Thymic stromal cell subsets for T cell development

scientific article published on 29 January 2016

Thymic stromal cell subsets for T cell development is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S00018-015-2107-8
P698PubMed publication ID26825337

P2093author name stringHarumi Suzuki
Takeshi Nitta
P2860cites workCloning of a novel MHC-encoded serine peptidase highly expressed by cortical epithelial cells of the thymusQ22010693
Aire's partners in the molecular control of immunological toleranceQ24296286
New member of the winged-helix protein family disrupted in mouse and rat nude mutationsQ24308068
An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domainsQ24313206
Essential role for ZAP-70 in both positive and negative selection of thymocytesQ24321424
Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymusQ24597291
Six-of-the-best: unique contributions of γδ T cells to immunologyQ27010451
Antigen recognition by autoreactive CD4⁺ thymocytes drives homeostasis of the thymic medullaQ27324446
Regulation of CD8+ T cell development by thymus-specific proteasomesQ28116400
Positional cloning of the APECED geneQ28116470
Aire deficient mice develop multiple features of APECED phenotype and show altered immune responseQ28202432
Projection of an immunological self shadow within the thymus by the aire proteinQ28207164
Aire regulates negative selection of organ-specific T cellsQ28213185
Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymusQ28268867
p63 Is essential for the proliferative potential of stem cells in stratified epitheliaQ28300720
Thymic selection determines gammadelta T cell effector fate: antigen-naive cells make interleukin-17 and antigen-experienced cells make interferon gammaQ28386704
CCR7-mediated migration in the thymus controls γδ T-cell developmentQ60709836
FOXN1 mutation abrogates prenatal T-cell development in humansQ61696152
A Unique Thymic Fibroblast Population Revealed by the Monoclonal Antibody MTS-15Q62078522
Autoantigen-Specific Interactions with CD4+ Thymocytes Control Mature Medullary Thymic Epithelial Cell CellularityQ63190413
Disorganization and restoration of thymic medullary epithelial cells in T cell receptor-negative scid mice: evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironmentQ70212975
Differential expression of Mtv loci in MHC class II-positive thymic stromal cellsQ72404605
Thymic cortical epithelium is sufficient for the development of mature T cells in relB-deficient miceQ73128606
In vitro negative selection of viral superantigen-reactive thymocytes by thymic dendritic cellsQ73686482
Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymusQ74754504
Stromal cells provide the matrix for migration of early lymphoid progenitors through the thymic cortexQ78346775
Expression of Dll4 and CCL25 in Foxn1-negative epithelial cells in the post-natal thymusQ79421810
Lymphotoxin pathway-directed, autoimmune regulator-independent central tolerance to arthritogenic collagenQ79754995
Generalized multi-organ autoimmunity in CCR7-deficient miceQ79784858
Thymic alterations in EphA4-deficient miceQ79834573
Severe defect in thymic development in an insertional mutant mouse modelQ80087990
Lymphotoxin beta receptor is required for the migration and selection of autoreactive T cells in thymic medullaQ80139452
The autoimmune regulator directly controls the expression of genes critical for thymic epithelial functionQ80358531
Expression of a natural tumor antigen by thymic epithelial cells impairs the tumor-protective CD4+ T-cell repertoireQ80385175
Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient miceQ81377810
Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-toleranceQ82878815
Checkpoints in the development of thymic cortical epithelial cellsQ83088896
Intermediate expression of CCRL1 reveals novel subpopulations of medullary thymic epithelial cells that emerge in the postnatal thymusQ87458791
Journey through the thymus: stromal guides for T-cell development and selectionQ36402237
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levelsQ36402949
Developmental regulation of Foxp3 expression during ontogeny.Q36403564
Thymus-blood protein interactions are highly effective in negative selection and regulatory T cell inductionQ36426341
Immune tolerance. Regulatory T cells generated early in life play a distinct role in maintaining self-toleranceQ36455565
A two-step process for thymic regulatory T cell development.Q36470183
Thymic nurse cells provide microenvironment for secondary T cell receptor α rearrangement in cortical thymocytes.Q36483791
Murine thymic selection quantified using a unique method to capture deleted T cellsQ36712531
IRF7-dependent IFN-β production in response to RANKL promotes medullary thymic epithelial cell developmentQ36718149
On the road: progress in finding the unique pathway of invariant NKT cell differentiationQ36736609
TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T cellsQ36737068
Aire deficiency promotes TRP-1-specific immune rejection of melanomaQ36745323
The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte developmentQ36750060
Cbx4 regulates the proliferation of thymic epithelial cells and thymus functionQ28504649
NKT cells derive from double-positive thymocytes that are positively selected by CD1dQ28508188
