NOTCH and Graft-Versus-Host Disease

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NOTCH and Graft-Versus-Host Disease is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3389/FIMMU.2018.01825
P932PMC publication ID6096230
P698PubMed publication ID30147692

P2093author name stringMauro Di Ianni
Paolo Di Bartolomeo
Patrizia Accorsi
Stella Santarone
Paolo Sportoletti
Paola Olioso
Raffaella Giancola
Beatrice Del Papa
Franca Falzetti
Annalisa Natale
Ambra Di Tommaso
Bianca Fabi
Emanuela Rosati
Stefano Baldoni
Gabriele Papalinetti
P2860cites workConversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3Q24672849
Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7Q28591451
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responsesQ29619908
Double unit grafts successfully extend the application of umbilical cord blood transplantation in adults with acute leukemiaQ30415126
Consensus conference on clinical practice in chronic graft-versus-host disease (GVHD): first-line and topical treatment of chronic GVHD.Q33624804
CD39/adenosine pathway is involved in AIDS progressionQ33959186
Advances in graft-versus-host disease biology and therapyQ34031916
CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in miceQ34091467
Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantationQ34162461
A central role for Notch in effector CD8(+) T cell differentiationQ34517022
Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.Q34568892
Comparable survival after HLA-well-matched unrelated or matched sibling donor transplantation for acute myeloid leukemia in first remission with unfavorable cytogenetics at diagnosisQ34620456
Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new.Q34754302
Long-term survival and late deaths after allogeneic hematopoietic cell transplantationQ35023409
Profound depletion of host conventional dendritic cells, plasmacytoid dendritic cells, and B cells does not prevent graft-versus-host disease inductionQ35884088
Induction of acute GVHD by sex-mismatched H-Y antigens in the absence of functional radiosensitive host hematopoietic-derived antigen-presenting cellsQ35909695
Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling.Q36199919
Notch signalling during peripheral T-cell activation and differentiationQ36684906
Delta-like ligand 4 identifies a previously uncharacterized population of inflammatory dendritic cells that plays important roles in eliciting allogeneic T cell responses in miceQ36717891
Blockade of individual Notch ligands and receptors controls graft-versus-host diseaseQ36733439
Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cellsQ36843721
T cell-specific notch inhibition blocks graft-versus-host disease by inducing a hyporesponsive program in alloreactive CD4+ and CD8+ T cellsQ36863927
Notch signaling at a glanceQ36903753
Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease preventionQ36925951
Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemiaQ36973664
Characterizing and optimizing immune responses to leukaemia antigens after allogeneic stem cell transplantationQ37132892
Mechanisms Underlying CD4+ Treg Immune Regulation in the Adult: From Experiments to ModelsQ37317297
gamma-Secretase in biology and medicineQ37375252
The different faces of Notch in T-helper-cell differentiationQ37376021
Glucocorticoid-refractory acute graft-versus-host diseaseQ37680126
Pathophysiology of GvHD and Other HSCT-Related Major ComplicationsQ37710572
Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligandsQ37730667
T regulatory cell separation for clinical application.Q38026324
Clinical-Grade-Expanded Regulatory T Cells Prevent Graft-versus-Host Disease While Allowing a Powerful T Cell-Dependent Graft-versus-Leukemia Effect in Murine Models.Q38696697
Tregs: hype or hope for allogeneic hematopoietic stem cell transplantation?Q38742863
The mazy case of Notch and immunoregulatory cells.Q39178393
Antileukemic Effect of Graft-versus-Host Disease in Human Recipients of Allogeneic-Marrow GraftsQ39244446
"Designed" grafts for HLA-haploidentical stem cell transplantationQ39289225
Graft-versus-leukaemia reactivity induced by alloimmunisation without augmentation of graft-versus-host reactivityQ41110821
Graft-versus-leukemia reactions after bone marrow transplantationQ41198977
Separation of human CD4+CD39+ T cells by magnetic beads reveals two phenotypically and functionally different subsetsQ42066000
CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantationQ44408941
HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse.Q44458617
Cell contact, prostaglandin E(2) and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4+CD25(High) forkhead box P3+ regulatory T cells.Q45834735
A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral bloodQ46284741
An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD.Q47709978
Treg-protected donor lymphocyte infusions: a new tool to address the graft-versus-leukemia effect in the absence of graft-versus-host disease in patients relapsed after HSCT.Q48105490
Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic TargetsQ49552733
Acute Graft-versus-Host Disease - Biologic Process, Prevention, and TherapyQ49679320
New Insights into Graft-Versus-Host Disease and Graft Rejection.Q50425146
Notch pathway plays a novel and critical role in regulating responses of T and antigen-presenting cells in aGVHD.Q51369795
Bepridil exhibits anti-leukemic activity associated with NOTCH1 pathway inhibition in chronic lymphocytic leukemia.Q51765546
The NOTCH1/CD39 axis: a Treg trip-switch for GvHD.Q52872585
Peripheral tissues reprogram CD8+ T cells for pathogenicity during graft-versus-host disease.Q55260254
Toll-Like Receptors 3 and 4 Are Expressed by Human Bone Marrow-Derived Mesenchymal Stem Cells and Can Inhibit Their T-Cell Modulatory Activity by Impairing Notch SignalingQ61638150
Graft-versus-leukemia in rat MHC-mismatched bone marrow transplantation is merely an allogeneic effectQ72010900
Mesenchymal cells recruit and regulate T regulatory cellsQ80717999
A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responsesQ81357571
Inducing and expanding regulatory T cell populations by foreign antigenQ81392563
Notch signaling in the immune systemQ82881379
Notch1 modulates mesenchymal stem cells mediated regulatory T-cell inductionQ85476385
Haploidentical, unmanipulated, G-CSF-primed bone marrow transplantation for patients with high-risk hematologic malignanciesQ85486402
T-cell-replete HLA-haploidentical hematopoietic transplantation for hematologic malignancies using post-transplantation cyclophosphamide results in outcomes equivalent to those of contemporaneous HLA-matched related and unrelated donor transplantatiQ86169061
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P407language of work or nameEnglishQ1860
P921main subjectcellQ7868
transcription factorQ407384
membrane proteinQ423042
hematopoietic stem cell transplantationQ1128050
graft-versus-host diseaseQ1194520
hemic and immune systemsQ70202933
P304page(s)1825
P577publication date2018-01-01
2018-08-10
P1433published inFrontiers in ImmunologyQ27723748
P1476titleNOTCH and Graft-Versus-Host Disease
P478volume9