Blockade of individual Notch ligands and receptors controls graft-versus-host disease

scientific article published on April 2013

Blockade of individual Notch ligands and receptors controls graft-versus-host disease is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1172/JCI65477
P932PMC publication ID3613915
P698PubMed publication ID23454750
P5875ResearchGate publication ID235775797

P50authorIvan MaillardQ57728609
Christen L EbensQ58123426
P2093author name stringMinhong Yan
Amy Shelton
Christian W Siebel
Thomas Gridley
Pavan Reddy
Vedran Radojcic
Ashley R Sandy
Linda C Samuelson
Ann Friedman
Ivy T Tran
Jooho Chung
Alexis J Carulli
Gloria T Shan
P2860cites workTherapeutic antibody targeting of individual Notch receptorsQ27660544
Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivoQ28509550
Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cellsQ28512115
The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligandsQ28584296
Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathwayQ28592687
Direct regulation of Gata3 expression determines the T helper differentiation potential of NotchQ28594879
The canonical Notch signaling pathway: unfolding the activation mechanismQ29547725
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cellsQ29614268
Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice.Q30497988
The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host diseaseQ33559627
Identifying Foxp3-expressing suppressor T cells with a bicistronic reporterQ33936032
Hedgehog signaling is dispensable for adult hematopoietic stem cell functionQ34039421
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage developmentQ34197865
Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow graftsQ34313946
The history and future of T-cell depletion as graft-versus-host disease prophylaxis for allogeneic hematopoietic stem cell transplantationQ34446665
Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantationQ34561047
Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.Q34568892
Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cellsQ34627216
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signalingQ34811698
Graft-versus-leukemia effects of transplantation and donor lymphocytesQ34887477
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.Q34978382
Blockade of Notch ligand δ1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generationQ35401923
Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells.Q35655623
Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes.Q35847425
T cell-depleted partial matched unrelated donor transplant for advanced myeloid malignancy: KIR ligand mismatch and outcome.Q35871747
Regulation of lymphoid development, differentiation, and function by the Notch pathway.Q36072476
Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturationQ36229695
Peculiar immunobiology of bone marrow allografts. II. Rejection of parental grafts by resistant F 1 hybrid miceQ36271368
Prophylaxis and treatment of acute graft-versus-host diseaseQ36368115
Notch signaling is an important regulator of type 2 immunity.Q36403646
Induction of tumor immunity following allogeneic stem cell transplantationQ36490755
Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2.Q36528951
Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction.Q36657491
Immunobiology of allogeneic hematopoietic stem cell transplantationQ36665305
Notch signalling during peripheral T-cell activation and differentiationQ36684906
Graft-versus-host diseaseQ36793622
Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.Q36946535
Canonical notch signaling is dispensable for the maintenance of adult hematopoietic stem cellsQ37029646
Clinical strategies to enhance posttransplant immune reconstitutionQ37045948
Acute graft-versus-host disease-challenge for a broader application of allogeneic hematopoietic cell transplantationQ37066454
HLA-C-dependent prevention of leukemia relapse by donor activating KIR2DS1.Q37157198
Gamma-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemiaQ37215995
Targeting the Notch1 and mTOR pathways in a mouse T-ALL modelQ37234630
gamma-Secretase in biology and medicineQ37375252
The different faces of Notch in T-helper-cell differentiationQ37376021
Notch and disease: a growing fieldQ37988987
Killer-cell immunoglobulin-like receptors reactivity and outcome of stem cell transplantQ38007344
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesisQ40191484
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesisQ40191493
Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism.Q40271483
Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.Q40683787
Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic graftsQ40828092
T killer cells play a role in allogeneic bone marrow graft rejection but not in hybrid resistanceQ41487669
Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic miceQ42488991
An immunomodulatory function for neutrophils during the induction of a CD4+ Th2 response in BALB/c mice infected with Leishmania majorQ43424199
Durable engraftment of major histocompatibility complex-incompatible cells after nonmyeloablative conditioning with fludarabine, low-dose total body irradiation, and posttransplantation cyclophosphamideQ43806522
Deficient T cell fate specification in mice with an induced inactivation of Notch1.Q45345200
Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.Q45345202
Requirement for Notch1 signals at sequential early stages of intrathymic T cell developmentQ45345203
Notch signaling controls the generation and differentiation of early T lineage progenitorsQ45345206
Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cellsQ45863413
Notch1 expression on T cells is not required for CD4+ T helper differentiationQ47431184
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cellsQ47619638
Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches.Q50937939
Generation of new Notch2 mutant alleles.Q54623726
Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation.Q55033128
Induction of Immunity and of Unresponsiveness to Parental Marrow Grafts in Adult F1 Hybrid MiceQ58956448
Chronic DLL4 blockade induces vascular neoplasmsQ59082154
Natural killer (NK)-cell function and antileukemic activity of a large population of CD3+/CD8+ T cells expressing NK receptors for major histocompatibility complex class I after "three-loci" HLA-incompatible bone marrow transplantationQ71029776
An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxinQ71881409
Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cellsQ73399528
Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotypeQ77437408
Notch signaling in the immune systemQ82881379
Graft-versus-host diseaseQ83468020
Effect of Ly49 Haplotype Variance on NK Cell Function and EducationQ85057145
P4510describes a project that usesImageJQ1659584
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1590-1604
P577publication date2013-04-01
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleBlockade of individual Notch ligands and receptors controls graft-versus-host disease
P478volume123

Reverse relations

cites work (P2860)
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