Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla

scientific article published on 14 November 2012

Developmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.4049/JIMMUNOL.1201815
P932PMC publication ID3605790
P698PubMed publication ID23152561

P50authorJosef PenningerQ1674391
Graham AndersonQ56643596
Guillaume E DesantiQ60656139
William E. JenkinsonQ41592803
P2093author name stringEric J Jenkinson
Andrea J White
Jennifer E Cowan
Sonia M Parnell
Peter J L Lane
Song Baik
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Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-toleranceQ28585306
Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell toleranceQ34112986
Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cellsQ34576335
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell developmentQ34577749
Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizionQ59066328
Autoantigen-Specific Interactions with CD4+ Thymocytes Control Mature Medullary Thymic Epithelial Cell CellularityQ63190413
Disorganization and restoration of thymic medullary epithelial cells in T cell receptor-negative scid mice: evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironmentQ70212975
Checkpoints in the development of thymic cortical epithelial cellsQ83088896
The impact of cell re-entry into the primary lymphoid organs on lymphocyte repertoire and functionalityQ83158558
Foxp3+ regulatory T cells promiscuously accept thymic signals critical for their developmentQ34587142
The thymus as an inductive site for T lymphopoiesisQ34628878
Humoral immune responses in CD40 ligand-deficient miceQ34725239
Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unitQ34750367
Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epitheliumQ36011240
Spontaneous autoimmunity prevented by thymic expression of a single self-antigenQ36228141
Proliferative arrest and rapid turnover of thymic epithelial cells expressing AireQ36229072
Thymic emigration revisitedQ36229138
Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR.Q36371648
Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentationQ36399298
Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.Q36399327
Journey through the thymus: stromal guides for T-cell development and selectionQ36402237
Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.Q36946535
Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cellsQ37303952
Control of central self-tolerance induction by autoreactive CD4+ thymocytesQ37651855
Thymic epithelial cells: working class heroes for T cell development and repertoire selectionQ38010575
AIRE-induced apoptosis is associated with nuclear translocation of stress sensor protein GAPDH.Q39345151
Preparation of 2-dGuo-treated thymus organ cultures.Q40238298
Reaggregate thymus cultures.Q40238464
Transfection and ligation of CD40 in human oral keratinocytes affect proliferation, adhesion and migration but not apoptosis in vitroQ40314864
Thymus medulla consisting of epithelial islets each derived from a single progenitorQ40763624
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medullaQ41868543
Delta-like 4 is indispensable in thymic environment specific for T cell developmentQ42277361
CD40 ligation alters the cell cycle of differentiating keratinocytesQ42484193
The thymic medulla: a unique microenvironment for intercellular self-antigen transferQ42572856
Growth of epithelial cells in the thymic medulla is under the control of mature T cellsQ42769057
Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular inputQ43809296
Regulation of RAG-1 and CD69 expression in the thymus during positive and negative selectionQ44072201
Thymus-specific serine protease regulates positive selection of a subset of CD4+ thymocytesQ46089880
Continued maturation of thymic emigrants in the peripheryQ48022294
Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells.Q50766532
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.Q51949099
Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells.Q51972426
Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells.Q52010433
Thymic overexpression of CD40 ligand disrupts normal thymic epithelial organization.Q52523664
Mesenchymal cells regulate retinoic acid receptor-dependent cortical thymic epithelial cell homeostasis.Q53174108
Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance.Q53253030
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.Q53453365
Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.Q54380933
Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin.Q54558035
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)5519-5526
P577publication date2012-11-14
P1433published inJournal of ImmunologyQ3521441
P1476titleDevelopmentally regulated availability of RANKL and CD40 ligand reveals distinct mechanisms of fetal and adult cross-talk in the thymus medulla
P478volume189

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