The role of the T-cell receptor (TCR) in alpha beta/gamma delta lineage commitment: clues from intracellular TCR staining. |
| Q24544950 | The thymus in the mouse changes its activity during pregnancy: a study of the microenvironment |
| Q41065666 | The transcription factor NF-ATc1 regulates lymphocyte proliferation and Th2 cytokine production |
| Q36370712 | The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus |
| Q34937763 | Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus |
| Q36367357 | Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny |
| Q35216936 | Thymic generation and regeneration |
| Q41412407 | Thymocyte development in vitro: implications for studies of ageing and thymic involution. |
| Q30737100 | Thymosin-alpha1 stimulates maturation of CD34+ stem cells into CD3+4+ cells in an in vitro thymic epithelia organ coculture model |
| Q35818690 | Thymus cell-cell interactions |
| Q38343088 | Two distinct steps during thymocyte maturation from CD4-CD8- to CD4+CD8+ distinguished in the early growth response (Egr)-1 transgenic mice with a recombinase-activating gene-deficient background |
| Q41134314 | V(D)J recombination pathology. |
| Q37142168 | VEGF-mediated cross-talk within the neonatal murine thymus |
| Q33836359 | When immunization leads to autoimmunity: chronic inflammation as a result of thymic and mucosal dysregulation in IL-2 knock-out mice |
| Q30448775 | c-Myb is essential for early T cell development |
| Q36366527 | p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement. |
| Q26821842 | β-catenin/TCF-1 pathway in T cell development and differentiation |
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