Notch signaling regulates T cell accumulation and function in the central nervous system during experimental autoimmune encephalomyelitis.

scientific article published on 03 July 2013

Notch signaling regulates T cell accumulation and function in the central nervous system during experimental autoimmune encephalomyelitis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1301116
P932PMC publication ID3735619
P698PubMed publication ID23825310
P5875ResearchGate publication ID245029640

P50authorBenjamin M. SegalQ42612550
Ivan MaillardQ57728609
Joshua StoolmanQ59612986
P2093author name stringAshley R Sandy
Prae Pongtornpipat
Kelli Malott
P2860cites workNotch1 augments NF-kappaB activity by facilitating its nuclear retentionQ24297567
Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 CommitmentQ24301442
Transcription factor RORα is critical for nuocyte developmentQ24629126
Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cellsQ28594415
The canonical Notch signaling pathway: unfolding the activation mechanismQ29547725
Chemokines and chemokine receptors in leukocyte traffickingQ30309533
Localizing central nervous system immune surveillance: meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitisQ30510541
Notch and presenilin regulate cellular expansion and cytokine secretion but cannot instruct Th1/Th2 fate acquisitionQ33356044
Autoimmune T cell responses in the central nervous systemQ33620003
The role of notch in promoting glial and neural stem cell fatesQ34132317
Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.Q34568892
C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE.Q34967101
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.Q34978382
Delta-like ligand 4 regulates central nervous system T cell accumulation during experimental autoimmune encephalomyelitisQ35175775
Notch ligand delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell developmentQ35848780
Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen.Q36229473
AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of NotchQ36309139
Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis.Q36370963
The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitisQ36399022
Regulatory CD4(+) T cells expressing endogenous T cell receptor chains protect myelin basic protein-specific transgenic mice from spontaneous autoimmune encephalomyelitisQ36401257
Notch signaling is an important regulator of type 2 immunity.Q36403646
Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cellsQ36609701
Blockade of individual Notch ligands and receptors controls graft-versus-host diseaseQ36733439
T cell-specific notch inhibition blocks graft-versus-host disease by inducing a hyporesponsive program in alloreactive CD4+ and CD8+ T cellsQ36863927
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemiaQ37113435
The different faces of Notch in T-helper-cell differentiationQ37376021
The development of experimental autoimmune encephalomyelitis in the mouse requires alpha4-integrin but not alpha4beta7-integrinQ37388211
Notch and disease: a growing fieldQ37988987
T-cell trafficking in the central nervous systemQ38020964
Critical Influences of the Cytokine Orchestration on the Outcome of Myelin Antigen‐Specific T‐Cell Autoimmunity in Experimental Autoimmune Encephalomyelitis and Multiple SclerosisQ40433222
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cellsQ40757721
Cytokines modulate endothelial cell intracellular signal transduction required for VCAM-1-dependent lymphocyte transendothelial migrationQ40779647
Deficient T cell fate specification in mice with an induced inactivation of Notch1.Q45345200
Inhibition of Notch signaling enhances tissue repair in an animal model of multiple sclerosis.Q46806244
Notch signaling is necessary for adult, but not fetal, development of RORγt(+) innate lymphoid cells.Q51854388
Generation of new Notch2 mutant alleles.Q54623726
Inhibition of delta-like ligand 4 decreases Th1/Th17 response in a mouse model of multiple sclerosisQ58202308
A safety and pharmacokinetic study of intravenous natalizumab in patients with MSQ74670919
Cutting Edge: IL-12 inversely regulates T-bet and eomesodermin expression during pathogen-induced CD8+ T cell differentiationQ79370168
Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase C theta and attenuates experimental autoimmune encephalomyelitisQ80633672
JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitisQ81464305
Overcoming failure to repair demyelination in EAE: gamma-secretase inhibition of Notch signalingQ81469110
Notch signaling in the immune systemQ82881379
Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21Q95814547
Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activationQ95816367
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectnervous systemQ9404
experimental autoimmune encephalomyelitisQ494066
P304page(s)1606-1613
P577publication date2013-07-03
P1433published inJournal of ImmunologyQ3521441
P1476titleNotch signaling regulates T cell accumulation and function in the central nervous system during experimental autoimmune encephalomyelitis
P478volume191

Reverse relations

cites work (P2860)
Q48005388Absence of Notch1 in murine myeloid cells attenuates the development of experimental autoimmune encephalomyelitis by affecting Th1 and Th17 priming.
Q50530547Crosstalk of dynamic functional modules in lung development of rhesus macaques.
Q48495282Fasudil mediates cell therapy of EAE by immunomodulating encephalomyelitic T cells and macrophages
Q89722136GCNT1-Mediated O-Glycosylation of the Sialomucin CD43 Is a Sensitive Indicator of Notch Signaling in Activated T Cells
Q33766764IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
Q36405922Impact of Notch1 Deletion in Macrophages on Proinflammatory Cytokine Production and the Outcome of Experimental Autoimmune Encephalomyelitis.
Q47103681Neuroprotection of Botch in experimental intracerebral hemorrhage in rats
Q38299924Non-canonical notch signaling in cancer and immunity
Q40375954Notch Ligand Delta-like 4 Promotes Regulatory T Cell Identity in Pulmonary Viral Infection
Q47418597Notch Signaling Regulates the Homeostasis of Tissue-Restricted Innate-like T Cells.
Q38949407Notch Signaling and Alloreactivity.
Q59356160Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection
Q58796101Presenilin1 regulates Th1 and Th17 effector responses but is not required for experimental autoimmune encephalomyelitis
Q40172231T Cell-Restricted Notch Signaling Contributes to Pulmonary Th1 and Th2 Immunity during Cryptococcus neoformans Infection.
Q37688655TH9 cell differentiation, transcriptional control and function in inflammation, autoimmune diseases and cancer.
Q38796193Targeting the Notch Pathway to Prevent Rejection.
Q35164666Transient blockade of delta-like Notch ligands prevents allograft rejection mediated by cellular and humoral mechanisms in a mouse model of heart transplantation.

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