Thymic homing of activated CD4+ T cells induces degeneration of the thymic epithelium through excessive RANK signaling

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Thymic homing of activated CD4+ T cells induces degeneration of the thymic epithelium through excessive RANK signaling is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1085546312
P356DOI10.1038/S41598-017-02653-9
P932PMC publication ID5445095
P698PubMed publication ID28546567

P2093author name stringYu Zhang
Wei Wang
Hui Shen
Qing Ge
Chen Yin
Xiu-Yuan Sun
Ya-Nan Gao
Xiao-Yan Pei
P2860cites workThymic stromal cell subsets for T cell developmentQ38716135
Development and developmental potential of cortical thymic epithelial cellsQ38810880
Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medullaQ39207497
The development of T lymphocytes in fetal thymus organ cultureQ39239086
Osteoprotegerin-Mediated Homeostasis of Rank+ Thymic Epithelial Cells Does Not Limit Foxp3+ Regulatory T Cell Development.Q40646125
The differentiation of murine thymocytes in vivo and in vitroQ41034169
Suspension of thymic emigration promotes the maintenance of antigen-specific memory T cells and the recall responsesQ41755143
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medullaQ41868543
Delta-like 4 is indispensable in thymic environment specific for T cell developmentQ42277361
Growth of epithelial cells in the thymic medulla is under the control of mature T cellsQ42769057
Peripheral regulatory T lymphocytes recirculating to the thymus suppress the development of their precursors.Q46978934
Multilineage potential and self-renewal define an epithelial progenitor cell population in the adult thymus.Q50640787
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.Q51949099
Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells.Q52010433
Altered aging-related thymic involution in T cell receptor transgenic, MHC-deficient, and CD4-deficient mice.Q52168533
Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program.Q53067111
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.Q53453365
Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.Q54380933
Medullary thymic epithelial stem cells maintain a functional thymus to ensure lifelong central T cell tolerance.Q55058749
Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance.Q55059402
Phenotypical and morphological changes in the thymic microenvironment from ageing miceQ56896905
TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cellsQ56975249
Autoantigen-Specific Interactions with CD4+ Thymocytes Control Mature Medullary Thymic Epithelial Cell CellularityQ63190413
Induction of neonatal tolerance to Mlsa antigens by CD8+ T cellsQ68091136
Immunohistological analysis of immigration of thymocyte-precursors into the thymus: evidence for immigration of peripheral T cells into the thymic medullaQ69487077
Programmed differentiation of murine thymocytes during fetal thymus organ cultureQ72429456
An epithelial progenitor pool regulates thymus growthQ79675191
Lymphohematopoietic progenitors do not have a synchronized defect with age-related thymic involutionQ80753538
The aged thymus shows normal recruitment of lymphohematopoietic progenitors but has defects in thymic epithelial cellsQ81097950
Induction of central tolerance by mature T cellsQ81111387
Peripheral T lymphocytes recirculating back into the thymus can mediate thymocyte positive selectionQ81595327
Effects of RANKL on the thymic medullaQ84449609
Immunosenescence: emerging challenges for an ageing populationQ24655433
Thymic Crosstalk Coordinates Medulla Organization and T-Cell Tolerance InductionQ26800152
An overview of the intrathymic intricacies of T cell developmentQ26862512
Projection of an immunological self shadow within the thymus by the aire proteinQ28207164
Cbx4 regulates the proliferation of thymic epithelial cells and thymus functionQ28504649
Enhancement of an anti-tumor immune response by transient blockade of central T cell toleranceQ33569842
Adult thymus contains FoxN1(-) epithelial stem cells that are bipotent for medullary and cortical thymic epithelial lineagesQ34106631
Thymopoiesis in mice depends on a Foxn1-positive thymic epithelial cell lineageQ34151895
Thymic output in aged miceQ34694301
An evolutionary perspective on the mechanisms of immunosenescenceQ34987918
Young, proliferative thymic epithelial cells engraft and function in aging thymusesQ35783525
Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epitheliumQ36011240
Reentry of T cells to the adult thymus is restricted to activated T cellsQ36230121
Rare peripheral T cells migrate to and persist in normal mouse thymusQ36355543
TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activationQ36368029
Thymus: the next (re)generationQ36815662
Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cellsQ36932226
Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.Q36946535
Back to the thymus: peripheral T cells come homeQ37185779
Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell populationQ37288027
Thymic involution and immune reconstitution.Q37361275
Peripheral T cells in the thymus: have they just lost their way or do they do something?Q37364442
An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cellsQ37627734
Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitorsQ37650757
Mechanisms of T cell development and transformation.Q37899181
Thymic epithelial cells: working class heroes for T cell development and repertoire selectionQ38010575
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)2421
P577publication date2017-05-25
P1433published inScientific ReportsQ2261792
P1476titleThymic homing of activated CD4+ T cells induces degeneration of the thymic epithelium through excessive RANK signaling
P478volume7

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cites work (P2860)
Q98170847Robust intrathymic development of regulatory T cells in young NOD mice is rapidly restrained by recirculating cells
Q64882630Th1 Biased Progressive Autoimmunity in Aged Aire-Deficient Mice Accelerated Thymic Epithelial Cell Senescence.
Q64102143The RANKL-RANK Axis: A Bone to Thymus Round Trip