Regulatory T cell lineage specification by the forkhead transcription factor foxp3Q28510328
Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytesQ28512316
Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal gammadelta T cellsQ28584831
Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-toleranceQ28585306
Skint-1 identifies a common molecular mechanism for the development of interferon-γ-secreting versus interleukin-17-secreting γδ T cellsQ28587448
Dependence of self-tolerance on TRAF6-directed development of thymic stromaQ28590193
Normal thymic architecture and negative selection are associated with Aire expression, the gene defective in the autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)Q28590962
A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivoQ28592009
Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigrationQ28592508
Skint-1 is a highly specific, unique selecting component for epidermal T cellsQ28592602
Expression of relB is required for the development of thymic medulla and dendritic cellsQ28594949
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymusQ28613227
FOXP3+ regulatory T cells in the human immune systemQ29307487
Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)Q29391777
Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1Q29619644
Regulatory T cells: mechanisms of differentiation and functionQ29620731
CXCR4 acts as a costimulator during thymic beta-selectionQ30435358
Dynamics of thymocyte-stromal cell interactions visualized by two-photon microscopy.Q32127240
Regulation of thymocyte positive selection and motility by GIT2.Q33568538
Enhancement of an anti-tumor immune response by transient blockade of central T cell toleranceQ33569842
Differential developmental requirement and peripheral regulation for dermal Vγ4 and Vγ6T17 cells in health and inflammationQ33797349
The ability to rearrange dual TCRs enhances positive selection, leading to increased Allo- and Autoreactive T cell repertoires.Q33992446
Questionable thymic nurse cellQ34010379
Autonomous role of medullary thymic epithelial cells in central CD4(+) T cell toleranceQ34112986
"Promiscuous" expression of tissue antigens in the thymus: a key to T-cell tolerance and autoimmunity?Q34119793
Antigen processing by the proteasomeQ34193262
Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymusQ34247810
Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-kappa B/Rel familyQ34317095
Novel process of intrathymic tumor-immune tolerance through CCR2-mediated recruitment of Sirpα+ dendritic cells: a murine model.Q34345734
Foxp3 transcription factor is proapoptotic and lethal to developing regulatory T cells unless counterbalanced by cytokine survival signalsQ34349363
Thymus-specific serine protease contributes to the diversification of the functional endogenous CD4 T cell receptor repertoireQ34501485
Limitation of immune tolerance-inducing thymic epithelial cell development by Spi-B-mediated negative feedback regulationQ34533105
Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stroma.Q54380933
Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin.Q54558035
Thymic nurse cells--Ia-bearing epithelium involved in T-lymphocyte differentiation?Q54659497
Autoimmune regulator is expressed in the cells regulating immune tolerance in thymus medulla.Q55032978
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.Q55035366
Functional evidence for a single endodermal origin for the thymic epithelium.Q55038358
The cellular mechanism of Aire control of T cell tolerance.Q55041159
IMMUNOLOGICAL FUNCTION OF THE THYMUSQ56623510
Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for toleranceQ56701390
RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouseQ57161977
Aire-dependent thymic development of tumor-associated regulatory T cellsQ36754190
Thymoproteasome subunit-β5T generates peptide-MHC complexes specialized for positive selectionQ36799097
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptorQ36825857
MicroRNAs control the maintenance of thymic epithelia and their competence for T lineage commitment and thymocyte selectionQ36911011
Aire-expressing thymic medullary epithelial cells originate from β5t-expressing progenitor cellsQ36932226
Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.Q36946535
Clonal deletion of thymocytes can occur in the cortex with no involvement of the medullaQ36946557
The variable immunological self: genetic variation and nongenetic noise in Aire-regulated transcriptionQ36949002
Generating intrathymic microenvironments to establish T-cell tolerance.Q36997113
Signal integration and crosstalk during thymocyte migration and emigrationQ37010225
Thymus development and functionQ37134900
Overlapping gene coexpression patterns in human medullary thymic epithelial cells generate self-antigen diversityQ37173204
Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiationQ37181662
Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell populationQ37288027
Lymphotoxin signals from positively selected thymocytes regulate the terminal differentiation of medullary thymic epithelial cellsQ37303952
The lymphotoxin pathway regulates Aire-independent expression of ectopic genes and chemokines in thymic stromal cellsQ37382924
CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigensQ37386006
TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial developmentQ37421214
Thymic medullary epithelium and thymocyte self-tolerance require cooperation between CD28-CD80/86 and CD40-CD40L costimulatory pathwaysQ37501186
An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcriptionQ37544045
The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors.Q37552560
An essential role for medullary thymic epithelial cells during the intrathymic development of invariant NKT cellsQ37627734
Generation of both cortical and Aire(+) medullary thymic epithelial compartments from CD205(+) progenitorsQ37650757
Role of thymic cortex-specific self-peptides in positive selection of T cellsQ37761466
The role of the proteasome in the generation of MHC class I ligands and immune responsesQ37851052
Thymic epithelial cells: working class heroes for T cell development and repertoire selectionQ38010575
The transcriptional regulator Aire coopts the repressive ATF7ip-MBD1 complex for the induction of immunotolerance.Q38309456
Clonal deletion of thymocytes by circulating dendritic cells homing to the thymusQ38466522
Autoimmune regulator (Aire) controls the expression of microRNAs in medullary thymic epithelial cellsQ39299541
Synergistic, context-dependent, and hierarchical functions of epithelial components in thymic microenvironmentsQ39634242
Stabilized beta-catenin in thymic epithelial cells blocks thymus development and functionQ39881038
Intercellular MHC transfer between thymic epithelial and dendritic cellsQ39992060
Expression of tumor-associated differentiation antigens, MUC1 glycoforms and CEA, in human thymic epithelial cells: implications for self-tolerance and tumor therapyQ40222466
Osteoprotegerin-Mediated Homeostasis of Rank+ Thymic Epithelial Cells Does Not Limit Foxp3+ Regulatory T Cell Development.Q40646125
The thymic microenvironment.Q40769611
Thymocytes and RelB-dependent medullary epithelial cells provide growth-promoting and organization signals, respectively, to thymic medullary stromal cellsQ41107405
CCRL1/ACKR4 is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult miceQ41592760
Thymic nurse cells. Lymphoepithelial cell complexes in murine thymuses: morphological and serological characterizationQ41612029
RANK signals from CD4(+)3(-) inducer cells regulate development of Aire-expressing epithelial cells in the thymic medullaQ41868543
Thymic self-reactivity selects natural interleukin 17-producing T cells that can regulate peripheral inflammationQ41889460
Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cellsQ34576335
Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell developmentQ34577749
Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epitheliaQ34590391
Serial progression of cortical and medullary thymic epithelial microenvironmentsQ34617656
Gammadelta T cells: functional plasticity and heterogeneityQ34659133
Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in miceQ34876029
Neural crest-derived pericytes promote egress of mature thymocytes at the corticomedullary junctionQ35022130
NF-kappaB2 is required for the establishment of central tolerance through an Aire-dependent pathwayQ35070399
Lysosomal cysteine proteases regulate antigen presentationQ35140806
The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector functionQ35143413
IL-7 coordinates proliferation, differentiation and Tcra recombination during thymocyte β-selection.Q35202373
The requirements for natural Th17 cell development are distinct from those of conventional Th17 cellsQ35441515
Early T lineage progenitors: new insights, but old questions remainQ35591526
The thymic cortical epithelium determines the TCR repertoire of IL-17-producing γδT cells.Q35595498
Aire unleashes stalled RNA polymerase to induce ectopic gene expression in thymic epithelial cellsQ35673793
NF-kappaB2 is required for the control of autoimmunity by regulating the development of medullary thymic epithelial cellsQ35740901
Regenerative capacity of adult cortical thymic epithelial cellsQ35807736
Selection of the T-cell repertoire: receptor-controlled checkpoints in T-cell developmentQ35832518
Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central toleranceQ35861549
DeltaNp63 regulates thymic development through enhanced expression of FgfR2 and Jag2.Q35901203
Rank signaling links the development of invariant γδ T cell progenitors and Aire(+) medullary epitheliumQ36011240
Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T cellsQ36018570
A role for the IkappaB family member Bcl-3 in the control of central immunologic toleranceQ36025311
Natural Th17 cells are critically regulated by functional medullary thymic microenvironments.Q36062664
Controlling the thymic microenvironment.Q36070692
Heterogeneity of thymic dendritic cellsQ36157476
Contrasting models of promiscuous gene expression by thymic epitheliumQ36176868
Proliferative arrest and rapid turnover of thymic epithelial cells expressing AireQ36229072
Thymic emigration revisitedQ36229138
Early progression of thymocytes along the CD4/CD8 developmental pathway is regulated by a subset of thymic epithelial cells expressing transforming growth factor betaQ36363101
