Notch ligand delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development

scientific article published on 3 August 2011

Notch ligand delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1100725
P8608Fatcat IDrelease_j6dyifct2vhulivgorl7mubzgy
P932PMC publication ID3311114
P698PubMed publication ID21813770
P5875ResearchGate publication ID51544654

P50authorLeonardo V RiellaQ90788540
Samia J. KhouryQ37372486
Youmna LahoudQ64210775
P2093author name stringBing Zhu
Hideo Yagita
Wassim Elyaman
Ribal Bassil
P2860cites workDisruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouseQ24290693
Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3Q24672178
Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complexQ24675233
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseasesQ28131652
Notch signalling: a simple pathway becomes complexQ29555851
Differentiation of effector CD4 T cell populations (*)Q29614838
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3Q29619324
Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypesQ34066077
CD4+CD25+ regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivityQ34161141
Notch Ligand Delta-Like 4 Regulates Development and Pathogenesis of Allergic Airway Responses by Modulating IL-2 Production and Th2 ImmunityQ34306829
Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosisQ34311395
JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitisQ81464305
Notch signaling in the immune systemQ82881379
Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activationQ95816367
Structural conservation of Notch receptors and ligandsQ34489392
Interleukin 2 signaling is required for CD4(+) regulatory T cell functionQ34527240
Dendritic-cell control of pathogen-driven T-cell polarizationQ35597117
Nonredundant roles for Stat5a/b in directly regulating Foxp3Q35828667
FOXP3 acts as a rheostat of the immune responseQ36015032
CD8- DCs induce IL-12-independent Th1 differentiation through Delta 4 Notch-like ligand in response to bacterial LPSQ36229524
Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kip1 degradationQ36402940
The dynamics of effector T cells and Foxp3+ regulatory T cells in the promotion and regulation of autoimmune encephalomyelitisQ36533092
Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cellsQ36843721
The origin and application of experimental autoimmune encephalomyelitisQ36961600
TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4Q37036047
Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte developmentQ37360497
The different faces of Notch in T-helper-cell differentiationQ37376021
How are T(H)1 and T(H)2 effector cells made?Q37449444
Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cellsQ38299274
New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomesQ39691353
Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockadeQ39883638
Notch1 signaling and regulatory T cell functionQ40010266
Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation.Q41109029
Th2 differentiation is unaffected by Jagged2 expression on dendritic cellsQ41875479
Suppression of Th2 cell development by Notch ligands Delta1 and Delta4Q41962999
In vivo depletion of CD4+FOXP3+ Treg cells by the PC61 anti-CD25 monoclonal antibody is mediated by FcgammaRIII+ phagocytesQ43205921
Ameliorating effects of anti-Dll4 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating diseaseQ45373997
IL-2 is essential for TGF-beta to convert naive CD4+CD25- cells to CD25+Foxp3+ regulatory T cells and for expansion of these cellsQ46040716
Regulation of experimental autoimmune encephalomyelitis by CD4+, CD25+ and CD8+ T cells: analysis using depleting antibodiesQ47241697
Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cellsQ47438852
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cellsQ47619638
Active induction of experimental allergic encephalomyelitisQ48175463
Notch ligand Delta-like4 inhibits the development of murine experimental allergic conjunctivitis.Q51784180
IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells.Q51998742
Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system.Q53846430
Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling.Q53851403
Comment on "Cutting Edge: Anti-CD25 Monoclonal Antibody Injection Results in the Functional Inactivation, Not Depletion, of CD4+CD25+ T Regulatory Cells"Q61053509
CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2Q74660381
IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cellsQ75303125
Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitisQ78404404
Comment on "Cutting edge: anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells"Q80057929
Passive induction of experimental allergic encephalomyelitisQ80285957
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectexperimental autoimmune encephalomyelitisQ494066
P304page(s)2322-2328
P577publication date2011-08-03
P1433published inJournal of ImmunologyQ3521441
P1476titleNotch ligand delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development
P478volume187

Reverse relations

cites work (P2860)
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Q34533929Context- and cell-dependent effects of Delta-like 4 targeting in the bone marrow microenvironment
Q39103876Defects in CD4+ T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE.
Q51598621Dll4 in the DCs isolated from OVA-sensitized mice is involved in Th17 differentiation inhibition by 1,25-dihydroxyvitamin D3 in vitro.
Q85370236Expression levels of Notch1 and Delta-like 4 in peripheral lymphocytes and their relationship with T helper 17 (Th17) cells in renal transplant recipients
Q57116056Inhibition of Notch1 induces population and suppressive activity of regulatory T cell in inflammatory arthritis
Q104681823Mesenchymal stem cells instruct a beneficial phenotype in reactive astrocytes
Q40508949Modulating of ocular inflammation with macrophage migration inhibitory factor is associated with notch signalling in experimental autoimmune uveitis.
Q91993914Multi-Faceted Notch in Allergic Airway Inflammation
Q36799500Mycobacteria-responsive sonic hedgehog signaling mediates programmed death-ligand 1- and prostaglandin E2-induced regulatory T cell expansion.
Q98498881NOTCH1 and DLL4 are involved in the human tuberculosis progression and immune response activation
Q37681701Notch Ligand DLL4 Alleviates Allergic Airway Inflammation via Induction of a Homeostatic Regulatory Pathway
Q40375954Notch Ligand Delta-like 4 Promotes Regulatory T Cell Identity in Pulmonary Viral Infection
Q38949407Notch Signaling and Alloreactivity.
Q55422791Notch Signaling and Immune Regulation in Alloimmunity.
Q46795621Notch Signaling in Development, Tissue Homeostasis, and Disease
Q39274325Notch Signaling in T Helper Cell Subsets: Instructor or Unbiased Amplifier?
Q36609701Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells
Q39100271Notch regulates Th17 differentiation and controls trafficking of IL-17 and metabolic regulators within Th17 cells in a context-dependent manner
Q27002542Notch signaling and T-helper cells in EAE/MS
Q64262430Notch signaling pathway regulates CD4CD25CD127 regulatory T cells and T helper 17 cells function in gastric cancer patients
Q37075692Notch signaling regulates T cell accumulation and function in the central nervous system during experimental autoimmune encephalomyelitis.
Q40906691OX40L/Jagged1 cosignaling by GM-CSF-induced bone marrow-derived dendritic cells is required for the expansion of functional regulatory T cells
Q58796101Presenilin1 regulates Th1 and Th17 effector responses but is not required for experimental autoimmune encephalomyelitis
Q37173575RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression
Q38105858Regulation of innate and adaptive immunity by Notch
Q40461193Regulatory T cells exhibit neuroprotective effect in a mouse model of traumatic brain injury.
Q36939870Rheumatoid arthritis-associated RBPJ polymorphism alters memory CD4+ T cells
Q34295282Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors
Q89587286Shaping of the Tumor Microenvironment by Notch Signaling
Q38238962Signaling networks in MS: a systems-based approach to developing new pharmacological therapies
Q40172231T Cell-Restricted Notch Signaling Contributes to Pulmonary Th1 and Th2 Immunity during Cryptococcus neoformans Infection.
Q39008798Th9 cells in the pathogenesis of EAE and multiple sclerosis
Q35976619The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes

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