Multi-Faceted Notch in Allergic Airway Inflammation

scientific article published on 17 July 2019

Multi-Faceted Notch in Allergic Airway Inflammation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3390/IJMS20143508
P932PMC publication ID6678794
P698PubMed publication ID31319491

P2093author name stringBor-Luen Chiang
Chiao-Juno Chiu
Miao-Tzu Huang
P2860cites workThe notch ligands Dll4 and Jagged1 have opposing effects on angiogenesisQ45345843
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Antibody therapy for the management of severe asthma with eosinophilic inflammationQ47773104
Allergen exposure of mouse airways evokes remodeling of both bronchi and large pulmonary vesselsQ47921757
Anti-Dll4 Antibody Inhibits the Differentiation of Th17 Cells in Asthmatic MiceQ47947293
Notch Balances Th17 and Induced Regulatory T Cell Functions in Dendritic Cells by Regulating Aldh1a2 ExpressionQ47988873
Beyond epithelial-to-mesenchymal transition: Common suppression of differentiation programs underlies epithelial barrier dysfunction in mild, moderate, and severe asthma.Q48298703
Dynamic Ligand Discrimination in the Notch Signaling Pathway.Q49344558
The CD46-Jagged1 interaction is critical for human TH1 immunityQ24301407
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Angiogenesis in the pathogenesis of inflammatory joint and lung diseasesQ24805418
Resolution of airway inflammation and hyperreactivity after in vivo transfer of CD4+CD25+ regulatory T cells is interleukin 10 dependent.Q25255561
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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domainQ28273268
Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1Q28509366
Activation of c-Kit in dendritic cells regulates T helper cell differentiation and allergic asthmaQ28584858
Nuclear access and action of notch in vivoQ28646384
The canonical Notch signaling pathway: unfolding the activation mechanismQ29547725
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Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesisQ29614939
The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasisQ29616351
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cellsQ29618126
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generationQ29620116
Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathwayQ33775328
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Enhancing the understanding of asthmaQ34216556
A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiotaQ34243359
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Notch Ligand Delta-Like 4 Regulates Development and Pathogenesis of Allergic Airway Responses by Modulating IL-2 Production and Th2 ImmunityQ34306829
Intrinsic activity of the Lin-12 and Notch intracellular domains in vivoQ34352020
A phase I dose escalation and expansion study of the anticancer stem cell agent demcizumab (anti-DLL4) in patients with previously treated solid tumors.Q34443946
Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell functionQ34456711
Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell functionQ34458950
A role for eosinophils in airway remodelling in asthmaQ34550355
Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis.Q34605909
Notch signalling limits angiogenic cell behaviour in developing zebrafish arteriesQ34607158
Airway remodelling in the pathogenesis of asthmaQ34607541
Mast cells can promote the development of multiple features of chronic asthma in miceQ34619598
Asthma: an epidemic of dysregulated immunityQ34765268
Notch signaling in vascular developmentQ35077358
Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesisQ35081904
Type 2 inflammation in asthma--present in most, absent in manyQ35322784
Influence of intestinal bacteria on induction of regulatory T cells: lessons from a transfer model of colitisQ35597887
The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching.Q35652503
Notch regulation of lymphocyte development and function.Q35676281
Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusionQ35828791
Notch ligand delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell developmentQ35848780
IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contractionQ35874754
Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in miceQ35946087
γ-Secretase Inhibitor Alleviates Acute Airway Inflammation of Allergic Asthma in Mice by Downregulating Th17 Cell DifferentiationQ35962890
Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmaticsQ36001230
Notch system in the linkage of innate and adaptive immunityQ36055999
Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemiaQ36137651
Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung.Q36209876
Reversal of airway hyperresponsiveness by induction of airway mucosal CD4+CD25+ regulatory T cellsQ36228134
Notch ligand Delta-like 4 regulates disease pathogenesis during respiratory viral infections by modulating Th2 cytokinesQ36229204
Recent insights into the role of Notch signaling in tumorigenesisQ36314431
TLR4 signaling in stromal cells is critical for the initiation of allergic Th2 responses to inhaled antigen.Q50784151
Intestinal commensal bacteria promote T cell hyporesponsiveness and down-regulate the serum antibody responses induced by dietary antigen.Q51045890
Type 2 cytokines in the pathogenesis of sustained airway dysfunction and airway remodeling in mice.Q51636510
Notch signaling confers antigen-presenting cell functions on mast cells.Q51782619
Notch ligand Delta-like4 inhibits the development of murine experimental allergic conjunctivitis.Q51784180
Anti-DLL4 has broad spectrum activity in pancreatic cancer dependent on targeting DLL4-Notch signaling in both tumor and vasculature cells.Q52629451
Cutting edge: Plasmacytoid dendritic cells induce IL-10 production in T cells via the Delta-like-4/Notch axis.Q52906696