Cathepsin L regulates CD4+ T cell selection independently of its effect on invariant chain: a role in the generation of positively selecting peptide ligandsQ36370268
Thymic medullary epithelial cell differentiation, thymocyte emigration, and the control of autoimmunity require lympho-epithelial cross talk via LTbetaR.Q36371648
Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentationQ36399298
Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.Q36399327
Delta-like 4 is indispensable in thymic environment specific for T cell developmentQ42277361
The thymic medulla: a unique microenvironment for intercellular self-antigen transferQ42572856
Growth of epithelial cells in the thymic medulla is under the control of mature T cellsQ42769057
Lymphoid development in mice congenitally lacking T cell receptor alpha beta-expressing cellsQ42806482
Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice.Q42809389
An evolutionarily conserved mutual interdependence between Aire and microRNAs in promiscuous gene expressionQ42923236
Thymic T cell development and progenitor localization depend on CCR7.Q42971206
CCR7 signals are essential for cortex-medulla migration of developing thymocytes.Q42971212
CCX-CKR deficiency alters thymic stroma impairing thymocyte development and promoting autoimmunityQ43453611
Absence of thymus crosstalk in the fetus does not preclude hematopoietic induction of a functional thymus in the adultQ43571237
Sequential phases in the development of Aire-expressing medullary thymic epithelial cells involve distinct cellular inputQ43809296
Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes.Q43967840
Clonal analysis reveals a common progenitor for thymic cortical and medullary epitheliumQ44781101
A regulatory role for TGF-β signaling in the establishment and function of the thymic medullaQ44996730
Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells.Q45745937
Human thymic stromal lymphopoietin promotes dendritic cell-mediated CD4+ T cell homeostatic expansion.Q45955592
Thymus-specific serine protease regulates positive selection of a subset of CD4+ thymocytesQ46089880
CCR7 directs the migration of thymocytes into the thymic medullaQ46102908
Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphateQ46494392
Development of interleukin-17-producing γδ T cells is restricted to a functional embryonic waveQ46618556
Calcium oscillations regulate thymocyte motility during positive selection in the three-dimensional thymic environmentQ46769839
CCR7-dependent cortex-to-medulla migration of positively selected thymocytes is essential for establishing central toleranceQ46941016
The MHC class I ligand-generating system: roles of immunoproteasomes and the interferon-gamma-inducible proteasome activator PA28.Q47700046
Differential Features of AIRE-Induced and AIRE-Independent Promiscuous Gene Expression in Thymic Epithelial CellsQ48180343
Cutting edge: the chemokine receptor CXCR3 retains invariant NK T cells in the thymusQ49129693
Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice.Q50493740
αPIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes.Q50683226
Thymocyte selection regulates the homeostasis of IL-7-expressing thymic cortical epithelial cells in vivo.Q50883531
IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes.Q50981594
Critical Role for CXCR4 Signaling in Progenitor Localization and T Cell Differentiation in the Postnatal ThymusQ51016385
Lymphotoxin β receptor regulates the development of CCL21-expressing subset of postnatal medullary thymic epithelial cells.Q51068690
Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes.Q51127244
Three-dimensional visualization of the mouse thymus organization in health and immunodeficiency.Q51286881
Exclusive expression of proteasome subunit {beta}5t in the human thymic cortex.Q51766517
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.Q51949099
Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells.Q51972426
CCR7 deficiency causes ectopic lymphoid neogenesis and disturbed mucosal tissue integrity.Q51978848
Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation.Q51993917
Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells.Q52010433
Formation of a functional thymus initiated by a postnatal epithelial progenitor cell.Q52014296
Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T cell development.Q52086717
NF-kappa B-inducing kinase establishes self-tolerance in a thymic stroma-dependent manner.Q52093900
Inhibition of gamma delta T cell development and early thymocyte maturation in IL-7 -/- mice.Q52199817
Two genetically separable steps in the differentiation of thymic epithelium.Q52201522
Stat3 in thymic epithelial cells is essential for postnatal maintenance of thymic architecture and thymocyte survival.Q52543788
Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program.Q53067111
Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t.Q53255947
Thymoproteasome shapes immunocompetent repertoire of CD8+ T cells.Q53350619
The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.Q53453365
Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells.Q54067406
P433issue5
P304page(s)1021-1037
P577publication date2016-01-29
P1433published inCellular and Molecular Life SciencesQ5058352
P1476titleThymic stromal cell subsets for T cell development
P478volume73