Jagged1 on dendritic cells and Notch on CD4+ T cells initiate lung allergic responsiveness by inducing IL-4 production.Q53378578
Is IgE or eosinophils the key player in allergic asthma pathogenesis? Are we asking the right question?Q55370774
Impaired regulatory T cell function in germ-free miceQ56901969
Increased surface expression of NOTCH on memory T cells in peripheral blood from asthma patientsQ57184851
NK Cell Deficiency Predisposes to Viral-Induced Th2-Type Allergic Inflammation via Epithelial-Derived IL-25Q57966252
Acute Allergen-Induced Airway Remodeling in Atopic AsthmaQ57966293
Boosting airway T-regulatory cells by gastrointestinal stimulation as a strategy for asthma controlQ58385177
Jagged gives an edge to TH1 cellsQ62002305
Notch-Hes1 pathway is required for the development of IL-17-producing T cellsQ62735634
IL-23 and Th17 Cells Enhance Th2-Cell–mediated Eosinophilic Airway Inflammation in MiceQ62735710
Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesisQ73431447
Increased vascularity of the bronchial mucosa in mild asthmaQ73528703
Bronchial angiogenesis in severe glucocorticoid-dependent asthmaQ73966635
Linked suppression in peripheral T cell tolerance to the house dust mite derived allergen Der p 1Q77388868
Remodeling and airway hyperresponsiveness but not cellular inflammation persist after allergen challenge in asthmaQ79711349
JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitisQ81464305
Epithelial cell-intrinsic Notch signaling plays an essential role in the maintenance of gut immune homeostasisQ83328392
Regulatory T cells negatively regulate neovasculature of airway remodeling via DLL4-Notch signalingQ84558490
Asthma and allergy: Complementing the IL-17 axis in asthmaQ85108020
Asthma and allergy: An IFNγ bias in severe asthmaQ85619272
A first-in-human phase 1a study of the bispecific anti-DLL4/anti-VEGF antibody navicixizumab (OMP-305B83) in patients with previously treated solid tumorsQ91528336
The use of biologics for immune modulation in allergic diseaseQ92435887
Regulation of T cell activation by Notch ligand, DLL4, promotes IL-17 production and Rorc activationQ95816367
Jagged 1 Rescues the Duchenne Muscular Dystrophy PhenotypeQ36344905
CD4+CD25+ T cells protect against experimentally induced asthma and alter pulmonary dendritic cell phenotype and functionQ36403998
Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cellsQ36432890
Notch regulates IL-10 production by T helper 1 cellsQ36491342
Essential role of Notch signaling in effector memory CD8+ T cell-mediated airway hyperresponsiveness and inflammation.Q36639992
Blockade of individual Notch ligands and receptors controls graft-versus-host diseaseQ36733439
Notch signaling in blood vessels: who is talking to whom about what?Q36843651
TLR9 regulates the mycobacteria-elicited pulmonary granulomatous immune response in mice through DC-derived Notch ligand delta-like 4Q37036047
Obesity and Asthma: Microbiome-Metabolome InteractionsQ37088255
Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrityQ37126807
Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulationQ37143667
The different faces of Notch in T-helper-cell differentiationQ37376021
Notch Ligand DLL4 Alleviates Allergic Airway Inflammation via Induction of a Homeostatic Regulatory PathwayQ37681701
Canonical and non-canonical Notch ligandsQ37785194
Mechanism and significance of cis-inhibition in Notch signalling.Q37826900
Pathophysiology of allergic inflammationQ37891126
Asthma phenotypes and the use of biologic medications in asthma and allergic disease: the next steps toward personalized careQ38348052
Cellular and molecular mechanisms of inflammation-induced angiogenesisQ38433996
Anti-DLL4, a cancer therapeutic with multiple mechanisms of actionQ38540667
Notch in T Cell Differentiation: All Things ConsideredQ38652678
Gamma secretase inhibitors: a patent review (2013 - 2015).Q38738605
γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinctQ38766437
Notch signaling in lung diseases: focus on Notch1 and Notch3.Q38845270
Notch signalling in contextQ38923306
JAG1-Mediated Notch Signaling Regulates Secretory Cell Differentiation of the Human Airway EpitheliumQ39742269
Sequential Notch activation regulates ventricular chamber developmentQ39752995
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesisQ40191484
Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesisQ40191493
Notch Ligand Delta-like 4 Promotes Regulatory T Cell Identity in Pulmonary Viral InfectionQ40375954
PTTG1IP and MAML3, novel genomewide association study genes for severity of hyperresponsiveness in adult asthmaQ40552310
Bronchial biopsies in asthma. An ultrastructural, quantitative study and correlation with hyperreactivity.Q40768651
Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.Q40862987
Notch signaling mediates granulocyte-macrophage colony-stimulating factor priming-induced transendothelial migration of human eosinophilsQ41110691
The immunology of asthmaQ41673436
Suppression of Th2 cell development by Notch ligands Delta1 and Delta4Q41962999
A Notch ligand, Delta-like 1 functions as an adhesion molecule for mast cells.Q42814849
Inhaled corticosteroids decrease vascularity of the bronchial mucosa in patients with asthmaQ43650596
Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammationQ44191932
Th17/Treg dysregulation in allergic asthmatic children is associated with elevated notch expressionQ45058212
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue14
P921main subjectasthmaQ35869
signal transductionQ828130
P577publication date2019-07-17
P1433published inInternational Journal of Molecular SciencesQ3153277
P1476titleMulti-Faceted Notch in Allergic Airway Inflammation
P478volume20

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